Modern approaches to the treatment of bacterial vaginosis and mixed nonspecific vaginitis

2017 ◽  
pp. 89-95
Author(s):  
O.V. Golyanovsky ◽  
◽  
V.V. Mehedko ◽  
M.A. Budchenko ◽  
◽  
...  
Keyword(s):  
Bacterial Vaginosis ◽  
Standard Treatment ◽  
Main Group ◽  
Reproductive Age ◽  
Control Group ◽  
Complete Disappearance ◽  
Complete Elimination ◽  
Women Of Reproductive Age ◽  
High Effectiveness ◽  
Treatment Regimens

The objective: to evaluate the effectiveness of treatment of women with various dysbiotic vaginal conditions with Limenda. Materials and methods. 58 women of reproductive age with BV and mixed nonspecific vaginitis participated in the study. The main group included 30 women, whose treatment was carried out with Limenda drug. The control group consisted of 28 women, whose treatment was performed according to the standard scheme using a combination of drugs. Results. Based on the results of control tests, complete elimination of pathogens occurred in 29 (96.67%) patients of the main group and in 26 (92.86%) patients of the control group. Five days after the treatment, all 30 (100%) women in the main group noted complete disappearance of symptoms on the control visit, and 2 (7.14%) of the control group complained of minor discomfort in the vagina, which required continued treatment. The conclusion. For the treatment of nonspecific vaginitis and bacterial vaginosis, especially chronic and often recurrent forms, it is better to use combined local remedies. The results of this study reliably testify to the high effectiveness of the combined drug Limenda compared with standard treatment regimens. Key words: vaginitis, bacterial vaginosis, vaginal biocenosis, conditional resistance, metronidazole, miconazole, Limenda.

scholarly journals Analysis of leech therapy effects in patients with chronic apical periodontitis

2020 ◽  
pp. 83-85
Author(s):  
AI Abdullaeva ◽  
AG Prityko ◽  
PA Voronin ◽  
EG Mikhailova
Keyword(s):  
Standard Treatment ◽  
Main Group ◽  
Apical Periodontitis ◽  
Control Group ◽  
Gingival Index ◽  
Treatment Regimens ◽  
Pain Scores ◽  
Study Participants ◽  
Positive Effect ◽  
Novel Therapeutic

Chronic apical periodontitis (CAP) is characterized by tissue inflammation around the tooth tip. Unstable outcomes of current treatments against CAP dictate the need for novel therapeutic techniques and medications. The aim of this study was to analyzed the effects of hirudotherapy on the treatment course in patients with CAP. Forty-one study participants aged 25 to 40 years were divided into the main group (20 patients) and the control group (21 patients). Pain level and the gingival index (GI) were measured in all study participants. During the first visit, pain scores did not differ significantly between the control (5.81 ± 0.65) and the main (5.75 ± 0.92) groups. During the second visit, pain was almost unnoticeable in the main group patients (1.05 ± 0.34), whereas pain scores were higher in the control group (4.10 ± 0.7). Our findings suggest a positive effect of hirudotherapy used in combination with standard treatment regimens.

scholarly journals Characteristics of phenotypes (clinical variants) of polycystic ovary syndrome in women of reproductive age

2021 ◽  
Vol 2 ◽  
pp. 27-31
Author(s):  
V.G. Syusyuka ◽  
M.Y. Sergienko ◽  
G.I. Makurina ◽  
O.A. Yershova ◽  
A.S. Chornenka
Keyword(s):  
Polycystic Ovary ◽  
Free Testosterone ◽  
Main Group ◽  
Reproductive Age ◽  
Control Group ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome ◽  
Comprehensive Examination ◽  
Clinical Variants ◽  
Research Show

