Clinical and statistical analysis of the characteristics of women’s reproductive health in repeated unsuccessful attempts at IVF

The objective: to conduct a clinical and statistical analysis of the characteristics of the somatic and reproductive history in women with repeated unsuccessful attempts of assisted reproductive technologies and to determine significant medical and social factors in the formation of chronic endometritis. Materials and methods. A clinical and statistical analysis of 177 outpatient cards was carried out: Group I – 127 women under the age of 45 with a history of two or more ineffective attempts at in vitro fertilization; Group II – there were 50 healthy women without reproductive disorders. The comprehensive examination included data from anamnesis, general clinical and gynecological examination, laboratory and instrumental methods according to the data of outpatient observation cards at the MC LLC «Isida – IVF». The diagnosis of chronic endometritis was verified by the data of the histological examination of the endometrium obtained by the pipel biopsy method on days 4 –9 of the menstrual cycle. Results. The incidence of inflammatory diseases of the uterine appendages in patients of group I was 47.2%, inflammatory diseases of the endometrium – 41.7%; р1.2<0.01. The incidence of acute endometritis among patients of group I was 6.3%; р1.2>0.05 and was due to the implementation of the infectious process after abortion. In the first group, sexually transmitted infections were noted in 67.7% of patients, р1.2>0.05; bacterial vaginosis was recorded 1.5 times more often – 28.4%; р1.2<0.05. In the first group, one-time artificial termination of pregnancy appeared in 15.0%, twice – in 15.7% (р1.2<0.05). Laparoscopies were previously performed in 59.8% of women, laparotomies – in 62.2%, while operations were repeated in 25.4% of women. Unilateral tubectomy for ectopic pregnancy was performed in 25.4% of women, bilateral in 12.7%. Removal of fallopian tubes due to sactosalpinxes in 25.4% of women, unilateral removal of appendages appeared in patients in 3.9% of cases. The most significant risk factors for the development of chronic endometritis in the studied groups are acute post-abortion endometritis VR (relative risk) = 1.439, p=0.029 and postoperative peritonitis, which was caused by complications of appendectomy – RR=1.430, p=0.084. We did not reveal a significant effect of inflammatory diseases of the uterine appendages on the implementation of chronic endometritis (RR=45.132, CI (6.151-31.167), p=0.001. Analysis of reproductive failures as a risk factor for the development of chronic endometritis in women of group I showed a significant relative risk: with a history of PR RR=1.44, p=0.039, with repeated artifactual abortions RR=1.5, p<0.001, SV RR=1.572, p=0.001. A higher relative risk of developing XE was observed during pregnancy – RR=1.597, p=0.001. Conclusions. Clinical and statistical analysis of the reproductive health of women with repeated unsuccessful attempts at ART has shown that these women have a high frequency of intrauterine interventions, a low frequency of using alternative and safe methods of abortion, and there is no system of health measures after reproductive failures. There is a significant increase in spontaneous abortion in the early stages and the absence of a decrease in premature birth. Preserving the reproductive health of women is an important medical and social problem, the solution of which depends on the joint efforts of state and public organizations and health authorities, as well as on the responsibility of the population for their health. The development and implementation of pregravid health improvement and pregnancy planning programs for women with repeated unsuccessful attempts at ART against the background of chronic endometritis should be a priority in the health care system. Keywords: assisted reproductive technologies, chronic endometritis, ineffective attempts at fertilization, reproductive health, pregnancy.

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Does endometrioma surgery affect assisted reproductive technologies cycle outcome in patients with decreased ovarian reserve diagnosed by Bologna criteria?

Journal of Endometriosis and Pelvic Pain Disorders ◽

10.1177/22840265211012119 ◽

2021 ◽

pp. 228402652110121

Author(s):

Inci Kahyaoglu ◽

Cavidan Gülerman ◽

Nafiye Yılmaz ◽

Mehmet Ufuk Ceran ◽

Ayşe Seval Ozgu-Erdinc ◽

...

