scholarly journals Wide field scanning by optical fluorescence of oral squamous cell carcinoma (SCC): case report

Author(s):  
Ismael Lucas PINTO ◽  
Jairo G. CARLOS ◽  
Ana Paula OLIVEIRA DE ARAÚJO ◽  
Clóvis Milton Duval WANNMACHER

ABSTRACT Optical fluorescence detection aims to identify precursor lesions, little noticeable to the human eye, and oral cancer. Squamous cell carcinoma or spinocellular carcinoma is a malignant neoplasm that affects the mouth more. In this article, two clinical cases are analyzed, treated with the use of two types of equipment, namely: the photoevidenciation by optical fluorescence of light-emitting violet wavelength of 405nm, power of 100mW, which is luminous radiation, not Ionizing and in the adjuvant treatment, we used low-power laser therapy, power 100mW, with two wavelengths of 808nm infrared, for pain relief, and the red 660nm, for oral mucositis. In Photodynamic therapy, the Photosensitizing Chimiolux® (methylene blue) was used to control Candida albicans. From these cases, we discuss how a more assertive diagnostic hypothesis can save a life and save time, resources, and efforts for the correct diagnosis of the pathology compared to a biopsy and histopathology negative for neoplasia. We conclude that optical fluorescence has excellent social relevance due to its potential to help the professional not specialized in the establishment of early diagnosis of oral cancer. Early diagnosis improves the rates of death caused by this carcinoma, which would extend the post-diagnosis survival and decrease the financial and emotional costs for the patient and family.

2015 ◽  
Vol 05 (04) ◽  
pp. 022-025
Author(s):  
Manav Chaturvedi ◽  
Sreelatha S. V. ◽  
Pushparaja Shetty

AbstractSquamous cell carcinoma is the most common malignant neoplasm of the oral cavity. Betel nut chewing, cigarette smoking and alcohol drinking are thought to be the major environment risk factors responsible for the development of oral squamous cell carcinoma (OSCC).Reports of OSCC in patients who never used tobacco and alcohol are infrequent.The aim of this article is to review the current data concerning the possible etiological factors causing OSCC other than tobacco like viral infections, diet, nutrition, chronic irritation, genetic mutations and other. Although it is well known that the incidence of OSCC increases with age, recent trends for a rising incidence particularly relates to cancer in young individuals. Investigations can be routine ranging from simple oral examination, blood test, bone marrow analysis, diet chart analysis as well as molecular analysis through techniques like PCR, ISH (in situ hybridization), DNA sequencing, southern blot and antibody test.This review critically examines numerous publications devoted to oral cancer in young individuals who never used tobacco and alcohol. Most studies suggest that 4-6% of oral cancer occur in such individualsAwareness of this possibility is important since it can lead to potentially fatal consequences.Thus providing clinicians a broader vision for diagnosis which will lead to effective treatment and prevention in the future.