The objective: on the basis of a comprehensive examination of women of reproductive age to establish the frequency of phenotypes (clinical variants) of polycystic ovary syndrome (PCOS).Materials and methods. 34 patients (main group) who complained of menstrual disorders and/or dermatopathies by recommendation of a dermatologist were examined. The control group is represented by 30 women without gynecological and somatic pathology. The mean age of women in the main group was 26,4±0,9 years and 29,1±0,9 years in the control group (p>0,05). The age of women in the study groups ranged from 18 to 35 years. Patients underwent a comprehensive examination to assess the severity of hirsutism and the severity of acne, as well as the body mass index was determined. All women underwent ultrasound examination in the dynamics and quantitative assessment of the concentration of hormones in the blood plasma, namely cortisol, thyroid-stimulating hormone, prolactin, free testosterone and its index, androstenedione, dehydroepiandrosterone sulfate, 17-α-OH-progesterone, sex hormone binding globulin. Variation-statistical processing of the results was carried out using the program «STATISTICA 13».Results. The results of the conducted research show that 73,5% had menstrual irregularities, and 52,9% – infertility. Acne and hirsutism in every 3rd woman were combined and were diagnosed in 47,1% and 41,2% of women, respectively. Ultrasound signs of polycystic ovaries were found in 94,1% of patients according to the criteria for the diagnosis of PCOS, and in 88,2% – anovulation. According to the laboratory examination, hyperadrogenism was found in 55,9%, which is confirmed by statistically significant (p<0,05) predominance in the main group compared with the control group of androstenedione, free testosterone and its index. In addition, it should be noted statistically significant (p<0,05) higher levels of 17-α-OH-progesterone and prolactin in the main group, but their indicators were within the reference values of the norm. Analyzing the frequency of phenotypes (clinical variants) of PCOS, it was found that phenotype A (classical) occurred in 32,4%. Phenotype B (incomplete classical) was diagnosed in 14,7%, and phenotype C (ovulatory) – only 8,8%. The most often, namely in 15 (44,1%) women with PCOS, the phenotype D (non-androgenic) was established.Conclusions. The results of the conducted research show that in women with PCOS clinical symptoms are characterized by menstrual dysfunction (73,5%), infertility (52,9%) and dermatopathies, namely acne (47,1%) and hirsutism (41,2%). According to the laboratory exanination, hyperadrogenism was found in 55,9%, which is confirmed by statistically significant (p<0,05) predominance in the main group compared with the control group of androstenedione, free testosterone and its index. Among the clinical variants of PCOS, the non-androgenic phenotype (phenotype D) was the most often diagnosed, the frequency of it was 44,1%. Classical (phenotype A) and incomplete classical (phenotype B) were found in 32,4% and 14,7%, respectively. It should be noted that only 8,8% of women with PCOS are diagnosed with phenotype C (ovulatory).

scholarly journals Clinical considerations for the management of psoriasis in women with disorders of the menstrual cycle

2021 ◽  
Vol 11 (9) ◽  
pp. 816-827
Author(s):  
Olga Dyulmesova-Bilash
Keyword(s):  
Social Status ◽  
Standard Treatment ◽  
Main Group ◽  
Reproductive Age ◽  
Control Group ◽  
Study Group ◽  
Hormonal Changes ◽  
Dry Extract ◽  
Menstrual Irregularities ◽  
Psoriasis Therapy

Introduction. Psoriasis in women of reproductive age is one of the most pressing medical and social problems. The consequence of psoriasis disease is a significant decrease in the quality of life, disability of patients, difficulties in creating a family and deterioration of family relations, significant psychological discomfort. Objective of the study: to increase the effectiveness of treatment of women with psoriasis with menstrual irregularities by means of pathogenetically substantiated therapy based on the study of hormonal changes. Materials and research methods. The study included 130 women who were divided into three groups: the main group – 75 women with psoriasis with menstrual irregularities, who were randomized into 3 subgroups: 1a – 25 patients who will receive standard psoriasis therapy; 1b – 25 patients, in addition to the standard treatment of psoriasis, will receive gestagens for 3 months; 1c – 25 patients, in addition to the standard treatment of psoriasis, will receive a preparation of an dry extract of herb of creeping anchors for 3 months. The comparison group consisted of 25 women with psoriasis without hormonal disorders, comparable in age and social status with the study group. The control group – 30 apparently healthy women, comparable in age and social status with the study group. Research results. In patients of the main group who received standard psoriasis therapy (1a); who received progestogens for 3 months in addition to standard psoriasis treatment (1b) and, in addition to the standard treatment of psoriasis, who received the preparation of an dry extract of herb of anchors creeping for 3 months (1c), before the start of the treatment, the ratio of LH / FSH – luteinizing hormone (LH) and follicle-stimulating hormone (FSH) was below normal, which indicates a certain deficit in LH production relative to FSH values. In parallel, in these cohorts, the production of prolactin was increased, which suppresses the formation of FSH and LH in the pituitary gland. Changes in the production of gonadotropic hormones are a reaction to the existing deficiency or excess of sex hormones. In the main 1a, 1b and 1c in groups, estradiol values ​​were within the normal range with progesterone deficiency in the luteal phase. The testosterone value in all study groups did not deviate from the standard values. Conclusions. The obtained results of the survey indicate the need to increase the effectiveness of treatment of women with psoriasis with menstrual irregularities by involving measures aimed at correcting hormonal status in complex therapy.

