FEATURES OF PROINFLAMMATORY CYTOKINES EXPRESSION IN PELVIC ADHESIONS TISSUE AT WOMEN WITH PELVIC CHRONIC INFLAMMATORY DISEASES

Chronic inflammatory diseases such as periodontitis have been associated with increased risk for various medical conditions including diabetes and cardiovascular disease. Endotoxin (lipopolysaccharide, LPS), derived from gram-negative periodonto-pathogens, can induce the local accumulation of mononuclear cells in the inflammatory lesion, increasing proinflammatory cytokines and matrix metalloproteinases (MMPs). This ultimately results in the destruction of periodontal connective tissues including alveolar bone. Curcumin is the principal dyestuff in the popular Indian spice turmeric and has significant regulatory effects on inflammatory mediators but is characterized by poor solubility and low bioactivity. Recently, we developed a series of chemically modified curcumins (CMCs) with increased solubility and zinc-binding activity, while retaining, or further enhancing, their therapeutic effects. In the current study, we demonstrate that a novel CMC (CMC 2.5: 4-methoxycarbonyl curcumin) has significant inhibitory effects, better than the parent compound curcumin, on proinflammatory cytokines and MMPs inin vitro, in cell culture, and in an animal model of periodontal inflammation. The therapeutic potential of CMC 2.5 and its congeners may help to prevent tissue damage during various chronic inflammatory diseases including periodontitis and may reduce the risks of systemic diseases associated with this local disorder.

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Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress

International Journal of Molecular Sciences ◽

10.3390/ijms22052549 ◽

2021 ◽

Vol 22 (5) ◽

pp. 2549 ◽

Cited By ~ 1

Author(s):

Shin-ichi Hirano ◽

Yusuke Ichikawa ◽

Bunpei Sato ◽

Haru Yamamoto ◽

Yoshiyasu Takefuji ◽

...

Keyword(s):

Proinflammatory Cytokines ◽

Inflammatory Diseases ◽

Inflammasome Activation ◽

Oxygen Species ◽

Chronic Inflammatory Diseases ◽

Mitochondrial Ros ◽

Nlrp3 Inflammasome Activation ◽

Intracellular Organelles ◽

Mitochondrial Oxidation ◽

Nlrp3 Inflammasomes

Mitochondria are the largest source of reactive oxygen species (ROS) and are intracellular organelles that produce large amounts of the most potent hydroxyl radical (·OH). Molecular hydrogen (H2) can selectively eliminate ·OH generated inside of the mitochondria. Inflammation is induced by the release of proinflammatory cytokines produced by macrophages and neutrophils. However, an uncontrolled or exaggerated response often occurs, resulting in severe inflammation that can lead to acute or chronic inflammatory diseases. Recent studies have reported that ROS activate NLRP3 inflammasomes, and that this stimulation triggers the production of proinflammatory cytokines. It has been shown in literature that H2 can be based on the mechanisms that inhibit mitochondrial ROS. However, the ability for H2 to inhibit NLRP3 inflammasome activation via mitochondrial oxidation is poorly understood. In this review, we hypothesize a possible mechanism by which H2 inhibits mitochondrial oxidation. Medical applications of H2 may solve the problem of many chronic inflammation-based diseases, including coronavirus disease 2019 (COVID-19).

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Faculty Opinions recommendation of Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726216597.793518864 ◽

2016 ◽

Author(s):

Rahul Kuver

Keyword(s):

Inflammatory Diseases ◽

Chronic Inflammatory Diseases ◽

New Associations ◽

Disease Specific

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Chronic Inflammatory Diseases: Progress and Prospect with Herbal Medicine

Current Pharmaceutical Design ◽

10.2174/1381612822666151112151419 ◽

2015 ◽

Vol 22 (2) ◽

pp. 247-264 ◽

Cited By ~ 4

Author(s):

Nilanjan Ghosh ◽

Asif Ali ◽

Rituparna Ghosh ◽

Shaileyee Das ◽

Subhash C. Mandal ◽

...

Keyword(s):

Herbal Medicine ◽

Inflammatory Diseases ◽

Chronic Inflammatory Diseases

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Exploiting Anti-Inflammation Effects of Flavonoids in Chronic Inflammatory Diseases

Current Pharmaceutical Design ◽

10.2174/1381612826666200408101550 ◽

2020 ◽

Vol 26 (22) ◽

pp. 2610-2619 ◽

Cited By ~ 2

Author(s):

Tarique Hussain ◽

Ghulam Murtaza ◽

Huansheng Yang ◽

Muhammad S. Kalhoro ◽

Dildar H. Kalhoro

Keyword(s):

