scholarly journals The morphological changes in placentas in women with deficit of bodyweight in combination with anemia, pyelonephritis and gestosis (Message II)

1998 ◽  
Vol 47 (3-4) ◽  
pp. 46-49
Author(s):  
M. F. Dodhoeva ◽  
V. N. Parusov
Keyword(s):  
Body Weight ◽  
High Frequency ◽  
Morphological Changes ◽  
Morphological Features ◽  
Brain Circulation ◽  
Normal Children ◽  
Small Weight ◽  
Compensatory Reactions

The morphological features of placenta are investigated in the women with a deficit of body weight in a combination with anemia (22), pyelonephritis (10) and gestosis (9). At specified conditions a significant involutive-dystrophical processes on a background of 100 % поп-ready placentas are accompanied by maximum realization of compensatory reactions, which promoted birth of normal children, but with small weight of a body at urgent labor and high frequency of development in them of brain circulation disturbances.

scholarly journals Features of the morphological structure of the placenta in pregnant women with preeclampsia

2021 ◽  
pp. 10-15
Author(s):  
Volodymyr I. Chermak ◽  
Ihor I. Chermak ◽  
Chukwuanyinonso O. Ikeotuonye ◽  
Anatolii Ya. Senchuk
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
High Frequency ◽  
Morphological Changes ◽  
Morphological Structure ◽  
Morphological Features ◽  
Placental Insufficiency ◽  
Control Group ◽  
Basic Group ◽  
Adaptive Reactions

To study morphological features of the placenta in women in labor, pregnancy which complicated by preeclampsia we studied 26 placentae, of which 17 were from pregnant women with mild to moderate preeclampsia (basic group) and 9 from healthy women (control group). Histologically the study was conducted with methodically recommendations of T.D. Zadorozhnaya et al. for light microscopy. During the study of morphological features of the placenta in women in labor with preeclampsia were installed morphological changes in the placenta, which reflect a tendency to develop compensatory-adaptive reactions following their stress and exhaustion, which is a sign of placental insufficiency. Received data allow claiming a high frequency of development placental insufficiency in pregnant women with risk factors such as chronic salpingo-oophoritis, anemia, late preeclampsia, and inflammation diseases kidney.

scholarly journals Teratogenic Effect of Usnic Acid from Cladonia substellata Vainio during Organogenesis

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
C. R. Silva ◽  
K. S. N. Marinho ◽  
T. D. S. Silva ◽  
D. K. S. Ferreira ◽  
G. M. Aguiar ◽  
...  
Keyword(s):  
Body Weight ◽  
Histological Analysis ◽  
Morphological Changes ◽  
Biological Activities ◽  
Usnic Acid ◽  
Teratogenic Effect ◽  
Oral Toxicity ◽  
Control Groups ◽  
Natural Substances ◽  
Weight Gain During Pregnancy

Studies about toxicological potential of usnic acid are limited. This way, the vast majority of data available in the literature are related only to biological activities. This is the first study that aimed to evaluate the oral toxicity of usnic acid during the period of organogenesis. Females rats were distributed in the control groups, treated I and II, at doses of 15 and 25 mg/kg, administered by gavage during the 6° to 15° days of pregnancy. After 20 days the fetuses were removed and analyzed. A reduction in weight gain during pregnancy, increased resorption, reduction in the number of viable fetuses, and their body weight were observed. Morphological changes in the litter were visualized as exposure of the eye and atrophy of the limbs at the dose of 25 mg/kg. Histological analysis of the liver of the fetus showed reduction in the number of megakaryocytes between experimental groups and increase in the number of hepatocytes in a dose of 25 mg/kg. The experimental model used in this study reveals teratogenic effect of usnic acid in the period of organogenesis. Since this achievement, the importance of evaluating the toxic effects of natural substances is imperative, in order to elucidate the care in their indication as drug.

scholarly journals Effects of proportional high-protein/low-carbohydrate formulated diet consumption in diabetic rats: Beneficial impact on glycemic and weight control

2020 ◽  
Vol 20 (07) ◽  
pp. 16984-16996
Author(s):  
MMC Anyakudo ◽  
◽  
DO Adeniji ◽  
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Treated Group ◽  
Morphological Features ◽  
High Protein ◽  
Control Group ◽  
Formulated Diet ◽  
Low Carbohydrate ◽  
Male Wistar Rats ◽  
And Control