Clinical experience of non-hormonal correction of the luteal phase deficiency in women of reproductive age

2019 ◽  
pp. 24-26
Author(s):  
T.R. Streltsova ◽  
◽  
N.R. Simonov ◽  
Keyword(s):  
Menstrual Cycle ◽  
Blood Loss ◽  
Luteal Phase ◽  
Main Group ◽  
Reproductive Age ◽  
Control Group ◽  
Second Phase ◽  
Menstrual Disorders ◽  
Women Of Reproductive Age ◽  
Cycle Disorders

The objective: to study the clinical efficacy of two schemes of using the monocomponent herbal preparation Cyclodynon® in women of reproductive age with complaints of various menstrual cycle disorders diagnosed with latent hyperprolactinemia and second phase failure of the menstrual cycle based on the results of clinical and hormonal studies. Materials and methods. The study included 60 patients aged 25–38 years suffering from PMS. The main group (n = 30) received Cyclodynon® in an ascending pattern: from 1 to the 14th day of the menstrual cycle – 40 drops 1 time a day and from the 15th day to the end of the cycle – 40 drops 2 times a day. The control group (n = 30) – 40 drops 1 time per day until the end of the cycle for three menstrual cycles. Results. After 3 months in the main group there was a more significant decrease in the level of prolactin (from 28.3 to 18.4 ng / ml) as compared with the control (from 27.8 to 23.1 ng / ml). Increased progesterone and estradiol production was also more significantly observed in the main group. The dynamics of normalization of the duration of the menstrual cycle and the volume of blood loss was also more significant in the main group and amounted to 93.3%. Conclusion. The use of an increasing treatment regimen with Cyclodynon® in women with a luteal phase deficiency on the background of hyperprolactinemia has advantages over the use of a standard continuous regimen with respect to a more rapid normalization of hormonal homeostasis, the duration of the menstrual cycle and blood loss. Key words: luteal phase deficiency, hyperprolactinemia, menstrual disorders, Cyclodynon®.

scholarly journals Clinical and Anamnestic, Immunological, Echographic, and Hysteroscopic Features of Chronic Endometritis Associated with Impaired Reproductive Function

2018 ◽  
Vol 73 (1) ◽  
pp. 5-15
Author(s):  
A. I. Ishenko ◽  
A. L. Unanyan ◽  
E. A. Kogan ◽  
T. A. Demura ◽  
J. M. Kossovich
Keyword(s):  
Immunohistochemical Analysis ◽  
Reproductive Technologies ◽  
Main Group ◽  
Reproductive Age ◽  
High Expression ◽  
Control Group ◽  
Women Of Reproductive Age ◽  
Chronic Endometritis ◽  
Infertile Women ◽  
Subgroup Ii

