Ultrasensitive C-reactive protein as biomarker of cardiometabolic risk in a group of obese children and adolescents

Objective: To establish the importance of evaluating ultrasensitive C-reactive protein (us-CRP) in a pediatric group with obesity as the main biomarker, detecting, as early as possible, cardiometabolic complications. Methods: This is a control-case, cross-sectional study involving the biochemical and anthropometric evaluation of 342 children and adolescents participating in the Preventive Medicine Service, in Aracaju, Sergipe, Brazil. When evaluated anthropometrically, it was observed that, in 235 of the cases, the body mass index (BMI) above the 97th percentile or the Z-score greater than +2 allowed their classification as obese. The control group consisted of 107 non-obese individuals. The sample was divided into three age groups according to the International Diabetes Federation (FID): 6-10 years, 10-16 years and >16 years, representing 45%, 39% and 14% of the sample population, respectively. Results: The CRP-us showed an average value of 2.36 +- 1.28 mg/dL in the obese group, while in the control group, the result found was 0.01 +- 0.1 mg/dL. There was a significant correlation between the increase in CRP levels in the obese group and other biochemical and anthropometric findings in the same group, such as: reduced HDL, elevated triglycerides, higher BMI, and increased abdominal circumference (AC). Homocysteine, in turn, proved to be a biomarker with little specificity in the sample in question. Conclusion: The ultra-sensitive C-reactive protein, already fundamentally correlated with increased cardiovascular risk in adults, demonstrates to be a validated biomarker, showing high sensitivity even in pediatric obese populations.

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C-reactive protein and its relation to high blood pressure in overweight or obese children and adolescents

Revista Paulista de Pediatria ◽

10.1590/s0103-05822013000300009 ◽

2013 ◽

Vol 31 (3) ◽

pp. 331-337 ◽

Cited By ~ 9

Author(s):

Juliana Andreia F. Noronha ◽

Carla Campos M. Medeiros ◽

Anajás da Silva Cardoso ◽

Nathalia Costa Gonzaga ◽

Alessandra Teixeira Ramos ◽

...

Keyword(s):

Blood Pressure ◽

Children And Adolescents ◽

High Blood Pressure ◽

Severe Obesity ◽

The Body ◽

Obese Children ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Hs Crp

OBJECTIVE To investigate the association between C-reactive protein (CRP) and high blood pressure (BP) in overweight or obese children and adolescents. METHODS Cross-sectional study with 184 overweight or obese children and adolescents aged from two to 18 years old, from April, 2009 to April, 2010. The classification of nutritional status used the body mass index (BMI). Based on the Centers for Disease Control and Prevention curve, individuals were classified as: overweight (BMI between the 85th-95th percentiles), obesity (BMI between 95th-97th percentiles) and severe obesity (BMI >97th percentile). Abnormal values were considered for systolic BP (SBP) and/or diastolic (DBP) if ≥90th percentile of the BP curve recommended for children and adolescents in the V Brazilian Guidelines on Hypertension, for waist circumference (WC) if ≥90th percentile of the curve established by the National Cholesterol Education Program, and for high sensitive CRP (hs-CRP) if >3mg/dL. To evaluate the association of inadequate values of CRP and the studied groups, chi-square test and analysis of variance were applied, using the Statistical Package for the Social Sciences version 17.0 and adopting a significance level of 5%. RESULTS Among the evaluated sample, 66.3% were female, 63.5%, non-white, 64.1% had severe obesity, 78.3% had altered WC and 70.6% presented high BP. There was a significant association of CRP high levels with altered WC and BMI ≥97th percentile. In adolescents, high CRP was related to high SBP. CRP mean values were higher in individuals with elevated SBP. CONCLUSIONS Inadequate values of hs-CRP were associated with severe obesity and high SBP in the studied population. These markers can be used to identify children and adolescents at higher risk for developing atherosclerosis.

