scholarly journals Combination of GI-RADS and 3D-CEUS for differential diagnosis of ovarian masses

2019 ◽  
Vol 65 (7) ◽  
pp. 959-964
Author(s):  
Xiali Wang ◽  
ShupingYang ◽  
Guorong Lv ◽  
Jianmei Liao ◽  
Shufen Wu ◽  
...  
Keyword(s):  
Scoring System ◽  
Multiple Logistic Regression Analysis ◽  
Three Dimensional ◽  
Area Under The Curve ◽  
Chi Square ◽  
Kappa Value ◽  
Long Term Follow Up ◽  
Chi Square Test ◽  
Contrast Enhanced Ultrasonography ◽  
Ovarian Masses

SUMMARY OBJECTIVE The purpose of this study is to evaluate the efficacy of the combination of gynecologic imaging reporting and data system (GI-RADS) ultrasonographic stratification and three-dimensional contrast-enhanced ultrasonography (3D-CEUS) in order to distinguish malignant from benign ovarian masses. METHODS In this study, 102 patients with ovarian masses were examined by both two-dimensional ultrasound(2D-US) and 3D-CEUS. Sonographic features of ovarian masses obtained from 3D-CEUS were analyzed and compared with 2D-US. All patients with ovarian masses were confirmed by operational pathology or long-term follow-up results. RESULTS (1)The Chi-square test and multiple Logistic regression analysis confirmed that there were only eight independent predictors of malignant masses, including thick septa (≥3mm), thick papillary projections(≥7mm), solid areas, presence of ascites, central vascularization, contrast enhancement, distribution of contrast agent, and vascular characteristics of the solid part and their odds ratios which were 5.52, 5.39, 4.94, 4.34, 5.92, 7.44, 6.09, and 7.67, respectively (P<0.05). (2)These eight signs were used to combine the GI-RADS with 3D-CEUS scoring system in which the corresponding value of the area under the curve (AUC) was 0.969, which was superior to using GI-RADS lonely (Z-value=1.64, P<0.025). Using 4 points as the cut-off, the scoring system showed the performance was clearly better than using GI-RADS alone (P<0.05). (3) The Kappa value was 0.872 for two different clinicians with equal experience. CONCLUSIONS The combination of GI-RADS and 3D-CEUS scoring system would be a more effective method to distinguish malignant from benign ovarian masses.

Performance of Abbreviated Protocols Versus Unenhanced MRI in Detecting Occult Breast Lesions of Mammography in Patients with Dense Breasts

2021 ◽  
Author(s):  
Suhong Zhao ◽  
Peipei Chen ◽  
Guangrui Shao ◽  
Baijie Li ◽  
Huikun Zhang ◽  
...  
Keyword(s):  
Reading Time ◽  
Area Under The Curve ◽  
Lesion Size ◽  
Lower Sensitivity ◽  
Chi Square ◽  
Dense Breast Tissue ◽  
Negative Findings ◽  
Chi Square Test ◽  
The Difference ◽  
Sensitivity Specificity

Abstract Objective: To assess the diagnostic ability of abbreviated protocols of MRI (AP-MRI) compared with unenhanced MRI (UE-MRI) in mammographically occult cancers in patients with dense breast tissue.Materials and Methods: The retrospective analysis consisted of 102 patients without positive findings on mammography who received preoperative MRI full diagnostic protocols (FDP) between January 2015 and December 2018. Two breast radiologists read the UE, AP, and FDP. The interpretation times were recorded. The comparisons of the sensitivity, specificity and area under the curve of each MRI protocol, and the sensitivity of these protocols in each subgroup of different size tumors used the Chi-square test. The paired sample t-test was used for evaluating the difference of reading time of the three protocols.Results: Among 102 women, there were 68 cancers and two benign lesions in 64 patients and 38 patients had benign or negative findings. Both readers found the sensitivity and specificity of AP and UE-MRI were similar (p>0.05), whereas compared with FDP, UE had lower sensitivity (Reader 1/Reader 2: p=0.023, 0.004). For different lesion size groups, one of the readers found that AP and FDP had higher sensitivities than UE-MRI for detecting the lesions ≤10 mm in diameter (p=0.041, p=0.023). Compared with FDP, the average reading time of UE-MRI and AP was remarkably reduced (p < 0.001).Conclusion: AP-MRI had more advantages than UE-MRI to detect mammographically occult cancers, especially for breast tumors ≤10 mm in diameter.