Keyword(s):

Ovarian Reserve ◽

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

Bologna Criteria ◽

Stimulation Parameters ◽

Group I ◽

Significant Difference ◽

History Of ◽

Group Ii ◽

Research And Education

Objectives: Data regarding whether the assisted reproductive technologies (ART) outcome of patients with decreased ovarian reserve (DOR) secondary to an endometrioma surgery differs from that of patients with DOR secondary to other etiologies is limited. The aim of this study was to compare the ART outcomes of DOR patients diagnosed by Bologna criteria secondary to a previous endometrioma surgery with DOR patients without a history of an endometrioma surgery. Methods: This retrospective cohort study was conducted in the assisted reproduction unit of a tertiary research and education hospital. Medical records of the patients with DOR were reviewed retrospectively. Group I included 23 cycles of DOR patients secondary to a previous endometrioma surgery and Group II consisted of 260 cycles of DOR patients without a history of endometrioma surgery. Results: No significant difference was demonstrated between groups regarding demographic features except for the age (32 (24–41) in Group I vs 35 (23–47) in Group II, p = 0.031). The data comparing the controlled ovarian stimulation parameters and ART outcomes showed similar results in both groups. No statistically significant difference was found between groups regarding pregnancy rates per transfer (23% vs 22.2 %) and per cycle (13% vs 15.4%) ( p > 0.05). Conclusion: Cycle outcomes of DOR patients secondary to an endometrioma surgery did not differ from that of DOR without an endometrioma surgery history.

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A STATISTICAL ANALYSIS OF WOMEN’S REPRODUCTIVE HEALTH CHARACTERISTICS AFTER INEFFECTIVE REATTEMPTS OF USING ART

Wiadomości Lekarskie ◽

10.36740/wlek202104124 ◽

2021 ◽

Vol 74 (4) ◽

pp. 940-947

Author(s):

Tamara H. Romanenko ◽

Anastasiia D. Haiduk ◽

Svetlana V. Turbanist

Keyword(s):