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THE IMPACT OF COMBINATION OF BREASTFEEDING AND EFFLEURAGE MASSAGE IN REDUCING PAIN RESPONSE IN INFANTS INDUCED BY BLOOD SAMPLING IN C-REACTIVE PROTEIN TEST: AN OBSERVATIONAL CROSS-SECTIONAL STUDY

Belitung Nursing Journal ◽

10.33546/bnj.353 ◽

2018 ◽

Vol 4 (2) ◽

pp. 242-248

Author(s):

Alfi Maziyah ◽

Diyah Fatmasari ◽

Desak Made Wenten Parwati ◽

Rr. Sri Endang Pujiastuti

Keyword(s):

Intervention Group ◽

Cross Sectional Study ◽

Blood Sampling ◽

Control Group ◽

Pain Response ◽

Sectional Study ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Massage Group

Background: C-reactive protein test is one of clinical assessments to minimize risks of infection in infants. However, its procedure may cause pain. Pain in the infant may result in negative metabolic behavior, physiology and metabolic response. Objective: This study was to describe the infant's pain response by administering a combination of breastfeeding and an effleurage massage on the blood sampling procedure of C-reactive protein examination. Methods: This was a descriptive observational cross-sectional study. There were 30 infants selected using consecutive sampling technique, which 15 samples assigned in an intervention group (combination of breastfeeding and effleurage massage) and a control group. Premature Infant Pain Profile (PIPP) instrument was used to measure pain. Univariate analysis was performed with the aim to describe data in mean and median.Results: The average of pain response at 1-minute observation in the combination of breastfeeding and effleurage massage group was 7.47 ± 1.356, and the average of pain response in the control group was 10.80 ± 1.897. The average pain at 5-minutes in the intervention group was 3.53 ± 1.922 and control group was 6.00 ± 1.852. Conclusions: Pain responses in the combination of breastfeeding and effleurage massage group were lower than the pain response in the control group.

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MON-099 The Association Between C-Reactive Protein, Metabolic Syndrome, and Pre-Diabetes in Korean Children and Adolescents

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa046.015 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

Author(s):

Jihyun Kim ◽

Jong Bin Lee ◽

Jung Sub Lim

Keyword(s):

Metabolic Syndrome ◽

Children And Adolescents ◽

Geometric Mean ◽

High Sensitivity ◽

Low Grade ◽

C Reactive Protein ◽

Hscrp Level ◽

Cross Sectional ◽

Korean Children ◽

Reactive Protein

Abstract Objective: Cardiovascular disease (CVD) is a leading cause of death worldwide, including in Korea. In adults, the risk for CVD is increased approximately three-fold in subjects with metabolic syndrome (MetS), and the hazard ratio for subjects with MetS has been reported as 1.37 for mortality from CVD after adjustment for other confounders. Furthermore, MetS in childhood predicts adult MetS and T2DM 25 to 30 years later. Because MetS is a state of chronic low-grade inflammation, measurements of the circulating levels of the inflammatory molecules might provide diagnostic and therapeutic approaches to modulate or alter disease progression. High sensitivity C-reactive protein (hsCRP), a biomarker of inflammation, has emerged as an independent predictor of CVD and T2DM development. The aim of this paper is to evaluate the association between hsCRP and MetS and its components in Korean children and adolescents. Methods: We performed a cross-sectional analysis using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2017. We analyzed the data of 1,247 subjects (633 males, 14.2 ± 2.7 years) from the KNHANES 2016–2017. MetS were defined by the modified NCEP-ATP III criteria. Results: Among the 1,247 subjects (mean age: 14.2 ± 2.7 years), the prevalence of MetS was 5.8% (7.0% in male subjects and 4.6% in female subjects; p = 0.070). The mean hsCRP level was 0.861 ± 1.567 mg/l (median and interquartile range: 0.370 and 0.430mg/l). Subjects with MetS had higher hsCRP levels than subjects without MetS (geometric mean: 1.08 vs. 0.46 mg/l, p < 0.001). The prevalence of MetS in the lowest, second, third, and highest hsCRP quartiles were 1.8%, 2.4%, 3.5%, and 15.2%, respectively. Compared to the lowest quartile, the odds ratio (OR) for having MetS in the highest quartile was 8.414 (3.272–21.638), adjusting for age and sex. The OR for having abdominal obesity and low HDL-C in the highest quartile were 9.657 (4.818–19.355) and 2.408 (1.286–4.510), adjusting for age, sex, and other components of the MetS. Additionally, the OR for having pre-diabetes (HbA1c ≥ 5.7%) in the highest quartile was 2.061 (1.097–3.870). Conclusion: Serum hsCRP level is positively associated with MetS and pre-diabetes in Korean children and adolescents.

