scholarly journals Exposure risk to carbonyl compounds and furfuryl alcohol through the consumption of sparkling wines

2019 ◽  
Vol 49 (3) ◽  
Author(s):  
Gabriela Pelizza Peterle ◽  
Karolina Cardoso Hernandes ◽  
Luana Schmidt ◽  
Júlia Barreto Hoffmann Maciel ◽  
Claudia Alcaraz Zini ◽  
...  
Keyword(s):  
Environmental Contamination ◽  
Carbonyl Compounds ◽  
Furfuryl Alcohol ◽  
Ethyl Carbamate ◽  
The Other ◽  
Exposure Risk ◽  
Low Levels ◽  
First Time

ABSTRACT: The goals of this study were to verify the occurrence of furfuryl alcohol (FA) and carbonyl compounds (acetaldehyde, acrolein, ethyl carbamate (EC), formaldehyde and furfural) in sparkling wines and to evaluate, for the first time, whether the consumption of the samples under study could represent risk to consumers health. These compounds are electrophilic; and therefore, may covalently bind to DNA, which may result in mutagenicity. EC and formaldehyde were present at low levels (<1μg L-1) in all samples. Acetaldehyde, furfural and acrolein were also found in low levels (<1.5, 1.4 and 1.0μg L-1, respectively) in 57, 71 and 76% of samples. In the other samples, levels of acetaldehyde, furfural and acrolein ranged from 5.2 to 54.8, 10.5 to 41.0 and 20.3 to 36.7μg L-1, respectively. Furfuryl alcohol was also reported in all samples in levels from 10.4 to 33.5μg L-1. Acrolein was the only compound reported at levels sufficient to represent risk to health, which occurred in 24% of the samples. A study focused on the origin of acrolein deserves attention, investigating the influence of the concentration of precursors and the role of fermentation in the formation of this aldehyde, besides the evaluation of possible environmental contamination of grapes during cultivation.

The Activities of the Tube Feet of Asterias Rubens L

1947 ◽  
Vol s3-88 (1) ◽  
pp. 1-14
Author(s):  
J. E. SMITH
Keyword(s):  
Forward Direction ◽  
The Other ◽  
Asterias Rubens ◽  
Ideal Form ◽  
First Time ◽  
Intrinsic Musculature ◽  
Tube Feet ◽  
Postural Muscles ◽  
The Ideal

1. An account is given of the muscular anatomy of the foot and ampulla of Asterias rubens. An intrinsic musculature of the sucker figured by Cuénot (1891) and Chadwick (1923) is shown not to be present; on the other hand, postural muscles responsible for orientating the podium, levator fibres which ‘cup’ the sucker, and radial fibres which flatten it are described and figured for the first time. 2. The role of the different muscle systems, the collagen connective tissue, and the fluid of the hydrocoel in protracting and retracting the foot, and in effecting the attachment and detachment of the sucker, is discussed. 3. Evidence is presented, to show that postural pointing of the foot is brought about by the contraction of a ring of muscles encircling the base of the podium. The orienting muscles are functionally, but not anatomically, distinct from the longitudinal fibres of the retractor sheath. 4. The ambulatory step is shown to comprise a series of linked phases of static posture and of movement. Each phase is characterized by the contraction of one member of each of the two opposing pairs of muscles engaged in the development of the step. The two pairs of muscles are (1) the anterior and posterior orienting fibres, and (2) the protractors and retractors of the foot. In its ideal form the step comprises four phases of static posture alternating with four movements. Each movement is ushered in by a reversal of the contraction-relaxation relationships of one of the two pairs of opposing muscle systems. Four such changes are possible and they occur in a sequence that ensures the orderly succession of the four movements of protraction, swing back, retraction, and swing forward, of which movements the idealized stepping cycle is composed. 5. The actual locomotory step departs from the ideal form in two respects: (1) it is liable to become disrupted by a delay in the initiation of the protraction or of the backswing movement, and (2) withdrawal of the podium occurs simultaneously with its re-orientation in the forward direction. It is pointed out that these variations are explicable on the assumption that, in the two series of opposing muscle pairs, the retractor fibres are more readily excited to contract than are their antagonists, and the anterior postural muscles than the posterior postural fibres.

