scholarly journals A study of thyroid function in premenopausal and postmenopausal women of Dibrugarh town, Assam, India

2018 ◽  
Vol 6 (9) ◽  
pp. 3015 ◽  
Author(s):  
Gitartha Bordoloi ◽  
Wasima Jahan
Keyword(s):  
Postmenopausal Women ◽  
Thyroid Function ◽  
Body System ◽  
Female Population ◽  
Controlling Mechanism ◽  
Thyroid Hormone Levels ◽  
Postmenopausal Female ◽  
Serum Tsh ◽  
Healthy Females ◽  
Apparently Healthy

Background: Ageing process can cause some changes in body system controlling mechanism. Consequently thyroid hormone levels may show variations reflected by TSH level in elderly people, more so in females.Methods: Serum TSH level were measured in 304 apparently healthy females of Dibrugarh town, Assam. Unbound T3 and T4 were measured if TSH level was abnormal. TSH levels were compared among different age groups.Results: The prevalence of hypothyroidism was found to be 8.2% in premenopausal and 12.7% in postmenopausal women. There were more cases of subclinical hypothyroidism than clinical hypothyroidism. Difference of Mean± SEM of TSH level in these two groups was significant though there was no correlation between age and TSH level.Conclusions: The study reveals decreasing thyroid function in postmenopausal female population of Dibrugarh town.

scholarly journals The Effect of Droloxifene and Estrogen on Thyroid Function in Postmenopausal Women1

2000 ◽  
Vol 85 (11) ◽  
pp. 4407-4410
Author(s):  
Ellen Marqusee ◽  
Lewis E. Braverman ◽  
Jennifer E. Lawrence ◽  
Judith S. Carroll ◽  
Ellen W. Seely
Keyword(s):  
Postmenopausal Women ◽  
Treatment Period ◽  
Thyroid Function ◽  
Free T4 ◽  
Double Blind ◽  
Stimulatory Action ◽  
Serum Free ◽  
Serum T4 ◽  
Conjugated Estrogen ◽  
Serum Tsh

Estrogen is known to increase serum T4-binding globulin (TBG) concentrations, thereby increasing serum total T4 concentrations. Serum free T4 concentrations, however, remain normal. Tamoxifen, a selective estrogen receptor modifier (SERM), also raises serum TBG concentrations, but whether newer SERMs with less stimulatory action on the endometrium do so is not known. We, therefore, compared the effect of droloxifene, a SERM, and conjugated equine estrogen on pituitary-thyroid function in normal postmenopausal women. Ten women were treated for 6 weeks with conjugated estrogen (Premarin), 0.625 mg/day, and droloxifene, 60 mg/day, in a double-blind crossover study with an intervening 4-week no-treatment period. We measured serum T4, T3, TBG, free T4 index, and TSH at baseline and at the end of each 6-week period. The baseline values were compared with the 6-week values using paired t tests. The mean (±sd) serum TBG concentrations increased significantly during both treatment periods (baseline, 1.5 ± 0.4 mg/dL; conjugated estrogens, 2.7 ± 0.6 mg/dL; droloxifene, 2.1 ± 0.6 mg/dL; P < 0.001 and P= 0.001, respectively). There were no significant changes in the serum free T4 index. Serum T4 and T3 concentrations increased during both treatment periods, however, the increase was significant only for T4 during the conjugated estrogen treatment period. The serum TSH concentrations increased significantly during both treatment periods (18% during conjugated estrogen and 11% during droloxifene), and the values remained within the normal range in all women. Administration of both conjugated estrogen and droloxifene for 6 weeks increases serum TSH and TBG concentrations, but does not alter free T4 index values in postmenopausal women.

scholarly journals Study of Thyroid Function in Patients of Srikakulam, Andhra Pradesh, Who Were Suffering from Various Depressive Disorders

