scholarly journals Bariatric surgery: is it reasonable before the age of 16?

2016 ◽  
Vol 43 (5) ◽  
pp. 360-367
Author(s):  
LILIAN HELENA POLAK MASSABKI ◽  
LETÍCIA ESPOSITO SEWAYBRICKER ◽  
KEILA HAYASHI NAKAMURA ◽  
ROBERTO TEIXEIRA MENDES ◽  
ANTONIO DE AZEVEDO BARROS FILHO ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Bariatric Surgery ◽  
Children And Adolescents ◽  
Total Cholesterol ◽  
Acanthosis Nigricans ◽  
Laboratory Data ◽  
Z Score ◽  
Indication For Surgery ◽  
Frequent Change ◽  
Cross Sectional

ABSTRACT Objective: to assess the severity of obesity in children and adolescents through the presence of comorbidities and the potential indication of bariatric surgery. Methods: we conducted a cross-sectional study with clinical and laboratory data of the first consultation of patients at the childhood obesity clinic at a tertiary hospital from 2005 to 2013. We divided the patients into groups with or without potential indication for surgery, and recorded age, gender, birth weight, age of obesity onset, BMI Z score, presence of acanthosis nigricans, blood pressure, total cholesterol and fractions, triglycerides, blood glucose and fasting insulin, HOMA1-IR, CRP and ESR. The group with potential indication for surgery included: BMI > 40 or between 35-40 with comorbidities (Triglycerides >130mg/dl, glucose levels >100mg/dl, HOMA1-IR >3.16, Total Cholesterol >200mg/dl, LDL >130mg/dl and HDL <45mg/dl), regardless of age, epiphysis consolidation and previous treatment. Results: of the 296 patients included in the study, 282 (95.3%) were younger than 16 years. The most frequent change was the HDL (63.2%), followed by HOMA1-IR (37.5%). Of the group of 66 patients with potential indication for surgery (22.3%), only ten (15.1%) had more than 16 years. Acanthosis nigricans, the average HOMA1-IR, insulin, CRP, ESR, age, BMI Z score and systolic and diastolic blood pressure were significant in the group with potential surgical indication. Conclusion: bariatric surgery might be indicated by BMI and comorbidities in children and adolescents under 16 years.

scholarly journals PFAS Concentrations and Cardiometabolic Traits in Highly Exposed Children and Adolescents

2021 ◽  
Author(s):  
Cristina Canova ◽  
Andrea Di Nisio ◽  
Giulia Barbieri ◽  
Francesca Russo ◽  
Tony Fletcher ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Children And Adolescents ◽  
Density Lipoprotein ◽  
Positive Association ◽  
Additive Models ◽  
Lipoprotein Cholesterol ◽  
Surveillance Program ◽  
Z Score ◽  
Large Area ◽  
Cross Sectional

Background: Residents of a large area of North-Eastern Italy were exposed for decades to high concentrations of perfluoroalkyl and polyfluoroalkyl substances (PFAS) via drinking water. Despite the large amount of evidence in adults of a positive association between serum PFAS and metabolic outcomes, studies focusing on children and adolescents are limited. We evaluated the associations between serum PFAS concentrations and lipid profile, blood pressure and body mass index (BMI) in highly exposed adolescents and children. Methods: A cross-sectional analysis was conducted in 6669 adolescents (14-19 years) and 2693 children (8-11 years) enrolled in the health surveillance program of the Veneto Region. Non-fasting blood samples were obtained and analyzed for perfluorooctanoic acid (PFOA) perfluorooctane sulfonate (PFOS), perfluorohexanesulfonic acid (PFHxS), perfluorononanoic acid (PFNA), total cholesterol (TC) high-density lipoprotein cholesterol (HDL-C) and triglycerides. Low-density lipoprotein cholesterol (LDL-C) was calculated. Systolic and diastolic blood pressure (BP) were measured and BMI z-score accounting for age and sex was estimated. The associations between ln-transformed PFAS (and categorized into quartiles) and continuous outcomes were assessed using generalized additive models. Analyses were stratified by gender and adjusted for potential confounders. Results: Among adolescents, significant associations were detected between all investigated PFAS and TC, LDL-C, and to a fewer extent HDL-C. Among children, PFOS and PFNA had significant associations with TC, LDL-C and HDL-C, while PFOA and PFHxS had significant associations with HDL-C only. Increased serum concentrations of PFAS, particularly PFOS, were associated with decreased BMI z-score. No statistically significant associations were observed between PFAS concentrations and BP. Conclusions: Our study supports a consistent association between PFAS concentration and serum lipids, stronger for PFOS and PFNA and with a greater magnitude among children compared to adolescents, and a negative association of PFAS with BMI.