Comments on the updated recommendations of the American College of Rheumatology (ACR) for the treatment of gout. Lifestyle (part 2)

2021 ◽  
Vol 15 (2) ◽  
pp. 83-88
Author(s):  
M. S. Eliseev
Keyword(s):  
Body Weight ◽  
Food Habits ◽  
The Other ◽  
Obese Patients ◽  
American College Of Rheumatology ◽  
The Russian Federation ◽  
The One ◽  
Effective Drugs ◽  
First Time

Updated ACR recommendations for the treatment of gout concerning lifestyle are discussed. Factors related to a lifestyle, above all food habits, for many years were of leading importance in the treatment of patients with gout, even after application of effective drugs. The authors of the updated ACR recommendations for the first time offered to reconsider the role of environmental factors in the genesis of gout and objectively assess the possibility of its non-drug treatment. On the one hand, regardless of the activity of the disease, the need for restrictions of the alcohol, purine-rich products and fructose-containing beverages, as well as the decrease of body weight in obese patients and vitamin C usage unviability are confirmed. On the other hand, these recommendations are conditional. Their new version of ACR recommendations is significantly different from both its previous version and other international and national recommendations, including recommendations on the diagnosis and treatment of gout used in the Russian Federation.

scholarly journals The Figure of Distrust: Prince A.S. Menshikov in the Maritime Department during the Period of Reforms, 1826–1828

2020 ◽  
Vol 4 (3) ◽  
pp. 702-733
Author(s):  
Kseniya V. Donik
Keyword(s):  
Methodological Approach ◽  
The Other ◽  
General Situation ◽  
Functional Characteristics ◽  
Problem Context ◽  
Agent Based ◽  
The One ◽  
First Time ◽  
Official Records

The article considers the role of Prince A. Menshikov as a specific type of agent of supreme authority in the process of reforming the maritime administration. The problem context of reforms resulted from the involvement of the naval generals and officials in abuses, which was a consequence of nepotism and unrest in the navy. The involvement of sailors in the Decembrist revolt significantly affected the attitude of the tsar to the general situation in the naval environment. Distrustful of the existing naval administration, Nicholas I needed an intermediary who would implement his idea of the arrangement of the navy on the one hand, and provide him with an objective “impartial” account of maritime problems, on the other hand. As a result of that, Adjutant General Prince A. Menshikov, who had had nothing to do with the naval service earlier, joined the navy to become the monarch’s agent in charge of the naval issues in the bodies of autocratic authority. The objective of the article is to identify the functions of such an agent based on the example of the Maritime Department. The sources of the article include official records and personal documents, some of which are introduced into scientific circulation for the first time. The principal methodological approach to the problem under study is an attempt to bring the appointment of Menshikov beyond the scope of narrow departmental history which was based on the unmotivated decision of the emperor and to propose an interpretation of the events in the context of tsarist government via agents, which has already been described in historiography. The author makes a conclusion about the interconnection between the crisis in the naval department, the attitude of the supreme authority towards it, and the appearance of the monarch’s agent with a number of his own functional characteristics.

scholarly journals Late Paleogene herpetofaunas from the crossroads between two continents – new amphibian and reptile remains from the Oligocene of southern Balkans and Anatolia

2021 ◽  
Author(s):  
Georgios L. GEORGALIS ◽  
Andrej ČERŇANSKÝ ◽  
undefined Serdar MAYDA
Keyword(s):  
Eastern Europe ◽  
Central Europe ◽  
The Other ◽  
Southeastern Europe ◽  
Dispersal Route ◽  
First Time ◽  
Southern Balkans