The metabolic response to nutrient ingestion and the rate of digestion and absorption of nutrient molecules in bowel physiology plays an important role in the metabolic control of some human chronic non-infectious diseases. This experimentally-controlled designed nutritional study which lasted eight weeks aimed to determine the effects of proportional high-protein/low-carbohydrate (HP/LC) formulated diet on glycemic tolerance, glycemic control, body weight, organ weight and organ morphometry in healthy and diabetic adult male Wistar rats. Twenty-four male Wistar rats purchased from a disease-free stock were randomly categorized into four groups (n = 6, each) after two weeks acclimatization period in raised stainless steel cages with 6 mm2mesh floor and replaceable numbered blotters papers placed under each cage in a well-ventilated animal house. Animal groups include: Healthy control group (HC), Healthy treated group (HT), Diabetic control group (DC) and Diabetic treated group (DT. The animals were fed according to the experimental design with water ad libitumfor eight weeks. Diabetes was inducted with freshly prepared alloxan monohydrate solution (150 mg/kg bw, intraperitoneally). Body weights and fasting blood sugar concentrations were measured twice weekly, while oral glucose tolerance test was conducted on the last day of the eighth-week study and subsequently followed by organs extraction after anesthesia for weight and gross assessment. Proportional high-protein/low-carbohydrate formulated diet caused significant reduction in mean body weight of treated diabetic (DT: 22.6%; P= .001) and healthy (HT: 5.8%; P= .007) rats while the control animals on control diet recorded significant (P< .05) increase in body weight gain (DC: 12.4%; HC: 11.2%). Glycemic tolerance and control improved significantly in diabetic treated rats over that of the healthy treated rats. Gross morphometry of the extracted organs (kidneys, liver, heart, lungs, spleen and testes) revealed sustained normal morphological features without any visible lesion. In conclusion, consumption of proportional high-protein/low-carbohydrate formulated diet enhanced body weight reduction and sustained normal organ morphological features with good glycemic tolerance and control in experimental rats, suggesting its dietary potentiality, safety and suitability to ameliorate obesity-related diabetes.

scholarly journals Medical and social characteristics of families and psychological characteristics of mothers of children born with a body weight of less than 1500 g

2020 ◽  
Vol 64 (6) ◽  
pp. 45-52
Author(s):  
E. A. Matveeva ◽  
A. I. Malyshkina ◽  
O. M. Filkina ◽  
O. Yu. Kocherova ◽  
N. V. Dolotova
Keyword(s):  
Body Weight ◽  
High Frequency ◽  
First Trimester ◽  
Premature Baby ◽  
Psychological Characteristics ◽  
Social Characteristics ◽  
Stressful Situation ◽  
Intellectual Activity ◽  
Mothers And Fathers ◽  
The Impact

In order to study the medical and social characteristics of families, an analysis of the biological and social history of mothers and fathers of children born with a body weight less than 1500 was carried out. To identify the psychological characteristics, mothers were tested.It has been established that the social characteristics of the families of children born with a body weight of less than 1500 g was favorable – most families were two-parent, had satisfactory living conditions, mothers and fathers of these children were working and had education not lower than secondary special. The majority of fathers (80%) considered themselves healthy, the state of health of mothers was characterized by a high frequency of somatic pathology, only 27% of women were healthy. The majority of fathers and mothers noted the impact of occupational hazards, while the mothers’ adverse factors were mainly associated with intellectual activity, and the fathers – with physical labor. Half of mothers and 70% of fathers belonged to the age group of 30 years and older. Despite the favorable characteristics of reproductive behavior at the stage of pregravid preparation and in the first trimester of pregnancy, mothers who gave birth to children weighing less than 1500 g were characterized by an unfavorable obstetric gynecological history and a high incidence of gynecological pathology. Psychological features of mothers consisted in a high frequency of accentuation of hyperthymic character traits, a desire to emphasize determination and masculinity, anxiety, impulsivity, which may indicate a compensatory reaction to a stressful situation – the birth of a premature baby. This is also indicated by the high frequency of psychosomatic (45.9%) and authoritarian (29.5%) types of attitude to the problems of the child. In this regard, only 62.2% of mothers established optimal emotional contact with the child by the end of the neonatal period. The revealed psychological characteristics of mothers require early psychological and psychotherapeutic correction to successfully overcome the stress of giving birth to a premature baby and consolidate all the efforts of a woman for habilitation.

