A prospective study of clinical manifestations of snake bite in government general hospital

Background: Snake bite is an occupational and rural hazard because India has always been a land of exotic snakes. Although full burden of human suffering attributable to snake bite remains obscure, hundreds of thousands of people are known to be envenomed and tens of thousands are killed or maimed by snakes every year. This study is aimed at studying the clinical manifestations in snake bite at government general hospital.Methods: This Prospective Observational study was done from March 2019 to August 2019 in Government General Hospital Nalgonda. A total of 60 cases male and female admitted with snake bite were studied based on inclusion and exclusion criteria. All patients were done routine investigations, ECG was done to rule out cardiac anomalies. Patients below 12 years, pregnant women and patients with previous heart ailments were excluded from the study. The study was carried out in all patients fulfilling the inclusion and exclusion criteria.Results: A total of 60 patients 35 females and 25 males presented during the study period. Most of the patients presented with pain at the site 40(66%), Nausea 30(50%), Swelling 25(42%), Paraesthesia 25(42%), Bleeding 15(25%), Ptosis 15(25%), Sweating 10(17%), Cellulitis 10(17%) and dyspnoea 5(9%). Among the ECG manifestations- Tachycardia- 30(50%), Ischaemia 5(9%), Sinus arrythmia 2(4%), Myocardial Infarction-0.Conclusions: It was Observed from the study that the pt. had more of Haemolytic presentation than neuroparalytic presentation. Pain at the site was the most common presentation followed by nausea. Some patients developed neuroparalytic symptoms like cellulitis, and paraesthesia. Further it was observed that timely shifting to the Hospital and administration of Anti-Snake venom prevented major manifestations in the patients.

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Clinical manifestations in calotropis poisoning: a prospective study in Government General Hospital Nalgonda, India

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20193292 ◽

2019 ◽

Vol 6 (4) ◽

pp. 1314 ◽

Cited By ~ 1

Author(s):

C. Yadavendra Reddy

Keyword(s):

Abdominal Pain ◽

Observational Study ◽

Prospective Study ◽

Prospective Observational Study ◽

Clinical Manifestations ◽

Calotropis Procera ◽

Common Symptom ◽

Accidental Ingestion ◽

Male And Female ◽

A Prospective Study

Background: Calotropis procera commonly known as Madar is common shrub all over India. Its chemical component Calotropin, which is derived from latex is known to cause injury to eyes and oral mucosa. Toxic manifestations following accidental ingestion are mostly gastrointestinal. This study was aimed at studying the various clinical manifestations of Calotropis poisoning in patients admitted to GGH Nalgonda.Methods: This prospective observational study was done from Feb 2019 to May 2019.All patients both male and female admitted to GGH Nalgonda during this period were studied. Patients below 12 years, pregnant women and patients with earlier gastritis, hepatitis, stomatitis were excluded from the study. The study was carried out in all patients fulfilling the inclusion and exclusion criteria.Results: A total of 60 patients 45 females and 15 males presented during the study period. Most of the patients presented with abdominal pain 15 (25%), hepatitis 10 (16.6%), stomatitis 12 (20%), vomiting 8 (13.3%), diarrhea 6 (10%), hyperkalemia 3 (5%), tachycardia 5 (8.3%), convulsion 1 (1.6%).Conclusions: It was observed from the study that most of the patients had abdominal pain as the major symptom. Stomatitis was the second most common symptom. It was observed consumption of the toxin in lesser quantities produced these symptoms in large quantities produced tachycardia, hyperkalemia and convulsions.

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A prospective study of clinical pattern of febrile thrombocytopenia in government general hospital, Nalgonda

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20210268 ◽

2021 ◽

Vol 8 (2) ◽

pp. 224

Author(s):

Yadavendra C. Reddy ◽

Karunakar .