We describe here new amphibian and reptile remains from three Oligocene localities of Turkey. Two of the localities (Kavakdere and Kocayarma) are situated in southeastern Europe and the other one (Kargi 2) in Anatolia, both areas where Oligocene herpetofauna is practically almost unknown. The material consists of albanerpetontids, pelobatid anurans, turtles, crocodylians, lacertids, scinciformatans, anguines, and “tropidophiids”. Albanerpetontids are for the first time identified in southeastern Europe, with the material being reminiscent of the younger species Albanerpeton inexpectatum Estes & Hoffstetter, 1976; the material potentially represents the oldest record of that species. Pelobatids, scinciformatans, and “tropidophiids” represent the oldest occurrences of these clades in the northeastern Mediterranean. The anguine genus Ophisaurus Daudin, 1803 is identified for the first time in the Paleogene of Eastern Europe. The “tropidophiids” are referred to two genera, Falseryx Szyndlar & Rage, 2003 and tentatively also to Platyspondylia Rage, 1974, with the latter having been so far exclusively known from western and central Europe. The role of a potential southern dispersal route of taxa among Asia and Europe, involving the area of southern Balkans and Anatolia, similarly to what has been recently demonstrated for mammals, is highlighted also for amphibians and reptiles.

scholarly journals Effects of Activating Background Knowledge in Listening Skill and How to Improve IELTS Listening

2021 ◽  
Vol 3 (6) ◽  
pp. 13-25
Author(s):  
Nguyen Nu Nhu Linh
Keyword(s):  
Learning Styles ◽  
Background Knowledge ◽  
The Other ◽  
Efl Learners ◽  
Listening Skill ◽  
The World ◽  
Efl Students ◽  
First Time ◽  
International English

Among the well-known international English tests, IELTS has been seen as one of the most well-trusted and popular to EFL learners throughout the world. In Vietnam, most of the universities require their EFL students to have an IELTS score of 6.5 or 7.0 to fulfil their bachelor degree program, which is not quite an easy job. The paper emphasizes the role of background knowledge in improving IELTS Listening scores for EFL students at Saigon University. The research was done by observing two groups of students learning Listening Module 3 at the institution. They were required to do the same test; however, while a group was constructed with pre-listening activities, the other simply listened and completed the task without preparation. The result showed little difference between the two groups in terms of efficiency, but most of the students in the first group were able to complete their test in the first time listening while some members of the latter group needed a second time. They were then required to complete a survey, including learning styles and attitudes. The results also tell us that EFL students pay much attention to pre-listening activities, and they believe such tasks can help them do their listening test better.

scholarly journals Evolution of Lyrical Image in Ballets of Azerbaijani Composers

2021 ◽  
Vol 4 (2) ◽  
pp. 179-187
Author(s):  
Lala Huseynli
Keyword(s):  
Cultural Context ◽  
The Other ◽  
Musical Culture ◽  
Specific Content ◽  
Historical Approach ◽  
Historical Method ◽  
Other Hand ◽  
History Of ◽  
First Time

This article is devoted to the study of the evolution of the lyrical image in the ballets of Azerbaijani composers. The presented article emphasizes that the Azerbaijani ballet on the extension of the history of the Azerbaijani school of composition functioned indefinitely as an important component of the Azerbaijani musical culture. The theme of this article is actualized in the aspect of the historical approach, as each ballet of Azerbaijani composers, on the other hand, reflected the significant features of the artistic, historical and cultural context. On the other hand, the study of the evolution of the lyrical image in the Azerbaijani ballets reflects the dynamics of the development of the Azerbaijani school of composition. Moreover, the figurative system in Azerbaijani ballets represents the slender line of artistic connections of Azerbaijani culture. The purpose of the research is to study the role of the lyrical image in the evolution of the Azerbaijani ballet. The research methodology is based is based on the use of a historical approach to determine the basic definitions of the study. The expediency of the historical method is due to the fact that the development in the space of historical time should be based on certain basic categories that would reflect the school of composition, its national specifics. The scientific novelty of the research is that for the first time the peculiarities of the evolution of the lyrical image in Azerbaijani ballets – from its origin to modern functioning – are analyzed; the nuances of style creation in the Azerbaijani school of composers in the specified aspect are considered, and also certain art processes are systematized. Conclusions. It is proved that the combination of deep lyricism with dramatic emotions is characteristic of the transfer of lyricism in the drama of ballets at all historical stages of development, in different stylistic contexts. Lyrical images in the ballets of Azerbaijani composers have similar features and are due to the specific content of the national worldview.