Background: The widespread prevalence of infertility, the low effectiveness of assisted reproductive technologies (ART), and the high incidence of chronic endometritis (CE) in infertile women determine the relevance of the considered problem. The aim of the study was to determine the clinical and anamnestic, laboratory, and instrumental features of CE associated with infertility and unsuccessful IVF cycles in women of reproductive age. Materials and methods: The study enrollred 150 women of reproductive age with morphologically established CE (main group, n=120) and without CE (control group, n=30). A subgroup I of the main group included 64 patients with infertility and IVF failures, a subgroup II – 56 fertile women. In addition to anamnesis collection and identification of CE clinical features, all patients underwent infectious screening, immunological and immunohistochemical analysis, ultrasound examination of pelvic organs with dopplerometry, and office hysteroscopy. A comparative analysis of the data obtained from subgroups of the main group was conducted. Results: Histological study of endometrial pipelle-biopsy specimens on the 7−10th day of the cycle revealed CE in all patients of the main group. We found prevalence of mean duration of CE in the subgroup I relative to subgroup II ― 5.5±0.06 years and 2.4±0.07 years, respectively (p0.001). Infectious screening showed that 58 (90.6%) patients of the I subgroup had sterile endometrial seeding which was 16.9 times higher than in subgroup II (p0.0001). Immunological analysis determined the presence of AEAT in all patients of the subgroup I, 43 of which (67.2%) were above 265 U/ml, while 51 (91.1%) of subgroup II had no AEAT (p0.001). Immunohistochemical analysis of the endometrium on the 18th−24th day of the cycle established high expression of CD16 , CD20 , CD56 , and HLA-DRII in 58 (90.6%) patients of the subgroup I, whereas in 54 patients (96.4%) of II subgroup high expression of CD16 and CD20 with low amount of CD56- and HLA-DRII-positive cells was registered (p0.001). We determined prognostically significant clinical and anamnestic risk factors predisposing to the development of infertility in patients with CE (p0,05). We revealed certain echographic, dopplerometric, and hysteroscopic criteria of CE demonstrating the critical disruption of endometrial receptivity in infertile women. Conclusion: Most patients (90.6%) with infertility had autoimmune component of CE characterized by prolonged (more than 5 years) course, high serum level of AEAT, sterile endometrial crops, and high expression of inflammation markers CD16 , CD20 , CD56 and HLA-DRII .

Stress reactions in women with infertility, operated on the uterine appendages in a planned and urgent order

2018 ◽  
pp. 98-101
Author(s):  
A.E. Dubchak ◽  
◽  
O.V. Milevskiy ◽  
N.M. Obeid ◽  
◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Sleep Disturbances ◽  
Surgical Intervention ◽  
Well Being ◽  
Main Group ◽  
Reproductive Age ◽  
Control Group ◽  
Stress Reactions ◽  
Women Of Reproductive Age ◽  
Psychoemotional State

The objective: the study of the psychoemotional state in women with infertility, who underwent surgical treatment on the uterine appendages in the planned and urgent order. Materials and methods. 120 women of reproductive age with a tubal peritoneal factor of infertility and benign ovarian formations, an ectopic pregnancy, who underwent organ-preserving surgical intervention on the uterine appendages (the main group) were examined. Planned surgical treatment was performed in 76 (63.7%) of the examined main group (group 1); In urgent order, 44 (36.7%) patients of the main group (the second group) underwent surgical treatment. Depending on the access, laparoscopy (LP) with the use of monopolar or bipolar electrosurgery was performed in 54 women of the 1st group and in 24 patients of the 2nd group, and laparotomy (LT) in 22 patients of the 1st group and in 20 patients - 2 nd group. The control group included 20 patients with reproductive function without infertility (3rd group). Twenty women of reproductive age with infertility without surgery entered the comparison group (group 4). Results The article examines the effect of surgical treatment on the uterine appendages in 120 women with infertility on the psychoemotional state depending on the planned nature of the surgical intervention. Women who underwent surgical treatment in urgent order found that pronounced depression and neurotic manifestations are closely related to sleep disturbances, decreased mood, crying, irritability. Conclusion. A month after surgery, depression, anxiety, nervousness decreased, which indicates positive changes in the mental state of patients and an improvement in the state of internal comfort as a result of the recovery of somatic well-being, increased optimism and self-confidence, which is the result of cosmetic effect and organ-preserving surgical treatment. Key words: infertility, operations on the appendages of the uterus, psychoemotional state

Functional state of the vaginal mucosa in bacterial vaginosis and its correction

2017 ◽  
pp. 77-82
Author(s):  
V.O. Beyuk ◽  
◽  
O.A. Shcherba ◽  
L.D. Lastovetska ◽  
◽  
...  
Keyword(s):  
Bacterial Vaginosis ◽  
Anaerobic Bacteria ◽  
Reproductive Age ◽  
High Rate ◽  
Control Group ◽  
Vaginal Mucosa ◽  
Women Of Reproductive Age ◽  
Results Of Treatment ◽  
Group I ◽  
Group Ii

