FEATURES OF THE TECHNOLOGICAL COMPONENT OF THE IVANOVO REGION HEALTH SYSTEM POLICY IN MALIGNANT TUMORS EARLY DIAGNOSIS

Diagnosis of malignant tumors is an urgent problem of the modern world. Early diagnosis depends on General practitioners. The doctor should conduct a systematic examination of the patient regularly, taking into account the risk groups, gender and age. With mass screening, signs of dysplasia or an early focus, developing cancer can «slip away» [1]. Optimization of analysis and examination algorithms is required, which is not always possible for one person. Positive application of the digital program with elements of imaging in Oncology, we were able to create such a class of tasks for the preliminary subjective-objective survey of patients in three versions: with a widescreen screen and consoles for patients (group version up to 15 or more patients), interactive (touch) and tablet. The results of the survey are sent through the accepted channels to the doctor with recommendations for further examination, and the patient is given a coupon. The pilot program showed that the system of such robotic technologies in the future can replace the oncologist in its development to artificial intelligence at the stage of the primary link.

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Impact and paybacks of biomedical research findings in Malaysia 2005–2015

Evidence & Policy A Journal of Research Debate and Practice ◽

10.1332/174426421x16328403229964 ◽

2021 ◽

Author(s):

Pei Kuan Lai ◽

S Nalliah ◽

CL Teng ◽

NLP Chen

Keyword(s):

Decision Making ◽

Health System ◽

Capacity Building ◽

Biomedical Research ◽

Knowledge Production ◽

Future Research ◽

Relevant Research ◽

Research Findings ◽

The Impact ◽

Health System Policy

Background: Impact in research encompasses health, economic, and cultural benefits beyond adding to the knowledge base. Funders are under immense pressure to be accountable for the paybacks from funded research.Aims and objectives: The aim of this study was to look into the impact of funded biomedical research between the years 2005 and 2015 in Malaysia from the aspects of knowledge production, research targeting and capacity building, as well as health system policy and decision making.Methods: This study employed a convergent parallel mixed-methods research design. Biomedical projects related to breast cancer, coronary heart disease, and dengue, funded by the Ministry of Health (MOH), Ministry of Higher Education (MOHE), and Ministry of Science, Technology, and Innovation (MOSTI) between the years 2005 and 2015, were included.Findings: From the questionnaire responses (n=58), on average each funded project managed to produce two outputs and one higher degree student. More than half (61.4%) of the funded projects led to subsequent future research. However, low citations in systematic reviews (10.3%), health policies (6.9%), and clinical practice guidelines (5.2%) were reported. In-depth interviews with the key opinion leaders also saw that most of the local research findings were found to be irrelevant to be adopted into policies by the policymakers.Discussion and conclusions: Paybacks on knowledge production as well as research targeting and capacity building had been achieved, but impact on health system policy and decision making had not been well attained, due to the lack of relevant research findings needed by the policymakers. Key messages <ul><li>Payback on knowledge production was achieved, as there had been a lot of new knowledge generated as captured in academic publications, conference proceedings, policy briefs, technical reports, and research highlights, which is important to advance the frontiers of knowledge.</li> <li>Payback on research targeting was achieved, with the current research leading to future study with identification of the knowledge gap and generation of new ideas for new research.</li> <li>Payback on capacity building was achieved with the training of researchers, building up research capacity and competencies, production of MSc and PhD graduates, promotion of lecturers, and development of new partnerships and networks.</li> <li>Impact on health system policy and decision making was not well attained. There had been a lack of relevant research data and findings being incorporated into policymaking, due to the basic and fundamental nature of most of the funded biomedical research in Malaysia.</li></ul>

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Detection of Circulating Tumor Cells and Its Application in Prostate Cancer

Nepalese Journal of Cancer ◽

10.3126/njc.v4i1.31685 ◽

2020 ◽

Vol 4 (1) ◽

pp. 3-7

Author(s):

Jin-Qi Song ◽

Ya-Nan Zhou ◽

Gang-Liang Tu ◽

Chang-Li Xu ◽

Hui Xu

Keyword(s):

Prostate Cancer ◽

Early Diagnosis ◽

Tumor Cells ◽

Circulating Tumor Cells ◽

Malignant Tumors ◽

Depth Study ◽

Tumor Research ◽

The Common ◽

Development And Evolution

In recent years, circulating tumor cells have become the focus of tumor research. In-depth study of the role of circulating tumor cells in the genesis, development, and evolution of tumors will be of great significance for the early detection, early diagnosis, early treatment, and prognosis of tumors. Prostate cancer is one of the common male malignant tumors, and the role of circulating tumor cells in prostate cancer has been increasing year by year. This article will focus on the progress of circulating tumor cells detection and its application in prostate cancer.