2021 ◽  
pp. 11-14
Author(s):  
T.D. Bubliy ◽  
L.I. Voloshina ◽  
L.I. Dubovaya

Oral squamous cell carcinoma is the most prevalent manifestations of malignant tumors in the cranial and cervical regions and they cannot be frequently established until symptoms appear. So there is an urgent need to device methods for the detection of oral premalignant lesions and oral cancer at an early stage in order to improve further patients’ conditions. The whole world was suddenly affected the uncontrolled spread of the coronavirus. All spheres of life were affected, especially medicine. The strict quarantine for 2 months created problems for the patients. Patients who needed dental care they also suffered from it. Dental medical institutions provided only emergency medical care during the period of quarantine restrictions. The planned treatment was postponed until the quarantine restrictions stopped. In fact, the entire population of the country was in a state of significant psycho-emotional stress. This was combined with the state of chronic stress, and influenced the number of cancers. This trend can be traced worldwide. According to the literature, in the United States, squamous cell carcinoma of the oral cavity takes 3% of all cancers in men and 2% in women. The tendency of this disease in people 50 years older observed all over the world, however, the disease occurs in people aged 32-49 years. About 40% of intraoral squamous cell carcinomas begin on the floor of the mouth or on the lateral and ventral surfaces of the tongue. About 38% of all oral squamous cell carcinomas occur on the lower lip; these are usually solar-related cancers on the external surface. The symptoms of this disease in the initial stages are absolutely nonspecific. Many patients do not attach importance to them. Quarantine restrictions on the provision of advisory assistance make this problem of particular relevance. The authors of the article have determined that their goal to attract the attention of dentists and family doctors to the problem of early diagnosis of oncological diseases and oral cancer is enough important nowadays. Early, curable lesions are rarely symptomatic; thus, preventing fatal disease requires early detection by screening. The main goal for such investigations is to attract the attention of dentists and family doctors to the problem of early diagnosis of cancer, including oral cavity. The article presents the clinical characteristics of squamous cell carcinoma of the oral cavity. Particularly, doctors should pay attention to the variety of symptoms characteristic of the initial period of the disease. Patients may complain of thickening of the tissues of the oral cavity, the presence of white spots, ulcerative lesions, which may be covered with plaque. Slight painful sensations are distinguished as manifestations of other diseases. Sometimes the symptoms are relieved by taking analgesics. Patients self-medicate and postpone visiting a specialized specialist for an indefinite time. This does not trouble both patients and some health workers. It should be noted that a typical symptom in the developed period is fetid odor from the mouth due to decay and infection of the tumor. Oral lesions are asymptomatic initially, highlighting the need for oral screening. Most dental professionals carefully examine the oral cavity and oropharynx during routine care and may do a brush biopsy of abnormal areas. The lesions may appear as areas of erythroplakia or leukoplakia and may be exophytic or ulcerated. Cancers are often indurated and firm with a rolled border. As the lesions increase in size, pain, dysarthria, and dysphagia may result. During the period of neglect, cancer of the oral cavity organs quickly spreads and destroys the surrounding tissues, infiltrates the floor of the oral cavity, palatine arches, pharynx, etc. To illustrate the problems outlined in the article, the authors took a clinical case that combines the problems of early diagnosis of oral cancers. It should be noted that in addition to the “inactivity” of the patient in solving problems that occurred in the oral cavity, the resolution of the situation was inhibited by the introduced quarantine measures.


Author(s):  
Mehwish Feroz Ali

Oral cancer, the most challenging and life threatening disease in the field of dentistry, may start as a reactive lesion due to constant stimulus from tobacco consumption, transform into a pre-malignant lesion (dysplastic lesion) and ultimately develop into a cancerous lesion (Invasive carcinoma). There is a fundamental revolution taking place in the analyzing methods; extraction of biological protein from the saliva rather than from tissues or blood. Several of the biomarkers have been studied with pro-carcinogenic effects like Interleukins (ILs), tumor necrosis factor (TNF) and leptin, but only a few have been stated in the literature, which show anti-cancer characteristics like adiponectin and zinc alpha-2 glycoprotein. This review explored the diagnostic and prognostic values of a biomarkers zinc alpha-2 glycoprotein (ZAG) in adults suspected of oral squamous cell carcinoma (OSCC). The PubMed, EMBASE and Google Scholar were searched for scientific studies reported on the potential mechanism of zinc alpha-2 glycoprotein. All the research articles were selected in which ZAG is applied solely or in conjunction with other biomarkers in oral cancer and other cancers. These literatures were carefully assessed to find out and compile the diagnostic and prognostic values and to inquire therapeutic action of ZAG in the process of carcinogenesis.