Bacterial vaginosis is the most common cause of the treatment of women of reproductive age to the gynecologist. It accounts for up to 50% of cases of pathological discharge from the genital organs. In 50-75% of cases, bacterial vaginosis is asymptomatic. The examination of the patient occupies one of the key positions in the effective treatment of the patient. Nitrosamines, which are metabolites of obligate anaerobic bacteria and coenzymes of carcinogenesis, and may be one of the cause for the genesis of cervical cancer. The objective: assess the condition of the mucous membrane of the vagina and cervix in bacterial vaginosis, the effectiveness of its treatment in women of reproductive age. Materials and methods. Оf investigation 64 women of reproductive age with bacterial vaginosis were examined and treated, of which 34 patients (group I of the study) conducted our therapy which received the Tyloron and the local combined preparation of dexpanthenol and chlorhexidine bigluconate, followed by the introduction of lactobacilli in standard doses. 30 patients (group II of the study) received standard treatment. The control group consisted of 27 healthy women. Results. Results of treatment of bacterial vaginosis in women of reproductive age are presented. In 94.1% and a group of cases, we achieved a clinically significant effect, compared with group II (76.7%) of 10 days of treatment. Three months after the end of treatment, 97.1% of the patients in the main group recovered (group II – 86.6%). Conclusions. The use of the complex therapy of bacterial vaginosis proposed by us showed a high rate of recovery, and a low rate of recurrence in women of reproductive age. Key words: bacterial vaginosis, diagnosis, treatment, tyrolon, dexpanthenol, chlorhexidine.

scholarly journals THE SPECIFICITY OF THE OVARIAN RESERVE OF WOMEN WITH CHRONIC SALPINGOOPHORITIS

2018 ◽  
Vol 25 (6) ◽  
pp. 119-126
Author(s):  
V. A. Novikova ◽  
F. R. Autleva ◽  
A. A. Sorochenko ◽  
D. I. Fayzullina ◽  
E. V. Nurgalieva
Keyword(s):  
Ovarian Reserve ◽  
Reproductive Period ◽  
Main Group ◽  
Reproductive Age ◽  
Control Group ◽  
Regression Equations ◽  
Women Of Reproductive Age ◽  
Antral Follicles ◽  
Preconception Consultation ◽  
The Impact

Aim. The research was conducted for the assessment of the impact of chronic salpingoophoritis on the ovarian reserve of women in various phases of reproductive age.Materials and methods. A prospective, controlled and open cohort study was performed in 2013-2018 (n=202). The main group consisted of women with chronic salpingoophoritis (ChrSO) who applied for preconception consultation (n=138). In accordance with the reproductive age phase, the main group was divided into subgroups: the early reproductive age period (ERP, n=44), the peak reproductive age period (PRP, n=56), the late reproductive period (LRP, n=38). The control group consisted of conditionally healthy women of reproductive age (n=64). The ovarian reserve (OR) was estimated on the basis of the serum level of antimullerian hormone (AMH), inhibin B, estradiol, follicle stimulating hormone (FSH), an ultrasoundbased assessment of the number of antral follicles (AF), and the ovarian volume. Results. The age of women ranged from 18 to 40 years. Based on the discriminant analysis, it was found that the main indicators determining the specificity of the OR in ChrSO, depending on the phase of reproductive age, are the number of antral follicles, estradiol level and AMH (Wilks’ lambda = 0.35503, p<0.0001). The specificity of the OR of women with ChrSO (difference from the control group), regardless of the phase of reproductive age, initially and when evaluated after 6 months, is determined by the number of AF and the level of estradiol and AMH; the number of AF and AMH is determined with a similar estimate after 12 months. The specificity of the OR in ChrSO, which is dependent on the reproductive age phase, has been proved through the analysis with the neural networks training(the proportion of correct answers is more than 80%). The linear relationships were established between the values of each OR parameter in women with ChrSO. Initially, when estimating after 6 and 12 months, linear regression equations were calculated, allowing the values of individual OR parameters to be calculated over 6 and 12 months.Conclusion. Chronic salpingoophoritis (ChrSO) is associated with a decrease in ovarian reserve in women of reproductive age. The effect of ChrSO on some parameters of the ovarian reserve depends on the age phase of the reproductive period, which increases with time (after 6, 12 months). The presence of ChrSO in women planning future pregnancies requires preventive and therapeutic measures aimed at preserving the ovarian reserve and the preferred implementation of fertility in early reproductive age before the ovarian reserve starts to decline.

