scholarly journals Comparative evaluation of microbial contamination in and periodontitis and periimplantitis. Review

2021 ◽  
pp. 101-109
Author(s):  
N. A. Tuneva ◽  
◽  
N. V. Bogacheva ◽  
Keyword(s):  
Periodontal Diseases ◽  
Positive Outcome ◽  
Pathological Process ◽  
Scientific Data ◽  
Microbial Pathogens ◽  
Oral Microbiota ◽  
Term Survival ◽  
Periodontal Tissues ◽  
Dental Implantation ◽  
Therapeutic Measures

At the present stage of the development of dentistry, dental implantation occupies a leading place in the system of complex rehabilitation of patients with defects in the dentition. The success of dental implant placement depends on many factors. Among the significant reasons influencing the positive outcome of transplantation, the state of microbiocinosis of the oral cavity of patients should be noted. The perimplant zone is a favorable habitat for anaerobes. The pathological process in the form of periodontitis, which is often the reason for the loss of teeth and the placement of implants, contributes to the progression of the inflammatory process in the periodontal tissues. This article provides an overview of the scientific litera-ture devoted to the study of microflora in inflammatory periodontal diseases. We conducted a comparative assessment of the microbiota in periodontitis and peri-implantitis, which, according to individual authors, are different ecosystems in terms of the composition of microorganisms. Alternative views on this issue were considered. Based on the analyzed scientific data, we made a conclusion about the similarities and differences in the oral microbiota in periodontitis and peri-implantitis, as well as in their combined course. We substantiated the feasibility of assessing microbial pathogens in the peri-implant area in order to develop preventive and therapeutic measures aimed at the long-term survival of dental implants.

scholarly journals SOME ASPECTS OF THE EATIOLOGY OF PARODONTUS DISEASES. (LITERATURE REVIEW)

2018 ◽  
pp. 54-59
Author(s):  
N.N. Saveleva ◽  
I.I. Sokolova ◽  
S.I. German ◽  
T.V. Tomilina
Keyword(s):  
Gastrointestinal Tract ◽  
Periodontal Disease ◽  
Structural Damage ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Clinical Manifestations ◽  
Pathological Process ◽  
Chronic Obstructive ◽  
Internal Organs ◽  
Periodontal Tissues

The review of the scientific literature is devoted to the topical issues of studying the etiology of periodontal diseases, which are one of the most common and complex pathologies of the maxillofacial region. Analysis of recent studies proves a stable relationship between the development of periodontal diseases and disorders in the immune system, the neurohumoral system, metabolic disorders, genetic predisposition, and so on. The article presents the data obtained in the course of studying the literature on the role of disorders in the functioning of individual organs (gastrointestinal tract, liver, lungs, heart, and urinary system) in the development of chronic periodontal diseases. The article notes that the anatomical and physiological proximity of the periodontal and digestive tract tissues, the generality of innervation and humoral regulation create prerequisites for the involvement of periodontal disease in the pathological process in diseases of the gastrointestinal tract. One of the main etiological factors in the development of inflammatory diseases of the gastrointestinal tract and periodontium is Helicobacter pylori, which is found in the loci of the oral cavity: in the oral and gingival fluid, on the mucous membrane of the tongue and cheeks, and in the periodontal pockets. It is pointed out that the liver also occupies a special place in the development of periodontal diseases, which is explained by the performance of its significant functions for the human body: regulatory, metabolic, antitoxic and other. There is evidence that the pathology of periodontal disease plays a leading role in the structure of dental diseases in patients with chronic obstructive pulmonary diseases, which is clinically manifested by symptoms of generalized periodontitis of the І-ІІ degrees of development and its complications - partial or complete secondary adentia, and with tooth preservation - defects in dental series and violations of occlusion, function, aesthetics. Scientists suggest a general biological mechanism for the development of generalized periodontitis and cardiovascular diseases, linking the development of periodontal diseases in patients with cardiovascular pathology with microcirculatory disorders. The dependence of the severity of inflammatory changes in the periodontal tissues on the disturbances of salt metabolism in urolithiasis is proved. The data obtained indicate that diseases of the internal organs contribute to the structural damage of periodontal tissues and they are a risk factor for periodontal diseases, which necessitate the presence of not only theoretical knowledge and practical skills in dentistry, but also their awareness of the features and clinical manifestations of somatic pathology. An urgent and justified step in the treatment of periodontal diseases is also the involvement in the process of rendering complex dental care to internist doctors capable of quickly and qualitatively assessment the condition of the internal organs and the basic systems of the patient's body.