Oxidative Stress ◽

Chronic Diseases ◽

Inflammatory Diseases ◽

Therapeutic Option ◽

Cellular Level ◽

Antiinflammatory Drugs ◽

Suitable Alternative ◽

Chronic Inflammatory Diseases

Background: Inflammation is a complex response of the host defense system to different internal and external stimuli. It is believed that persistent inflammation may lead to chronic inflammatory diseases such as, inflammatory bowel disease, neurological and cardiovascular diseases. Oxidative stress is the main factor responsible for the augmentation of inflammation via various molecular pathways. Therefore, alleviating oxidative stress is effective a therapeutic option against chronic inflammatory diseases. Methods: This review article extends the knowledge of the regulatory mechanisms of flavonoids targeting inflammatory pathways in chronic diseases, which would be the best approach for the development of suitable therapeutic agents against chronic diseases. Results: Since the inflammatory response is initiated by numerous signaling molecules like NF-κB, MAPK, and Arachidonic acid pathways, their encountering function can be evaluated with the activation of Nrf2 pathway, a promising approach to inhibit/prevent chronic inflammatory diseases by flavonoids. Over the last few decades, flavonoids drew much attention as a potent alternative therapeutic agent. Recent clinical evidence has shown significant impacts of flavonoids on chronic diseases in different in-vivo and in-vitro models. Conclusion: Flavonoid compounds can interact with chronic inflammatory diseases at the cellular level and modulate the response of protein pathways. A promising approach is needed to overlook suitable alternative compounds providing more therapeutic efficacy and exerting fewer side effects than commercially available antiinflammatory drugs.

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Lipid, fatty acid, carnitine- and choline derivative profiles in rheumatoid arthritis outpatients with different degrees of periodontal inflammation

Scientific Reports ◽

10.1038/s41598-021-84122-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Kathrin Beyer ◽

Stein Atle Lie ◽

Bodil Bjørndal ◽

Rolf K. Berge ◽

Asbjørn Svardal ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Fatty Acid ◽

Mitochondrial Dysfunction ◽

Inflammatory Diseases ◽

Whole Body ◽

Cross Sectional ◽

Chronic Inflammatory Diseases ◽

Periodontal Inflammation ◽

Inflammatory Status ◽

Lipid Fatty Acid

AbstractRheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases with several pathogenic pathways in common. Evidence supports an association between the diseases, but the exact underlying mechanisms behind the connection are still under investigation. Lipid, fatty acid (FA) and metabolic profile alterations have been associated with several chronic inflammatory diseases, including RA and periodontitis. Mitochondria have a central role in regulating cellular bioenergetic and whole-body metabolic homeostasis, and mitochondrial dysfunction has been proposed as a possible link between the two disorders. The aim of this cross-sectional study was to explore whole-blood FA, serum lipid composition, and carnitine- and choline derivatives in 78 RA outpatients with different degrees of periodontal inflammation. The main findings were alterations in lipid, FA, and carnitine- and choline derivative profiles. More specifically, higher total FA and total cholesterol concentrations were found in active RA. Elevated phospholipid concentrations with concomitant lower choline, elevated medium-chain acylcarnitines (MC-AC), and decreased ratios of MC-AC and long-chain (LC)-AC were associated with prednisolone medication. This may indicate an altered mitochondrial function in relation to the increased inflammatory status in RA disease. Our findings may support the need for interdisciplinary collaboration within the field of medicine and dentistry in patient stratification to improve personalized treatment. Longitudinal studies should be conducted to further assess the potential impact of mitochondrial dysfunction on RA and periodontitis.

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Techniques to Study Inflammasome Activation and Inhibition by Small Molecules

Molecules ◽

10.3390/molecules26061704 ◽

2021 ◽

Vol 26 (6) ◽

pp. 1704

Author(s):

Diego Angosto-Bazarra ◽

Cristina Molina-López ◽

Alejandro Peñín-Franch ◽

Laura Hurtado-Navarro ◽

Pablo Pelegrín

Keyword(s):

Inflammatory Response ◽

Small Molecules ◽

Mechanism Of Action ◽

Inflammatory Diseases ◽

Inflammasome Activation ◽

Chronic Inflammatory Diseases ◽

Anti Inflammatory ◽

Inhibitory Molecules ◽

Inflammasome Inhibitors

Inflammasomes are immune cytosolic oligomers involved in the initiation and progression of multiple pathologies and diseases. The tight regulation of these immune sensors is necessary to control an optimal inflammatory response and recover organism homeostasis. Prolonged activation of inflammasomes result in the development of chronic inflammatory diseases, and the use of small drug-like inhibitory molecules are emerging as promising anti-inflammatory therapies. Different aspects have to be taken in consideration when designing inflammasome inhibitors. This review summarizes the different techniques that can be used to study the mechanism of action of potential inflammasome inhibitory molecules.

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Impact of COVID-19 on initiation of biologic therapy prescriptions for chronic inflammatory diseases

Joint Bone Spine ◽

10.1016/j.jbspin.2021.105253 ◽

2021 ◽

pp. 105253

Author(s):

Pascal Richette ◽

Matthieu Allez ◽

Vincent Descamps ◽

Lucas Perray ◽

Simon Pilet ◽

...

Keyword(s):

Biologic Therapy ◽

Inflammatory Diseases ◽

Chronic Inflammatory Diseases

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The mercapturomic profile of health and non-communicable diseases

High-Throughput ◽

10.3390/ht8020010 ◽

2019 ◽

Vol 8 (2) ◽

pp. 10 ◽

Cited By ~ 4

Author(s):

Gonçalves-Dias ◽

Morello ◽

Semedo ◽

Correia ◽

Coelho ◽

...

Keyword(s):

Environmental Exposure ◽

Inflammatory Diseases ◽

Communicable Diseases ◽

Non Communicable Diseases ◽

Chronic Inflammatory Diseases ◽

Cardiometabolic Diseases ◽

Health And Disease ◽

Endogenous Metabolites

The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans—the mercapturomic profile—in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.

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