scholarly journals Blood pressure and resting heart rate in 3-17-year-olds in Germany in 2003–2006 and 2014–2017

2021 ◽  
Author(s):  
Giselle Sarganas ◽  
Anja Schienkiewitz ◽  
Jonas D. Finger ◽  
Hannelore K. Neuhauser
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Children And Adolescents ◽  
Selection Rule ◽  
Age Groups ◽  
Resting Heart Rate ◽  
Cross Sectional ◽  
National Examination ◽  
School Aged Children ◽  
Analysis Measurement

AbstractTo track blood pressure (BP) and resting heart rate (RHR) in children and adolescents is important due to its associations with cardiovascular outcomes in the adulthood. Therefore, the aim of this study was to examine BP and RHR over a decade among children and adolescents living in Germany using national examination data. Cross-sectional data from 3- to 17-year-old national survey participants (KiGGS 2003–06, n = 14,701; KiGGS 2014–17, n = 3509) including standardized oscillometric BP and RHR were used for age- and sex-standardized analysis. Measurement protocols were identical with the exception of the cuff selection rule, which was accounted for in the analyses. Different BP and RHR trends were observed according to age-groups. In 3- to 6-year-olds adjusted mean SBP and DBP were significantly higher in 2014–2017 compared to 2003–2006 (+2.4 and +1.9 mm Hg, respectively), while RHR was statistically significantly lower by −3.8 bpm. No significant changes in BP or in RHR were observed in 7- to 10-year-olds over time. In 11- to 13-year-olds as well as in 14- to 17-year-olds lower BP has been observed (SBP −2.4 and −3.2 mm Hg, respectively, and DBP −1.8 and −1.7 mm Hg), while RHR was significantly higher (+2.7 and +3.7 bpm). BP trends did not parallel RHR trends. The downward BP trend in adolescents seemed to follow decreasing adult BP trends in middle and high-income countries. The increase in BP in younger children needs confirmation from other studies as well as further investigation. In school-aged children and adolescents, the increased RHR trend may indicate decreased physical fitness.

scholarly journals Normal Non-HDL Cholesterol, Low Total Cholesterol, and HDL Cholesterol Levels in Sickle Cell Disease Patients in the Steady State: A Case-Control Study of Tema Metropolis

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Richard K. D. Ephraim ◽  
Patrick Adu ◽  
Edem Ake ◽  
Hope Agbodzakey ◽  
Prince Adoba ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Steady State ◽  
Sickle Cell Disease ◽  
Total Cholesterol ◽  
Sickle Cell ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Lipoprotein Cholesterol ◽  
Cell Disease ◽  
Cross Sectional