2020 ◽  
Vol 10 (1) ◽  
pp. 3-5
Author(s):  
Parometa Barma ◽  
Ibrahim Khalil ◽  
Tanzima Yeasmin

Developing country like Bangladesh among 90% of oral malignant neoplasm are arising from squamous layer of oral epithelium which are third leading of this country with severe disfiguration, functiolaesa, psychological impairments and socio-economic hardship. In this study we found the prevalence of OSCC was 6.5% among total cancer patients in the two tertiary level hospitals of Bogura. Male (70%) are affected more than in females (30%). In response to male and female parameter, sex distribution ratio was 2.3:1. The prevalent average age was 55.40 years. About 80% of ulcer site was buccal mucosa then 10 % were lip mucosa. About 80% people were habituated by betel nut, leaf with tobacco chewers. Moreover 46.7% of them were maltreated by quack doctors before. Majority of the patient was in Grade II (56.7%). Correlation between variable in respect of age and cancer grading was explained. According to these study OSCC patients in north bangle region like Bogura was quite high on ( significant p-value ≤ 0.05). Description of oral squamous cell carcinoma on the basis of demographic and clinical profile was the major aim . Most of the cases report with intermediate grade of the disease which often leads to decrease the chance of survival of a patient. So new strategies should be considered to overcome the present situation must be undertaken by oral health programs for the early diagnosis and prevention, build up awareness and management and follow up of oral cancer. Update Dent. Coll. j: 2020; 10 (1): 3-5


2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Wen Chen ◽  
Chenzhou Wu ◽  
Yafei Chen ◽  
Yuhao Guo ◽  
Ling Qiu ◽  
...  

AbstractC18 ceramide plays an important role in the occurrence and development of oral squamous cell carcinoma. However, the function of ceramide synthase 1, a key enzyme in C18 ceramide synthesis, in oral squamous cell carcinoma is still unclear. The aim of our study was to investigate the relationship between ceramide synthase 1 and oral cancer. In this study, we found that the expression of ceramide synthase 1 was downregulated in oral cancer tissues and cell lines. In a mouse oral squamous cell carcinoma model induced by 4-nitroquinolin-1-oxide, ceramide synthase 1 knockout was associated with the severity of oral malignant transformation. Immunohistochemical studies showed significant upregulation of PCNA, MMP2, MMP9, and BCL2 expression and downregulation of BAX expression in the pathological hyperplastic area. In addition, ceramide synthase 1 knockdown promoted cell proliferation, migration, and invasion in vitro. Overexpression of CERS1 obtained the opposite effect. Ceramide synthase 1 knockdown caused endoplasmic reticulum stress and induced the VEGFA upregulation. Activating transcription factor 4 is responsible for ceramide synthase 1 knockdown caused VEGFA transcriptional upregulation. In addition, mild endoplasmic reticulum stress caused by ceramide synthase 1 knockdown could induce cisplatin resistance. Taken together, our study suggests that ceramide synthase 1 is downregulated in oral cancer and promotes the aggressiveness of oral squamous cell carcinoma and chemotherapeutic drug resistance.


2021 ◽  
Vol 10 (1) ◽  
pp. 10-12
Author(s):  
Farooq Ahmed ◽  
Honieh Bolooki ◽  
Senathrajah Ariyaratnam ◽  
Michael N. Pemberton

Oral cancer is a significant cause of morbidity and mortality worldwide. In this article we present two cases of potentially innocuous looking lesions, initially thought to be traumatic in origin, but later diagnosed as cancer. The first patient presented with a persistent laceration thought to be caused by an accidental shaving injury, which was subsequently diagnosed as squamous cell carcinoma. The second patient presented with a hyperplastic mucosal lesion, suspected as forming due to denture-clasp irritation, which was subsequently diagnosed as proliferative verrucous carcinoma. The importance of early detection and palpation of suspicious lesions is emphasised in this article.