Est-il possible de définir un profil plus efficace? Comparaison entre enseignants français et italiens

CADMO ◽  
2012 ◽  
pp. 65-94
Author(s):  
Francesca Corradi
Keyword(s):  
Public Schools ◽  
Participant Observation ◽  
Three Dimensional ◽  
Reggio Emilia ◽  
Historical Period ◽  
General View ◽  
Structured Interviews ◽  
Chi Square ◽  
Chi Square Test ◽  
Teachers Attitudes

Kindergarten teachers' attitudes toward immigrant children and children of immigrant families is the subject of research conducted between 2009 and 2010. The study compares teachers in the public schools of Avignon, France, with state school teachers of Reggio Emilia, Italy. The analysis conducted mainly considered relations between two variables. However, the research tools used (participant observation, Likert type-scale questionnaire and semi-structured interviews) also allowed for the triangulation of data. The intent of this article is to elaborate on the methodological contribution to the research using multivariate analysis. This analysis provides both three-dimensional representations of the teachers' attitudes as well as individualized representations of relevant relations between variables. The statistic test of the null hypotheses, the "chi-square test" is used. The analysis points out attitude and behaviour differences between Reggio Emilia teachers and Avignon teachers. Differences are mostly observed in the synchronic dimension data analysis. Nevertheless, if the point of observation is changed and data are studied in the diachronic dimension, that general view demonstrates how a current historical period influences educational choices within a particular educational system and consequently influences teachers' attitudes.

scholarly journals Tuberculum sellae meningiomas: A series of 41 cases; surgical and ophthalmological outcomes with proposal of a new prognostic scoring system

2012 ◽  
Vol 03 (03) ◽  
pp. 286-293 ◽  
Author(s):  
Arun Palani ◽  
Manas K Panigrahi ◽  
Anirudh K Purohit
Keyword(s):  
Prognostic Factors ◽  
Scoring System ◽  
Visual Outcome ◽  
Categorical Variables ◽  
P Value ◽  
Visual Recovery ◽  
Chi Square ◽  
Factors Affecting ◽  
Chi Square Test ◽  
Tuberculum Sellae

ABSTRACT Context: Tuberculum sellae meningiomas have proved difficult to treat, partly because of their intimate association with the optic nerves and chiasma, hypothalamus, and internal carotid arteries. Aims: The aim of this study is to analyze the degree of influence of various prognostic factors affecting visual outcome; the pattern of visual recovery and develop a scoring system for prognostication. Settings and Design: This is a retrospective study carried out from January 2004 till June 2011. Materials and Methods: Patients were analyzed on the basis of clinical, radiological, and surgical factors that appeared to affect the outcome. A special scoring system (according to the guidelines of the German Ophthalmological Society) was adopted to quantify the extent of ophthalmological disturbances. Statistical Analysis Used: Comparison of categorical variables between the two was performed using chi-square test and a P value of ≤ 0.05 was considered significant. Logistic regression was used when multivariate analysis was required. Results: Vision improved in 27% and deteriorated in 7.3%. A prognostic scoring system (score 4–13) was developed depending on the degree of influence of significant prognostic factors. The patients with a score of ≤6 had improved vision postoperatively (44%), whereas none of those with a score > 6 improved. Completeness of visual recovery was perceived in 100% of patients within 3 months. Complete resectability was achieved in 73% of patients. Conclusions: The proposed scoring system is very useful in prognosticating the visual outcome of these patients. The patients with a score of ≤6 have the best visual outcome postoperatively. Complete resectability is better achieved with extended bifrontal and unilateral frontal approaches. Short-term postoperative visual outcome is a strong indicator of permanent visual outcome after surgery.