scholarly journals Features of substitution of defects of tooth rows in persons with periodontal tissue diseases of different severity

2021 ◽  
Vol 105 (1) ◽  
pp. 82-87
Author(s):  
O. Doroshenko ◽  
◽  
O. Bida ◽  
Keyword(s):  
Periodontal Disease ◽  
Bone Tissue ◽  
Dental Implants ◽  
Alveolar Bone ◽  
Periodontal Diseases ◽  
Pathological Process ◽  
Periodontal Tissue ◽  
Dental Implantation ◽  
Orthopedic Rehabilitation ◽  
Abutment Teeth

Resume. The high prevalence of periodontal disease causes the urgency of finding ways to improve methods of diagnosis, treatment and prevention of complications of this disease. The complex clinical picture requires a differentiated approach to the choice of orthopedic rehabilitation of such patients taking into account the patient's age, degree of pathological changes and activity of the pathological process with mandatory immobilization of movable teeth by different types of splints and splint dentures. Depending on the degree of pathological changes in periodontal tissues, the size and topography of dentition defects and the severity of destructive-resorptive processes in the alveolar bone, the replacement of dentition defects should be planned using dental implants and splinttype dentures. The aim of the study. Improving the effectiveness of orthopedic treatment of periodontal diseases, burdened by defects of the dentition through the differentiated use of dental implants and splinting structures. Materials and methods. A comprehensive clinical and laboratory examination of 237 patients with clinically diagnosed periodontitis I–III degree, burdened by partial loss of teeth. From the specified contingent of persons we carried out orthopedic treatment of 98 patients aged from 30 to 69 years with periodontal diseases of various severity, aggravated by defects of dentitions of various size and localization. Cone-beam computed tomography was used for objective quantitative and qualitative assessment of periodontal tissue and bone tissue of the edentulous jaw in individuals with various clinical forms of periodontal disease, to determine the relative densitometric density of bone tissue, when planning dental implantation and for control its results. The localization of supracontacts was determined by occlusion. Diagnosis and elimination of traumatic occlusion were performed according to Jenkelson and Schuller [3]. Evaluation of the stability of dental implants was performed by frequency – resonance analysis of the stability of dental implants using the Osstell ISQ device. Results. According to the results of examination of 237 people and the division of patients into three age groups, the clinical features of the pathological process in the age aspect were established. The results of computed tomography of the dental apparatus of the subjects showed that periodontal disease in the age aspect in the dynamics is accompanied by the severity of destructive-resorptive processes in the alveolar bone, which are manifested in a decrease in the relative densitometric density of bone marrow and bone loss. Orthopedic rehabilitation of this contingent of persons was performed with the use of biologically indifferent structural materials and splinting orthopedic structures, including splinting of abutment teeth, removable prosthetics and dental implantation, as well as accompanying physiotherapy of prostheses. In the case of periodontitis of I–II degree with sufficient volume and density of bone tissue in the area of the dentition defect, high clinical efficacy was shown by the use of dental implantation in the case of gradual loading of the dental implant using a superstructure of own development. In the presence of medium and large defects of the dentition on the background of periodontitis II–III severity in the presence of significant pathological mobility of abutment teeth and insufficient volume and density of bone tissue in the area of the defect sufficient clinical effectiveness showed the use of removable dentures own design. Conclusions. Periodontal diseases in the age aspect in the dynamics are accompanied by pronounced destructive-resorptive processes in the alveolar bone, which are manifested by a decrease in the relative densitometric density of bone tissue and progressive loss of height of the alveolar process. Timely application of dental implantation due to the dosed gradual occlusal load on the alveolar bone helps to preserve the structure of the alveolar bone and the height of the alveolar process. In the presence of medium and large defects of the dentition on the background of periodontitis II–III severity in the presence of significant pathological mobility of abutment teeth and insufficient volume and density of bone tissue in the area of the dentition defect, the use of removable dentures of splinttype design is shown. To prevent complications of prosthetics and prolong the use of orthopedic structures, it is advisable to use photodynamic maintenance therapy. Key words: periodontal tissue disease, dentition defect, dental implantation, splint-type denture.

THE USE OF PLATELET AUTOPLASMA IN THE COMPLEX TREATMENT OF PERIODONTAL DISEASES

2021 ◽  
Vol 2 (2) ◽  
pp. 5-8
Author(s):  
M.T. Safarov ◽  
◽  
F.A. Khusanbaeva ◽  
K.M. Tashpulatova ◽  
A.M. Khodjiberganov
Keyword(s):  
Quality Of Life ◽  
Chronic Infection ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Pathological Process ◽  
Systemic Diseases ◽  
General State ◽  
Complex Treatment ◽  
Periodontal Tissues

The search for new ways of early detection and improving the effectiveness of treatinginflammatory periodontal diseases is one of the urgent tasks in modern dentistry. Inflammatory diseases in the periodontal tissues lead to the loss of teeth, the appearance offoci of chronic infection in the oral cavity, a decrease in the body's reactivity, microbial sensitization, and the development of allergic conditions. This pathological process is not a strictly limited pathology but, as a rule, is just one of the manifestations of more serious systemic diseases. The general state of human health, the quality of life, his socio-mental status and even his role in society suffer.Keywords:periodontium, inflammation, platelet autoplasm

Clinical outcome of innovative rehabilitation therapy for chronic periodontal diseases

2020 ◽  
pp. 65-70
Author(s):  
Inessa Minenko ◽  
Nelli Vanchenko
Keyword(s):  
Clinical Outcome ◽  
Oral Hygiene ◽  
Inflammatory Process ◽  
Healthy Lifestyle ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Dental Health ◽  
Healthy Person ◽  
Periodontal Tissues ◽  
Therapeutic Measures

A smile is an important part of the attractiveness and beauty of a modern person [1]. Today, more than ever, it’s important to be a well-groomed and healthy person, in whom “...everything should be fine...” as the classic said. The vast majority of patients tend to lead a healthy lifestyle, which includes dental health as well [3]. Health of periodontal tissues directly depends not only on the proper oral hygiene carried out by patients at home, but also on an individually selected set of therapeutic measures performed by the dentist [4, 5]. Thus, dentists and related specialists should provide highly professional medical care in the treatment of inflammatory diseases of periodontal tissues to achieve maximum results, stop the inflammatory process and restore the periodontium as a whole [6, 7].

ANALYSIS OF THE CONTENTS OF THE PERIODONTAL POCKET IN CHRONIC PERIODONTITIS

2021 ◽  
pp. 51-55
Author(s):  
Станислав Валерьевич Микляев ◽  
Ольга Михайловна Леонова ◽  
Андрей Валерьевич Сущенко ◽  
Антон Дмитриевич Козлов
Keyword(s):  
Oral Cavity ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Pathological Process ◽  
Economic Problem ◽  
The Body ◽  
Periodontal Pocket ◽  
Periodontal Tissues ◽  
Normal Microflora ◽  
Obligate Anaerobic

Микрофлора человека - сложная саморегулирующая система, способная восстанавливаться при грамотной коррекции. Исследования последних лет показали, что нарушение нормального микробиоценоза полости рта растет из года в год и у жителей Российской Федерации превышает 90 %, вызывая при этом воспалительные заболевания в тканях пародонта, и, как правило, сопровождается дисбиозом полости рта, выраженность которого соответствует степени поражения пародонта. Одно из ведущих мест в развитии данной патологии занимает резидентная облигатно-анаэробная и микроаэрофильная микрофлора полости рта. Изучение микробиологического состава пародонтальных карманов (ПК) при воспалительных заболеваниях тканей пародонта (ВЗТП) имеет большое значение непосредственно для эффективного лечения и понимания патогенетических этапов этих заболеваний. Достаточно серьезной проблемой современной стоматологии как в нашей стране, так и за рубежом являются заболевания пародонта. Указанная патология снижает принятый ВОЗ критерий качества жизни и приводит к преждевременной потере зубов и представляет серьезную медицинскую, социальную и экономическую проблему. Первичным фактором, вызывающим поражение пародонта, являются бактерии зубного налета. Этиологическая структура инфекционных процессов в последнее десятилетие значительно изменилась, что связано с постоянной эволюцией микробов и вовлечением в патологический процесс условно-патогенных микробов, которые могут выступать в качестве комменсалов в составе нормальной микрофлоры и проявлять свою патогенность при снижении иммунного статуса организма The human microflora is a complex self-regulating system that can be restored with proper correction. Recent studies have shown that the violation of the normal microbiocenosis of the oral cavity increases from year to year and in the residents of the Russian Federation exceeds 90 %, causing inflammatory diseases in the periodontal tissues, and, as a rule, is accompanied by dysbiosis of the oral cavity, the severity of which corresponds to the degree of periodontal damage. One of the leading places in the development of this pathology is occupied by the resident obligate-anaerobic and microaerophilic microflora of the oral cavity. The study of the microbiological composition of periodontal pockets (PC) in inflammatory diseases of periodontal tissues (VSTP) is of great importance directly for the effective treatment and understanding of the pathogenetic stages of these diseases. Quite a serious problem of modern dentistry both in our country and abroad are periodontal diseases. This pathology reduces the WHO-accepted quality of life criterion and leads to premature tooth loss, and is a serious medical, social and economic problem. The primary factor that causes periodontal disease is plaque bacteria. The etiological structure of infectious processes has changed significantly in the last decade, which is due to the constant evolution of microbes and the involvement of conditionally pathogenic microbes in the pathological process, which can act as commensals in the normal microflora and show their pathogenicity with a decrease in the immune status of the body