Statistical Analysis ◽

Relative Risk ◽

Reproductive Health ◽

Inflammatory Disease ◽

Medical Records ◽

Past History ◽

Chronic Endometritis ◽

Women’S Reproductive Health ◽

Women's Reproductive Health ◽

Group 1

The aim: To carry out a statistical analysis of physical and reproductive health characteristics in women after ineffective reattempts of using assisted reproductive technologies and identify significant medical and social factors contributing to the development of chronic endometritis. Materials and methods: We carried out a statistical analysis involving 177 outpatient medical records: group 1 includes 127 women aged under 45 with two or more ineffective attempts of in vitro fertilization; group 2 comprised 50 healthy women without reproductive disorders. The complete physical exam included past history, clinical and gynecologic examination, lab techniques and medical imaging according to outpatient medical records obtained during the follow-up care in Isida-IVF Medical Center LLC. Chronic endometritis was recognized by means of histologic examination of endometrium, with the samples obtained by an endometrial pipelle biopsy on day 4-9 of the menstrual cycle. Results: The prevalence of pelvic inflammatory disease in patients of group 1 comprised 47.2%, endometritis – 41.7%; p1.2 <0.01. The prevalence of acute endometritis among patients of group 1 comprised 6.3%; p1.2 >0.05 and was associated with an infection after abortion. In group 1, sexually transmitted infections were reported in 67.7% of patients, p1.2> 0.05, bacterial vaginosis was registered 1.5 times more often – 28.4%; p1.2 <0.05. In group 1, single induced abortion was reported in 15.0%, while 2 times it took place in 15.7% (p1.2 <0.05). Laparoscopies were previously performed in 59.8% of women, laparotomies – in 62.2%, while in 25.4% of women these interventions were reperformed. Unilateral salpingectomy, due to ectopic pregnancy, was performed in 25.4% of women, bilateral – in 12.7%. Fallopian tube removal, due to sactosalpinx, was performed in 25.4% of women, unilateral salpingectomy took place in 3.9% of cases. The most significant risk factors of chronic endometritis in groups studied are acute postabortal endometritis, RR (relative risk) = 1.439, p = 0.029 and postoperative peritonitis provoked by the complications of appendectomy, RR = 1.430, p = 0.084. We detected none of significant effects of pelvic inflammatory disease on the development of chronic endometritis (RR = 45.132, Confidence interval (CI) (6.151-331.167), p = 0.001). The analysis of reproductive failures, as a risk factor of chronic endometritis in women of group 1, showed a significant relative risk: with the past history of premature birth, RR = 1.44, p = 0.039, in case of reattempts of induced abortions, RR = 1.5, p<0.001, Spontaneous miscarriage RR = 1.572, p = 0.001. A higher relative risk of developing chronic endometritis was observed during pregnancy – RR = 1.597, p = 0.001. Conclusions: Statistical analysis of women’s reproductive health after ineffective reattempts of using ART revealed that the high rate of fetal interventions, low rate of alternative and safe abortion methods are registered in these women, as well as the nonavailability of any system of health measures after reproductive failures. A significant increase in miscarriage at early stages takes place, as well as the absence of a tendency for preterm labor to decrease in the rate. Maintaining women’s reproductive health is a considerable medical and social issue, whose resolving depends on joint efforts of governmental and public entities, healthcare agencies and the population responsibility for own health. Designing and adopting the program of preconception care and planning for pregnancy in women after ineffective reattempts of using ART, with chronic endometritis as a primary disease, should be the top priority area of a health care system.

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Re-imagining Reproduction: Unsettling Metaphors in the History of Imperial Science and Commercial Surrogacy in India

Somatechnics ◽

10.3366/soma.2015.0149 ◽

2015 ◽

Vol 5 (1) ◽

pp. 88-103 ◽

Cited By ~ 14

Author(s):

Kalindi Vora

Keyword(s):

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

The Body ◽

Body Parts ◽

Colonial History ◽

Women's Bodies ◽

Commercial Surrogacy ◽

Art Practices ◽

History Of ◽

Travel Industry

This paper provides an analysis of how cultural notions of the body and kinship conveyed through Western medical technologies and practices in Assisted Reproductive Technologies (ART) bring together India's colonial history and its economic development through outsourcing, globalisation and instrumentalised notions of the reproductive body in transnational commercial surrogacy. Essential to this industry is the concept of the disembodied uterus that has arisen in scientific and medical practice, which allows for the logic of the ‘gestational carrier’ as a functional role in ART practices, and therefore in transnational medical fertility travel to India. Highlighting the instrumentalisation of the uterus as an alienable component of a body and subject – and therefore of women's bodies in surrogacy – helps elucidate some of the material and political stakes that accompany the growth of the fertility travel industry in India, where histories of privilege and difference converge. I conclude that the metaphors we use to structure our understanding of bodies and body parts impact how we imagine appropriate roles for people and their bodies in ways that are still deeply entangled with imperial histories of science, and these histories shape the contemporary disparities found in access to medical and legal protections among participants in transnational surrogacy arrangements.

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Features of psychoemotional condition and stress-assosiatate hormons bioproduction in pregnant women after application of assisted reproductive technologies

HEALTH OF WOMAN ◽

10.15574/hw.2018.132.121 ◽

2018 ◽

pp. 118-121

Author(s):

L.M. Vygivska ◽

◽

I.A. Usevych ◽

I.V. Maidannyk ◽

V.F. Oleshko ◽

...

