scholarly journals A comparative study of efficacy of argyreia speciosa and orlistat for their anti-obesity action in high fat diet induced obese rats

2017 ◽  
Vol 6 (3) ◽  
pp. 613 ◽  
Author(s):  
Suhas H. Patil ◽  
Satkar Rajbhoj ◽  
Seema V. Bhalerao ◽  
Puja Jha ◽  
Manasi V. Limaye ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Atherogenic Index ◽  
Root Extract ◽  
Sprague Dawley ◽  
Serum Lipase ◽  
Sprague Dawley Rats ◽  
Animal House ◽  
Post Hoc

Background: To compare the anti-obesity action of Argyreia speciosa root extract with standard anti-obesity drug orlistat. Healthy Sprague-Dawley rats (100-200g, n=50) were obtained from the animal house. Dose of Orlistat was 32.4mg/kg/day and Dose of Argyreia speciosa root was 500mg/kg/day.Methods: Food induced obesity model was used. Following parameters were evaluated: Total Cholesterol (mg/dl), Triglyceride (mg/dl), HDL-cholesterol (mg/dl), LDL cholesterol (mg/dl), atherogenic index, serum lipase (U/L). Analysis was done by one way ANOVA followed by post-hoc test and Graph Pad Prism version 5.00 was used for the analysis.Results: Total cholesterol, triglcerides, LDL cholesterol and Atherogenic index was significantly lesser in the rats fed with CD+O group and CD+ASE group than in the animals from CD group (p<0.05). It was also significantly lesser in the rats fed with CD+O+ASE than in the animals from CD group (p<0.05). HDL cholesterol was significantly greater in the rats fed with CD+O group and CD+ASE group than in the animals from CD group (p<0.05). It was also significantly greater in the rats fed with CD+O+ASE than in the animals from CD group (p<0.05).Conclusions: ASE significantly reduces total cholesterol (mg/dl), triglyceride (mg/dl), LDL cholesterol (mg/dl) and atherogenic index, it significantly increases HDL- cholesterol (mg/dl) and it is comparable to orlistat. Thus the anti-obesity action of ASE is comparable to orlistat.

scholarly journals PENGARUH SINBIOTIK KEFIR PISANG BATU TERHADAP KADAR KOLESTEROL-LDL DAN KOLESTEROL-HDL TIKUS MODEL SINDROM METABOLIK

2020 ◽  
Vol 7 (2) ◽  
pp. 280-288
Author(s):  
Dina Khoiriyah ◽  
Taufik Maryusman ◽  
Santi Herlina
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Positive Control ◽  
Negative Control ◽  
Sprague Dawley ◽  
Musa Balbisiana ◽  
Cholesterol Levels ◽  
Sprague Dawley Rats

Effect of Banana Kefir Synbiotic on LDL-Cholesterol and HDL-Cholesterol of Metabolic Syndrome Rats Metabolic syndrome (SM) is characterized by several risk factors including dyslipidemia. This study aims to analyze the effect of kefir synbiotic produced from banana stone flour (Musa balbisiana) on LDL-cholesterol and HDL-cholesterol of metabolic syndrome rat model. The 24 Sprague Dawley rats were divided into four groups, namely negative control (healthy rats fed standard feed), positive control (metabolic syndrome rats fed standard feed), treatment I and treatment II (metabolic syndrome rats each given synbiotic kefir banana stone flour 1.8 mL/200 g mouse BW/day and 3.6 mL/200 g mouse BW/day, respectively). The intervention was carried out for three weeks. After the intervention, the levels of LDL-cholesterol in treatment I and II experienced a decrease of 44.66% and 56.94%, respectively, while the-HDL-cholesterol levels in treatment I and II experienced an increase of 104.5% and 172.71%, respectively. The biggest change occurred in treatment II. Synbiotic kefir banana stone flour improved lipid profile in metabolic syndrome rats. Sindrom metabolik (SM) ditandai dengan beberapa faktor risiko termasuk dislipidemia. Penelitian ini bertujuan untuk menganalisis pengaruh sinbiotik kefir tepung pisang batu (Musa balbisiana) terhadap kadar kolesterol-LDL dan kolesterol-HDL tikus model SM. Subjek menggunakan 24 ekor tikus Sprague Dawley yang dibagi menjadi empat kelompok, yaitu kontrol negatif (tikus sehat yang diberi pakan standar), kontrol positif (tikus model SM yang diberi pakan standar), perlakuan I dan perlakuan II (tikus model SM yang masing-masing diberi sinbiotik kefir tepung pisang batu 1,8 mL/200 g BB tikus/hari dan 3,6 mL/200 g BB tikus/hari). Proses intervensi dilakukan selama tiga minggu. Setelah intervensi, kadar kolesterol-LDL perlakuan I dan II mengalami penurunan sebesar 44,66% dan 56,94%, sedangkan kadar kolesterol-HDL perlakuan I dan II mengalami peningkatan sebesar 104,5% dan 172,71%. Perubahan terbesar terjadi pada perlakuan II. Sinbiotik kefir tepung pisang batu memperbaiki profil lipid tikus sindrom metabolik.