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Hubungan Jumlah Leukosit dan C-Reactive Protein (CRP) dengan Luaran Pasien Cedera Otak Traumatik (COT) berdasarkan Skor Glasgow Coma Scale (GCS) di RSUD Ulin Banjarmasin

Jurnal Neuroanestesi Indonesia ◽

10.24244/jni.v10i1.267 ◽

2021 ◽

Vol 10 (1) ◽

pp. 8-15

Author(s):

Irvan Maulana ◽

◽

Kenanga Marwan Sikumbang ◽

Asnawati Asnawati ◽

Keyword(s):

Glasgow Coma Scale ◽

Leukocyte Count ◽

The Body ◽

Outcome Analysis ◽

C Reactive Protein ◽

Cross Sectional ◽

Coma Scale ◽

Reactive Protein ◽

Spearman Correlation Test ◽

Severe Tbi

Background and Objective: The severity of traumatic brain injury (TBI) can be assessed using the Glasgow Coma Scale (GCS). When head injury occurs, the body releases various inflammatory mediators, leukocytes and inflammatory markers, namely c-reactive protein (CRP). The purpose of this study was to determine whether there is a correlation between the leukocyte count and CRP levels with the outcome of TBI patients based on GCS scores in Ulin Hospital Banjarmasin. Subject and Method: This research is an analytic observational with cross-sectional approach. Data acquired with consecutive sampling method. Result: We Obtained 45 subjects with the highest mean of leukocytes count and the highest CRP levels in patients with severe TBI followed by moderate TBI and mild TBI. On the 7th day, 41 patients had good outcome and 4 patients had bad outcome. Analysis using the Spearman correlation test showed that there was a relationship between the leukocyte count (p = 0.004; r = 0.424) and CRP levels with the outcome of TBI patients (p = 0.043; r = 0.361). Conclusion: It was concluded that there is a correlation between leukocyte count and CRP levels with the outcome of TBI patients based on GCS scores

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A study to observe quantitative levels of C- Reactive Protein in Cerebrospinal fluid in patients with Meningitis as an add-on routine investigation- a case-control study

International Journal of Medical Research and Review ◽

10.17511/ijmrr.2021.i04.05 ◽

2021 ◽

Vol 9 (4) ◽

pp. 235-240

Author(s):

Manoj Kumar ◽

◽

Chandrashekhar Tiwari ◽

Nandita Prabhat ◽

Pooja Dhaon ◽

...

Keyword(s):

Case Control Study ◽

Case Control ◽

Viral Meningitis ◽

The Body ◽

Control Group ◽

P Value ◽

C Reactive Protein ◽

Acute Phase Reactants ◽

Reactive Protein ◽

Control Study

Introduction: C-reactive protein (CRP) is a member of the class of acute phase reactants as itslevel rises dramatically during inflammatory processes occurring in the body. Measuring and chartingCRP values can prove useful in determining the disease progress. Aim: To estimate the CRP level inCerebrospinal fluid (CSF) of patients with meningitis; and to evaluate whether CRP levels could beused to differentiate the various types of meningitis in adults. Materials and Methods: This studywas a case-control study. 80 enrolled patients were subjected to a protocol that included detailedclinical history including duration of illness, symptoms and signs, history or any treatment history.Written informed consent was taken from the patients/guardian. Results: Meningitis was morecommon in the 18-30 years age group. Mean values of CSF CRP were- viral meningitis (2.70 mg/L)and pyogenic meningitis (91.13 mg/L) and control group (1.54 mg/L). CSF CRP can be used as adiagnostic tool to differentiate between pyogenic and viral meningitis as it is significantly raised inpyogenic meningitis in comparison to viral meningitis (p-value <0.0001). Conclusion: CRP in CSF isa valuable, rapid, bedside diagnostic test for differentiating between pyogenic and viral meningitis;with reasonably good sensitivity, specificity and positive predictive value. The absence of CRP in CSFrather than its presence is more important for the diagnosis of viral meningitis.

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Is there any relationship between C-reactive protein/albumin ratio and clinical severity of childhood community-acquired pneumonia

Turkish Journal of Biochemistry ◽

10.1515/tjb-2020-0228 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Hayrunnisa Bekis Bozkurt

Keyword(s):

Severe Pneumonia ◽

Multivariate Regression Analysis ◽

Blood Parameters ◽

Community Acquired Pneumonia ◽

Clinical Severity ◽

Control Group ◽

C Reactive Protein ◽

Cross Sectional ◽

Albumin Ratio ◽

Reactive Protein

Abstract Objectives To investigate the relationship between the ratios of C-reactive protein (CRP)/albumin, neutrophil/lymphocyte (NLR), monocyte/lymphocyte (MLR), mean platelet volume (MPV)/platelet and erythrocyte sedimentation rate (ESR)/albumin in pediatric patients diagnosed with community-acquired pneumonia based on the severity of the disease. Methods This retrospective cross-sectional study included 52 patients with mild pneumonia, 30 with severe pneumonia, and 46 healthy controls. Whole blood parameters, CRP, ESR, and albumin values and ratios were recorded at the time of admission. The multivariate regression analysis, Pearson’s correlation and ROC curve analyses were performed. Results The CRP/albumin, ESR/albumin, NLR and CRP values were significantly higher in the severe pneumonia group compared to both the other pneumonia group and the control group (p<0.005). According to the regression and correlation analyses, these values were positively correlated (p<0.001). For CRP/Albumin ratio, ESR/albumin ratio calculated OR were 2.103 (CI: 1.675–2.639); 1.907 (CI: 1.552–2.344); respectively. Conclusions The data presented can be a guide in the follow-up and treatment of this patient group.

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EFFECT OF RED MULBERRY JUICE (MORUS RUBRA) ON THE INFLAMMATORY RESPONSE IN MALE WISTAR RATS DUE TO EXPOSURE TO CIGARETTE SMOKE

Media Gizi Indonesia ◽

10.20473/mgi.v16i3.233-237 ◽

2021 ◽

Vol 16 (3) ◽

pp. 233

Author(s):

Rivan Virlando Suryadinata ◽

Merryana Adriani ◽

Stefani Cornelia Sardjono

Keyword(s):

Inflammatory Response ◽

Cigarette Smoke ◽

Wistar Rats ◽

Positive Control ◽

The Body ◽

Positive Control Group ◽

Control Group ◽

C Reactive Protein ◽

Reactive Protein ◽

Mulberry Juice

The increasing number of tobacco users will directly impact to an increase in the number of passive smokers. Various harmful substances that enter the respiratory tract can cause health problems. The airway will recognize these substances as pathogen and activate immune response accordingly. Inﬂammatory response becomes one of the eﬀects of body compensation due to an increased pathogen. This eﬀect is indicated by the elevation of C-Reactive Protein as one systemic inﬂammatory response parameters in the body. This study aimed to determine the eﬃcacy of red mulberry juice to reduce levels of C-Reactive Protein in Wistar rats because exposure to cigarette smoke. This is an experimental study with a post-test control group design. Animals were divided into negative control group, positive control group, and 3 treatment groups with diﬀerent red mulberry doses. The positive control group showed the highest increase in C-Reactive Protein levels compared with the red mulberry intake group (p<0,001). In conclusion, the administration of red mulberry juice can reduce inﬂammatory response in rats because of exposure to cigarette smoke.

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C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

Revista de Nutrição ◽

10.1590/1415-52732014000300002 ◽

2014 ◽

Vol 27 (3) ◽

pp. 279-288 ◽

Cited By ~ 1

Author(s):

Anajás da Silva Cardoso ◽

Renata Oliveira Cardoso ◽

Danielle Franklin de Carvalho ◽

Neusa Collet ◽

Carla Campos Muniz Medeiros

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Waist Circumference ◽

Children And Adolescents ◽

Cardiometabolic Risk ◽

Severe Obesity ◽

Cardiometabolic Risk Factors ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein

OBJECTIVE: To investigate the relationship between ultrasensitive C-reactive protein and cardiometabolic risk factors in overweight or obese childrenand adolescents. METHODS: Cross-sectional study conducted at the Center for Childhood Obesity in the period from April 2009 to April 2010, involving 185 overweight children and adolescents aged 2 to 18 years. Measures of ultrasensitive C-reactive protein according to age, nutritional status, gender, race, cardiometabolic risk factors (waist circumference, lipid profile, impaired fasting glucose, high blood pressure and presence of insulin resistance) were compared through the Chi-square test and analysis of variance. All analyses were performed using the Statistical Package for the Social Sciences software version 17.0, adopting a significance level of 5%. RESULTS: Altered high-density lipoprotein was the most frequent cardiometabolic risk factor, and there was a significant association between altered ultrasensitive C-reactive protein values and severe obesity (p=0.005), high waist circumference (p<0.001), hypertriglyceridemia (p=0.037) and insulin resistance (p=0.002), as well as significantly higher body mass index (p=0.000), waist circumference (p=0.001), insulin (p=0.005) and index of glucose homeostasis values(p=0.005). CONCLUSION: High prevalence of altered ultrasensitive C-reactive protein and significant association with severe obesity, waist circumference, hypertriglyceridemia and insulin resistance were observed.

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A study of procalcitonin and c-reactive protein in chronic h.pylori gastritis and it’s relation to severity of the disease

QJM ◽

10.1093/qjmed/hcab100.101 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Mohamed A. M Makhlouf ◽

Mohamed M Salama ◽

Hagar A. A Elessawy ◽

Ramy M Abd El-Hady

Keyword(s):

Chronic Gastritis ◽

Primary Diagnosis ◽

Diagnostic Methods ◽

Control Group ◽

C Reactive Protein ◽

University Hospitals ◽

Cross Sectional ◽

Reactive Protein ◽

H Pylori ◽

Group B

Abstract Background Gastritis is an important premalignant lesion and recent studies suggested a production of inflammatory cytokine-like C-reactive protein during gastritis. This study aimed to determine any relationship between high sensitive Creactive protein (hs-CRP) and inflammation activity among patients with gastritis. Aim and objectives the aim of the study is to compare the levels of procalcitonin and CRP in serum between positive and negative H. pylori chronic gastritis, to correlate their levels with the severity of inflammation of chronic gastritis[h.pylori related and non h.pylori related]and to suggest any effect of different regimens of treatment and their levels in serum. Subjects and methods This is a Cross sectional comparative study, was carried out at Internal Medicine medicine departments of Ain Shams university hospitals, from September 2019 till March 2020,on 75 patients divided into 3 groups: (Group A); positive H. Pylori chronic gastritis,(Group B); negative H. Pylori chronic gastritis,(Group C); normal control group. Results There was positive highly significant correlation between H. Pylori severity and each of CRP and Procalcitonin where (r = 0.929; P < 0.001) and (r = 0.928; P < 0.001) respectively. Conclusion PCT and CRP were effective markers for primary diagnosis, as well as eradication follow-up after therapy, when they were used in parallel with conventional diagnostic methods.

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