11 The Role of National Parliaments in the Making of European Law

1998 ◽  
Vol 1 ◽  
pp. 217-231
Author(s):  
Timothy Pratt
Keyword(s):  
European Union ◽  
Maastricht Treaty ◽  
The Body ◽  
The Other ◽  
European Law ◽  
The European Union ◽  
National Parliaments ◽  
Treaty Of Amsterdam ◽  
First Time

While the Community Treaties provided the institutional framework for the European Community, much of what now makes up the constitution of the European Union was not provided for in those Treaties, but evolved within that framework. This is certainly true of the role of national parliaments. There is nothing about the role of national parliaments in any of the Treaties concluded prior to the Maastricht Treaty, and even then the references appear not in the body of the Treaty, but only in two Declarations annexed to it, one on the role of national parliaments in the European Union and the other on the Conference of the Parliaments. While the former states that it is important to encourage greater involvement of national parliaments in the activities of the European Union, it gives no indication of what that involvement should be. The Treaty of Amsterdam goes a step further. It includes a protocol on the role of national parliaments. This is important in that, for the first time, it gives substantive treaty recognition to their involvement in European Union activities. But, while it is markedly more supportive than the Maastricht Declarations, it does not confer any specific powers on national parliaments, nor does it attempt to define their functions.

Noah's Wife Again

PMLA ◽  
1941 ◽  
Vol 56 (3) ◽  
pp. 613-626 ◽  
Author(s):  
Anna Jean Mill
Keyword(s):  
Middle Ages ◽  
The Other ◽  
York Cycle ◽  
The Bible ◽  
Important Member ◽  
Important Study ◽  
First Time ◽  
The Devil ◽  
The Middle Ages

In her important study of the Wakefield Group in the Towneley cycle, Dr. Millicent Carey has much to say regarding the various English versions of the play of Noah and his wife. Here, says Dr. Carey, “Noah's wife appears as a speaking character for the first time ... Although she is mentioned in all the other versions from the Bible on, she is never known to utter a word until the dramatists of the Middle Ages make her an important member of their dramatis personae.” For the unbiblical Newcastle introduction of the devil and the temptation of Noah's wife—unique in the English miracle plays—Dr. Carey says that she has found no hint in Jewish legend. She considers the suggestion of Brotanek, who favors derivation by analogy with the Eve legend; of Brandl, who argues an approximation to Morality play construction; and of Cushman, who, rejecting the two former theories, remarks on the ubiquitous rôle of the devil as tempter in medieval legend generally. She points out an English dramatic parallel in the incident of the appearance of the devil to Pilate's wife in the York cycle, itself perhaps derived through analogy from the Eve story, and refers to certain other Continental parallels where the devil is a well-recognized device for registering “obstruction to the expressed wishes of God”—a device which may have originated in the Eve story or “may simply be a reflection of the mediaeval tendency to explain all evil as caused by the devil.”

scholarly journals Zlata Tkach’s Concerto for Piano and Orchestra as a Culmination of the Composer Symphonic Thinking

2021 ◽  
Vol 4 (2) ◽  
pp. 287-295
Author(s):  
Alyona Vardanyan
Keyword(s):  
Research Methodology ◽  
Deep Understanding ◽  
The Other ◽  
Late Period ◽  
Piano Concerto ◽  
Thematic Structure ◽  
Creative Personality ◽  
First Time