scholarly journals Pengaruh propolis terhadap profil lipid plasma tikus model hiperkolesterolemia

2012 ◽  
Vol 8 (3) ◽  
pp. 106
Author(s):  
Krisnansari Diah ◽  
Ariadne Tiara Hapsari ◽  
Evy Sulistyoningrum ◽  
Agus Prastowo
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Plasma Cholesterol ◽  
Hdl Cholesterol ◽  
Sprague Dawley ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Group I ◽  
Before And After

Background: Nowadays, cardiovascular disease caused by hypercholesterolemia has become the main cause of death. Propolis has been used widely to reduce plasma cholesterol levels.Objective: The aims of this research was to study the effect of propolis on lipid profile of hypercholesterolemic Sprague Dawley rats.Method: This was an experimental study with pre-post test. Twenty four (24) male Sprague Dawley rats aged 12-16 week old, weighing 125-200 g were allocated into 4 groups. Group I received standard meal + aquadest-gavage; group II received high cholesterol meal + PTU 0,01 + aquadest gavage; group III received high cholesterol meal + PTU 0,01 + 0,027 g propolis gavage; group IV received high cholesterol meal + PTU 0,01 + 0,054 g propolis gavage. Total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol levels before and after treatment were measured. The data were then analyzed with One Way Anova.Results: The study showed that there were no significant differences in changes of body weight. There were significant differences in total cholesterol levels between all groups of treatment. Triglyceride levels were significantly different among all groups, except between group I and IV. Furthermore, the HDL cholesterol levels of group I vs III and group I vs IV were significantly different. However, there were no differences found in LDL cholesterol levels among all groups of treatment.Conclusion: Provision of 0,027 g and 0,054 g propolis improve lipid profile (total cholesterol, triglyceride and HDL cholesterol levels) of hypercholesterolemic rats.

scholarly journals Characteristics of Purple Sweet Potato Yogurt and Its Effect on Lipid Profiles of Sprague Dawley Rats Fed with High Fat Diet

2020 ◽  
pp. 2
Author(s):  
Lily Arsanti Lestari ◽  
Qisthira Swasti Amirina ◽  
Dina Septari Anindyah ◽  
Ainun Nisa ◽  
Annisa Nurul Huda ◽  
...  
Keyword(s):  
Cholesterol Level ◽  
Sweet Potato ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Lipid Profiles ◽  
Control Group ◽  
Anthocyanin Content ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Purple Sweet Potato

The objectives of this study were to evaluate the effect of purple sweet potato (PSP) yogurt on thelipid profile of Sprague Dawley rats. The PSP yogurt was made from fresh PSP (F-PSP) and its powder (P-PSP).The viscosity, pH, total titratable acid, proximate, antioxidant activity, anthocyanin content, and total lacticacid bacteria (LAB) between those yogurts were compared. Selected yogurt was given to Sprague Dawley ratsfor 4 weeks. Serum lipid profiles were determined after 2 and 4 weeks of treatment. F-PSP yogurt has betterphysical, chemical and microbiological properties compared to P-PSP yogurt. The serum cholesterol andtriglyceride levels in F-PSP yogurt group was not significantly different compared to control group (P>0.05).However, the reduction of serum LDL cholesterol in F-PSP yogurt group was significantly higher than controlgroup. The serum HDL cholesterol in the yogurt group decreased after 2 weeks of treatment, but it increasedafter 4 weeks of treatment. F-PSP yogurt could be used as an alternative functional food that could lower theblood cholesterol level because of the ability to reduce the LDL cholesterol level.

scholarly journals PENGARUH PEMBERIAN BUAH PEPAYA (Carica papaya L.) TERHADAP KADAR KOLESTEROL LDL DAN KOLESTEROL HDL PADA TIKUS SPRAGUE DAWLEY DENGAN HIPERKOLESTEROLEMIA

2012 ◽  
Vol 1 (1) ◽  
pp. 258-264
Author(s):  
Widitha Gustining Asmariani ◽  
Enny Probosari
Keyword(s):  
Cholesterol Level ◽  
Ldl Cholesterol ◽  
Direct Method ◽  
Hdl Cholesterol ◽  
Control Group ◽  
Sprague Dawley ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Post Hoc

Background: Increased LDL cholesterol concentrations and low plasma HDL cholesterol concentrations are well-established risk factors for cardiovascular disease. Diet modification is one of recommended theraphy to decrease LDL cholesterol level by increasing fiber intake from fruit. Papaya contains niacin, fiber, and antioxidant which can decrease LDL cholesterol level. It also contains quercetin to increase HDL cholesterol level. The aim of this study was to prove the effect of papaya of different dosages on LDL and HDL cholesterol of hypercholesterolemic rats. Methods: This research was true-experimental using pre-post test with control group design. Subjects were male Sprague Dowley rats, 7-8 weeks old, 100-200 grams weight, inducted hypercholesterolemia, given papaya diet using 5,4 gr, 7,2 gr, and 9,0 gr dosage for 4 weeks. LDL cholesterol and HDL cholesterol were measured by direct method using LDL-C Select (DiaSys) reagent and CHOP-PAP methods respectively. Normality of the data was tested by Shapiro Wilks test. Data were analyzed by paired t test continued with One Way Anova.and post-hoc LSD. Result: The study revealed that papaya of dosage 5,4 gr/day decreased LDL cholesterol (p<0,05) significantly from 45,29±9,05 mg/dl to 30,29±5,31 mg/dl but nonsignificantly decrease HDL cholesterol level (p=0,930) from 25,71 ± 5,09 to 25,57 ± 3,59 mg/dl at the same dosage. Other dosage of 7,2 mg/day and 9,0 gr/day neither significantly decrease LDL cholesterol level nor increase HDL cholesterol level. Conclusion: Papaya couldn’t decreased LDL cholesterol and increased HDL cholesterol in hypercholesterolemic rats.

scholarly journals PENGARUH PEMBERIAN SARI DAUN CINCAU HIJAU (PREMNA OBLONGIFOLIA MERR) TERHADAP KADAR KOLESTEROL HDL DAN KOLESTEROL LDL TIKUS SPRAGUE DAWLEY DISLIPIDEMIA

2012 ◽  
Vol 1 (1) ◽  
pp. 265-272
Author(s):  
Ananda Eka Astirani ◽  
Hesti Murwani Rahayuningsih
Keyword(s):  
Fruits And Vegetables ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Cholesterol Concentration ◽  
Sprague Dawley ◽  
Fat Consumption ◽  
Sprague Dawley Rats ◽  
Post Test ◽  
Experimental Laboratory ◽  
Randomized Control

Background : Dyslipidemia is an increase in total cholesterol, LDL-cholesterol and triglycerides and also decrease HDL-cholesterol concentration from normal range. Restricting fat consumption, increasing intake of fruits and vegetables rich in fiber and antioxidant can help manage dyslipidemia. Green grass jelly (Premna oblongifolia Merr) rich in fiber and chlorophyll which can increase HDL-cholesterol and decrease LDL cholesterol. Objective : to analyze the effect of green grass jelly extract on HDL-cholesterol and LDL-cholesterol alteration. Methods : This research was experimental laboratory using pre-post test with randomized control groups design. Sample were male Sprague Dawley rats, 7-8 weeks old, inducted dyslipidemia, given green grass jelly diet using 2,7 ml and 5,4 ml dosage for 28 days. HDL-cholesterol and LDL-cholesterol were measured by CHOD-PAP and diasis reagent. Normality data were tested by Saphiro Wilk test. Data were analyzed by paired t test/wilcoxon and Anova/ Kruskal wallis. Result : Green grass jelly (Premna oblongifolia Merr) extract 5,4 ml/day can significantly increase HDL-cholesterol in Sprague dawley dyslipidemia rats from 22,29±4,82 mg/dl to 27,29±3,82 mg/dl (p<0,05) but have no effect for decreasing LDL-cholesterol serum. Conclusion : Green grass jelly (Premna oblongifolia Merr) extract 5,4 ml/day can significantly increase HDL-cholesterol in Sprague dawley dyslipidemia rats for about 22%.

scholarly journals Aktivitas antidislipidemia Tepung tempe dan susu kedelai pada profil lipid tikus diabetes yang diinduksi streptozotocin

2017 ◽  
Vol 4 (3) ◽  
pp. 147 ◽  
Author(s):  
Kartika Nugraheni ◽  
Siti Harnina Bintari
Keyword(s):  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Sprague Dawley ◽  
Fermented Soybean ◽  
Sprague Dawley Rats ◽  
The Difference ◽  
Antidyslipidemic Activity

<p><strong>ABSTRACT</strong></p><p><strong>Background :</strong> dyslipidemia increases risk of cardiovascular disease on diabetes patients. Soybean contain many bioactive compounds which can help control lipid profile.</p><p><strong>Objectives :</strong> analyze the difference between fermented soybean (tempe flour) and unfermented soybean (soymilk) on lipid profile in diabetic rats.</p><p><strong>Methods : </strong>thirty male sprague dawley rats divided into 3 groups (1) diabetic control (2) tempe flour 1,8 gr (3) soymilk 1,35 gr. Tempe flour and soymilk were given for 28 days. Profile lipid measured including total cholesterol, triglycerides, LDL cholesterol and HDL cholesterol. The data then were analyzed using Anova with confidence level of 95%.</p><p><strong>Results :</strong> the decrease values of total cholesteril, triglycerides and LDL cholesterol were better in tempe flour group (p&lt;0,05). In addition, tempe flour group also showed better increase in the value of HDL cholesterl (p&lt;0,05)</p><strong>Conclusion :</strong>fermented soybean (tempe flour) showed better antidyslipidemic activity than unfermented ones<p> </p>

Effects of diacerein intake on cardiometabolic profiles in type 2 diabetics: a systematic review and meta-analysis of clinical trials.

2020 ◽  
Vol 27 ◽  
Author(s):  
Peyman Nowrouzi-Sohrabi ◽  
Reza Tabrizi ◽  
Mohammad Jalali ◽  
Navid Jamali ◽  
Shahla Rezaei ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Body Weight ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Meta Analysis ◽  
Hdl Cholesterol ◽  
Cochrane Central Register ◽  
Statistical Heterogeneity

Introduction: A systematic review and meta-analysis of clinical trials was undertaken to evaluate the effect of diacerein intake on cardiometabolic profiles in patients with type 2 diabetes mellitus (T2DM). Methods: Electronic databases such as PubMed, EMBASE, Scopus, Web of Science, Google Scholar, and Cochrane Central Register of Controlled Trials were searched from inception to 31 July 2019. Statistical heterogeneity was evaluated using Cochran’s Q test and I-square (I2 ) statistic. Data were pooled using random-effect models and weighted mean difference (WMD). Results: From 1,733 citations, seven clinical trials were eligible for inclusion and meta-analysis. A significant reduction in hemoglobin A1c (HbA1c) (WMD -0.73; 95%CI -1.25 to -0.21; P= 0.006; I2 = 72.2%) and body mass index (BMI) (WMD -0.55; 95%CI -1.03 to -0.07; P= 0.026; I2 = 9.5%) were identified. However, no significant effect of diacerein intake was identified on fasting blood sugar (FBS) (WMD - 9.00; 95%CI -22.57 to 4.57; P= 0.194; I2 = 60.5%), homeostatic model assessment for insulin resistance (HOMA-IR) (WMD 0.39; 95%CI 0.95 to 1.73; P= 0.569; I2 = 2.2%), body weight (WMD -0.54; 95%CI -1.10 to 0.02; P= 0.059), triglycerides (WMD -0.56; 95%CI -24.16 to 23.03; P= 0.963; I2 = 0.0%), total-cholesterol (WMD -0.21; 95%CI -12.19 to 11.78; P= 0.973; I2 = 0.0%), HDL-cholesterol (WMD -0.96; 95%CI -2.85 to 0.93; P= 0.321; I2 = 0.0%), and LDL-cholesterol levels (WMD -0.09; 95%CI -8.43 to 8.25; P= 0.983; I2 = 37.8%). Conclusion: Diacerein intake may reduce HbA1c and BMI; however, no evidence of effect was observed for FBS, HOMA-IR, body weight, triglycerides, total-cholesterol, HDL-cholesterol or LDL-cholesterol.