Keyword(s):

General Hospital ◽

Prospective Observational Study ◽

Clinical Presentation ◽

Viral Infections ◽

Elisa Test ◽

Exclusion Criteria ◽

Usual Condition ◽

Clinical Pattern ◽

Low Platelet Count ◽

A Prospective Study

Background: Febrile thrombocytopenia is a usual condition caused by infections such as dengue, malaria, typhoid, septicimea and certain viral infections. The present study is aimed to study the aetiology of fever with thrombocytopenia and the clinical presentation in the patients admitted in Government General Hospital.Methods: This prospective observational study was done from August 2019 to September 2019 in Government General Hospital Nalgonda. A total of 100 cases male and female admitted with febrile thrombocytopenia were studied based on inclusion and exclusion criteria. All patients were done routine investigations and ELISA test for dengue done in susceptible patients. Patients below 12 years, pregnant women and patients with previous bleeding manifestations were excluded from the study. The study was carried out in all patients fulfilling the inclusion and exclusion criteria.Results: A total of 100 patients 60 females and 40 males presented during the study period. Most of the fevers with low platelet count were viral 30 (30%), dengue 25 (25%), typhoid 20(20%), malaria 15 (15%), hepatitis 10 (10%). The patients presented with fever 25 (25%), nausea 20 (20%), headache 20 (20%) abdominal ain 15 (15%), diarrhea 10 (10%), bleeding manifestations 5 (5%), myalgia 5 (5%).Conclusions: It was observed from the study that the viral infections were predominant cause for the fevers with thrombocytopenia followed by dengue, typhoid and malaria, furthur it was observed that apart from fever nausea and headache were predominant symptoms in patients presenting with febrile thrombocytopenia. Major complications were avoided by timely admission and proper care of the patients.

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Outcome of Endoscopic Third Ventriculostomy: An Experience of 80 Treated Patients

Pakistan Journal Of Neurological Surgery ◽

10.36552/pjns.v23i4.384 ◽

2019 ◽

Vol 23 (4) ◽

Author(s):

MUMTAZ ALI ◽

AKRAM ULLAH ◽

SAJID KHAN ◽

ZUBAIR BASHIR ◽

RAMZAN HUSSAIN

Keyword(s):

Success Rate ◽

General Hospital ◽

Posterior Fossa ◽

Teaching Hospital ◽

Prospective Observational Study ◽

Endoscopic Third Ventriculostomy ◽

Aqueductal Stenosis ◽

Third Ventriculostomy ◽

Posterior Fossa Tumors ◽

Exclusion Criteria

Objective: To examine the outcome of Endoscopic Third Ventriculostomy in 80 consecutive patients operated in Irfan General Hospital and Prime Teaching Hospital Peshawar.Materials and Methods: Prospective observational study was conducted in the neurosurgery department of Prime Teaching Hospital and Irfan General Hospital Peshawar. 80 patients (48 male and 32 female) were followed for 3 months. The inclusion criteria all patients with Third ventricular hydrocephalus were included in this study and the exclusion criteria unwilling patients and those who opted for VP shunting rather than ETV. Data was analyzed using SPSS version 22.Results: ETV was performed in 80 patients. With highest success rate inAqueductal stenosis and posterior fossa tumors 88% and 87% respectively. ETV had a lowest success score of 50% in patients with Hydrocephalus TBM. Common post-operative complications were seizures and CSF leakage.Conclusion: ETV is less invasive and effective treatment for non-communicating hydrocephalus.ETV is most effective in treating aqueductal stenosis and posterior fossa tumors. The overall success rate of ETV is 74%. Based on these findings, it is recommended that ETV should be attempted as first line treatment for patients with triventricular hydrocephalus due to various pathologies.

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Preprocedural SARS-CoV-2 Testing to Sustain Medically Needed Health Care Delivery During the COVID-19 Pandemic: A Prospective Observational Study

Open Forum Infectious Diseases ◽

10.1093/ofid/ofab022 ◽

2021 ◽

Vol 8 (2) ◽

Author(s):

Ghady Haidar ◽

Ashley Ayres ◽

Wendy C King ◽

Mackenzie McDonald ◽

Alan Wells ◽

...