2021 ◽  
Vol 8 (3) ◽  
pp. 364-368
Author(s):  
Ishani Gupta ◽  
Rekha Rani ◽  
Jyotsna Suri

Oral cancer is one of a major health problem in some parts of the world especially in the developing countries. Oral cancer is the sixth most common cancer in the world whereas in India it is one of the most prevalent cancer. Oral cavity lesions are usually asymptomatic. Accurate diagnosis of the lesion is the first step for the proper management of patients and histopathology is considered as the gold standard. The objective is to study the different patterns of oral cavity lesions seen in a tertiary care hospital of Jammu: One year retrospective study. Post graduate department of pathology.: It was a retrospective study carried out in a tertiary care centre for a period of one year from March 2020 to Feb 2021. 148 cases of oral cavity lesions were included in this study. The parameters that were included in the study were sociodemographic data, site of the lesion, clinical features and histological diagnosis. Data collected was analysed.148 cases of oral lesions were identified during the period of study. The age of patients varied from 5 to 78years and Male to Female ratio was 2.2:1. Buccal mucosa (30%) was the most common site involved which was followed by tonsil (19%). Out of 148 cases 70 cases were malignant, 10 cases pre malignant and 21 cases were benign. Squamous cell carcinoma (33.7%) was the most common lesion present in our study. Oral cavity lesions have a vast spectrum of diseases which range from tumour like lesions to benign and malignant tumours. Our study concluded that squamous cell carcinoma was the most common malignant lesion of oral cavity. Histological typing of the lesion is important for confirmation of malignancy and it is essential for the proper management of the patient.


2017 ◽  
Vol 1 (2) ◽  
pp. 91
Author(s):  
Samuel P Haslam ◽  
Lindy S Ross ◽  
Alison C Lowe ◽  
Brent C Kelly

Differentiating hypertrophic lichen planus (LP) from well-differentiated squamous cell carcinoma (SCC) is a histological challenge given the numerous histopathologic similarities between SCC and pseudoepitheliomatous hyperplasia (PEH) arising in the setting of hypertrophic LP. Multiple reports have shown that SCC can arise from hypertrophic LP not infrequently, but that the LP-to-SCC sequence is poorly understood, and many cases defy diagnosis due to histologic similarities. However, there are several clinical clues and histopathologic details that have shown to have some value when trying to ascertain the correct diagnosis. To the contrary, immunohistochemical tests have shown little promise in differentiating hypertrophic LP from SCC. Although multiplex PCR has shown some potential in differentiating PEH from SCC, this has only been in the setting of patients diagnosed with prurigo and lichen simplex chronicus, but not necessarily in the case hypertrophic LP. 


PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e6732 ◽  
Author(s):  
Chung-Ji Liu ◽  
Jen-Hao Chen ◽  
Shih-Min Hsia ◽  
Chiu-Chu Liao ◽  
Hui-Wen Chang ◽  
...  

Background The X-linked tumor suppressor gene LDOC1 is reported to be involved in oral cancer. The detection of biomarkers in salivary RNA is a non-invasive strategy for diagnosing many diseases. The aim of the present study was to investigate the potential of salivary LDOC1 as a biomarker of oral cancer. Methods We determined the expression levels of LDOC1 in the saliva of oral squamous cell carcinoma (OSCC) subjects, and investigated its correlation with various clinicopathological characteristics. The expression levels of salivary LDOC1 were detected in 53 OSCC subjects and 43 healthy controls using quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis. We used Fisher’s exact test to analyze the correlations between expression levels and clinicopathological characteristics. Results Salivary LDOC1 was significantly upregulated in females with OSCC (p = 0.0072), and significantly downregulated in males with OSCC (p = 0.0206). Eighty-nine percent of male OSCC subjects who smoked expressed low levels of LDOC1. OSCC cell lines derived from male OSCC subjects expressed low levels of LDOC1. Conclusions A high level of salivary LDOC1 expression is a biomarker of OSCC in females. A high percentage of male OSCC subjects who smoke express low levels of salivary LDOC1. A low level of salivary LDOC1 expression is a biomarker of OSCC in males.


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