Differential Effects of Maternal Diets on Birth Outcomes and Metabolic Parameters in Rats After Ethanol Consumption during Pregnancy

2020 ◽  
pp. 1-25
Author(s):  
Yidi Wang ◽  
Bradley A. Feltham ◽  
Michael N. A. Eskin ◽  
Miyoung Suh
Keyword(s):  
Total Cholesterol ◽  
Birth Outcomes ◽  
Maternal Nutrition ◽  
Maternal Diet ◽  
Hdl Cholesterol ◽  
Nutrition Intervention ◽  
Metabolic Parameters ◽  
Nutrition Status ◽  
Sprague Dawley ◽  
Metabolic Outcomes

Abstract Maternal nutrition status plays an important role in the development of fetal alcohol spectrum disorders (FASD), but its direct evidence is lacking. This study compared a standard chow with a semi-purified energy dense (E-dense) diet on birth and metabolic outcomes in rats after ethanol (EtOH) consumption during pregnancy. Pregnant Sprague-Dawley rats were randomized into four groups: chow (n=6), chow+EtOH (20% v/v) (n=7), E-dense (n=6), and E-dense+EtOH (n=8). Birth outcomes including litter size, body and organ weights were collected. Metabolic parameters were measured in dams and pups at postnatal day (PD) 7. Maternal EtOH consumption decreased body weights (p <0.0001) and litter sizes (p <0.05) in chow-fed dams. At PD7, pups born to dams fed E-dense diet had higher body (p <0.002) and liver weights (p <0.0001). These pups also had higher plasma total cholesterol (p <0.0001), triacyclglycerol (p <0.003) and alanine aminotransferase (p <0.03) compared to those from chow-fed dams. Dams fed E-dense diet had higher plasma total- (p <0.0001) and HDL-cholesterol (p <0.0001) and lower glucose (p <0.0001). EtOH increased total cholesterol (p <0.03) and glucose (p <0.05) only in dams fed the E-dense diet. Maternal exposure to E-dense diet attenuated prenatal EtOH-induced weight loss and produced different metabolic outcomes in both dams and pups. While the long-lasting effects of these outcomes are unknown, this study highlights the importance of maternal diet quality for maternal health and infant growth, and suggests that maternal nutrition intervention may be a potential target for alleviating FASD.

scholarly journals Fasting Is Not Routinely Required for Determination of a Lipid Profile: Clinical and Laboratory Implications Including Flagging at Desirable Concentration Cutpoints—A Joint Consensus Statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine

2016 ◽  
Vol 62 (7) ◽  
pp. 930-946 ◽  
Author(s):  
Børge G Nordestgaard ◽  
Anne Langsted ◽  
Samia Mora ◽  
Genovefa Kolovou ◽  
Hannsjörg Baum ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Familial Hypercholesterolemia ◽  
Apolipoprotein B ◽  
Ldl Cholesterol ◽  
Clinical Chemistry ◽  
Hdl Cholesterol ◽  
Lipid Profiles ◽  
Apolipoprotein A1 ◽  
Lipoprotein A ◽  
Remnant Cholesterol