Assessment of Thrombotic Risk in Cancer Patients: Proposal of a Scoring System. A Monocentric Study.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3991-3991
Author(s):  
Giulio Giordano ◽  
Giuliana Farina ◽  
Tambaro Rosa ◽  
Silvia Piano ◽  
Monica Specchia ◽  
...  
Keyword(s):  
Cancer Patient ◽  
Total Cholesterol ◽  
Predictive Value ◽  
Scoring System ◽  
Chemotherapeutic Agents ◽  
Chi Square ◽  
Thrombotic Risk ◽  
Antithrombotic Prophylaxis ◽  
The Real ◽  
Chi Square Test

Abstract Background Deep venous thrombosis (DVT) is present in about 3–15% of cancer patient. Paraneoplastic thrombosis pathogenesis is multifactorial. Antithrombotic prophylaxis frequently is not oriented to the real thrombotic or haemorragic risk of the patients. Aim Aim of our study is to define the real thrombotic risk in neoplastic patient. With this purpose we considered in our patients complement fraction C3 and C4 and circulating immune-complexes (CIC) because they activate macrophages and platelets and increase tissue factor level. Moreover we evaluated also total cholesterol and triglycerides level, because they are linked with factor VII activation. Chemotherapy dose density and chemotherapeutic agents used were also included in our investigation as pro-inflammatory/pro-thrombotic risk factors. Methods We considered C3, C4, CIC, cholesterol and triglycerides level, dose density and chemotherapeutic agents used in 119 patients with solid neoplasms (62 colon, 27 lung, 18 gastric, 12 others) and without anticoagulant prophilaxis. Of these only 105 were evaluable because in these all the data were available. Median age was 68.5 years (R 57–83). M/F ratio was 72/47. The threshold value of third quartile was chosen as risk cut-off (C3: 130mg/dl; C4: 32mg/dl; ICC: 2.9 mcg/ml; total cholesterol: 205mg/dl; triglycerides 123mg/dl). We elaborated a scoring system in which 1 point was attributed to each value inferior to the third quartile. One point was added or removed if patient received or not Irinotecan. In fact this drug was the only variable that in univariate analysis showed an high Yates corrected chi square test (4, p 0.045). The statistical analysis was conducted with Yates corrected chi square test, Odds Ratio (OR), realtive risk (RR). Furthermore Erythrocyte Sedimentation Rate (ESR) and C-reactive Protein (CRP) were also evaluated. Results 27 patients (26%) showed DVT. Of these 23(85%) had a score ≤3 and 4 (15%) ≥4. 78 patients (74%) did not show DVT. Of these 46(59%) had a score ≥4 and 26 ≤3. Yates corrected chi square test is 15.68 (p <0.0001), with an OR of 8.2 (95%CI 2.7–24.9) and a RR of 5.2 (95%CI 2.1–13.9). Negative predictive value is 0.92 (95%CI 0.83–0.96) and positive predictive value is 0.42 (95%CI 0.34–0.46). Sensitivity was 0.85 (95%CI 0.70–0.93) and specificity was 0.59 (95%CI 0.53–0.62). Duration of chemotherapy was not influent on DVT onset (Chi-Square 0.8, p 0.3; OR 0.6). CRP and ESR at Pearson’s test were not related with C3, C4, CIC, total cholesterol and triglyceride levels. Colon and stomach cancer were frequently related with DVT onset (62% of all DVT cases). Summary/Conclusions The neoplastic patient frequently shows haemorrhagic risk (eg in chemotherapy induced thrombocytopenia). Therefore anti-thrombotic prophylaxis should be used considering the real thrombotic and haemorragic risk of neoplastic patient. Our scoring system is useful in distinguishing cancer patient with low thrombotic risk and consent to avoid antithrombotic prophylaxis in patient with higher bleeding and lower thombotic risk. Nevertheless these data need confirmation on a larger cohort of patients.

scholarly journals Increased prevalence of autoimmune disease in patients with unilateral compared with bilateral moyamoya disease

2016 ◽  
Vol 124 (5) ◽  
pp. 1215-1220 ◽  
Author(s):  
Jian-Bin Chen ◽  
Yi Liu ◽  
Liang-Xue Zhou ◽  
Hong Sun ◽  
Min He ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Autoimmune Diseases ◽  
Moyamoya Disease ◽  
Multiple Logistic Regression Analysis ◽  
Disease Prevalence ◽  
Prevalence Rates ◽  
Chi Square ◽  
Autoimmune Thyroid ◽  
Chi Square Test ◽  
Moyamoya Vessel