Keyword(s):

Pregnant Women ◽

Emotional State ◽

Assisted Reproductive Technologies ◽

Past History ◽

Reproductive Technologies ◽

Main Group ◽

Psychological Status ◽

Perinatal Complications ◽

History Of ◽

High Level

The article represents the results of a prospective clinical and paraclinical examination of women with a history of infertility, pregnancy in which occurred as a result of the assisted reproductive technologies application. The objective: was to study the dynamics of pregnancy features of the psycho - emotional state and the concentration of stress-associated hormones in the serum of pregnant women after the application of assisted reproductive technologies in order to improve the tactics of antenatal care and prevention of obstetric and perinatal complications. Materials and methods. The main group consisted of 80 pregnant women with endocrine infertility, in which pregnancy occurred as a result of therapeutic cycles of ART, control – 50 first-pregnant women with spontaneous fertilization, taken in an arbitrary order of clinical, statistical and laboratory and instrumental studies. In pregnant women of the study groups, in order to determine the psycho emotional state in the screening mode, a clinical interview was conducted by filling out questionnaires that contained the Spilberger test questions in modification of Y.L. Hanina and «Test of relationof pregnant» by the method of I.V. Dobryakova. In the dynamics of pregnancy, the concentration of prolactin (PRL) and cortisol (K) was determined by the enzyme immunoassay on the Reader-MSR-1000 apparatus using test systems manufactured by Hema-Medicament (Russia). Results. Pregnant women with infertility in past history were characterized by a state of chronic stress. According to the results of the Spielberger test in modification Y .L. Hanina every second pregnant of main group had a high level of reactive and every fourth personal anxiety. Almost 90.0% of pregnant women after art are characterized by the presence of pathological PKGD, among which an alarming and depressive type was registered in every sixth and twelfth pregnant woman, respectively. The obtained data are confirmed by the results of the study of the level of K and PRL. For women with a history of infertility and pregnancy, which is the result of therapeutic cycles of ART, inherent in increasing concentrations of stress-associated hormones – cortisol and prolactin, which is one of the reasons for the complicated course of pregnancy and requires reasonable pathogenetic correction. Conclusion. For women who are pregnant as a result of the use of therapeutic cycles of art characterized by a high level of personal and reactive anxiety and PKGD, which confirm the presence of neuropsychiatric and afferent disorders. Increasing the concentration of stress-associated hormones is one of the causes of complicated pregnancy and requires a reasonable pathogenetic correction. Key words: pregnancy, infertility, assisted reproductive technologies, psychological status, cortisol, prolactin.

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Clinical and statistical analysis of obstetrics and perinatal complications in singleton and multiple pregnancy after assisted reproductive technology

HEALTH OF WOMAN ◽

10.15574/hw.2020.153.67 ◽

2018 ◽

pp. 67-73

Author(s):

T.G. Romanenko ◽

◽

O.M. Sulimenko ◽

S.O. Ovcharenko ◽

◽

...

Keyword(s):