scholarly journals Стоматологічний статус осіб, схильних до регулярного активного куріння

2017 ◽  
Author(s):  
O. Ya. Lavrin ◽  
V. V. Shcherba ◽  
I. Ya. Krynytska
Keyword(s):  
Periodontal Disease ◽  
Periodontal Diseases ◽  
Pathological Process ◽  
Control Group ◽  
Periodontal Tissue ◽  
Active Smoking ◽  
Periodontal Tissues ◽  
Increased Risk ◽  
Periodontal Index ◽  
Central District

Smoking is associated with significantly increased risk of diseases of organs and tissues of the oral cavity, especially periodontal pathology and cancer of the mouth.The aim of the study – to investigate the prevalence, structure and clinical course of periodontal tissue diseases in people prone to regular active smoking.Materials and Methods. A study of 120 visitors who had undergone preventive examinations in the Clinic of Zbarazh Central District Municipal Hospital exposed to regular active smoking was performed. To assess the degree of inflammation in periodontal tissues we used marginally-papillary-alveolar index, periodontal index, the Green-Vermilyon index.Results and Discussion. Dental examination of persons exposed to regular active smoking, revealed periodontal disease in 102 individuals (85.0 %), intact periodont – 18 persons (15.0 %). At the same time, investigation of 30 control individuals showed periodontal disease in 12 persons (40.0 %), clinically healthy periodontal tissue – in 18 persons (60.0 %). PMA index of individuals exposed to regular active smoking, treated as severe gingivitis and was significantly higher than data of the control group in 2.5 times. Average numerical values of periodontal index in patients exposed to regular active smoking answered moderate periodontitis and significantly were higher than data of the control group in 4 times. Oral hygiene status in 62 % of those exposed to regular active smoking, was poor, 7 % – very poor, 22 % – satisfactory, 9 % – good. Average numerical values of Green-Vermilyon index in smokers was significantly higher than data of the control group in 3.1 times.Conclusions. Thus, smoking contributes to increasing of diffuse periodontal diseases and deepening of pathological process.

scholarly journals Assessment of the Level of Competence of Dentists in the Diagnosis and Classification of Periodontal Tissue Diseases

2021 ◽  
Vol 7 (5) ◽  
pp. 239-247
Keyword(s):  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Pathological Process ◽  
Periodontal Tissue ◽  
Periodontal Tissues ◽  
Diagnosis And Classification ◽  
Adequate Evaluation ◽  
Diagnostic Research ◽  
Inflammatory Changes