scholarly journals Morphological features of the corneal endothelium in patients with pseudoexfoliative glaucoma

2018 ◽  
Vol 11 (4) ◽  
pp. 31-44 ◽  
Author(s):  
Inessa S. Beletskaya ◽  
Sergey Yu. Astakhov ◽  
Natalya V. Tkachenko
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Corneal Endothelium ◽  
Morphological Changes ◽  
Open Angle Glaucoma ◽  
Morphological Features ◽  
Endothelial Cell Density ◽  
Control Group ◽  
Eye Drops ◽  
Pseudoexfoliative Glaucoma

Purpose. To study the main morphological features of the corneal endothelium in patients with pseudoexfoliative glaucoma (PEG). Methods. We included 193 subjects aged from 55 to 75 years. The main study group (PEG) included 96 patients (192 eyes), the primary open angle glaucoma (POAG) group included 36 patients (72 eyes) with POAG, the PEX group included 31 patients (62 eyes) with pseudoexfoliation syndrome without glaucoma. The control group consisted of 30 healthy subjects (60 eyes). Main corneal endothelium parameters were evaluated using a non-contact endothelial microscope EM-935 (Haag Streit, Switzerland). Data were analyzed by STATISTICA 9 software for Windows. Results. The patients with PEG had lower endothelial cell density (ECD) in comparison to the control group (p < 0.01), and PEX group (p < 0.05). The polymegatism level in patients with PEG and POAG was higher than in the control group (p < 0.001, and p < 0.01, correspondingly). In patients with moderate and advanced PEG, the ECD was significantly lower (p < 0.01), and the polymegatism level was significantly higher (p < 0.01) than the same parameters in patients with early PEG. The lowest ECD and the highest polymegatism percentage were observed in PEG patients with more pronounced PEX manifestations, p < 0.05. No effect of IOP-lowering eye drops on the corneal endothelium parameters was revealed, p < 0.05. Conclusions. Significant morphological changes of the corneal endothelium (decreased endothelial cell density, increased polymegatism percentage) were revealed in patients with PEG. It was established that the severity of these changes is associated with the PEG and PEX severity. No effect of IOP-lowering eye drops on the corneal endothelium parameters was detected.

scholarly journals Morphological Features Of The Immune Structures Of The Thin Intestine Of Laboratory Animals With Various Characters Of Nutrition

2020 ◽  
Vol 2 (09) ◽  
pp. 72-74
Author(s):  
Khusanov Erkin ◽  
Ortikbaeva Nilufar ◽  
Korzhavov Sherali
Keyword(s):  
Small Intestine ◽  
Digestive Tract ◽  
Structural Organization ◽  
Morphological Changes ◽  
Comparative Morphology ◽  
Morphological Features ◽  
The Body ◽  
Laboratory Animals ◽  
Chemical Processing ◽  
Digestive Tube

The nutritional nature of mammals, which has developed during a long evolution, leads to adaptive - morphological changes in their digestive tract and its immune structures, although the general laws of their structural organization are identical. The literature has data on the study of the immune structures of the small intestine under normal conditions and under the influence of certain factors. In the structure of immune structures there are numerous parallelisms, however, in each class of vertebrates, complication of this organization is achieved independently. The small intestine is an important section of the digestive tube, where the final chemical processing of the chyme and the absorption of nutrients into the body take place. However, the comparative morphology of the immune structures of the small intestine in mammals with different nutrition patterns remains poorly understood.

scholarly journals MON-161 Body Weight Reduction Not Always Reduced Adrenal Gland Volume in Obese Patients

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Tao Chen
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Sleeve Gastrectomy ◽  
Adrenal Gland ◽  
Morphological Changes ◽  
Normal Weight ◽  
Obese Patients ◽  
Gland Volume ◽  
Significant Difference ◽  
Adrenal Gland Volume