Statistical Analysis ◽

Fetal Growth ◽

Growth Retardation ◽

Assisted Reproductive Technologies ◽

Multiple Pregnancy ◽

Fetal Distress ◽

Reproductive Technologies ◽

Fetal Growth Retardation ◽

Multiple Pregnancies ◽

Perinatal Complications

The objective: conduct a comparative clinical and statistical analysis of obstetric and perinatal complications in singleton and multiple pregnancies after assisted reproductive technologies (ART) according to archival documents (pregnancy observation data and birth history) and identify features of multiple pregnancy. Materials and methods. During the period 2017–2019, 522 women gave birth in maternity hospital «Leleka» after assisted reproductive technologies, 331 women were observed in the maternity hospital «Leleka». 445 women gave birth with a singleton pregnancy and 77 with a multiple pregnancy. A clinical and statistical analysis of 150 pregnancy and childbirth histories was performed. All pregnant women were divided into two groups: Group I – 75 pregnant women with singleton pregnancies after ART; Group II – 75 pregnant women with multiple pregnancies after ART. The selection criteria for comparative clinical and statistical analysis were women whose pregnancies occurred as a result of ART, namely by in vitro fertilization (IVF) using five-day frozen embryos. Mathematical research methods were performed in accordance with the recommendations of O.P. Minzer (2013). The reliability of the cancellation of the mean pairs was calculated using the Student’s and Fisher’s criteria. Graphs were designed using the program «Microsoft Excel». Results. Complications of early pregnancy in multiple pregnancies were: anemia (47.8% vs. 22.9%; p<0.01), placental dysfunction (43.3% vs. 22.9%; p<0.01), the threat of abortion (41.8% vs. 28.6%; p<0.01). Complications of the second half of pregnancy: preeclampsia (52.7% vs. 20.6%; p<0.01), fetal growth retardation (20.0% vs. 7.4%; p<0.01), gestational anemia (76,4% vs. 32.4%; p<0.01), placental dysfunction (47.3% vs. 22.1%; p<0.05). Complications in childbirth in women with multiple pregnancies were as follows: premature rupture of membranes (30.9% vs. 10.3%; p<0.05), anomalies of labor activity (16.4% vs. 5.9%; p>0.05), fetal distress (29.1% vs. 14.7%; p<0.05), premature placental abruption (3.6% vs. the absence of this indicator in group I). In patients of group II with multiple pregnancies 3.7 times more often the pregnancy ended prematurely compared with singleton (21.8% vs. 5.9%; p<0.05). Early preterm births predominated, of which births occurred in 3.6% of cases at 22–28 weeks, 7.3% at 28–32 weeks, and 6.4% at 32–34 weeks. Significant increase in the frequency of 32.7% of abdominal births in multiple pregnancies against 11.8% of patients in pregnancy with a single fetus (p<0.01). The structure of indications in patients of group II was as follows: severe preeclampsia 27.8%, development of fetal growth retardation and fetal distress of 11.1%, respectively, premature placental abruption 16.7%, the following single indications (pelvic presentation of the fetus, transverse or oblique position of the fetus, clinically narrow pelvis, abnormalities of labor, scar on the uterus) – 33.3%. Significant increase in the total frequency of neonatal asphyxia of varying severity in multiple pregnancies (35.0% vs. 5.9%; p<0.05), fetal growth retardation (27.3% vs. 11.8%; p<0.01). Conclusions. Multiple pregnancies are a high risk factor for gestational anemia, preeclampsia, placental dysfunction, early fetal growth retardation, and fetal distress during pregnancy and childbirth. This causes a high level of abdominal delivery. Therefore, further research to predict and prevent obstetric and perinatal complications in multiple pregnancies after ART is relevant today. Keywords: obstetric and perinatal complications of pregnancy, multiple pregnancy, assisted reproductive technologies.

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FACTORS THAT DETERMINE THE OUTCOME OF PREGNANCY AND HEALTH OF CHILDREN BORN TO WOMEN WITH GENITOURINARY SYSTEM DISEASES USING ASSISTED REPRODUCTIVE TECHNOLOGIES

PEDIATRIA Journal named after G N SPERANSKY ◽

10.24110/0031-403x-2021-100-1-52-59 ◽

2021 ◽

Vol 100 (1) ◽

pp. 52-59

Author(s):

A.N. Plaksina ◽

◽

O.P. Kovtun ◽

S.L. Sinotova ◽

O.V. Limanovskaya ◽

...