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The Mechanism and Clinical Significance of Circular RNAs in Hepatocellular Carcinoma

Frontiers in Oncology ◽

10.3389/fonc.2021.714665 ◽

2021 ◽

Vol 11 ◽

Author(s):

Ziyue Huang ◽

Haoming Xia ◽

Shuqiang Liu ◽

Xudong Zhao ◽

Risheng He ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Early Diagnosis ◽

Molecular Mechanisms ◽

Immune Escape ◽

Clinical Symptoms ◽

Malignant Tumors ◽

Research Progress ◽

Circular Rnas ◽

Transcriptional Level ◽

Specificity And Sensitivity

Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors worldwide. In view of the lack of early obvious clinical symptoms and related early diagnostic biomarkers with high specificity and sensitivity, most HCC patients are already at the advanced stages at the time of diagnosis, and most of them are accompanied by distant metastasis. Furthermore, the unsatisfactory effect of the follow-up palliative care contributes to the poor overall survival of HCC patients. Therefore, it is urgent to identify effective early diagnosis and prognostic biomarkers and to explore novel therapeutic approaches to improve the prognosis of HCC patients. Circular RNA (CircRNA), a class of plentiful, stable, and highly conserved ncRNA subgroup with the covalent closed loop, is dysregulated in HCC. Increasingly, emerging evidence have confirmed that dysregulated circRNAs can regulate gene expression at the transcriptional or post-transcriptional level, mediating various malignant biological behaviors of HCC cells, including proliferation, invasion, metastasis, immune escape, stemness, and drug resistance, etc.; meanwhile, they are regarded as potential biomarkers for early diagnosis and prognostic evaluation of HCC. This article reviews the research progress of circRNAs in HCC, expounding the potential molecular mechanisms of dysregulated circRNAs in the carcinogenesis and development of HCC, and discusses those application prospects in the diagnosis and prognosis of HCC.

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Case Report: Gastric Cancer Combined With Bilateral Ovarian Metastasis In Pregnancy

10.21203/rs.3.rs-871687/v1 ◽

2021 ◽

Author(s):

Zhenhua Zhang ◽

Gang Lv ◽

Mei Liu ◽

Miaohui Lin ◽

Meilin Xie ◽

...

Keyword(s):

Gastric Cancer ◽

Case Report ◽

Early Diagnosis ◽

Malignant Tumors ◽

Ovarian Metastasis ◽

Ovarian Mass ◽

Health Checkup ◽

Case Presentation ◽

Treatment Plans ◽

In Pregnancy

Abstract Background: The early manifestations of gastric cancer during pregnancy are non-specific. Ovarian mass and ascites are the main manifestations of late ovarian metastasis. Case presentation: A case of late gastric cancer with bilateral ovarian metastasis in pregnancy was reported in our study. Cesarean section and full staging of ovarian malignant tumors were performed at 28+5 weeks of pregnancy, and the prognosis was poor. We performed Cesarean delivery and extracted a vital male newborn of 35 cm, 1020 g, Ap score 3. The newborn is alive and grows normally. Three months later the mother died. The key to improving the prognosis is early diagnosis, and the pre-pregnancy health checkup must be emphasized. Conclusions: During pregnancy, ultrasound, gastroscopy, MRI and other related examinations should be performed to confirm the diagnosis, and individualized treatment plans should be formulated to maximize the protection of the mother and child's interests.