2021 ◽  
Vol 10 (35) ◽  
pp. 2980-2984
Author(s):  
Silla Vijaya Bhaskara Gupta ◽  
M. Padma Geetanjali ◽  
Ladi Bharati Kumari Devi
Keyword(s):  
Depressive Disorder ◽  
Thyroid Function ◽  
Andhra Pradesh ◽  
Depressive Disorders ◽  
Overt Hypothyroidism ◽  
Government Medical College ◽  
Medical College ◽  
Rural And Urban ◽  
Thyroid Hormone Levels ◽  
Serum Tsh

BACKGROUND Thyroid disorder patients are more prone to develop depressive symptoms. Depression is also associated with various thyroid abnormalities.1 Slight change in thyroid hormone levels show symptoms of depression, anxiety, increasing fatigability and psychomotor slowing. The depressive symptoms are more in elderly patients with rapid changes in thyroid hormone levels.1 In depressive disorder patients, 1 % to 4 % have primary (Overt Hypothyroidism) and 4 % to 40 % have subclinical Hypothyroidism.2 Overt thyroid dysfunction is usually mild. Thyroid abnormality is not a causal factor, it is mainly a risk factor for depression.2 We intended to study the thyroid function in various depressive disorder patients of Srikakulam district at Government medical college & General hospital Srikakulam. Srikakulam district has been chosen for this study for its backwardness in the residuary state of Andhra Pradesh. The objectives were to find out thyroid function levels like serum TSH, T3 and T4 in various depressive disorder patients and compare with the severity of clinical score, analyse and correlate with various depressive disorder patients of different age and sex groups, locality (both rural and urban areas). METHODS This observational study of thyroid function was conducted among 61 various depressive disorder patients of both males and females of 21 to 60 years age group who attended OPD and IPD of Psychiatry, Government medical college and general hospital, Srikakulam. We analysed and correlated serum TSH, T3 & T4 levels with various depressive disorders. RESULTS It was observed that subclinical hypothyroidism had a clinical severity of 16.39 %, overt hypothyroidism was 1.63 %, secondary hyperthyroidism was 1.63 % and euthyroidism was 80.33 % of various depressive disorders and was more common in females than in males and equal in distribution in both the rural and urban population. CONCLUSIONS Hypothyroidism was found to have been associated with various depressive disorders, cognitive function and psychosis among female patients and hyperthyroidism was associated with psychosis, anxiety, depression and cognitive impairment. KEY WORDS Depression, Hypothyroidism, Hyperthyroidism, Euthyroidism

Genetic and environmental interrelations between measurements of thyroid function in a healthy Danish twin population

2007 ◽  
Vol 292 (3) ◽  
pp. E765-E770 ◽  
Author(s):  
Pia Skov Hansen ◽  
Thomas Heiberg Brix ◽  
Ivan Iachine ◽  
Thorkild I. A. Sørensen ◽  
Kirsten Ohm Kyvik ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Free Triiodothyronine ◽  
Environmental Correlations ◽  
Serum Free ◽  
Hormone Levels ◽  
Opposite Sex ◽  
Thyroid Hormone Levels ◽  
Serum Tsh ◽  
Danish Twin

Serum thyrotropin (TSH), free thyroxine (T4), and free triiodothyronine (T3) levels illustrate the thyroid function set point, but the interrelations between these have never been characterized in detail. The aim of this study was to examine the associations between TSH and thyroid hormone levels in healthy euthyroid twins and to determine the extent to which the same genes influence more than one of these biochemical traits; 1,380 healthy euthyroid Danish twins (284 monozygotic, 286 dizygotic, 120 opposite-sex twin pairs) were recruited. Genetic and environmental associations between thyroid function measurements were examined using quantitative genetic modeling. In bivariate genetic models, the phenotypic relation between two measurements was divided into genetic and environmental correlations. Free T4 and free T3 levels were positively correlated ( r = 0.32, P < 0.0001). The genetic correlation between serum free T4 and free T3 levels was rg = 0.25 (95% CI 0.14–0.35), suggesting that a set of common genes affect both phenotypes (pleiotropy). The correlation between the environmental effects was re = 0.41 (0.32–0.50). From this we calculated that the proportion of the correlation between free T4 and free T3 levels mediated by common genetic factors was 48%. Only 7% of the genetic component of serum free T3 levels is shared with serum free T4. Serum TSH and thyroid hormone levels did not share any genetic influences. In conclusion, thyroid hormone levels are partly genetically correlated genes that affect free T4 levels and exert pleiotropic effects on free T3 levels, although most of the genetic variance for these measurements is trait specific.