Keyword(s):

Assisted Reproductive Technologies ◽

Risk Group ◽

Perinatal Period ◽

Reproductive Technologies ◽

Parasitic Diseases ◽

Genitourinary System ◽

System P ◽

History Of ◽

External Causes ◽

Mental And Behavioral Disorders

Objective of the research: identification of risk factors that potentially affect the outcomes of pregnancies achieved by assisted reproductive technologies (ART), with an assessment of the health status of children born to women with genitourinary system (GUS) diseases. Materials and methods: a retrospective uncontrolled non-randomized multicenter study of 821 women and 836 children under the age of 3 years. Results: gynecological history of women has little effect on pregnancy outcomes achieved by ART (Matthews coefficient <0,2). Children born to mothers with GUS diseases are statistically significantly more likely to have some infectious and parasitic diseases (p=0,0002), mental and behavioral disorders (p=0,009), diseases of the nervous system (p=0,031), respiratory system (p=0,009), oral cavity, salivary glands and digestion (p=0,002), musculoskeletal system and connective tissue (p=0,001), genitourinary system (p=0,009), certain conditions arising in the perinatal period (p=0,009), as well as trauma, poisoning, and some other consequences of external causes (p=0,009) than children from mothers without GUS diseases. Conclusion: children born by ART from women with GUS pathology are a risk group for the development of diseases in early age.

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Infecundity and Infertility

Oxford Research Encyclopedia of Global Public Health ◽

10.1093/acrefore/9780190632366.013.184 ◽

2019 ◽

Author(s):

Marie Thoma ◽

Carie Cox ◽

Jasmine Fledderjohann ◽

Rudolph Kantum Adageba

Keyword(s):

Public Health ◽

Reproductive Health ◽

Sexual And Reproductive Health ◽

Assisted Reproductive Technologies ◽

Significant Proportion ◽

Well Being ◽

Reproductive Technologies ◽

Reproductive Age ◽

Increased Risk ◽

Global Epidemiology

This is an advance summary of a forthcoming article in the Oxford Research Encyclopedia of Global Public Health. Please check back later for the full article. Infertility remains a neglected area in sexual and reproductive health, yet its consequences are staggering. Infertility is estimated to impact about 15% (estimates range from 48 million to 180 million) of couples of reproductive age worldwide. It is associated with adverse physical and mental health outcomes, financial distress, severe social stigma, increased risk of domestic abuse, and marital instability. While men and women are equally likely to be infertile, women often bear the societal burden of infertility, particularly in societies where a woman’s identity and social value is closely tied to her ability to bear children. Despite these consequences, disparities in access to infertility treatment between low- and high-income populations persist, given the high cost and limited geographic availability of diagnostic services and assisted reproductive technologies. In addition, a significant proportion of infertility arises from preventable factors, such as smoking, sexually transmitted infections, pregnancy-related infection or unsafe abortion, and environmental contaminants. Accordingly, programs that address the equitable prevention and treatment of infertility are not only in keeping with a reproductive rights perspective, but can also improve public health. However, progress on infertility as a global concern in the field of sexual and reproductive health and rights is stymied by challenges in understanding the global epidemiology of infertility, including its causes and determinants, barriers to accessing quality infertility care, and a lack of political will and attention to this issue. Tracking and measurement of infertility is highly complex, resulting in considerable ambiguity about its prevalence and stratification of reproduction globally. A renewed global focus on infertility epidemiology, risk factors, and access to and receipt of quality of care will support individuals in trying to reach their desired number and spacing of children and improve overall health and well-being.

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“Man Cannot Exist Alone”: The Challenge of Health Care to Honor the Role of Women in Society

The Linacre Quarterly ◽

10.1177/0024363918807684 ◽

2018 ◽

Vol 85 (4) ◽

pp. 327-330

Author(s):

Jonathan Scrafford

Keyword(s):

Health Care ◽

Reproductive Health ◽

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

Natural Family Planning ◽

Social And Emotional ◽

Emotional Bonds ◽

Parents And Children ◽

Women's Role ◽

Over Time

Women’s roles in society are changing. While most of those changes recognize and enhance the contributions of feminine ingenuity to human development, some threaten to isolate women physically, socially, and emotionally. Developments in reproductive health care, and the writings of Pope Saint John Paul II, offer lenses by which to evaluate the shifting landscape of women’s role in society. On the one hand, practices such as contraception, abortion, surrogacy, and assisted reproductive technologies over time will weaken the physical, social, and emotional bonds that procreation has held between man and woman, parents and children, and families and society. On the other hand, the expansion of different modes of natural family planning and pregnancy support centers offers to preserve those bonds. Summary: Women’s role in families, and therefore society, is invaluable. Several approaches to reproductive health offered by medicine may isolate women over time, and some evidences suggest we are already seeing that effect. Other approaches to women’s health may be able to preserve the physical, emotional, and social bonds that integrate women to the family, and therefore society.