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Early Detection of Cancer: Recommendations for Eastern Mediterranean Region Background and Context

Journal of Global Oncology ◽

10.1200/jgo.18.95700 ◽

2018 ◽

Vol 4 (Supplement 2) ◽

pp. 238s-238s

Author(s):

S. Rengaswamy ◽

I. Fadhil

Keyword(s):

Early Detection ◽

Early Diagnosis ◽

Health System ◽

Early Detection Of Cancer ◽

Eastern Mediterranean Region ◽

Cancer Control ◽

Member States ◽

Adequate Treatment ◽

Screening Programs ◽

Cancer Early Detection

Background and context: Increasing cancer burden in EMR is of major concern to all member states and is a priority for WHO. Almost all countries in EMR, have gaps in cancer control programs. Policymakers are looking for concrete advice on how to address these gaps and meet the increasing needs and demands for cancer care. Aim: To draw on the experience of WHO/EMRO in developing guidance for member states to establish early detection program for 5 priority cancers (breast, colorectal, cervical, oral, prostate). Strategy/Tactics: Implementation of suitable and effective cancer control policies including early detection of cancer that benefit from effective treatment. Program/Policy process: In the EMR, the most common cancers amenable to early diagnosis/screening are breast, colorectal, cervix, prostate and oral cancers. Work to develop early detection policy statements for EMR countries draws on the recommendations of a series of consultative meetings/process conducted throughout 2014-2016, taking into consideration the various health system levels and profile of cancer in the region. Outcomes: A strategic approach to strengthen cancer early detection focusing on the 5 priority cancers by level of development of health system in EMR countries. What was learned: Half of all cancers in EMR are amenable to early detection and potential cure with adequate treatment and follow-up. Early diagnosis is critical and should be implemented in all countries irrespective of level of income/health system development. Primary care professionals have a great role to advance cancer early detection programs. It is important to pilot any screening programs prior to national roll-out.

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Improved prognosis for recurrent epithelial ovarian cancer by early diagnosis and 125I seeds implantation during suboptimal secondary cytoreductive surgery: a case report and literature review

Journal of Ovarian Research ◽

10.1186/s13048-020-00744-2 ◽

2020 ◽

Vol 13 (1) ◽

Author(s):

Lin Xiao ◽

Junying Tang ◽

Wenbo Li ◽

Xuexun Xu ◽

Hao Zhang

Keyword(s):

Ovarian Cancer ◽

Early Diagnosis ◽

Epithelial Ovarian Cancer ◽

Cytoreductive Surgery ◽

Malignant Tumors ◽

Recurrent Ovarian Cancer ◽

R0 Resection ◽

Iliac Vessel ◽

Secondary Cytoreductive Surgery ◽

125I Seeds

Abstract Background Epithelial ovarian cancer (EOC) has the worst prognosis in all of gynecologic malignant tumors because of its high recurrence and eventually chemo-resistance. Early diagnosis of recurrence is crucial to avoid diffuse dissemination. Failure of traditional treatment in recurrent epithelial ovarian cancer remains a challenge for clinicians. On the other hand, 125I brachytherapy has been accepted as a useful and hopeful treatment for multiple advanced cancers in recent years. However, its success in advanced epithelial ovarian cancer is limited. Here we report a case of recurrent ovarian cancer who had been early diagnosis of isolated recurrence and successfully treated with 125I seeds implantation during suboptimal cytoreductive surgery. Case presentation A 59-year-old woman presented with recurrent epithelial ovarian cancer who have had a history of ovarian cancer stage IIIB and an R0 resection had been achieved nearly 2 years before presented in our hospital. She underwent suboptimal secondary cytoreductive surgery after four cycles of chemotherapy with little effectiveness and severe chemotherapy-related side effects. Approximately 70% of the cancer-bulk was resected during surgery. For residual lesion which fixed around the right ureter and right external iliac vessel, 125I seeds implantation was performed. Postoperatively, the patient was treated with two cycles of combination chemotherapy with paclitaxel and carboplatin. The patient was free of disease at 26 months’ follow-up period. Conclusion In recurrent EOC patients with unresectable isolated lesion, salvage 125I seeds implantation are feasible and may contribute to survival.

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Circulating serum exosomal miR-92a-3p as a novel biomarker for early diagnosis of gastric cancer

Future Oncology ◽

10.2217/fon-2020-0792 ◽

2021 ◽

Vol 17 (8) ◽

pp. 907-919

Author(s):

Xu Lu ◽

Jianxin Lu ◽

Siqi Wang ◽

Yu Zhang ◽

Ye Ding ◽

...