Linear modulation of serum thyrotrophin by thyroid hormone treatment in hypothyroidism

1980 ◽  
Vol 95 (4) ◽  
pp. 472-478 ◽  
Author(s):  
A. Eugene Pekary ◽  
Jerome M. Hershman ◽  
Clark T. Sawin
Keyword(s):  
Thyroid Hormone ◽  
Hormone Replacement ◽  
Hormone Treatment ◽  
Significant Negative Correlation ◽  
Thyroid Hormone Replacement ◽  
Basal Serum ◽  
Thyroid Hormone Levels ◽  
Peak Versus ◽  
Hypothyroid Patients ◽  
Serum Tsh

Abstract. Basal serum TSH and the peak TSH response to a 500 μg TRH bolus were measured in 57 euthyroid and in 29 hypothyroid subjects either receiving graded thyroid hormone replacement or acutely removed from full replacement therapy. Serum TSH, total T4 and T3 were determined by sensitive radioimmunoassay methods. The peak versus basal TSH data for hypothyroid patients were linear within individuals. The regression slope of the peak versus basal TSH data for all hypothyroid subjects did not differ significantly from the corresponding slope for all euthyroid subjects. Basal and peak TSH versus T3 and T4 data for hypothyroid patients were also linear within each individual. Moreover, the regression of the basal TSH values averaged over the non-replacement to full replacement state against the TSH versus T3 slope had a significant negative correlation. This trend leads to an array of regression lines which average to the familiar hyperbolic relationship between thyrotrophin and thyroid hormone levels in man.

Vitamin D Status in a Rural Postmenopausal Female Population

2006 ◽  
Vol 25 (5) ◽  
pp. 395-402 ◽  
Author(s):  
Joan M. Lappe ◽  
K. Michael Davies ◽  
Dianne Travers-Gustafson ◽  
Robert P. Heaney
Keyword(s):  
Vitamin D ◽  
Vitamin D Status ◽  
Female Population ◽  
Postmenopausal Female

scholarly journals IFLUENCE OF AQUEOUS EXTRACT FROM FEIJOA LEAVES ON THYROID FUNCTION IN RATS WITH EXPERIMENTAL HYPOTHYROIDISM

2019 ◽  
Vol 3 ◽  
pp. 9-14
Author(s):  
Alevtyna Kononenko ◽  
Vera Kravchenko
Keyword(s):  
Body Weight ◽  
Thyroid Function ◽  
Aqueous Extract ◽  
Rectal Temperature ◽  
Albino Rats ◽  
Reference Drug ◽  
Functional Changes ◽  
Thyroid Mass ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels

The present work studied the effect of aqueous extract from Feijoa leaves on thyroid function of rats with experimental hypothyroidism. Healthy albino rats weighing between 120 gand 150 gwere used. The animals were randomly allotted into four groups, each containing eight rats respectively. Three of the groups (II, III and IV), induced with hypothyroidism, were treated by 0.05 % solution of thiamazole with drinking water for 30 days. Control (vehicle) rats were given normal saline. After 13 days hypothyroid groups (III and IV) of rats were treated with aqueous extract from Feijoa leaves at a dose 1.0 ml/100 g of body weight and with Iodomarin 200 (reference drug) at a dose 12 µg/kg daily orally for 21 days. Results obtained from the study showed that the introduction of thiamazole leads to functional changes in the thyroid gland in rats, accompanied by decreasing sings of rectal temperature and level of thyroid hormones. It was found, that treatment with AEFL normalizes serum thyroid hormone levels, increases rectal temperature and reduces the thyroid mass. The investigated extract can be attributed to the regulators of the thyroid hypofunction and is promising for further study of its effectiveness as a thyroid-stimulating agent.

scholarly journals Thyroid Function Changes and Pubertal Progress in Females: A Longitudinal Study in Iodine-Sufficient Areas of East China

