C-reactive protein and its relation to high blood pressure in overweight or obese children and adolescents

OBJECTIVE To investigate the association between C-reactive protein (CRP) and high blood pressure (BP) in overweight or obese children and adolescents. METHODS Cross-sectional study with 184 overweight or obese children and adolescents aged from two to 18 years old, from April, 2009 to April, 2010. The classification of nutritional status used the body mass index (BMI). Based on the Centers for Disease Control and Prevention curve, individuals were classified as: overweight (BMI between the 85th-95th percentiles), obesity (BMI between 95th-97th percentiles) and severe obesity (BMI >97th percentile). Abnormal values were considered for systolic BP (SBP) and/or diastolic (DBP) if ≥90th percentile of the BP curve recommended for children and adolescents in the V Brazilian Guidelines on Hypertension, for waist circumference (WC) if ≥90th percentile of the curve established by the National Cholesterol Education Program, and for high sensitive CRP (hs-CRP) if >3mg/dL. To evaluate the association of inadequate values of CRP and the studied groups, chi-square test and analysis of variance were applied, using the Statistical Package for the Social Sciences version 17.0 and adopting a significance level of 5%. RESULTS Among the evaluated sample, 66.3% were female, 63.5%, non-white, 64.1% had severe obesity, 78.3% had altered WC and 70.6% presented high BP. There was a significant association of CRP high levels with altered WC and BMI ≥97th percentile. In adolescents, high CRP was related to high SBP. CRP mean values were higher in individuals with elevated SBP. CONCLUSIONS Inadequate values of hs-CRP were associated with severe obesity and high SBP in the studied population. These markers can be used to identify children and adolescents at higher risk for developing atherosclerosis.

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High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents.

Acta Endocrinologica ◽

10.1530/eje-08-0212 ◽

2008 ◽

Vol 159 (1) ◽

pp. R1-R4 ◽

Cited By ~ 37

Author(s):

Leandro Soriano-Guillén ◽

Bárbara Hernández-García ◽

Jimena Pita ◽

Nieves Domínguez-Garrido ◽

Genoveva Del Río-Camacho ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cardiovascular Risk ◽

Children And Adolescents ◽

Hdl Cholesterol ◽

High Sensitivity ◽

Oral Glucose ◽

Obese Children ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp

ObjectiveWe intend to assess the utility of the high-sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese children and adolescents.MethodsThe study included children and adolescents between 6 and 18 years of age with a body mass index (BMI) higher than 2 SDS. All the patients had their blood pressure taken and hs-CRP, hepatic function, lipid profile and uric acid were determined after 12 h of fasting. Likewise, an oral glucose tolerance test was performed, determining basal glucose and insulin levels, and after stimulus. We considered the presence of metabolic syndrome when the obese children and teenagers showed at least two of the following conditions: decreased high density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, hypertension or alteration in glucose metabolism.ResultsOut of the 115 obese children studied, 24% showed signs of metabolic syndrome. Those with metabolic syndrome presented higher levels of hs-CRP (mean: 3.8 mg/l; 95% CI: 2.8–4.8) in comparison with the obese patients who did not show signs of metabolic syndrome (mean: 2 mg/l; 95% CI: 1.5–2.5). After a multivariate analysis, the variables that appear to influence the changes in hs-CRP were BMI, triglycerides and HDL-cholesterol levels.ConclusionThe hs-CRP is a useful tool for early diagnosis of cardiovascular risk in obese children and teenagers.

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Ultrasensitive C-reactive protein as biomarker of cardiometabolic risk in a group of obese children and adolescents

10.1101/2020.08.14.20175182 ◽

2020 ◽

Author(s):

Giovanna Lucia Oliveira Bonina Costa ◽

Bianca Carolina da Silva Medeiros ◽

Yara Nobre Araujo ◽

Leandro Silva Menezes Junior ◽

Paulo Uendel da Silva Jesus ◽

...