Keyword(s):

Health Care ◽

New York ◽

Prospective Observational Study ◽

Care Delivery ◽

Community Hospitals ◽

Symptom Screening ◽

Academic Hospitals ◽

Hospital Patients ◽

Polymerase Chain ◽

A Prospective Study

Abstract Background We implemented a preprocedural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) screening initiative designed to sustain health care during a time when the extent of SARS-CoV-2 infection was unknown. Methods This was a prospective study of patients undergoing procedures at 3 academic hospitals in Pittsburgh, Pennsylvania (April 21–June 11), and 19 community hospitals across Middle/Western Pennsylvania and Southwestern New York (May 1–June 11). Patients at academic hospitals underwent symptom screening ≤7 days preprocedure, then SARS-CoV-2 nasopharyngeal polymerase chain reaction (PCR) testing 1–4 days preprocedure. A subset also underwent day-of-procedure testing. Community hospital patients underwent testing per local protocols. We report SARS-CoV-2 PCR positivity rates, impact, and barriers to testing encountered through June 11. PCR positivity rates of optional preprocedural SARS-CoV-2 testing for 2 consecutive periods following the screening initiative are also reported. Results Of 5881 eligible academic hospital patients, 2415 (41.1%) were tested (April 21–June 11). Lack of interest, distance, self-isolation, and nursing home/incarceration status were barriers. There were 11 PCR-positive patients (10 asymptomatic) among 10 539 patients tested (0.10%; 95% CI, 0.05%–0.19%): 3/2415 (0.12%; 95% CI, 0.02%–0.36%) and 8/8124 (0.10%; 95% CI, 0.04%–0.19%) at academic and community hospitals, respectively. Procedures were performed as scheduled in 40% (4/10) of asymptomatic PCR-positive patients. Positivity increased during subsequent coronavirus disease 2019 (COVID-19) surges: 54/34 948 (0.15%; 95% CI, 0.12%–0.20%) and 101/24 741 (0.41%; 95% CI, 0.33%–0.50%) PCR-positive patients from June 12–September 10 and September 11–December 15, respectively (P < .0001). Conclusions Implementing preprocedural PCR testing was complex and revealed low infection rates (0.24% overall), which increased during COVID-19 surges. Additional studies are needed to define the COVID-19 prevalence threshold at which universal preprocedural screening is warranted.

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The association of bullous pemphigoid with dipeptidyl-peptidase 4 inhibitors: a ten-year prospective observational study

BMC Endocrine Disorders ◽

10.1186/s12902-021-00689-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Vaia Lambadiari ◽

Aikaterini Kountouri ◽

Foteini Kousathana ◽

Emmanouil Korakas ◽

Georgios Kokkalis ◽

...

Keyword(s):

Bullous Pemphigoid ◽

Prospective Observational Study ◽

Dipeptidyl Peptidase ◽

Dermatology Department ◽

Steroid Administration ◽

Dipeptidyl Peptidase 4 ◽

Increased Risk ◽

Dipeptidyl Peptidase 4 Inhibitors ◽

A Prospective Study

Abstract Background Bullous pemphigoid is the most common bullous chronic autoimmune skin disease. Recent studies have suggested dipeptidyl-peptidase 4 inhibitors as possible predisposing agents of bullous pemphigoid. The objective of our study was to prospectively estimate the association between gliptins and the development of bullous pemphigoid. Methods We conducted a prospective study which included all patients diagnosed with biopsy-proven bullous pemphigoid in the Dermatology Department of our hospital between April 1, 2009 and December 31,2019. The diagnosis of bullous pemphigoid was based on specific clinical, histological and immunological features. Results Overall 113 consecutive patients (age 75 ± 13 years, 62 females) with the diagnosis of bullous pemphigoid were enrolled. Seventy-six patients (67.3%) suffered from type 2 Diabetes and 52 (46%) were treated with dipeptidyl-peptidase 4 inhibitors. The most frequent prescribed gliptin was vildagliptin, being administered to 45 cases (39.8% of total patients enrolled, 86.5% of the patients treated with gliptins). Gliptins were withdrawn immediately after the diagnosis of bullous pemphigoid, which together with steroid administration led to remission of the rash. Conclusions This study revealed that treatment with dipeptidyl-peptidase 4 inhibitors, especially vildagliptin, is significantly associated with an increased risk of bullous pemphigoid development.