OBJECT This study explored whether there were differences between the autoimmune disease prevalence rates in unilateral and bilateral moyamoya disease (MMD). METHODS The authors performed a retrospective review of data obtained from the medical records of their hospital, analyzing and comparing the clinical characteristics and prevalence rates of all autoimmune diseases that were associated with unilateral and bilateral MMD in their hospital from January 1995 to October 2014. RESULTS Three hundred sixteen patients with bilateral MMD and 68 with unilateral MMD were identified. The results indicated that patients with unilateral MMD were more likely to be female than were patients with bilateral MMD (67.6% vs 51.3%, p = 0.014, odds ratio [OR] 1.99). Overall, non-autoimmune comorbidities tended to be more prevalent in the unilateral MMD cases than in the bilateral MMD cases (17.6% vs 9.8%, p = 0.063, OR 1.97, chi-square test). Autoimmune thyroid disease and other autoimmune diseases also tended to be more prevalent in the unilateral MMD cases than in the bilateral MMD cases (19.1% vs 10.8%, p = 0.056, OR 1.96 and 8.8% vs 3.5%, p = 0.092, OR 2.77, respectively, chi-square test). The overall autoimmune disease prevalence in the unilateral MMD cases was significantly higher than in the bilateral MMD cases (26.5% vs 13.6%, p = 0.008, OR 2.29, 95% CI 1.22–4.28, chi-square test). Multiple logistic regression analysis showed that autoimmune disease was more likely to be associated with unilateral than with bilateral MMD (p = 0.039, OR 10.91, 95% CI 1.13–105.25). CONCLUSIONS This study indicated a higher overall autoimmune disease prevalence in unilateral than in bilateral MMD. Unilateral MMD may be more associated with autoimmune disease than bilateral MMD. Different pathogenetic mechanisms may underlie moyamoya vessel formation in unilateral and bilateral MMD.

scholarly journals Influence of intracanal post on apical periodontitis identified by cone-beam computed tomography

2009 ◽  
Vol 20 (5) ◽  
pp. 370-375 ◽  
Author(s):  
Carlos Estrela ◽  
Mike Reis Bueno ◽  
Olavo César Lyra Porto ◽  
Cleomar Donizeth Rodrigues ◽  
Jesus Djalma Pécora
Keyword(s):  
Computed Tomography ◽  
Cone Beam Computed Tomography ◽  
Apical Periodontitis ◽  
Cone Beam ◽  
Chi Square ◽  
Significance Level ◽  
Anterior Teeth ◽  
Kappa Value ◽  
Chi Square Test ◽  
Periapical Radiography

The determination of the success of endodontic treatment has been often discussed based on outcome obtained by periapical radiography. The aim of this study was to verify the influence of intracanal post on apical periodontitis detected by cone-beam computed tomography (CBCT). A consecutive sample of 1020 images (periapical radiographs and CBCT scans) taken from 619 patients (245 men; mean age, 50.1 years) between February 2008 and September 2009 were used in this study. Presence and intracanal post length (short, medium and long) were associated with apical periodontitis (AP). Chi-square test was used for statistical analyses. Significance level was set at p<0.01. The kappa value was used to assess examiner variability. From a total of 591 intracanal posts, AP was observed in 15.06%, 18.78% and 7.95% using periapical radiographs, into the different lengths, short, medium and long, respectively (p=0.466). Considering the same posts length it was verified AP in 24.20%, 26.40% and 11.84% observed by CBCT scans, respectively (p=0.154). From a total of 1,020 teeth used in this study, AP was detected in 397 (38.92%) by periapical radiography and in 614 (60.19%) by CBCT scans (p<0.001). The distribution of intracanal posts in different dental groups showed higher prevalence in maxillary anterior teeth (54.79%). Intracanal posts lengths did not influenced AP. AP was detected more frequently when CBCT method was used.

