Blood biochemical abnormalities of intensive care unit patients with SARS-CoV-2 infection, single center experience in Bangladesh

Background: Since its emergence, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide, and led to ever-increasing mortality. SARS-CoV-2 infection perturbs the function of the body’s vital organs, making patients of all ages susceptible to the disease. Nevertheless, individuals developing critical illness with poor outcomes were mostly the elderly and people with co-morbid conditions, who constituted the vast majority of coronavirus disease 2019 (COVID-19) fatalities. Complications of COVID-19 mostly involve the respiratory, renal and cardiovascular systems, and in severe cases secondary infections leading to pneumonia and acute respiratory distress syndrome, which may precede the death of the patient. Multi-organ failure in individuals with COVID-19 could be a consequence of their co-morbidities. It is hoped that the review will lead to more comprehensive understanding of this complex disease. The aim of the study was to evaluate biochemical abnormalities during SARS-CoV-2 infection of ICU patients.Methods:This observational study was conducted in Square Hospital Limited, Dhaka, Bangladesh, on 50 patients received ICU treatment with moderate to severe COVID-19 symptoms admitted to this hospital from 15 July to 15 September 2020.Results: Among the participants most of them were 19 (38%) belongs to 65-74 years age group male 38 (78.00%) were dominating the gender distribution. IL6, CRP, creatinine and troponin were found the most significant in biochemical blood parameters. The maximum level of comorbidity was observed due to diabetes mellitus, ischemic heart disease, and hypertension.Conclusions:Biochemical parameters may be used as an indicator of COVID-19 infections and the severity of ICU patients. For the consistency of the course of patients, the markers could be used.

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Abstract TP17: Outcomes in Octogenarians Undergoing Mechanical Thrombectomy for Acute Ischemic Stroke: A Single Center Experience

Stroke ◽

10.1161/str.51.suppl_1.tp17 ◽

2020 ◽

Vol 51 (Suppl_1) ◽

Author(s):

Hassan Aboul Nour ◽

Owais Khadem Alsrouji ◽

Devashi Dharaiya ◽

Ghada Mohamed ◽

Alex Chebl ◽

...

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Clinical Outcomes ◽

Mechanical Thrombectomy ◽

Retrospective Chart Review ◽

The Elderly ◽

Single Center ◽

Younger Patients ◽

Single Center Experience ◽

Poor Outcomes

Background: Mechanical thrombectomy (MT) for acute ischemic stroke (AIS) in the elderly presents a unique set of challenges and opportunities. Most existing studies include patients up to the age of 90 with stricter criteria of inclusion for patients ≥ 80 years of age. The following study compares the outcomes in octogenarians compared to younger patients in a single center. Methods: We conducted a retrospective chart review of patients who were ≥ 80yo who underwent MT from March 2016 to July 2019. Data on age, recanalization score measured by Thrombolysis in Cerebral Infarction (TICI) score and clinical outcomes were compared to 126 patients < 80 years of age treated during the same time period. Clinical outcomes were classified based on modified Rankin score (mRS) at discharge. Poor outcomes were defined as mRS 4-6. Good recanalization was defined as TICI score 2b or 3. Results: Eighty-three patients with a median age of 86±4.34yo were compared to 126 patients with median age of 63±12.48yo (p<0.0001). Good recanalization was achieved in 74% of patients ≥80yo compared to 84% in patients <80yo (p= 0.06). Poor outcomes were reported in 74.6% of patients ≥80yo compared to 47.0% in patients <80yo (p<0.0001). All-cause mortality was 28.9% in the ≥80yo vs 12.9% in the < 80yo (p=0.006). Conclusion: In our cohort, the clinical outcomes among octogenarians receiving MT were worse than in younger patients despite no difference in recanalization. Various factors may be responsible including overall health status, comorbid conditions and neuroplasticity. Further prospective multicentral studies are needed to better understand the benefit of MT in octogenarians.

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Outcome of total arterial versus conventional myocardial revascularization in the elderly: a single center experience

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0034-1367217 ◽

2014 ◽

Vol 62 (S 01) ◽

Author(s):

A. Haneya ◽

J. Jussli-Melchers ◽

S. Eckmann ◽

R. Berndt ◽

A. Thiem ◽

...