The polyethiology of periodontal diseases introduces certain difficulties in the diagnosis and adequate selection of treatment methods and dictates the conditions under which the complexity and individual approach are the main conditions for successful treatment. Therefore, it is very important to timely diagnose and correctly determine the prognosis of the disease, which directly depends on the level of professional knowledge of dentists. The aim of the study was to analyze the level of competence of dentists on the methods of diagnosis and classification of periodontal tissue diseases in patients in Bishkek. Questioning of respondents — 87, statistical. For the study, a questionnaire “Dentist’s awareness of modern principles of diagnosis and treatment of periodontal tissues” was developed, containing 14 questions that reveal the ideas of dentists-therapists about modern principles of classification, diagnosis and methods of treatment of inflammatory diseases of periodontal tissues. According to the results of the survey, low competence in the diagnosis of periodontal diseases was revealed: 34.5% of the respondents are well aware of classification issues; adequate evaluation indices for assessing the hygienic state of the oral cavity and inflammatory changes in the tissues of the gums are used only in 20.7% and 77.0% of cases, respectively; laboratory and diagnostic research methods are used only by 59.8%. The use of a large number of diagnostic and prognostic indices in periodontics makes it possible to objectively control the dynamics of the disease, assess the depth and prevalence of the pathological process, carry out mathematical processing of the results obtained and compare the effectiveness of various methods of treating periodontitis.

scholarly journals Periodontal Disease: The Good, The Bad, and The Unknown

2021 ◽  
Vol 11 ◽  
Author(s):  
Lea M. Sedghi ◽  
Margot Bacino ◽  
Yvonne Lorraine Kapila
Keyword(s):  
Periodontal Disease ◽  
Disease Progression ◽  
Inflammatory Responses ◽  
Bacterial Species ◽  
Systemic Disease ◽  
Microbial Pathogens ◽  
Oral Microbiota ◽  
Periodontal Pathogens ◽  
Periodontal Health ◽  
Periodontal Tissues

Periodontal disease is classically characterized by progressive destruction of the soft and hard tissues of the periodontal complex, mediated by an interplay between dysbiotic microbial communities and aberrant immune responses within gingival and periodontal tissues. Putative periodontal pathogens are enriched as the resident oral microbiota becomes dysbiotic and inflammatory responses evoke tissue destruction, thus inducing an unremitting positive feedback loop of proteolysis, inflammation, and enrichment for periodontal pathogens. Keystone microbial pathogens and sustained gingival inflammation are critical to periodontal disease progression. However, recent studies have revealed the importance of previously unidentified microbes involved in disease progression, including various viruses, phages and bacterial species. Moreover, newly identified immunological and genetic mechanisms, as well as environmental host factors, including diet and lifestyle, have been discerned in recent years as further contributory factors in periodontitis. These factors have collectively expanded the established narrative of periodontal disease progression. In line with this, new ideologies related to maintaining periodontal health and treating existing disease have been explored, such as the application of oral probiotics, to limit and attenuate disease progression. The role of systemic host pathologies, such as autoimmune disorders and diabetes, in periodontal disease pathogenesis has been well noted. Recent studies have additionally identified the reciprocated importance of periodontal disease in potentiating systemic disease states at distal sites, such as in Alzheimer’s disease, inflammatory bowel diseases, and oral cancer, further highlighting the importance of the oral cavity in systemic health. Here we review long-standing knowledge of periodontal disease progression while integrating novel research concepts that have broadened our understanding of periodontal health and disease. Further, we delve into innovative hypotheses that may evolve to address significant gaps in the foundational knowledge of periodontal disease.

Vitamin D Effects on Guided Bone Regeneration and Osseointegration of Dental Implants (Literature Review)

2020 ◽  
Vol 75 (5) ◽  
pp. 552-560
Author(s):  
Sergey Yu. Ivanov ◽  
Svetlana Yu. Kalinchenko ◽  
Nidjat A. Guseynov ◽  
Aleksander A. Muraev ◽  
Aigul Т. Safi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Tissue ◽  
Dental Implants ◽  
Scientific Data ◽  
Reparative Regeneration ◽  
Jaw Bone ◽  
Dental Implantation ◽  
Oral Reconstruction ◽  
Phosphate Exchange ◽  
Regeneration Of Bone

Background.Due to the prevalence of Vitamin D deficiency as well as the frequency of reconstructive surgical interventions followed by dental implantation, the issue arises concerning the effect of Vitamin D on reparative regeneration of bone and osseointegration of dental implants.The purpose using literature data we are conducting an impact assessment of vitamin D on reparative regeneration of bone tissue, in particular, after oral reconstruction surgeries and dental implantation.Methods.Retrieval, systematization and analysis of scientific data on application of vitamin D supplementation and its effect on reparative regeneration of jaw bone tissue.The conclusions.For the most part, the positive effect exerted on reparative regeneration of jaw bone tissue and osseointegration of dental implants is due to the role of vitamin D in physiological processes evolving in bone tissue, namely maintenance of calcium and phosphate exchange through intestinal absorption and TNF, RANKL (Receptor activator of nuclear factor kappa-B ligand) and consequently differentiation of precursors to osteoclasts into osteoclasts through VDR stimulation (VitaminD Receptor) receptors for further osteogenesis. Also, according to literature data, FGF23 (Fibroblast Growth Factor) protein is a marker of osteoblasts differentiation into osteocytes, it is also known that FGF23 and 1,25(ОН)2D3 are genetically related. FGF23 is the main regulator of both phosphate exchange in bones and metabolism of vitamin D and its metabolites. Besides, indirect anti-inflammatory effect has been observed thanks to inhibition of pro-inflammatory cytokine secretion. Taking into account the abovementioned data, of particular relevance is the definition of serum concentration 25(ОН)D and development of schemes of vitamin D level pre-surgery correction in patients, who have to undergo oral reconstruction surgeries and dental implantation. Mass spectrometry is a promising diagnostic method for determining the level of vitamin D in a body, as it allows to identify the actual amount of vitamin D free from admixture of other steroid hormones. The introduction of this method into clinical practice will allow to monitor the level of vitamin D in patients, receiving reconstructive and rehabilitative treatment.

Comparative analysis of polymorphic variants of IL-17A and MMP-1 genes with the risk of developing chronic periodontitis in petrochemical workers

2020 ◽  
Vol 60 (10) ◽  
pp. 687-693
Author(s):  
Iskander I. Zaidullin ◽  
Denis O. Karimov ◽  
Lilija K. Karimova ◽  
Milyausha F. Kabirova ◽  
Rasima R. Galimova ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Clinical Manifestations ◽  
Control Group ◽  
Periodontal Tissues ◽  
Dental Examination ◽  
Number Of Patients ◽  
Increased Risk ◽  
Harmful Substances

The susceptibility to the development and progression of inflammatory periodontal diseases, which depends on genetic and external factors (smoking, stress, oral hygiene), varies widely. In the development of these diseases, an important role is played not only by the presence of periodontal pathogenic microorganisms, but also by the presence of congenital or acquired immunodeficiency, immunoregulatory defects. The immune system plays a key role in the physiological and pathological processes of periodontal tissues. In this regard, IL17, produced by CD4+ Th cells, which has both Pro-inflammatory and protective activity, is of particular interest in the pathogenesis of periodontitis. The aim of study was to identify the relationship between polymorphic loci of the IL-17A (rs2275913) and MMP-1 (rs1799750) genes and clinical manifestations of chronic periodontitis in petrochemical workers. Dental examination was performed in 92 ethylene oxide production workers with chronic periodontitis and 74 patients with chronic periodontitis who did not come into contact with chemical factors (control group). Genotyping of polymorphisms rs2275913 of the IL17A gene and rs1799750 of the MMP1 gene was performed by allele-specific real-time polymerase chain reaction (PCR). Hygienic assessment of the degree of air pollution of the working area with harmful substances was carried out by gas chromatography according to the guidelines for the determination of harmful substances in the air № 5098-89, № 3119-84. When comparing the results of studies of both groups, there were no statistically significant differences in the frequency distributions of allelic variants and genotypes of the IL-17A and MMP-1 genes. The AA/AG genotypes of the IL-17A gene were associated with an increased risk of severe disease compared to the GG genotype in workers in the main group (OR=6.1; 95% CI 1.33-28.5; p=0.021) and in the control group (OR=7.26; 95% CI 1.34-39.25; p=0.016). Carriers of the A allele in the control group increased the risk of severe chronic periodontitis by 2.4 times compared to carriers of the G allele (OR=2.41; 95% CI 1.19-4.87; p=0.014). During the dental examination of employees of the ethylene oxide plant, the clinical course of periodontal diseases was more severe in comparison with the control group, and the number of patients with severe periodontitis was twice as high. It was found that the AA/AG genotypes of the IL-17A gene and the carrier of the A allele are associated with increased susceptibility to the development of severe chronic periodontitis. The association between the MMP-1 gene polymorphism and the risk of severe forms of chronic periodontitis has not been established. A risk factor for the development of inflammatory periodontal diseases in employees of the petrochemical complex is a complex of harmful production factors.

Sign in / Sign up

Export Citation Format

Share Document