Abstract AIMS To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles. METHODS AND RESULTS Extensive observational data, in which random non-fasting lipid profiles have been compared with those determined under fasting conditions, indicate that the maximal mean changes at 1–6 h after habitual meals are not clinically significant [+0.3 mmol/L (26 mg/dL) for triglycerides; −0.2 mmol/L (8 mg/dL) for total cholesterol; −0.2 mmol/L (8 mg/dL) for LDL cholesterol; +0.2 mmol/L (8 mg/dL) for calculated remnant cholesterol; −0.2 mmol/L (8 mg/dL) for calculated non-HDL cholesterol]; concentrations of HDL cholesterol, apolipoprotein A1, apolipoprotein B, and lipoprotein(a) are not affected by fasting/non-fasting status. In addition, non-fasting and fasting concentrations vary similarly over time and are comparable in the prediction of cardiovascular disease. To improve patient compliance with lipid testing, we therefore recommend the routine use of non-fasting lipid profiles, whereas fasting sampling may be considered when non-fasting triglycerides are &gt;5 mmol/L (440 mg/dL). For non-fasting samples, laboratory reports should flag abnormal concentrations as triglycerides ≥2 mmol/L (175 mg/dL), total cholesterol ≥5 mmol/L (190 mg/dL), LDL cholesterol ≥3 mmol/L (115 mg/dL), calculated remnant cholesterol ≥0.9 mmol/L (35 mg/dL), calculated non-HDL cholesterol ≥3.9 mmol/L (150 mg/dL), HDL cholesterol ≤1 mmol/L (40 mg/dL), apolipoprotein A1 ≤1.25 g/L (125 mg/dL), apolipoprotein B ≥1.0 g/L (100 mg/dL), and lipoprotein(a) ≥50 mg/dL (80th percentile); for fasting samples, abnormal concentrations correspond to triglycerides ≥1.7 mmol/L (150 mg/dL). Life-threatening concentrations require separate referral for the risk of pancreatitis when triglycerides are &gt;10 mmol/L (880 mg/dL), for homozygous familial hypercholesterolemia when LDL cholesterol is &gt;13 mmol/L (500 mg/dL), for heterozygous familial hypercholesterolemia when LDL cholesterol is &gt;5 mmol/L (190 mg/dL), and for very high cardiovascular risk when lipoprotein(a) &gt;150 mg/dL (99th percentile). CONCLUSIONS We recommend that non-fasting blood samples be routinely used for the assessment of plasma lipid profiles. Laboratory reports should flag abnormal values on the basis of desirable concentration cutpoints. Non-fasting and fasting measurements should be complementary but not mutually exclusive.

scholarly journals Effects of yoghurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemia

2001 ◽  
Vol 86 (2) ◽  
pp. 233-239 ◽  
Author(s):  
Robert Volpe ◽  
Leena Niittynen ◽  
Riitta Korpela ◽  
Cesare Sirtori ◽  
Antonello Bucci ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Plant Sterols ◽  
Dependent Manner ◽  
Low Fat ◽  
Treatment Groups ◽  
Cholesterol Levels ◽  
Dose Dependent

The objective of the present study was to assess the effect of consumption of a yoghurt-based drink enriched with 1–2 g plant sterols/d on serum lipids, transaminases, vitamins and hormone status in patients with primary moderate hypercholesterolaemia. Thirty patients were randomly assigned to one of two treatment groups: a low-fat low-lactose yoghurt-based drink enriched with 1 g plant sterol extracted from soyabean/dv.a low-fat low-lactose yoghurt, for a period of 4 weeks. After a 2-week wash-out period, patients were crossed over for an additional 4-week period. Second, after a 4-week wash-out period, eleven patients were treated with 2 g plant sterols/d in a second open part of the study for a period of 8 weeks. The yoghurt enriched with plant sterols significantly reduced, in a dose-dependent manner, serum total cholesterol and LDL-cholesterol levels and LDL-cholesterol:HDL-cholesterol (P<0·001), whereas no changes were observed in HDL-cholesterol and triacylglycerol levels, either in the first or the second part of the study. There were only slight, not statistically significant, differences in serum transaminase, vitamin and hormone levels. To conclude, a low-fat yoghurt-based drink moderately enriched with plant sterols may lower total cholesterol and LDL-cholesterol effectively in patients with primary moderate hypercholesterolaemia.

Sign in / Sign up

Export Citation Format

Share Document