2021 ◽  
Vol 12 ◽  
Author(s):  
Yingying Wang ◽  
Dandan He ◽  
Chaowei Fu ◽  
Xiaolian Dong ◽  
Feng Jiang ◽  
...  
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Thyroid Function ◽  
Pubertal Development ◽  
Thyroid Stimulating Hormone ◽  
East China ◽  
Regression Analyses ◽  
Free Triiodothyronine ◽  
Serum Tsh

BackgroundThe onset of puberty is influenced by thyroid function, and thyroid hormones (THs) fluctuate substantially during the period of pubertal development. However, it needs to be further clarified how THs change at specific puberty stages and how it influences pubertal development in girls. So far, longitudinal data from China are scarce.MethodsA cohort study was conducted among girls during puberty in iodine-sufficient regions of East China between 2017 to 2019. Serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were determined for each participant. Thyroid homeostasis structure parameters (THSPs), including the ratio of FT4 to FT3 (FT4/FT3), Jostel’s TSH index (TSHI), and thyroid feedback quantile-based index (TFQI), were calculated. Puberty category scores (PCS), calculated based on the Puberty Development Scale (PDS), was used to assess the stage of puberty. Girls were grouped into three categories according to PCS changes (△PCS) and six categories according puberty stage (BPFP: pre-pubertal at both baseline and follow-up; BPFL: pre-pubertal at baseline and late-pubertal at follow-up, respectively; BPFT: pre-pubertal at baseline and post-pubertal at follow-up, respectively; BLFL: late-pubertal at both baseline and follow-up; BLFT: late-pubertal at baseline and post-pubertal at follow-up, respectively; BTFT: post-pubertal at both baseline and follow-up). Multiple linear regression analyses were used to evaluate the associations of THs changes with pubertal progress.ResultsThe levels of serum TSH and FT3 decreased while serum FT4 increased during the study period (P&lt;0.001). In multiple linear regression analyses, after adjustment for covariables, FT3 decreased by an additional 0.24 pmol/L (95% CI: -0.47 to -0.01) in the higher △PCS group than the lower △PCS group. Compared with the BLFL group, the BPFT group showed an additional decline in FT3 (β= -0.39 pmol/L, 95%CI: -0.73 to -0.04), the BTFT group showed a lower decline in TSH (β=0.50 mU/L, 95% CI: 0.21 to 0.80) and a lower decline in TSHI (β=0.24, 95%CI: 0.06 to 0.41), respectively. There was no association of △FT4 or △TFQI with △PCS or the puberty pattern.ConclusionsSerum TSH and FT3 decreased while serum FT4 increased among girls during puberty. Both the initial stage and the velocity of pubertal development were related to thyroid hormone fluctuations.

BIOLOGICAL EFFECTS OF 131I AND 125I ISOTOPES OF IODINE IN THE RAT

1976 ◽  
Vol 71 (1) ◽  
pp. 109-114 ◽  
Author(s):  
I. DONIACH ◽  
D. J. SHALE
Keyword(s):  
Thyroid Function ◽  
Biological Effects ◽  
Female Rats ◽  
Long Term Effects ◽  
Significant Elevation ◽  
Radioiodine Uptake ◽  
Male And Female ◽  
Male And Female Rats ◽  
Serum Tsh

SUMMARY From the differences in radiation profiles between 131I and 125I isotopes of iodine it would be expected that they would show different effects on thyroid function. The differences should lead to lower rates of thyroid gland destruction with 125I and hence less post-irradiation hypothyroidism. This difference in biological effect has been demonstrated in rats by indirect assessment of thyroid function. In this report the long-term effects of a range of similar doses of 131I and 125I were compared, in male and female rats, by direct assessment of thyroid function. Seventeen months after receiving 25 and 125 μCi of 131I, male and female rats showed significant elevation of serum TSH concentration and a reduction in 3 h radioiodine uptake. Rats receiving 1 and 5 μCi of 131I and all doses of 125I showed no significant changes in thyroid function. These findings confirm the previously reported differences in effect between the 131I and 125I isotopes of iodine in the rat.

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