Keyword(s):

Myocardial Revascularization ◽

The Elderly ◽

Single Center ◽

Single Center Experience

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Effects of Essential Oils-Based Supplement and Salmonella Infection on Gene Expression, Blood Parameters, Cecal Microbiome, and Egg Production in Laying Hens

Animals ◽

10.3390/ani11020360 ◽

2021 ◽

Vol 11 (2) ◽

pp. 360

Author(s):

Georgi Yu. Laptev ◽

Elena A. Yildirim ◽

Larisa A. Ilina ◽

Valentina A. Filippova ◽

Ivan I. Kochish ◽

...

Keyword(s):

Egg Production ◽

Salmonella Enteritidis ◽

Laying Hens ◽

Expression Profiles ◽

Blood Parameters ◽

Post Inoculation ◽

Production Traits ◽

Immunological Parameters ◽

Specific Expression ◽

Blood Biochemical

One of the main roles in poultry resistance to infections caused by Salmonella is attributed to host immunity and intestinal microbiota. We conducted an experiment that involved challenging Lohmann White laying hens with Salmonella Enteritidis (SE), feeding them a diet supplemented with an EOs-based phytobiotic Intebio®. At 1 and 7 days post-inoculation, the expression profiles of eight genes related to immunity, transport of nutrients in the intestine, and metabolism were examined. Cecal microbiome composition and blood biochemical/immunological indices were also explored and egg production traits recorded. As a result, the SE challenge of laying hens and Intebio® administration had either a suppressive or activating effect on the expression level of the studied genes (e.g., IL6 and BPIFB3), the latter echoing mammalian/human tissue-specific expression. There were also effects of the pathogen challenge and phytobiotic intake on the cecal microbiome profiles and blood biochemical/immunological parameters, including those reflecting the activity of the birds’ immune systems (e.g., serum bactericidal activity, β-lysine content, and immunoglobulin levels). Significant differences between control and experimental subgroups in egg performance traits (i.e., egg weight/number/mass) were also found. The phytobiotic administration suggested a positive effect on the welfare and productivity of poultry.

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Multi-Approach Assessment for Stress Evaluation in Rainbow Trout Females, Oncorhynchus mykiss (Walbaum, 1792) from Three Different Farms during the Summer Season

Animals ◽

10.3390/ani11061810 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1810

Author(s):

Paul Uiuiu ◽

Călin Lațiu ◽

Tudor Păpuc ◽

Cristina Craioveanu ◽

Andrada Ihuț ◽

...

Keyword(s):

Rainbow Trout ◽

Oncorhynchus Mykiss ◽

Biochemical Parameters ◽

Principal Component ◽

Environmental Parameters ◽

Blood Parameters ◽

Summer Season ◽

Farmed Fish ◽

Blood Profile ◽

Blood Biochemical

Blood biochemistry parameters are valuable tools for monitoring fish health. Their baseline values are still undefined for a multitude of farmed fish species. In this study, changes in the blood profile of rainbow trout females (Oncorhynchus mykiss) from three farms were investigated using different biomarkers during the summer season. In the given context, the main water physicochemical parameters were investigated and twelve biochemical parameters were measured from blood samples of rainbow trout reared in the Fiad, Șoimul de Jos, and Strâmba farms. We selected these farms because the genetic background of the rainbow trout is the same, with all studied specimens coming from the Fiad farm, which has an incubation station. Forty-five samples were collected monthly (May to August) throughout summer to observe the changes in the blood profile of rainbow trout. Principal component analysis showed a clear separation both among the studied farms and months. Furthermore, significant correlations (p < 0.05) between the majority of the biochemical parameters were found, indicating that the environmental parameters can influence several blood parameters at the same time. The present study provides several useful norms for assessing the welfare of rainbow trout, indicating that the relationships among different parameters are important factors in interpreting the blood biochemical profiles.

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Melanoma in the elderly and sentinel lymph node biopsy: a single center experience of 124 consecutive patients

BMC Geriatrics ◽

10.1186/1471-2318-9-s1-a3 ◽

2009 ◽

Vol 9 (Suppl 1) ◽

pp. A3

Author(s):

P Mainente ◽

R Gianesini ◽

S Faccin ◽

S Ricciardi ◽

E Mion ◽

...

Keyword(s):

Lymph Node ◽

Sentinel Lymph Node ◽

Sentinel Lymph Node Biopsy ◽

The Elderly ