Evaluation of KI-67 expression in uterine leiomyoma and in healthy myometrium: a pilot study

SUMMARY OBJECTIVE Evaluate the expression of KI-67 in uterine leiomyomas and adjacent myometrial tissue and verify the existence of a correlation between clinical parameters and KI-67 expression in tumors. METHODS This is a cross-sectional, controlled, analytical study. Samples of leiomyomas and myometrium were obtained from patients who underwent hysterectomy. The samples were processed by immunohistochemistry using KI-67 antibody, and the expression was evaluated by two blinded observers. Student›s T-test was used for comparison of means, and Pearson›s P test for correlation with clinical parameters. RESULTS A total of 9 patients were included in the study. The mean age was 40.7 years, ranging from 35 to 44 years. The mean expression of KI-67 in myometrium was 1.63%, and, in leiomyomas, 5.96% (p <0.001). The highest expression of KI-67 was moderately related to the severity of anemia, bleeding, and pain level. CONCLUSION The expression of KI-67 in normal myometrium was significantly lower than in leiomyomas. The highest expression of KI-67 was moderately related to the severity of anemia, bleeding, and pain level in the patients of this study.

Download Full-text

Relationship between Body Mass Index and Tooth Decay in a Population of 3–6-Year-Old Children in Iran

International Journal of Dentistry ◽

10.1155/2015/126530 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 6

Author(s):

Leila Shafie Bafti ◽

Maryam Alsadat Hashemipour ◽

Hamidreza Poureslami ◽

Zeinab Hoseinian

Keyword(s):

Body Weight ◽

Analytical Study ◽

Deciduous Teeth ◽

Tooth Decay ◽

Cross Sectional ◽

Dmft Index ◽

The Mean ◽

Iranian Children ◽

The Relationship

The aim of the present study was to evaluate the relationship between BMI and tooth decay in a population of Iranian children. In this cross-sectional descriptive/analytical study, 1482 children were selected from kindergartens and preschool centers in Kerman, Iran. The children underwent examination of deciduous teeth (using the dmft index) after determination of height and weight for calculation of BMI. The relationship between BMI (after adjustment for age) and dmft was determined using Poisson’s regression model. The mean of dmft in children with normal BMI was 1.5-fold that in subjects with extra body weight. Age had a significant effect on dmft. In addition, dmft was higher in boys compared to girls. The results of the present study showed that caries rate in the deciduous teeth of 3–6-year-old children decreases with an increase in body weight.

Download Full-text

Comparison of Quality and Lifestyle in Women with and Without Uterine Leiomyoma Referred to Gynecology Clinics of Shiraz University of Medical Sciences in 2018

Shiraz E-Medical Journal ◽

10.5812/semj.100815 ◽

2020 ◽

Vol In Press (In Press) ◽

Author(s):

Mahnaz Zarshenas ◽

Mozhgan Sorkhenezhad ◽

Marzieh Akbarzadeh

Keyword(s):

Quality Of Life ◽

Uterine Leiomyoma ◽

Healthy Lifestyle ◽

World Health ◽

Medical Sciences ◽

Cross Sectional ◽

World Health Organization Quality ◽

Significant Difference ◽

The Mean

Background: Uterine leiomyomas are considered as a major source of complications and the most common cause of hysterectomy. Objectives: The aim of this study was to compare the quality of life in women with and without uterine leiomyoma referred to gynecology clinics of Shiraz University of Medical Sciences in 2018. Methods: In this cross-sectional study, a total of 126 patients who referred to the clinics of Shiraz University of Medical Sciences were selected and divided into equal groups according to uterine leiomyoma, 1 - 7 cm uterine leiomyoma group and non-uterine leiomyoma group by convenience sampling. The World Health Organization Quality of Life and Healthy Lifestyle questionnaires were used for data collection. Independent t-test was used to analyze the data. Results: The mean quality of life of women with uterine leiomyoma was 47.20 ± 12.41 and women without uterine leiomyoma had a significant difference (51.11 ± 11.23, t = 3.93, P = 0.041). The mean lifestyle of women with uterine leiomyoma was 114.18 ± 25.48 and women without uterine leiomyoma had 149.11 ± 23.81 (t = 4.01, P = 0.029). Conclusions: The mean score of quality of life and lifestyle were significantly different in women with and without uterine leiomyoma. Therefore, it is necessary to improve the quality of life of women by improving their lifestyle and providing psychological counseling.

Download Full-text

Perubahan nilai laktat serum dan nilai leukosit pasca penanganan pasien multitrauma

JURNAL BIOMEDIK (JBM) ◽

10.35790/jbm.8.2.2016.12703 ◽

2016 ◽

Vol 8 (2) ◽

Author(s):

Jimmy Koan ◽

Laurens T. B. Kalesaran ◽

Heber B. Sapan

Keyword(s):

Blood Lactate ◽

Analytical Study ◽

Early Stage ◽

Cellular Level ◽

Metabolic Changes ◽

T Test ◽

Laboratory Markers ◽

The Mean ◽

Paired T Test

Abstract: Available laboratory markers in the early stage of injury are very helpful for the clinicians to predict the diturbances in cellular level concerning prevention of early decompensation, therefore, vital condition of the patient can improve faster. Lactate and leucocyte levels are assumed as sensitive markers of metabolic changes that occur at the time of injury. This study aimed to obtain the changes of lactate and leukocyte levels in multitraumatic patients after resusitation at Prof. Dr. R. D. Kandou Hospital Manado from August to September 2015. This was an observational analytical study. The results showed that there were 36 multitraumatic patients in this study, consisted of 27 males and 9 females. One patient died during this study. The mean decrease of blood lactate was 1.4611 mmol/L, meanwhile, of leukocytes was 5582.2000/mm3. The paired T test showed very significant changes of blood lactate and leukocyte levels (P < 0.001) after resusitation. Conclusion: Achievement of resusitation and improvement in cellular level could be monitored by using lactate and leukocyte levels after resusitation of multitraumatic patients although the definitive aim of the trauma was not final yet.Kata kunci: lactate, leukocyte, multitraumatic patientsAbstrak: Tersedianya penanda laboratorik pada fase awal cedera dapat memudahkan klinisi memrediksi kelainan yang terjadi di tingkat sel untuk mencegah terjadinya fase dekompensasi secara dini sehingga dapat memperbaiki kondisi vital pasien dengan segera. Kadar laktat dan jumlah leukosit telah lama dianggap sebagai salah satu penanda yang sensitif terhadap perubahan metabolisme yang terjadi saat cedera. Penelitian ini bertujuan untuk mengetahui perubahan nilai serum laktat dan leukosit darah yang terjadi pada pasien multitrauma setelah penanganan di RSUP Prof. Dr. R. D. Kandou Manado sejak bulan Agustus sampai dengan September 2015. Jenis penelitian ini observasional analitik dengan desain potong lintang. Hasil penelitian memperlihatkan terdapat 36 pasien multitrauma, terdiri dari 27 laki-laki dan 9 perempuan. Selama penelitian didapatkan 1 pasien meninggal saat penanganan. Pada pasca penanganan, rerata penurunan nilai asam laktat darah sebesar 1,4611 mmol/L dan nilai leukosit sebesar 5582,2000/mm3. Hasil uji T berpasangan memperlihatkan perubahan nilai laktat darah dan leukosit pasca penanganan yang sangat bermakna (P < 0,001). Simpulan: Tercapainya resusitasi dan perbaikan di tingkat sel dapat dimonitor dari nilai laktat dan leukosit darah pasca penanganan pasien multitrauma walaupun penanganan belum sampai pada tujuan definitif trauma.Kata kunci: asam laktat, leukosit, multitrauma

Download Full-text

Self-Management Status in Patients with Diabetes and Disease Control Indicators in Lamerd City, Iran

Jundishapur Journal of Chronic Disease Care ◽

10.5812/jjcdc.99992 ◽

2020 ◽

Vol 9 (2) ◽

Author(s):

Fereidoun Jahangir ◽

Esmaeil Kavi ◽

Behnam Masmouei ◽

Mohammad-Rafi Bazrafshan ◽

Hamed Delam ◽

...

Keyword(s):

Waist Circumference ◽

Disease Control ◽

Correlation Coefficient ◽

Pearson Correlation ◽

T Test ◽

The Self ◽

Self Management ◽

Pearson Correlation Coefficient ◽

Cross Sectional ◽

The Mean

Background: Diabetes is a global epidemic with serious complication and there is a clear need for paying special attention to self-management as the cornerstone to optimal control of the disease. Objectives: This study aimed to assess the self-management status and its correlation to disease control indicators in people with diabetes. Methods: In a descriptive cross-sectional study, 220 patients were selected from the list of the referred patients available in Lamerd public health network from December 2014 to June 2015. In the first step, data about demographic information and disease control were collected from the patients’ records. In the second step, the self-management status of each patient was assessed by the Diabetes Self-Management Questionnaire developed by Schmitt et al. To analyze the data, independent sample t-test and Pearson correlation coefficient were used. Results: The mean age of the male and female participants was 56.43 ± 13.50 and 56.46 ± 10.49 years old, respectively. The mean duration of the disease was 6.67 ± 4.72 years for men and 7.07 ± 5.30 years for women. Twenty-one (25.9%) men and 60 (43.7%) women had a history of smoking. The results of the Pearson correlation coefficient showed that there was an inverse and statistically significant relationship between diabetes self-management status and weight, body mass index (BMI), waist circumference, glucose tolerance test (GTT), LDL, and cholesterol. The results of the t-test did not show significant differences between the level of HbA1C (HbA1C7) and self-management scores of the patients (P > 0.05). Conclusions: Patients with better self-management status were in a better disease control condition with respect to weight, BMI, waist circumference, GTT, LDL, and cholesterol levels. Special attention to the control and management of LDL, cholesterol, HbA1C, BMI, and blood pressure levels is recommended in planning for these patients.

Download Full-text

KOMPARASI ELASTISITAS PEMBIAYAAN PENANGGULANGAN PENYAKIT MENULAR DIREGIONAL JAWA BALI DAN PAPUA

Buletin Penelitian Sistem Kesehatan ◽

10.22435/hsr.v21i2.287 ◽

2018 ◽

Vol 21 (2) ◽

pp. 133-140

Author(s):

Nuzulul Kusuma Putri ◽

Herti Maryani ◽

Thinni Nurul Rochmah ◽

Ernawaty Ernawaty

Keyword(s):

Analytical Study ◽

Communicable Disease ◽

Health Condition ◽

T Test ◽

Health Programs ◽

Health Index ◽

Cross Sectional ◽

Health Characteristic ◽

The Difference ◽

The Ideal

The rapid growth and the various communicable diseases should be compensated with qualifi ed health programs. The programs’ budget should be able to meet the need of communicable disease intervention. In the era of decentralization, differences in the ability of each district in handling health problems could triger the disparity between districts. This research analyzes the difference of budget elasticity that existed in the communicable disease intervention between districts in Java Bali and Papua region. This is an analytical study which analyze the difference of communicable disease budget elasticity based on the geographic characteristics, fi scal capacity, and health status in each districts. The data is collected cross sectional in all districts that exist in Java Bali and Papua as the population. The difference of elasticity based on each indicator used in this study was analysed using independent t-test. The elasticity of communicable disease prevention fi nancing is different among districts with different public health index inJava Bali and Papua regional. Themajority of communicable disease budget in districts are inelastic, in both regions. It is different with the assumption that budget elasticity of communicable disease should be responsive. The budget elasticity of communicable disease in Indonesia is infl uenced by its health condition of each district. This condition is contrast to the ideal budget elasticity that should be elastic in accordance to the communicable disease problems. The use of economic assumption for further research should be concerns to the uncertainty of health characteristic. Abstrak Tingginya laju pertumbuhan dan bervariasinya jenis penyakit menular harus diimbangi dengan upaya penanggulangan yang responsif. Pembiayaan penanggulangan penyakit menular harus menyesuaikan dengan perkembangan penyakit menular. Di era desentralisasi, terdapat perbedaan kemampuan tiap daerah dalam pembiayaan kesehatan sehingga menyebabkan adanya disparitas penyakit antar daerah. Penelitian ini bertujuan untuk melakukan komparasi elastisitas pembiayaan yang telah dikeluarkan oleh pemerintah daerah dalam penanggulangan penyakit menular di regional Jawa Bali dan Papua. Komparasi ini dilakukan sebagai analisis lanjut Riset Pembiayaan Kesehatan tahun 2015 oleh Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI. Penelitian analitik ini melakukan komparasi elastisitas pembiayaan penanggulangan penyakit menular berdasarkan perbedaan karakteristik geografi , kemampuanfiskal, dan status kesehatan pada setiap kabupaten/kota yang ada di regional Jawa Bali dan Papua. Data dikumpulkan secara cross sectional pada Dinas Kesehatan kabupaten/kota yang ada di regional Jawa Bali dan Papua. Komparasi elastisitas terhadap setiap indikator yang digunakan dalam penelitian ini dianalisis menggunakan independent t-test. Elastisitas pembiayaan penanggulangan penyakit menular antar Kabupaten/Kota berbeda pada regional Jawa Bali dan Papua dengan IPKM berbeda. Kondisi pembiayaan penanggulangan penyakit menular yang seharusnya elastis, tidak terjadi pada kedua regional. Mayoritas Kabupaten/Kota cenderung inelastis dalam membiayai penanggulangan penyakit menular di masing-masing daerah. Elasitisitas pembiayaan penanggulangan penyakit menular pada Kabupaten/Kota di Indonesia dipengaruhi oleh kondisi kesehatan masing-masing daerah. Kondisi ini bertolak belakang dengan asumsipembiayaan penanggulangan penyakit menular yang harusnya responsif sesuai dengan masalah penyakit menular yang muncul. Penggunaan asumsi yang juga memperhatikan beberapa masalah kesehatan lain merupakan hal yang perlu digunakan pada penelitian selanjutnya.

Download Full-text

Difference of Maternal Serum Interleukin-8 in Preterm Labor and Full Term Labor

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v2i4.404 ◽

2016 ◽

Author(s):

Komang W Budiartha

Keyword(s):

Preterm Labor ◽

Cross Sectional Study ◽

Maternal Serum ◽

T Test ◽

Full Term ◽

Interleukin 8 ◽

Cross Sectional ◽

The Mean ◽

The Difference ◽

Term Labor

Objective: To determine the difference of maternal interleukin-8 (IL-8) in preterm labor and full term labor. Method: This is a cross sectional study with 68 samples, 29 subjects with preterm labor and 39 subjects with full term labor. IL-8 concentration was obtained from blood samples of the subjects, which were examined at Prodia Laboratory Denpasar. Data was analyzed using t-test for independent samples with =0.05. Result: The mean IL-8 level for the preterm labor group was 23.56 10.69 pg/ml and 12.19 5.79 pg/ml for the full term labor group. Statistical analysis using independent samples t-test showed that the average IL-8 level of both groups were significantly different (p=0.001). Conclusion: We concluded from this study that serum IL-8 concentration in women who had preterm labor is significantly higher in comparison to women who had full term labor. [Indones J Obstet Gynecol 2014; 4: 185-187] Keywords: full term labor, interleukin-8, preterm labor

Download Full-text

Hubungan Stunting dengan Prestasi Belajar Anak Sekolah Dasar di Kecamatan Tikala Manado

e-CliniC ◽

10.35790/ecl.6.2.2018.22128 ◽

2018 ◽

Vol 6 (2) ◽

Author(s):

Gregorius Gunawan ◽

Jeanette I. Ch. Manoppo ◽

Rocky Wilar

Keyword(s):

Elementary School ◽

Elementary School Students ◽

Analytical Study ◽

T Test ◽

Learning Ability ◽

School Students ◽

Cross Sectional ◽

Learning Achievement ◽

Significant Difference ◽

Cross Sectional Design

Abstract: Stunting is a condition where height is not in accordance with age. It is due to chronic malnutrition which causes nonoptimal brain development that can affect children’s cognitive development, performance at school, and learning ability, as well as consequently influences learning achievement at school. This study was aimed to identify the correlation between stunting and learning achievement of elementary school students at Tikala Manado. This was an analytical study with a cross sectional design. Respondents were elementary school students at Tikala Manado aged 7-13 years that had their average grades. Data were analyzed by using unpaired T-test. The results showed that there were 232 students as respondents. Stunting was found in 103 students (44%) and not stunting in 129 students (56%). The average grade of stunting students was 67.16 and of not stunting students was 68.53. Statistical analysis showed that there was no significant difference between the average student grade in stunting students and not stunting students (P=0.215; α=0.05). Conclusion: There was no significant correlation between stunting and learning achievementKeywords: stunting, learning achievement Abstrak: Stunting merupakan keadaan dimana tinggi badan tidak sesusai dengan usia. Hal ini dapat menyebabkan perkembangan otak tidak optimal sehingga berpengaruh pada perkem-bangan kognitif dan performance anak di sekolah, serta kemampuan belajar, yang selanjutnya berpengaruh pada prestasi belajar anak di sekolah. Penelitian ini bertujuan untuk mengetahui hubungan stunting dan prestasi belajar pada siswa Sekolah Dasar di Kecamatan Tikala Manado. Jenis penelitian ialah analitik dengan desain potong lintang. Responden ialah siswa sekolah dasar di Kecamatan Tikala Manado yang berusia 7-13 tahun dan rerata nilai rapor siswa. Analisis uji statistik yang digunakan ialah uji T-test tidak berpasangan. Hasil penelitian mendapatkan 232 siswa sebagai responden. Stunting didapatkan pada 103 siswa (44%) dan yang tidak stunting 129 siswa (56%). Rerata nilai rapor pada siswa stunting 67,16 dan yang tidak stunting 68,53. Hasil uji analisis menunjukkan tidak terdapat perbedaan rerata prestasi belajar antara siswa stunting dan tidak stunting (P=0,215; α=0,05). Simpulan: Tidak terdapat hubungan bermakna antara stunting dan prestasi belajar.Kata kunci: stunting, prestasi belajar

Download Full-text

DOCTORS NEED ENHANCED ONCOLOGY KNOWLEDGE

The Professional Medical Journal ◽

10.29309/tpmj/2006.13.02.5037 ◽

2006 ◽

Vol 13 (02) ◽

pp. 313-316

Author(s):

TARIQ PARVEZ ◽

BABAR PARVEZ ◽

AMAL BEHANI

Keyword(s):

Analytical Study ◽

T Test ◽

Cross Sectional ◽

Improve Design ◽

Student’S T ◽

Test Result ◽

Student’S T Test

Objective: To assess oncology knowledge among doctors, andsuggestions to improve. Design: Cross sectional analytical study. Place and duration of study: This study was carriedout in the Department of Oncology, King Fahad Hospital, Madina Munawra, KSA and was completed in 8 months fromNovember 2004 to June 2005. Subjects and Methods: Series of five lectures were delivered on different subjects ofoncology. Participants were asked to answer an MCQ type questionnaire, which was structured regarding the contentof the lecture, before the lecture and after the lecture. Comparison was made by simple percentage calculation andstatistical analysis, student’s t-test. Result: Knowledge of the doctors rose from average 37% to 74% after the lecture.Conclusion: Doctors need enhanced knowledge in oncology and simple lecturing can make an improvement

Download Full-text

Socidemographic and health characteristics and their relationship with the perception of family support of elderly residents in peripheral areas

Revista de Enfermagem UFPE on line ◽

10.5205/reuol.1192-10319-1-le.0502201102 ◽

2011 ◽

Vol 5 (2) ◽

pp. 158

Author(s):

Luciana Araújo dos Reis ◽

Gilson De Vasconcelos Torres ◽

Thaiza Teixeira Xavier

Keyword(s):

Family Support ◽

Analytical Study ◽

Domain Adaptation ◽

Family Health ◽

State University ◽

Cross Sectional ◽

The Mean ◽

Peripheral Areas ◽

Cross Sectional Design ◽

State Examination

ABSTRACTObjective: to determine the influence of sociodemographic and health variables on the perception of family support of elderly residents in peripheral areas. Method: this is an analytical study with a cross-sectional design, using a sample of 150 seniors, mean age of 74.47 (± 9.42) years, enrolled in four Health Units in the municipality of Jequié, Brazil. The instruments used were: sociodemographic data, health conditions, Mini-Mental State Examination (MMSE) and the Perception of Family Support Inventory (PFSI). The research protocols were reviewed and approved by the Ethics in Human Research of the State University of Southwest Bahia (Opinion No. 189/2008). Results: with the application of Student t test between the mean areas of the Inventory of Perceived Family support and sociodemographic variables and health, there was statistical difference between the domain Autonomy and occupation of free time (p = 0.047) and between the domain adaptation and Family health problems (

Download Full-text

Fraction of Exhaled Nitric Oxide (FeNO) Norms in Healthy Tunisian Adults

BioMed Research International ◽

10.1155/2014/269670 ◽

2014 ◽

Vol 2014 ◽

pp. 1-13 ◽

Cited By ~ 4

Author(s):

Sonia Rouatbi ◽

Mohamed Ali Chouchene ◽

Ines Sfaxi ◽

Mohamed Ben Rejeb ◽

Zouhair Tabka ◽

...

Keyword(s):

Analytical Study ◽

Total Sample ◽

Cross Sectional ◽

Convenience Sample ◽

Natural Logarithm ◽

Upper Limit ◽

Additional Group ◽

Reference Equation ◽

The Mean ◽

Medical Questionnaire

Aims. To establish FeNOnorms for healthy Tunisian adults aged 18–60 years and to prospectively assess their reliability.Methods. This was a cross-sectional analytical study. A convenience sample of healthy Tunisian adults was recruited. Subjects responded to a medical questionnaire, and then FeNOlevels were measured by an online method (Medisoft, Sorinnes (Dinant), Belgium). Clinical, anthropometric, and plethysmographic data were collected. All analyses were performed on natural logarithm values of FeNO.Results. 257 adults (145 males) were retained. The proposed reference equation to predict FeNOvalue is lnFeNO(ppb) = 3.47−0.56× height (m). After the predicted FeNOvalue for a given adult was computed, the upper limit of normal could be obtained by adding 0.60 ppb. The mean ± SD (minimum-maximum) of FeNO(ppb) for the total sample was13.54±4.87(5.00–26.00). For Tunisian and Arab adults of any age and height, any FeNOvalue greater than 26.00 ppb may be considered abnormal. Finally, in an additional group of adults prospectively assessed, we found no adult with a FeNOhigher than 26.00 ppb.Conclusion. The present FeNOnorms enrich the global repository of FeNOnorms that the clinician can use to choose the most appropriate norms.

Download Full-text