Background.Abnormal lipid homeostasis in sickle cell disease (SCD) is characterized by defects in plasma and erythrocyte lipids and may increase the risk of cardiovascular disease. This study assessed the lipid profile and non-HDL cholesterol level of SCD patients.Methods.A hospital-based cross-sectional study was conducted in 50 SCD patients, in the steady state, aged 8–28 years, attending the SCD clinic, and 50 healthy volunteers between the ages of 8–38 years. Serum lipids were determined by enzymatic methods and non-HDL cholesterol calculated by this formula: non-HDL-C = TC-HDL-C.Results.Total cholesterol (TC) (p=0.001) and high-density lipoprotein cholesterol (HDL-C) (p<0.0001) were significantly decreased in cases compared to controls. The levels of non-HDL-C, low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) were similar among the participants. The levels of decrease in TC and HDL were associated with whether a patient was SCD-SS or SCD-SC. Systolic blood pressure and diastolic blood pressure were each significantly associated with increased VLDL [SBP,p=0.01, OR: 0.74 (CI: 0.6–0.93); DBP,p=0.023, OR: 1.45 (CI: 1.05–2.0)].Conclusion.Dyslipidemia is common among participants in this study. It was more pronounced in the SCD-SS than in SCD-SC. This dyslipidemia was associated with high VLDL as well as increased SBP and DBP.

scholarly journals The association between serum copper concentrations and elevated blood pressure in US children and adolescents: National Health and Nutrition Examination Survey 2011–2016

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Changsong Liu ◽  
Yanfen Liao ◽  
Zongyuan Zhu ◽  
Lili Yang ◽  
Qin Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Children And Adolescents ◽  
National Health ◽  
Serum Copper ◽  
Elevated Blood Pressure ◽  
Nutrition Examination Survey ◽  
Elevated Blood ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
Us Children

Abstract Background Copper is an essential trace metal with potential interest for cardiovascular effects. Few studies have explored the association between copper and blood pressure in children and adolescents. Method We conducted a cross-sectional analysis of 1242 children and adolescents aged 8–17 years who participated in the 2011 to 2016 National Health and Nutrition Examination Survey. Using 2017 American Academy of Pediatrics guidelines, elevated blood pressure (EBP) was defined as a mean systolic and/or diastolic blood pressure (BP) ≥ 90th percentile for sex, age, and height for children aged 1–12 years and systolic BP ≥ 120 mmHg or diastolic BP ≥ 80 mmHg for adolescent age 13–17 years. Mean serum copper was 114.17 μg/dL. Results After multiple adjustments, dose–response analyses revealed that EBP was associated with progressively higher serum copper concentrations in a nonlinear trend. In comparison with the lowest quartile of serum copper concentrations, the adjusted odds of EBP for the highest quartile was 5.26 (95% confidence interval, 2.76–10.03). Conclusion Our results suggested that high serum copper concentrations were significantly associated with EBP in US children and adolescents.

scholarly journals Acute malnutrition is associated with the high nutritional risk obtained by STRONGkids in children and adolescents with infectious diseases

2021 ◽  
Vol 10 (11) ◽  
pp. e407101119859
Author(s):  
Francisca Maria da Silva ◽  
Francisca Isabelle da Silva e Sousa ◽  
Alexandre Danton Viana Pinheiro ◽  
Ribanna Aparecida Marques Braga ◽  
Maria Luisa Pereira de Melo ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Children And Adolescents ◽  
Cross Sectional Study ◽  
Acute Malnutrition ◽  
Nutritional Risk ◽  
Categorical Variables ◽  
Z Score ◽  
Anthropometric Parameters ◽  
Chi Square ◽  
Cross Sectional

Objective: In this study, we aim to evaluate whether the presence of malnutrition in children and adolescents with infectious diseases is associated with high nutritional risk obtained by the STRONGkids instrument. Methods: A cross-sectional study comprising 237 hospitalized patients aged between 30 days and 18 years. Identification and diagnosis data, weight and height were collected. STRONGkids determined nutritional risk. Acute malnutrition was classified by BMI/age Z score < - 2 and chronic by Height/age Z score < - 2. Associations between categorical variables were verified using Pearson's chi-square test. A logistic regression analysis was performed to assess the association between anthropometric parameters of malnutrition and nutritional risk. It was considered significant p< 0,05. Results: In multiple analysis, it was observed that having malnutrition as of BMI/age increases the chance by 5.68 of having high nutritional risk by the STRONGKids instrument, regardless of age, sex and the presence of poverty-related infectious diseases (OR: 5.68; 95% CI: 1.54-20.93; p=0.009). Conclusion: In summary, for patients with infectious diseases, acute malnutrition (BMI/age) is associated directly with the diagnosis of high nutritional risk by STRONGkids.