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Sperm output and body condition are maintained independently of hibernation in an endangered temperate amphibian

Reproduction Fertility and Development ◽

10.1071/rd18073 ◽

2019 ◽

Vol 31 (4) ◽

pp. 796 ◽

Cited By ~ 1

Author(s):

Sinlan Poo ◽

Kristin M. Hinkson ◽

Edward Stege

Keyword(s):

Body Condition ◽

Assisted Reproductive Technologies ◽

Sperm Quality ◽

Reproductive Technologies ◽

Treatment Groups ◽

History Of ◽

Unexpected Findings ◽

Sperm Output ◽

Wyoming Toad ◽

Number Of Cells

Hibernation is an integral part of the life history of species living in seasonal environments. However, our knowledge about the link between hibernation and reproductive success in amphibians remains limited, which poses an obstacle for critical conservation efforts. To fill this gap, we quantified the effects of captive hibernation on sperm quality, sperm quantity and body condition in an endangered anuran, the Wyoming toad (Anaxyrus baxteri), and used naturally hibernated wild toads as a standard for comparison. We hypothesised that hibernation is essential for optimal sperm output but is detrimental to body condition. Sperm collection was performed using assisted reproductive technologies for both captive and wild toads. Contrary to our hypotheses, no differences were observed in sperm metrics (total number of cells, concentration, motility and viability) or in body condition across captive treatment groups (0, 30 or 60 days of hibernation). Moreover, no difference was found between sperm metrics of captive toads and wild toads. These unexpected findings suggest that hibernation may not be an essential process for spermiation in A. baxteri while using exogenous hormones, and illustrate the potential of temperate amphibians to adapt to varying environmental conditions during winter months.

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Impact of COVID-19 on assisted reproductive technologies and its multifacet influence on global bioeconomy

10.25259/jrhm_44_2020 ◽

2021 ◽

Vol 2 ◽

pp. 92-104

Author(s):

Olugbemi Tope Olaniyan ◽

Charles O. Adetunji ◽

Gloria E. Okotie ◽

Olorunsola Adeyomoye ◽

Osikemekha A. Anani ◽

...

Keyword(s):

Reproductive Health ◽

Global Economy ◽

Health Care Services ◽

Assisted Reproductive Technologies ◽

Work Load ◽

Reproductive Technologies ◽

Active Constituent ◽

Care Services ◽

Travel Restrictions ◽

Reproductive Services

Several nations of the world have issued instructions such as travel restrictions, border closure, and lockdown, plus other directives proposing that non-essential care must be withdrawn including assisted reproductive services, in an attempt to identify resources to ascertain the dissemination of SARS-CoV-2. This has led to massive shortage in medical supplies, inappropriate service delivery, hike in price, decrease in staff work load, salary cut, decrease in the utilization of qualitative maternal, and reproductive health-care services thereby creating high risk on reproductive health and global bioeconomy. The search for right candidate for the management of coronavirus disease 2019 and several reproductive health challenges begins with the screening of natural products to identify novel active constituent. Moreover, there is need to pay more attention to crucial phytochemical, bioactive fractions, phytoanalysis, and phytopharmacological investigation for effective drug discovery most especially these bioresources from beneficial microorganisms, plants, and ocean deposits that could help in mitigation of SARS-CoV-2 and reproduction health challenges through chemoinformatics, informatics, synthetic biology, nanotechnology, and metabolomics hence boosting the global economy.

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