Abstract Recent studies have shown that obesity is a major risk factor for idiopathic hyperaldosteronism (IHA). IHA patients have greater AGV than normal controls. However, it is unclear whether such changes are caused by obesity and whether losing weight could reverse the morphological and functional abnormalities of the adrenal gland. This study was to investigate the association of obesity with adrenal gland volume (AGV) and the effects of weight loss on AGV. This study recruited obese patients (N=25) who underwent sleeve gastrectomy and age- and sex-matched normal-weight (N=25) and overweight healthy volunteers (HV) (N=21). Thin-slice computed tomography was used to evaluate adrenal morphological changes. AGV was measured semiautomatically based on the digital imaging and communications in medicine (DICOM) image. The effects of weight loss on AGV were evaluated in patients for one year or more after sleeve gastrectomy. The results showed that left, right and total AGV were larger in obese patients than those in overweight and normal- weight HVs (6.77±0.36, 5.76±0.31, and 12.53±0.64 cm3 vs. 3.88±0.14, 3.09± 0.13 and 6.97± 0.24 cm3 vs. 3.38±0.23, 2.67±0.15 and 6.04±0.36 cm3). No statistically significant difference was identified between overweight and normal-weight HVs. Sleeve gastrectomy significantly reduced body weight (-27.1±2.5 kg), left AGV (-0.80±0.26 cm3), and right AGV (-0.88±0.20 cm2). However, the adrenal volume in five patients was not reduced, despite significant weight loss postsurgery. In brief, obesity leads to increased AGV, and in some cases, this effect seems to be irreversible. We speculate that obesity causes permanently adrenal morphological changes (increased volume or hyperplasia), and under certain circumstances, it results in excessive aldosterone secretion via altered adipokines (leptin, CTRP1, etc.).

EVALUATION OF PROPRANOLOL-GLUCAGON TEST

1977 ◽  
Vol 86 (2) ◽  
pp. 243-250 ◽  
Author(s):  
Y. Okada ◽  
K. Watanabe ◽  
T. Takeuchi ◽  
T. Hata ◽  
H. Mikam ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
False Negative ◽  
Human Growth ◽  
Maximum Level ◽  
Normal Children ◽  
Provocative Test ◽  
Glucagon Test ◽  
Control Subjects ◽  
Stimulation Of

ABSTRACT A propranolol-glucagon test was evaluated in 24 control normal children, 21 pituitary dwarfs, 15 patients with constitutional short stature, 2 with chromosome aberration and 4 with miscellaneous diseases. The dose of glucagon enough for the stimulation of human growth hormone (HGH) secretion is more than 20 μg/kg of body weight. During the test in the control subjects the serum HGH level increased from 2.3 ± 1.2 ng/ml to a maximum level of 30.0 ± 15.1 ng/ml, when 10 mg propranolol, regardless of body weight and 30 μg glucagon per kg of body weight are given. The dose of propranolol administered ranged from 0.2 to 1.0 mg/kg of body weight in normal children studied. Serum 11-OHCS also increased significantly from 14.5 ± 11.2 μg/100 ml to 30.1 ± 15.5 μg/100 ml (P <0.01). There was no difference in the maximum level of urinary total catecholamines in propranolol-glucagon test between 7 pituitary dwarfs and 7 control subjects. The mechanism of HGH response to propranolol-glucagon administration is unknown, but propranolol-glucagon administration is a sensitive and reliable provocative test for HGH secretion, since false negative responses of HGH are not observed in patients with non-pituitary disease.

Abstract P502: Abnormal Myocyte Calcium Dynamics And The Resultant Contraction Band Formation Of The Rat Heart Under Irreversible Injury By Membrane Permeabilization

2021 ◽  
Vol 129 (Suppl_1) ◽  
Author(s):  
Yuma Morishita ◽  
Shoko Tamura ◽  
Kentaro Mochizuki ◽  
Yoshinori Harada ◽  
Hideo Tanaka
Keyword(s):  
Fluorescence Intensity ◽  
High Frequency ◽  
Time Course ◽  
Morphological Changes ◽  
Confocal Imaging ◽  
Band Formation ◽  
Contraction Band Necrosis ◽  
Scanning Confocal Microscopy ◽  
The Individual ◽  
Contraction Band