Hyperuricemia and Metabolic Adverse Effect in Children and Adolescents with Autism Spectrum Disorder Treated with Risperidone

2017 ◽  
Vol 41 (S1) ◽  
pp. s305-s306
Author(s):  
C. Sukasem
Keyword(s):  
Uric Acid ◽  
Children And Adolescents ◽  
Laboratory Data ◽  
Autism Spectrum ◽  
High Dose ◽  
Model Assessment ◽  
Duration Of Treatment ◽  
Cross Sectional ◽  
Long Term Treatment ◽  
Adolescents With Asd

BackgroundAtypical anti-psychotics have been found to be associated with hyperuricemia. The aims of this study were to determine the prevalence of hyperuricemia and metabolic adverse events in children and adolescents with ASD treated with risperidone.MethodsIn this cross-sectional study, we recruited 127 Thai ASD children and adolescents aged 3–20 years receiving risperidone for more than 4 weeks. The clinical data and laboratory data were obtained and analyzed. Hyperuricemia was defined as serum uric acid > 5.5 mg/dL.ResultsHyperuricemia was present in 57.48% of total ASD patients treated with risperidone. Uric acid levels were significantly higher in adolescents as compared to children. Uric acid levels correlated with risperidone dose (P = 0.01), duration of treatment (P < 0.0001), BMI (P < 0.0001), waist circumference (P = 0.003), triglyceride (TG; P < 0.0001), triglycerides/high-density lipoprotein cholesterol ratio (TG/HDL-C; P < 0.0001), insulin (P = 0.04), homeostatic model assessment index (HOMA-IR; P = 0.03), high-sensitivity CRP (hs-CRP; P < 0.0001), and leptin levels (P < 0.0001). HDL-C and adiponectin levels were negatively correlated with uric acid levels (P < 0.0001). In multiple regressions analysis, age, BMI, TG/HDL-C, and adiponectin level remained significantly associated with uric acid levels (P < 0.0001).ConclusionHyperuricemia may play a role in metabolic adverse effects in children and adolescents with ASD receiving high dose and/or long-term treatment with risperidone.Disclosure of interestThe author has not supplied his/her declaration of competing interest.

scholarly journals Association of different obesity indices with blood pressure and blood lipids in children and adolescents

2008 ◽  
Vol 100 (1) ◽  
pp. 208-218 ◽  
Author(s):  
Sandra Plachta-Danielzik ◽  
Beate Landsberg ◽  
Maike Johannsen ◽  
Dominique Lange ◽  
Manfred James Müller
Keyword(s):  
Blood Pressure ◽  
Risk Assessment ◽  
Waist Circumference ◽  
Children And Adolescents ◽  
Blood Lipids ◽  
Prevention Study ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Obesity Index ◽  
Obesity Indices

The aim of the present study was to compare individual associations of BMI, triceps skinfold (TSF), waist circumference (WC) and percentage fat mass (%FM) with blood pressure (BP) and blood lipids in children and adolescents. Cross-sectional data on BMI, TSF, WC, %FM as well as on BP, TAG and HDL were analysed in 4220 (BP) and 729 (lipids) 9–11-year-old children and 3174 (BP) and 536 (lipids) 13–16-year-old adolescents as part of the Kiel Obesity Prevention Study. All obesity indices were similarly associated with BP and blood lipids. In girls, WC had closer correlations to BP than BMI (systolic BP: 0·27 and 0·24 for BMI, 0·34 and 0·28 for WC in 9–11- and 13–16-year-olds). Subjects with an obesity index ≥ 90th percentile had higher prevalences of elevated BP and blood lipids than subjects with a normal index. In children with normal BMI or WC, an additionally elevated second obesity index was associated with a 2·5–7·4-fold higher prevalence of high BP when compared with children with normal indices. In adolescents, an elevated WC plus an elevated second obesity index was associated with a 2·6–8·2-fold higher prevalence of high BP when compared with adolescents with an elevated WC plus a normal second index. We conclude that (i) both BMI and WC are appropriate to estimate CVD risk, (ii) the use of a second obesity index is recommended in children with normal BMI or normal WC as well as in adolescents with elevated WC and (iii) all obesity indices seemed to be appropriate for risk assessment.