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Lactobacillus Kefiri LKF01 (Kefibios®) for Prevention of Diarrhoea in Cancer Patients Treated with Chemotherapy: A Prospective Study

Nutrients ◽

10.3390/nu13020385 ◽

2021 ◽

Vol 13 (2) ◽

pp. 385

Author(s):

Michele Ghidini ◽

Mariaceleste Nicoletti ◽

Margherita Ratti ◽

Gianluca Tomasello ◽

Veronica Lonati ◽

...

Keyword(s):

Cancer Patients ◽

Prospective Observational Study ◽

Primary Outcome ◽

Final Analysis ◽

Clinical Effectiveness ◽

High Grade ◽

Combination Therapies ◽

Grade 3 ◽

Lactobacillus Kefiri ◽

A Prospective Study

Diarrhoea is one of the main side effects that cancer patients face. The literature showsthat the incidence of chemotherapy (CT)-induced diarrhoea (grade 3–4) in treated patients is in the range of 10–20%, particularly after 5-fluorouracil (5-FU) bolus or some combination therapies of irinotecan and fluoropyrimidines. The aim of the present study was to evaluate the clinical effectiveness of Lactobacillus kefiri LKF01 (Kefibios®) in the prevention or treatment of CT-related diarrhoea in the cancer population. We conducted a prospective observational study. Patients enrolled were adults treated for at least four months with 5-FU-based CT. Kefibios® was administered to patients every day. The primary outcome was the evaluation of the incidence of grade 3–4 CT-induced diarrhoea. We included 76 patients in the final analysis. A 6.6% incidence of high-grade diarrhoea was found in the evaluated population (4.7% of patients treated with 5-FU-based therapy and 8.5% of patients treated with capecitabine-based CT). The overall incidence of high-grade diarrhoea observed was higher in the 1st and 2nd cycles (3.9%), with a subsequent sharp reduction from the 3rd cycle (1.3%) and negativisation from the 5th cycle. Lactobacillus kefiri LKF01 (Kefibios®) is safe and effective in preventing severe diarrhoea in cancer patients receiving 5-FU or capecitabine-based treatment.

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Feasibility of telemedicine in the management strategy of patients with lymphoma amid the COVID-19 pandemic in Spain, a prospective study (Preprint)

10.2196/preprints.34128 ◽

2021 ◽

Author(s):

Raul Cordoba ◽

Alberto Lopez-Garcia ◽

Daniel Morillo ◽

Maria-Angeles Perez-Saenz ◽

Elham Askari ◽

...

Keyword(s):