scholarly journals Factors Associated with Serious Injuries among Adolescents in Ghana: Findings from 2012 Global School Health Survey

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Martin Ackah ◽  
Mohammed Gazali Salifu ◽  
Hosea Boakye
Keyword(s):  
Logistic Regression ◽  
Multiple Logistic Regression Analysis ◽  
Multiple Logistic Regression ◽  
School Students ◽  
Chi Square ◽  
Chi Square Test ◽  
Amphetamine Use ◽  
School Truancy ◽  
Serious Injuries ◽  
Smoking Marijuana

Introduction. Injuries are of public health concern and the leading cause of residual disability and death among teenagers, especially in low- and middle-income countries (LMICs). In Ghana, the burden of injury among adolescents is under-reported. Hence, the study sought to determine the prevalence of serious injuries (SI) and the potential factors influencing these injuries among school children in Ghana. Methods. This study was conducted in Ghana among Junior High School (JHS) and senior high school students (SHS) using the 2012 Global School-Based Student Health Survey (GSHS) data. The GSHS employed two-stage cluster sampling method. Serious injuries (SI) and independent factors were measured via self-administered questionnaires. Pearson chi-square test between each explanatory variable and serious injuries was conducted and the level of statistical significance was set at 5%. The significant variables from the chi-square test were selected for multiple logistic regression analysis. Multiple logistic regression was performed to estimate the adjusted odds ratio (AOR) at 95% confidence interval (CI). Results. The prevalence of SI in the past 12 months was 66% [CI=61.8–70.2] . The most common cause of SI was fall, 36%. The common types of injuries were cut/stab wounds and broken/dislocated bone. In the multiple logistic regression analysis, after controlling for other variables, educational level (AOR = 0.64, CI = 0.44–0.90, p  < 0.015), suicidal ideation (AOR = 1.58, CI = 1.00–2.48, p  < 0.002), suicidal attempt (AOR = 1.88, CI = 1.29–2.72, p  < 0.001), having at least one close friend (AOR = 1.49, CI = 1.17–1.89, p  < 0.002), school truancy (AOR = 1.66, CI = 1.31–2.09, p  < 0.000), smoking marijuana (AOR = 2.64, CI = 1.22–5.69), and amphetamine use (AOR = 2.95, CI = 1.46–5.69) were independently associated with SI. Conclusion. The findings of the study established a high prevalence of SI among adolescents in Ghana, with cut/stab wound and broken/dislocated bone being the most reported type of injuries. This study also revealed that factors such as educational level, suicidal ideation, suicidal attempt, at least one close friend, school truancy, smoking marijuana, and amphetamine use are associated with SI among the adolescents. Therefore, pragmatic interventional programs should be targeted at these factors to curb the rate of SI among junior and senior school students.

scholarly journals A Novel Scoring System for Early Assessment of the Risk of the COVID-19-associated Mortality in Hospitalized Patients: COVID-19 BURDEN

2022 ◽  
Author(s):  
Fatemeh Amirzadehfard ◽  
Mohammad Hossein Imanieh ◽  
Sina Zoghi ◽  
Faezeh sehatpour ◽  
Peyman Jafari ◽  
...  
Keyword(s):  
Risk Score ◽  
Scoring System ◽  
Virus Disease ◽  
Multiple Logistic Regression Analysis ◽  
Laboratory Data ◽  
Area Under The Curve ◽  
Diagnostic Efficiency ◽  
Early Assessment ◽  
Severity Of The Disease ◽  
Care Costs