Keyword(s):

Gastric Cancer ◽

Early Diagnosis ◽

Malignant Tumors ◽

Area Under The Curve ◽

Tumor Biomarker ◽

Diagnostic Efficiency ◽

Node Metastasis ◽

Tumor Node Metastasis Stage ◽

Combined Detection ◽

Serum Exosomes

Gastric cancer (GC) is one of the common malignant tumors with high mortality. The abundance of miRNAs in serum exosomes has proved to have a high application value as a new noninvasive diagnostic method. The purpose of this study was to investigate whether serum exosomal miR-92a-3p could be used as a new biomarker for early diagnosis of GC and evaluate its clinical application value by detecting the expression of serum exosomal miR-92a-3p in 131 patients with primary GC and 122 healthy controls by real-time quantitative (qRT)-PCR. The results showed that the expression level of serum exosomal miR-92a-3p in GC patients was significantly lower than that in normal controls (p < 0.0001). In addition, the level was closely correlated with lymph node metastasis and tumor node metastasis stage of GC patients. The area under the curve for serum exosomal miR-92a-3p was 0.829, significantly higher than for other indicators. Furthermore, combined detection of serum exosomal miR-92a-3p, CEA and CA19-9 was more sensitive than any of the three alone or any pair. These results showed that serum exosomal miR-92a-3p could be used as a novel new tumor biomarker to improve diagnostic efficiency in GC.

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Analysis and Evaluation of Ultrasound Imaging Features and Pathological Results of Ovarian Cancer

Journal of Medical Imaging and Health Informatics ◽

10.1166/jmihi.2021.3349 ◽

2021 ◽

Vol 11 (3) ◽

pp. 981-987

Author(s):

Yuqing Zhang ◽

Yan Li ◽

Mei Wu ◽

Feixue Zhang ◽

Guangrui Shao ◽

...

Keyword(s):

Ovarian Cancer ◽

Early Diagnosis ◽

Cancer Patients ◽

Ultrasound Imaging ◽

Malignant Tumors ◽

Maximum Diameter ◽

Pathological Examination ◽

Imaging Features ◽

Specificity And Sensitivity ◽

Different Ages

To compare and analyze the relationship between the characteristics of ultrasound images of ovarian cancer and the results of postoperative pathological examination. A retrospective analysis of 206 patients with suspected ovarian cancer confirmed by surgical pathology was taken as the research object. The location, size, morphology, partition and wall nodules, cystic solidity, and signal characteristics of the tumor were observed and compared with the results of postoperative pathological examination evaluation and analysis to improve the early clinical diagnosis of ovarian cancer patients. By regression analysis of the histological examination of patients with ovarian tumors of different ages and the proportion of cox postoperative recurrence risk regression models, 154 of 206 ovarian tumor patients were ovarian cancer. There were significant differences in pathological types, lesion locations, maximum diameter lengths, and internal echo in patients with ovarian malignant tumors at different ages (p < 0.05). Ultrasound of ovarian cancer shows that the tumor has large tumor body, strong echo, cyst wall has protrusions, and peripheral and internal blood flow that is mainly high-speed and low-resistance. The sensitivity, specificity, and accuracy of ultrasound for ovarian cancer diagnosis are 84.38%, 66.67%, 81.01%. The accuracy, specificity, and sensitivity of early diagnosis of clinical ovarian cancer patients by ultrasound imaging features provide sufficient imaging evidence to further promote the clinical judgment of benign and malignant tumors, which is beneficial to doctors’ clinical treatment of ovarian cancer patients. The early diagnosis and the higher clinical value were shown.

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Cognitive impairment in aging physicians

Neurology Clinical Practice ◽

10.1212/cpj.0000000000000829 ◽

2020 ◽

pp. 10.1212/CPJ.0000000000000829

Author(s):

Gayatri Devi ◽

Darren R. Gitelman ◽

Daniel Press ◽

Kirk R. Daffner

Keyword(s):

Patient Safety ◽

Cognitive Impairment ◽

Occupational Health ◽

Health System ◽

Cognitive Disorders ◽

Cognitively Impaired ◽

Occupational Health Physicians ◽

Risks And Benefits ◽

Health System Policy ◽

Practicing Physicians

Aging physicians are at a higher risk of cognitive impairment, undermining patient safety and unraveling physicians' careers. Neurologists, occupational health physicians, and psychiatrists will participate in both health system policy decisions and individual patient evaluations. We address cognitive impairment in aging physicians and attendant risks and benefits. If significant cognitive impairment is found after an appropriate evaluation, precautions to confidentially support physicians' practicing safely for as long as possible should be instituted. Understanding that there is heterogeneity and variability in the course of cognitive disorders is crucial to supporting cognitively impaired, practicing physicians. Physicians who are no longer able to practice clinically have other meaningful options.

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