Prospective Observational Study ◽

Digital Health ◽

Hematologic Malignancies ◽

Patient Portal ◽

Health Strategy ◽

Potential Risk Factors ◽

Hospital Visits ◽

A Prospective Study ◽

The Impact

BACKGROUND Recurrent hospital visits were potential risk factors for COVID-19 contagion. OBJECTIVE The aims of this prospective observational study was to analyze the consequences of COVID-19 pandemic in the health care of patients with lymphoma and the impact of telemedicine strategies such as the patient portal in their management. METHODS All data were obtained from the electronic medical record (EMR). Variables such as age, sex, matter of the visit, use of patient’s portal, changes in management, impact in clinical trials and suffering from COVID-19 contagion were recorded. RESULTS 290 patients were attended in the lymphoma clinic accomplishing 437 appointments. The median age was 66 years (range 18-94), and 157 (54.13%) were male. Of them, 109 out of 290 (37.58%) were aged older then 70 years. Regarding number of visits, 214 patients (73.79%) had only 1 visit to the hospital. Only 23 patients (7.93%) didn’t have access to patient’s portal. During the follow-up, only 7 patients (2.41%) suffered from COVID-19, with a median age of 66 years (51-80). CONCLUSIONS Telemedicine such as patient’s portal are feasible strategies in the management of patients with lymphoma during the COVID-19 pandemic, with a reduction of in-person visits to hospital and a very low contagion rate. This experience allowed us to continue with a new digital health strategy in the follow up of patients with hematologic malignancies. CLINICALTRIAL Not registered.

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Karakteristik Klinis Pasien Trombosis Sinus Venosus Serebral (TSVS) di Ruang Rawat Inap Neurologi Rumah Sakit Hasan Sadikin Bandung

Jurnal Neuroanestesi Indonesia ◽

10.24244/jni.v9i2.244 ◽

2020 ◽

Vol 9 (2) ◽

pp. 71-7

Author(s):

Lisda Amalia

Keyword(s):

General Hospital ◽

Clinical Manifestation ◽

Clinical Characteristics ◽

Sinus Thrombosis ◽

Clinical Manifestations ◽

Transverse Sinus ◽

Sinus Venosus ◽

Cortical Vein ◽

Sinus Transversus ◽

D Dimer

Latar Belakang dan Tujuan: Trombosis sinus venosus serebral (TSVS) merupakan penyakit akibat oklusi struktur vena intrakranial, termasuk sinus serebral, vena korteks, dan bagian proksimal vena jugularis. Keterlambatan diagnosis dan terapi dapat mengakibatkan terjadinya komplikasi seperti infark berdarah bahkan kematian.Tujuan penelitian ini adalah untuk mengetahui karakteristik klinis pasien TSVS yang diagnosisnya telah dikonfirmasi melalui pemeriksaan DSA. Metode: Penelitian ini bersifat deskriptif observasional retrospektif. Pada pasien yang telah didiagnosis TSVS di Bagian Neurologi Rumah Sakit Hasan Sadikin Bandung periode Juni 2015 sampai November 2017.Hasil: Terdapat 33 subjek dengan rentang usia 40-49 tahun (24,2%) dan mayoritas adalah perempuan sebanyak 22 orang (66,7%). Faktor resiko terbanyak adalah infeksi 8 orang (24,2%), dan kondisi protrombotik sebanyak 6 orang (18,2%). Gejala klinis terbanyak adalah nyeri kepala yaitu 27 orang (81,8%). Lokasi sinus yang tersering mengalami trombosis adalah sinus transversus pada 28 orang dengan gejala mayoritas nyeri kepala. Kadar D-Dimer ditemukan meningkat dengan rata-rata 1,21 mg/L.Simpulan: Pasien TSVS terjadi pada perempuan dengan rentang usia dekade pertengahan dan faktor resiko terbanyak adalah infeksi. Nyeri kepala merupakan gejala paling sering. Lokasi trombosis mayoritas terjadi pada sinus transversus dan ditemukan peningkatan D-Dimer. Clinical Characteristics of Cerebral Venous Sinus Thrombosis (CVST) Patients in Neurology Ward Hasan Sadikin General Hospital BandungAbstractBackground and Objective: CVST is an entity caused by intracranial vein, including cerebral sinuses, cortical vein and proximal part of the jugular vein. A delay in diagnosing and treating can result in brain infarct with hemorrhagic transformation, even death. The goal of this study is to learn the clinical characteristics of patients with CVST that had been confirmed by DSA.Method: This was a retrospective observational descriptive study and subjects were hospitalized patients which had been diagnosed CVST in Neurology ward Hasan Sadikin General Hospital from June 2015 to November 2017.Results: there was 33 subjects with most (22 patient/66.7%) being women between 40-49 years old. In this study the most frequently found risk factor was infection in 8 subjects (24.2%), prothrombotic conditions in 6 subjects (18.2%). The clinical manifestations were mainly headache in 27 subjects (81,8%). The sinus most often involved was the transverse sinus (28 subjects) with the clinical manifestation being headache. D-dimer levels were also increased with mean 1.21 mg/dl.Conclusion: CVST patients are mostly in women at the midle age of decade, with infection being the most frequent risk. Headache was the most frequent clinical manifestation. Location of thrombosis were more often found on the transverse sinus and D-Dimer level was increased.