Background: Corona Virus Disease 2019 (COVID-19) presentation resembles common flu or can be more severe; it can result in hospitalization with significant morbidity and/or mortality. We made an attempt to develop a predictive model and a scoring system to improve the diagnostic efficiency for COVID-19 mortality via analysis of clinical features and laboratory data on admission. Methods: We retrospectively enrolled 480 consecutive adult patients, aged 21-95, who were admitted to Faghihi Teaching Hospital. Clinical and laboratory features were extracted from the medical records and analyzed using multiple logistic regression analysis. Results: A novel mortality risk score (COVID-19 BURDEN) was calculated, incorporating risk factors from this cohort. CRP (> 73.1 mg/L), O2 saturation variation (greater than 90%, 84-90%, and less than 84%), increased PT (>16.2s), diastolic blood pressure (≤75 mmHg), BUN (>23 mg/dL), and raised LDH (>731 U/L) are the features comprising the scoring system. The patients are triaged to the groups of low- (score <4) and high-risk (score ≥ 4) groups. The area under the curve, sensitivity, and specificity for predicting non-response to medical therapy with scores of ≥ 4 were 0.831, 78.12%, and 70.95%, respectively. Conclusion: Using this scoring system in COVID-19 patients, the severity of the disease will be determined in the early stages of the disease, which will help to reduce hospital care costs and improve its quality and outcome.

scholarly journals ANALISA FAKTOR PENYEBAB RENDAHNYA KINERJA PERAWAT PELAKSANA DI RUMAH SAKIT KOTA MEDAN

2021 ◽  
Vol 4 (1) ◽  
pp. 106-112
Author(s):  
Kristina L. Silalahi ◽  
Patimah Sari Siregar
Keyword(s):  
Performance Appraisal ◽  
Three Dimensional ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
City Hospital ◽  
Chi Square ◽  
Cross Sectional ◽  
Nursing Services ◽  
Chi Square Test ◽  
Low Performance

Hospital is a health service with excellent and competitive service demands by its users. The function of the hospital was developed by the guidance of science and technology at its time. Performance appraisal is the most reliable tool for managers to control human resources and productivity and can be used effectively to direct employee behavior to produce nursing services based on high quality and quantity. The purpose of this study was to analyze the factors causing the low performance of nurses in Medan city hospital. This type of research is a quantitative study with a cross-sectional study design. This research was conducted at the Royal Prima Medan Hospital in July. The sample in this study were all nurses who served in the inpatient room. The sampling technique in this study using saturated sampling techniques totaling 159 nurses. Data collection using a questionnaire with the chi-square test. The results showed that the three-dimensional factors of nurse performance had a relationship with the performance of nurses, namely individual factors p = 0.000, psychological factors p = 0.006, and organization p = 0.002. This research concludes that the majority of nurses in the hospital still have low performance. The researcher's suggestion for the hospital is that the hospital pays more attention to the performance of the nurses who work in the inpatient room.

Sperm-Associated Antigen 9 Assumes Signifying Capacity in Hepatocellular Carcinoma Diagnosis

2020 ◽  
Author(s):  
Zhong Dai ◽  
Ke-Qing Yao ◽  
Xing-Sheng Hu ◽  
Yi-Qun Li ◽  
Yu-Tao Liu ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Roc Curve ◽  
Clinical Characteristics ◽  
Mrna Level ◽  
Area Under The Curve ◽  
Enzyme Linked Immunosorbent Assay ◽  
Clinical Value ◽  
Chi Square ◽  
Protein Levels ◽  
Chi Square Test

Abstract Background: Sperm-associated antigen 9 (SPAG9) has been proposed as a novel biomarker for early diagnosis of human tumors. This study was aimed to assess the clinical value of serum SPAG9 for HCC diagnosis.Methods: Serum SPAG9 was measured by quantitative real-time ploymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA). Chi-square test was applied to evaluate the association between serum SPAG9 mRNA level and clinical characteristics. The diagnostic accuracy of the serum SPAG9 mRNA was assessed using receiver operating characteristic (ROC) curve.Results: Serum SPAG9 level was significantly higher in HCC patients than that in healthy controls at both mRNA and protein levels (P<0.01 for all). Furthermore, serum SPAG9 mRNA level was positively correlated with TNM stage (P=0.047), tumor size (P=0.044), and lymph node metastasis (P=0.014). The area under the curve (AUC) of the ROC curve was 0.794, with a sensitivity of 71.4%, a specificity of 80.4%, suggesting the high diagnostic accuracy of serum SPAG9 mRNA for HCC. The cutoff value was 1.030.Conclusions: Serum SPAG9 is significantly increased in HCC, and positively correlated with aggressive clinical characteristics. SPAG9 may serve as a diagnostic biomarker for HCC.

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