The purpose of the article is to characterize Zlata Tkach’s Piano Concerto as the culminating composition in the genre of the composer’s symphonic music. The research methodology is based on the method of complex musicological analysis, due to which, the role of this work in the system of memorial genres of the author is determined, typical style features of her work late period are revealed, the thematic structure of the Concerto is characterized from the position of the manifestation of the principle of dialogicity and monothematism. The scientific novelty of the research is that for the first time, intonation processes in a Piano Concerto by Z. Tkach are systematically analyzed and the correlation of its traditional and innovative features is characterized. Being by genre attribution an opus with a pronounced desire to use modern means of expression, the concert is distinguished by the manifestation of the principle of microthematism and textural thematism. In the dramaturgical solution, the author conducts a constructive search in dynamic, timbre and rhythmic comparisons. At the same time, the intonational unity between the sections of the form, being the development of the romantic principle of poetry, is expressed in the form of monothematism. Conclusions. The creative method of Z. Tkach manifests itself in the synthesis of tradition and experiment. This is confirmed by the intonation-thematic structure of the Piano Concerto, in which the convergence of contrasting material contributes to the formation of an integral musical and dramatic concept. The motifs that form the basis of the monothematism complex establish intonation arches between the sections of a one-part composition, fastening them and subordinating them to a common plan. Important importance belongs to the opposition of the roles of the participants in the performance. Their dialogical activity is manifested in a peculiar way by the composer, primarily in the dialogue between the soloist and the orchestra: the interweaving of two contrasting figurative spheres is realized primarily in terms of content. The principle of monothematism is manifested especially vividly in the characterization of tragic reflections, painful reflections on the eternal conflict of the creative personality with the surrounding world, leading to a deep understanding of what exists. The other embodies the dynamism of life, dominating in the culmination of ‘action’, the accumulation of energy. Both the piano and the orchestra are equally involved in the development of both figurative principles. The resulting translational, purposeful movement towards the finale determines, along with the principle of monothematism, the integrity of the entire composition.

scholarly journals SUMOylome Modulates Intraflagellar Transport Machinery and Eukaryotic Cilia Motility

2021 ◽  
Author(s):  
Komal Sharma ◽  
Irina Sizova ◽  
Girdhar Pandey ◽  
Peter Hegemann ◽  
Suneel Kateriya
Keyword(s):  
Functional Role ◽  
Intraflagellar Transport ◽  
Small Gtpase ◽  
The Other ◽  
Signaling Proteins ◽  
Sumoylation Site ◽  
C Terminus ◽  
First Time ◽  
Insight Into

Abstract Translocation of channelrhodopsins (ChRs) is mediated by intraflagellar transport (IFT) machinery. However, the functional role of the network containing photoreceptors, IFT and other proteins in controlling cilia motility of the alga is still not fully delineated. In the current study, we identified two important motifs at the C-terminus of ChR1. One of them is similar to a known ciliary targeting sequence that specifically interacts with a small GTPase, and the other is a SUMOylation site. For the first time, experimental data provide an insight into the role of SUMOylation in the modulation of IFT & ChR1. Blocking of SUMOylation affected the phototaxis of C. reinhardtii cells. This implies SUMOylation based regulation of protein network controlling photomotility. The conservation of SUMOylation site pattern as analyzed for the relevant photoreceptors, IFT and its associated signaling proteins in other ciliated green algae suggested SUMOylation based photobehavioural response across the microbes. This report establishes a link between evolutionary conserved SUMOylation and ciliary machinery for the maintenance and functioning of cilia across the eukaryotes. Our enriched SUMOylome of C. reinhardtii comprehends the proteins related to ciliary development and, photo-signaling, along with homologue(s) associated to human ciliopathies as SUMO targets.

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