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The workload of stroke thrombolysis: A prospective study in a district general hospital setting

Acute Medicine Journal ◽

10.52964/amja.0443 ◽

2011 ◽

Vol 10 (1) ◽

pp. 10-12

Author(s):

Seán J Slaght ◽

◽

Nic U Weir ◽

Joanna K Lovett ◽

◽

...

Keyword(s):

Prospective Study ◽

General Hospital ◽

Hospital Setting ◽

District General Hospital ◽

Service Planning ◽

Stroke Severity ◽

Southampton General Hospital ◽

Stroke Thrombolysis ◽

Few Data ◽

A Prospective Study

Many hospitals are still setting up acute stroke thrombolysis services, often delayed by fears over workload. However, there are few data on how many patients require urgent assessment before one is treated. We prospectively studied all referrals to the 24-hour stroke thrombolysis service, February 2009 – January 2010, in Southampton General Hospital. 128 patients were referred to the thrombolysis team and 20 received thrombolysis. The most common reasons for treatment exclusion were: stroke severity (37%), time from onset (26%) or CT findings (15%). Approximately six patients required urgent assessment by the thrombolysis team for every one treated. These data are crucial to inform service planning.

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A PROSPECTIVE STUDY ON CLINICO-PATHOLOGY OF VARICOSE VEINS AND ITS' SURGICAL MANAGEMENT

10.36106/ijsr/8012081 ◽

2020 ◽

pp. 1-10

Author(s):

Om Prakash ◽

K. Govardhanan

Keyword(s):

Prospective Observational Study ◽

Varicose Veins ◽

College Hospital ◽

Medical College ◽

Experienced Radiologist ◽

Associated Symptoms ◽

Observational Study Design ◽

The Government ◽

A Prospective Study ◽

Symptoms And Signs

Background: Varicose veins primarily considered to be a cosmetic problem have been widely mistaken to be medically unimportant and given low priority for treatment. The associated pain, swelling, open ulceration and other morbidities increase cost of its management. The debilitation adds on to the time lost from work and wages. Aim: To study the aetiogenesis, pathology, presentation, complications, and management of varicose veins in the study populations. Methods: The current study followed a prospective observational study design among 60 patients visiting Meenakshi Medical College Hospital and Research Institute with symptoms and signs of varicose veins and clinically diagnosed as having varicose veins. Various presentations and complications and treatments were noted and finally followed up for minimum of 6 months. Results and Conclusion: It is found that varicose veins and their associated symptoms and complications constitute the most common chronic vascular disorders leading to surgical treatment. The incidence is on the rise. It is more common in middle- aged group and in males. Patients presented with spectrum of symptoms and signs, dilated and tortuous veins being more common presentations. Long saphenous system is the most common venous system affected. Ankle (lower perforator being the most common incompetent perforators. The outcome of cases of primary varicose vein depends on a thorough and complete clinical examination and duplex scan by an experienced radiologist. Operative line of treatment is a primary procedure in the management of varicose veins of lower Stripping of LSV up to knee and non-stripping of SSV is associated with less morbidity. Accurate assessment reduces the risk of recurrent varicose veins. There must be ample support from the Government so that even the poor will be benefited from the newer modality of treatment of varicose veins.

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