scholarly journals VULVOVAGINAL CANDIDIASIS IN COMBINATION WITH BACTERIAL VAGINOSIS IN WOMEN OF REPRODUCTIVE AGE: FEATURES OF PATHOGENESIS AND TREATMENT

2021 ◽  
pp. 12-17
Author(s):  
Svitlana Pandei ◽  
Dmytro Ledin ◽  
Oleksandra Lubkovska
Keyword(s):  
Bacterial Vaginosis ◽  
Adhesion Molecules ◽  
Vulvovaginal Candidiasis ◽  
Reproductive Age ◽  
Control Group ◽  
Women Of Reproductive Age ◽  
Combination Drug ◽  
Group I ◽  
Tnf Α ◽  
Topical Metronidazole

The aim. Reducing the recurrence of vulvovaginal candidiasis (VVC) in combination with bacterial vaginosis (BV) in women of reproductive age by studying the pathogenesis and improving the algorithm of treatment and prevention measures. Materials and methods. During the study, 150 women of reproductive age who had the same clinical manifestations of VVC and BV were selected and divided into 3 groups of 50 women: Group I was treated with an antimicrobial combination drug (miconazole with topical metronidazole), group II – the same drug in combination with probiotic (lactobacilli) in candles, group III – according to the algorithm improved by the authors. In addition, a control group was formed, which included healthy women of reproductive age.  To establish the pathogenesis of VVC in combination with BV in the studied women, the concentration of cytokines and adhesion molecules in the blood before and after treatment was determined and compared with the control group. The clinical effect of different treatments was assessed at 3, 7, 10, 14 days, and the presence of relapses – 1, 3, 6 months after treatment. Results. The occurrence of a combination of VVC and BV in women of reproductive age is accompanied by a significant increase in the level of intercellular adhesion molecules (ICAM-1) and vascular cell adhesion molecules (VCAM-1) along with a statistically significant increase in proinflammatory cytokines (interleukin-6) (IL-6), interleukin-8 (IL-8)) and tumor necrosis factor (TNF) - TNF-α. As a result of the application of the algorithm improved by the authors, higher clinical efficiency and the ability to avoid recurrence of VVC in combination with BV in women of reproductive age were obtained. Conclusions. The authors' substantiated improvement of the algorithm of VVC treatment in combination with BV in women of reproductive age makes it possible to reduce the frequency of their recurrence and restore the biocenosis of the vagina to normal. In the case of this pathology there is an increase in the level of pro-inflammatory cytokines (IL-6, IL-8), TNF-α and ICAM-1 and VCAM-1.

Microecosystem of the vagina of women of reproducible age and methods of their correction

2017 ◽  
pp. 44-50
Author(s):  
V.A. Benyuk ◽  
◽  
A.A. Shcherba ◽  
Keyword(s):  
Bacterial Vaginosis ◽  
Anaerobic Bacteria ◽  
Reproductive Age ◽  
Control Group ◽  
Women Of Reproductive Age ◽  
Results Of Treatment ◽  
Group I ◽  
Metabolic Products ◽  
Group Ii ◽  
Clinically Significant

The frequency of bacterial vaginosis (BV) ranges from 12 to 64% among diseases of the female body and in many respects depends on the contingent of the women being examined. Nitrosamines,the metabolic products of obligatory anaerobic bacteria, are coenzymes of carcinogenesis and can be one of the causes of the development of cervical cancer. The objective: is to evaluate the efficacy of bacterial vaginosis in women of reproductive age. Patients and methods. Of study 64 women of reproductive age with BV were examined and treated, which 34 patients (group I study) conducted our therapy with tinidazole and the local preparation Lactagel. 30 patients (group II) received standard treatment. The control group consisted of 27 healthy women. Results. The article presents the results of treatment of BV in women of reproductive age. In 94.1% of cases we’ve achieved a clinically significant effect in compared to Group II (76.7%) after 10 days of treatment. Three months after the end of treatment, recovery occurred in 97.1% of the patients in the main group (Group II – 86.6%). Conclusions. The application of the complex bacterial vaginosis treatment offered by us showed a high recovery rate and a low rate of relapse in women of reproductive age. Key words: bacterial vaginosis, diagnosis, treatment, Lactagel.

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