Keyword(s):

Children And Adolescents ◽

International Diabetes Federation ◽

The Body ◽

Obese Group ◽

Abdominal Circumference ◽

Control Group ◽

Sample Population ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein

Objective: To establish the importance of evaluating ultrasensitive C-reactive protein (us-CRP) in a pediatric group with obesity as the main biomarker, detecting, as early as possible, cardiometabolic complications. Methods: This is a control-case, cross-sectional study involving the biochemical and anthropometric evaluation of 342 children and adolescents participating in the Preventive Medicine Service, in Aracaju, Sergipe, Brazil. When evaluated anthropometrically, it was observed that, in 235 of the cases, the body mass index (BMI) above the 97th percentile or the Z-score greater than +2 allowed their classification as obese. The control group consisted of 107 non-obese individuals. The sample was divided into three age groups according to the International Diabetes Federation (FID): 6-10 years, 10-16 years and >16 years, representing 45%, 39% and 14% of the sample population, respectively. Results: The CRP-us showed an average value of 2.36 +- 1.28 mg/dL in the obese group, while in the control group, the result found was 0.01 +- 0.1 mg/dL. There was a significant correlation between the increase in CRP levels in the obese group and other biochemical and anthropometric findings in the same group, such as: reduced HDL, elevated triglycerides, higher BMI, and increased abdominal circumference (AC). Homocysteine, in turn, proved to be a biomarker with little specificity in the sample in question. Conclusion: The ultra-sensitive C-reactive protein, already fundamentally correlated with increased cardiovascular risk in adults, demonstrates to be a validated biomarker, showing high sensitivity even in pediatric obese populations.

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C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

Revista de Nutrição ◽

10.1590/1415-52732014000300002 ◽

2014 ◽

Vol 27 (3) ◽

pp. 279-288 ◽

Cited By ~ 1

Author(s):

Anajás da Silva Cardoso ◽

Renata Oliveira Cardoso ◽

Danielle Franklin de Carvalho ◽

Neusa Collet ◽

Carla Campos Muniz Medeiros

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Waist Circumference ◽

Children And Adolescents ◽

Cardiometabolic Risk ◽

Severe Obesity ◽

Cardiometabolic Risk Factors ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein

OBJECTIVE: To investigate the relationship between ultrasensitive C-reactive protein and cardiometabolic risk factors in overweight or obese childrenand adolescents. METHODS: Cross-sectional study conducted at the Center for Childhood Obesity in the period from April 2009 to April 2010, involving 185 overweight children and adolescents aged 2 to 18 years. Measures of ultrasensitive C-reactive protein according to age, nutritional status, gender, race, cardiometabolic risk factors (waist circumference, lipid profile, impaired fasting glucose, high blood pressure and presence of insulin resistance) were compared through the Chi-square test and analysis of variance. All analyses were performed using the Statistical Package for the Social Sciences software version 17.0, adopting a significance level of 5%. RESULTS: Altered high-density lipoprotein was the most frequent cardiometabolic risk factor, and there was a significant association between altered ultrasensitive C-reactive protein values and severe obesity (p=0.005), high waist circumference (p<0.001), hypertriglyceridemia (p=0.037) and insulin resistance (p=0.002), as well as significantly higher body mass index (p=0.000), waist circumference (p=0.001), insulin (p=0.005) and index of glucose homeostasis values(p=0.005). CONCLUSION: High prevalence of altered ultrasensitive C-reactive protein and significant association with severe obesity, waist circumference, hypertriglyceridemia and insulin resistance were observed.

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Fish oil capsule supplementation in children with obesity reduced c-reactive protein and improved blood pressure

Malaysian Journal of Nutrition ◽

10.31246/mjn-2019-0132 ◽

2020 ◽

Vol 26 (3) ◽

pp. 453-460

Author(s):

I Gusti Lanang Sidiartha ◽

◽

Putu Diah Vedaswari ◽

I Wayan Bikin Suryawan ◽

◽

...

Keyword(s):

Blood Pressure ◽

Diastolic Blood Pressure ◽

Analysis Of Covariance ◽

P Value ◽

Obese Children ◽

C Reactive Protein ◽

Primary Analysis ◽

Reactive Protein ◽

Epa And Dha ◽

Hs Crp

Introduction: Excessive accumulation of body fat in obesity increases morbidities such as hypertension and cardiovascular diseases. This study investigated the effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on the level of high-sensitivity C-reactive protein (hs-CRP) and blood pressure in children with obesity. Methods: Fifty obese children, aged 6-10 years, were randomly assigned to the supplementation group (n=25) who received EPA and DHA supplementation or to the placebo group (n=25) for eight weeks. The trial was done in a single centre in Denpasar, Bali, Indonesia. Randomisation and allocation to the trial group were done by a computer system. The primary analysis was comparing the blood pressure and hs-CRP level between groups. Analysis of covariance (ANCOVA) and multivariate analysis of covariance (MANCOVA) tests were done to compare the differences between groups, with a p-value <0.05 considered as significant. Results: A total of 44 children completed the study, 24 (54.5%) were males and 20 (45.5%) were females. Initially, the systolic/diastolic blood pressure and hs-CRP level in the supplementation and placebo groups were 109.5/72.7 mmHg and 3.5 mg/L, 107.9/68.4 mmHg and 2.8 mg/L, respectively. At the end, they were 106.3/67.7 mmHg and 1.7 mg/L, and 108.1/71.8 mmHg and 2.8 mg/L, respectively. Systolic-, diastolic blood pressure and hs-CRP level were decreased by -2.6 mmHg (95% CI: -6.9 to 1.6; p=0.220), -7.5 mmHg (95% CI: -12.4 to -2.6; p=0.004), and -1.15 mg/L (95% CI: -2.1 to -0.2; p=0.022), respectively. Conclusion: EPA and DHA supplementation in obese children showed significant decrease in diastolic blood pressure and hs-CRP level.

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Serum High Sensitive C - reactive protein in Male Smokers of Bangladesh

Journal of Bangladesh Society of Physiologist ◽

10.3329/jbsp.v10i1.24617 ◽

2015 ◽

Vol 10 (1) ◽

pp. 36-40

Author(s):

Shamima Jahan ◽

Qaz Shamima Akhter

Keyword(s):

Blood Pressure ◽

Cross Sectional Study ◽

Healthy Male ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Inflammatory Status ◽

Hs Crp ◽

High Level ◽

Apparently Healthy

Background: Smoking may cause systemic inflammation, and high level of serum high sensitive Creactive protein may be found in smoker as an indicator of inflammation.Objective: To assess the serum high sensitive C - reactive protein level in male smokers of Bangladesh.Methods: The present cross sectional study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka between July 2013 and June 2014. Hundred apparently healthy male regular cigarette smokers aged 20 to 40 years who smokes at least 5 sticks of cigarette per day for the last 5 years were included as study group. They were further divided in to 5-10 years, 11-15 years, 16-20 years and 1-10 cigarette sticks, 11- 20 cigarette sticks, more than 20 cigarette sticks/day depending on the duration of smoking and also according to consumption of number of sticks/day respectively. Age matched 100 apparently healthy male nonsmokers were included for control. To assess their inflammatory status, serum hs-CRP level was estimated by particles enhanced immunonephelometry using BN Systems in the Department of Microbiology & Immunology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. In addition, BMI and blood pressure were measured by standard method to observe their association with smoking.Results: The mean serum hs-CRP level was significantly higher in male smokers than that of non smokers which was progressively increased with duration of smoking and number of cigarette sticks consumed per day. Again, mean BMI was significantly lower and diastolic blood pressure was significantly higher in male smokers than those of non smokers.Conclusion: The result of this study can be concluded that serum hs-CRP level progressively increases with duration of smoking and number of cigarette sticks consumed per day in male smokers.Bangladesh Soc Physiol. 2015, June; 10(1): 36-40

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Adiponectin, leptin and high sensitivity C-reactive protein values in obese children – important markers for metabolic syndrome?

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2018-0378 ◽

2019 ◽

Vol 32 (1) ◽

pp. 27-31 ◽

Cited By ~ 7

Author(s):

Ramona F. Stroescu ◽

Otilia Mărginean ◽

Teofana Bizerea ◽

Mihai Gafencu ◽

Adrian Voicu ◽

...

Keyword(s):

Metabolic Syndrome ◽

Pediatric Population ◽

High Sensitivity ◽

Inflammatory Disorder ◽

Obese Children ◽

C Reactive Protein ◽

Cross Sectional ◽

Chronic Inflammatory Disorder ◽

Reactive Protein ◽

Hs Crp

Abstract Background Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C-reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity such as leptin, adiponectin and high sensitivity C-reactive protein (hs-CRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome (MetS) in pediatric population. Methods A cross-sectional study was conducted over a period of 1 year, between July 2013 and June 2014, on 122 cases of obesity in children diagnosed at the Louis Ţurcanu Emergency Hospital for Children Timişoara, in the departments of Diabetes and Nutritional Diseases, Endocrinology and Cardiology. The patients were divided into two groups, according to the presence of MetS. Results MetS was present in 27% of obese children. The groups were homogenous with respect to age, sex and body mass index (BMI). Adiponectin, leptin and hs-CRP were significantly modified in the group with MetS (p=0.04, p=0.04, p=0.01, respectively). Conclusions hs-CRP, leptin and adiponectin can be used as predictors of cardiovascular risk in pediatric population.

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The Predictive Role of Tooth Extractions, Oral Infections, and hs-C-Reactive Protein for Mortality in Individuals with and without Diabetes: A Prospective Cohort Study of a 12 1/2-Year Follow-Up

Journal of Diabetes Research ◽

10.1155/2017/9590740 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Lise Lund Håheim ◽

Kjersti S. Rønningen ◽

Morten Enersen ◽

Ingar Olsen

Keyword(s):

Blood Pressure ◽

Cohort Study ◽

C Reactive Protein ◽

Oral Infections ◽

Reactive Protein ◽

Predictive Role ◽

Hs Crp ◽

Tooth Extractions

The predictive role of high-sensitivity C-reactive protein (hs-CRP), number of tooth extractions, and oral infections for mortality in people with and without diabetes is unclear. This prospective cohort study is a 12 1/2-year follow-up of the Oslo II study, a health survey in 2000. In all, 12,764 men were invited. Health information was retrieved from 6434 elderly men through questionnaire information, serum measurements, and anthropometric and blood pressure measurements. Diabetes was reported by 425 men. Distinct differences were observed in baseline characteristics in individuals with and without diabetes. In the diabetes group, age and hs-CRP were statistically significant whereas in the nondiabetes group, age, hs-CRP, number of tooth extractions, tooth extractions for infections and oral infections combined, nonfasting glucose, systolic blood pressure, total cholesterol, regular alcohol drinking, daily smoking, and level of education were independent risk factors. The number of tooth extractions <5 was inversely related whereas more extractions increased the risk. Multivariate analyses showed that hs-CRP was a significant predictor in persons with diabetes and tooth extractions and oral infections combined; the number of teeth extracted and hs-CRP were for persons without diabetes. Infection and inflammation were associated with mortality in individuals both with and without diabetes.

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High Sensitivity CReactive Protein (hsCRP) Level on Premature Rupture of Membrane (PROM) at Term Pregnancy

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v5i1.458 ◽

2017 ◽

pp. 12-15

Author(s):

Meily Manoppo ◽

Hermie MM Tendean ◽

Joice MM Sondakh

Keyword(s):

High Sensitivity ◽

C Reactive Protein ◽

Term Pregnancy ◽

Premature Rupture ◽

Cross Sectional ◽

Reactive Protein ◽

Significant Difference ◽

Hs Crp ◽

Cross Sectional Design ◽

Parametric Statistical Test

Objective: To compare the level of high sensitivity C-Reactive Protein (hs-CRP) on patients with premature rupture of membranes (PROM) at term pregnancy. Methods: The study was cross-sectional design. The data collection included age, parity, gestational age, birth weight, and APGAR score on 28 pregnant women at term pregnancy consisting of 14 subjects of Premature Rupture of Membrane (PROM) less than 12 hours and the remaining one was equal or more than 12 hours. We took blood samples from the subjects for the examination of hs-CRP level. Data were analyzed using non-parametric statistical test and processed using Statistical Package for Social Sciences (SPSS) version 20. Results: The mean hs-CRP level on PROM <12-hour and 12-hour group was 12.9 and 17.8 mg/l. There was not significant difference on hs-CRP level between both of group at term pregnancy (p=0.734). Conclusion: The level of hs-CRP does not have association with the incidence of PROM. [Indones J Obstet Gynecol 2017; 5-1: 12-15] Keywords: high sensitivity C-Reactive Protein, premature ruptures of membranes, term pregnancy

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Serum High-Sensitivity C-Reactive Protein and Endogenous Sex Hormones in Diabetic Men

Journal of Biotechnology Research Center ◽

10.24126/jobrc.2016.10.1.463 ◽

2016 ◽

Vol 10 (1) ◽

pp. 48-52

Author(s):

Shakir F.T. Al-Aaraji

Keyword(s):

Sex Hormones ◽

Serum Testosterone ◽

Total Testosterone ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Hs Crp ◽

Dm Type 2 ◽

Endogenous Sex Hormones

The objective of this cross sectional study was to assess the effect of diabetes mellitus (DM) type 2 in men on endogenous sex hormones: estradiol (E2) and total testosterone (TT); pituitary gland hormones: follicle-stimulating hormone (FSH) and luteinizing hormone (LH) as well as high sensitive C-Reactive protein (hs-CRP) in men. This study comprised a total of (80) subjects out of which (40) were normal and (40) were diabetic males. The results obtained indicated a significant increasing (p≤ 0.05) of serum hs-CRP and E2 in men with DM type 2 comparison to non-diabetics, while a significant reduction (p≤ 0.05) of serum testosterone in men with DM type 2 comparison to non-diabetics, and non-significant reduction of serum LH, FSH in men with DM type 2 comparison to non-diabetics were observed. The data from this study show the role of endogenous sex hormones and hs-CRP in diabetes risk. Testosterone levels are partly influenced by insulin resistance, which may represent an important avenue for intervention

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Kadar High Sensitivity C-Reactive Protein Berkaitan dengan Lingkar Pinggang pada Lansia

Indonesian Journal of Human Nutrition ◽

10.21776/ub.ijhn.2021.008.01.3 ◽

2021 ◽

Vol 8 (1) ◽

pp. 21

Author(s):

Deny Yudi Fitranti ◽

Bunga Syifarahmi ◽

Martha Ardiaria ◽

Nurmasari Widyastuti

Keyword(s):

Physical Activity ◽

Vitamin D ◽

International Physical Activity Questionnaire ◽

High Sensitivity ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Consecutive Sampling ◽

Hs Crp ◽

Activity Questionnaire

Proses penuaan mempengaruhi peningkatan distribusi lemak abdominal dengan indikator lingkar pinggang (LP) dan rasio lingkar pinggang panggul (RLPP). Penimbunan lemak abdominal menyebabkan disfungsi jaringan adiposa sehingga mempengaruhi biomarker proinflamasi yaitu kadar serum high-sensitivity C-reactive Protein (hs-CRP). Penelitian bertujuan untuk mengetahui hubungan LP dan RLPP dengan kadar hs-CRP lansia wanita. Rancangan penelitian cross sectional pada 53 subjek dipilih secara consecutive sampling. Antropometri yang diukur adalah LP dan RLPP. Pengukuran kadar serum hs-CRP dianalisis dengan metode enyme-linked immunosorbent assay (ELISA). Wawancara yang dilakukan yaitu data diri, asupan, aktivitas fisik, dan riwayat konsumsi obat. Data asupan diperoleh dengan metode food recall 3x24 jam. Aktivitas fisik diperoleh menggunakan International Physical Activity Questionnaire (IPAQ). Analisis data digunakan uji korelasi Spearman. Hasil penelitian menunjukkan bahwa persentase LP pada lansia wanita yang berisiko sebesar 90,6%, RLPP yang berisiko sebesar 98,1%, dan kadar hs-CRP tinggi sebesar 30,2%. Terdapat hubungan positif antara LP dengan kadar serum hs-CRP (r=0,417 ; p=0,002). Dalam penelitian ini RLPP, aktivitas fisik, asupan energi, karbohidrat, protein, lemak, serat, vitamin A, vitamin C, vitamin D,vitamin E, dan selenium tidak berkorelasi dengan kadar hs-CRP. Simpulan penelitian ini adalah LP berkorelasi positif dengan kadar serum hs-CRP, namun RLPP tidak berkorelasi dengan kadar serum hs-CRP

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