scholarly journals Assessment of the influence of overweight and obesity on the development of prehypertension and hypertension in children aged 6-15

2021 ◽  
Vol 50 (4) ◽  
pp. 85-96
Author(s):  
Marijana Jandrić-Kočić
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Primary School ◽  
Children And Adolescents ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
Primary School Children ◽  
Cross Sectional ◽  
Significant Difference ◽  
Hypertension In Children

Introduction/Aim: 41 million children under the age of 5 and 340 million children and adolescents aged 5 to 19 are overweight or obese. Obesity in children and adolescents is the most important predictor of high blood pressure. The aim of the study was to examine the incidence of overweight and obesity in primary school children aged 6 to 15 years, as well as to examine the incidence of prehypertension and hypertension in children who were overweight and obese. Method: The study included 85 of 86 children from the Primary School "Krupa na Uni". Data were collected with the help of a questionnaire, while body weight and blood pressure were measured. The chi-square test and t-test were used for the statistical analysis of data Results: The cross-sectional study included 85 children, 45 (52.9%) boys and 40 (47.1%) girls with an average age of 10.87 ± 2.70 years. Normal weight was found in 54 (63.5%) subjects, underweight in 12 (14.1%), overweight in 5 (5.9%), and obesity in 14 (16.5%). 76 (89.4%) subjects had normal blood pressure values, 5 (5.9%) prehypertensive state, and 4 (4.7%) arterial hypertension. There was no significant difference between younger and older children regarding their nutritional status (p=0.477) and blood pressure levels (p=0.453). Children who were overweight and obese had prehypertension and hypertension significantly more often (p˂0.001). Conclusion: Every fifth child was overweight or obese, while prehypertension or hypertension were found in every tenth child. The timely change of diet and physical activity could contribute to the regulation of body weight and the regulation of blood pressure, as well.

scholarly journals Cardiometabolic risk in children and adolescents: mediation analysis of crosssectional study. [Riesgo cardiometabólico en niños y adolescentes: análisis de mediación de un estudio transversal].

2021 ◽  
Vol 17 (65) ◽  
pp. 204-220
Author(s):  
Noelia González-Gálvez ◽  
◽  
Jose Carlos Ribeiro ◽  
Jorge Mota ◽  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Children And Adolescents ◽  
Cardiorespiratory Fitness ◽  
Cardiometabolic Risk ◽  
Cross Sectional Study ◽  
Mean Blood Pressure ◽  
Sectional Study ◽  
Cross Sectional ◽  
Fitness Level

The aims of this study were a) to assess whether obesity acts as a mediator between i) cardiorespiratory fitness (CRF) and mean blood pressure; and ii) between between physical activity (PA) and mean blodd pressure in children and adolescents. A cross-sectional study was conducted with a 632 children and adolescents. It was measured mean blood pressure, body mass index, fat mass and waist circumference. CRF and PA was assessing with Course Navette test and ActiGraph. The analysis of the mediation was performed using Process macro for SPSS. The results indicate that obesity acts as a partial mediation in the association between CRF and mean blood pressure in 10-12 years old children (z=from -5.81 to -5.40; all p˂0.000). These results indicate that obesity acts as a complete mediator in the association between PA and mean blood pressure in 10-12 years old children (z=from -4.49 to -1.94; all p˂0.000). Our result reinforces the relevance of prevent weight increse and improve cardiorespiratory fitness level since erly age in children and adolescents to prevent high mean blood pressure. Increasing the level of physical activity can influence on obesity and cardiorespiratory fitness.

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