Ca 2+ overload is a cardinal feature of cardiomyocyte injury, and its progression to irreversible state leads to cell death. However, unknowns are the precise spatiotemporal changes in the myocyte Ca 2+ dynamics and the relevant cell morphology of irreversibly injured hearts. On the hypothesis that myocytes exhibit high-frequency Ca 2+ waves and contraction band necrosis in saponin-permeabilized injured heart, we observed changes in the Ca 2+ dynamics and the relevant morphological changes in the subepicardial myocardium of the Fluo4-loaded rat hearts (n = 14) by rapid-scanning confocal microscopy (100 frames/s) under Langendorff perfusion with 0.3 mM Ca 2+ -Tyrode solution including 0.4 % saponin at 30°C. Also performed was confocal imaging of tetramethylrhodamine methyl ester (TMRM) fluorescence of the myocardium. Under quasi-quiescence of the heart after dissection of the SA node, individual myocytes barely exhibited spontaneous Ca 2+ waves, whereas after commencement of saponin perfusion high-frequency (118 ± 9.7 /min/cell, mean ± SEM) Ca 2+ waves (hereafter, “agonal waves”) emerged within 1 min, showing asynchronous, oscillatory contractions in the individual myocytes with a V prop of 124 ± 2.5 μm/s (n = 60). Subsequently, the waves gradually decreased in frequency with concomitant slowing of its decay time course, and eventually, disappeared in 6 min; myocytes exhibited high, static Fluo4-fluorescence intensity. Along with the progression of Ca 2+ overload by saponin, the TMRM fluorescence intensity was discretely lost in individual myocytes. The myocytes showing the agonal waves exhibited contraction bands, i.e., band-like aggregations of the actin fibers. Under mechanical arrest of the heart by 2,3-butanedione monoxime (20 mM), saponin still induced the agonal waves with a frequency of 253 ± 10.6 /cell/min and V prop of 118 ± 2.1 μm/s (n = 60); however, contraction bands were barely seen.In conclusion, irreversible myocyte injury by saponin provoked agonal Ca 2+ waves and oscillatory contractions indicating progressive Ca 2+ overload and the following mitochondrial damage, which may provide deeper insights into understanding the mechanism of contraction band necrosis.

scholarly journals Better transport accessibility, better health: a health economic impact assessment study for Melbourne, Australia

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Vicki Brown ◽  
Alison Barr ◽  
Jan Scheurer ◽  
Anne Magnus ◽  
Belen Zapata-Diomedi ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Weight ◽  
Healthcare Cost ◽  
Public Transport ◽  
High Frequency ◽  
Cost Savings ◽  
Absolute Difference ◽  
Current Policy ◽  
Transport Accessibility ◽  
Business As Usual

Abstract Background Physical inactivity is a global public health problem, partly due to urbanization and increased use of passive modes of transport such as private motor vehicles. Improving accessibility to public transport could be an effective policy for Governments to promote equity and efficiency within transportation systems, increase population levels of physical activity and reduce the negative externalities of motor vehicle use. Quantitative estimates of the health impacts of improvements to public transport accessibility may be useful for resource allocation and priority-setting, however few studies have been published to inform this decision-making. This paper aims to estimate the physical activity, obesity, injury, health and healthcare cost-saving outcomes of scenario-based improvements to public transport accessibility in Melbourne, Australia. Methods Baseline and two hypothetical future scenario estimates of improved public transport accessibility for Melbourne, Australia, were derived using a spatial planning and decision tool designed to simulate accessibility performance (the Spatial Network Analysis for Multimodal Urban Transport Systems (SNAMUTS)). Public transport related physical activity was quantified by strata of age group and sex from Melbourne travel survey data (VISTA survey) and used with the SNAMUTS Composite Index to estimate input data for health impact modelling for the Melbourne population aged 20–74 years. A proportional multi-state, multiple cohort lifetable Markov model quantified the potential health gains and healthcare cost-savings from estimated changes in physical activity, body weight and injuries related to walking to access/egress public transport under two scenarios: (S1) public transport accessibility under current policy directions, and (S2) multi-directional, high-frequency network improvements. Results Multi-directional, high-frequency improvements to the public transport network (S2) resulted in significantly greater health and economic gains than current policy directions (S1) in relation to physical activity (mean 6.4 more MET minutes/week), body weight (mean 0.05 kg differential), health-adjusted life years gained (absolute difference of 4878 HALYs gained) and healthcare cost-savings (absolute difference of AUD43M), as compared to business as usual under both scenarios (n = 2,832,241 adults, over the lifecourse). Conclusions Based on our conservative analyses, improving accessibility to public transport will improve population health by facilitating physical activity and lead to healthcare cost savings compared with business-as-usual. These wider health benefits should be better considered in transport planning and policy decisions.

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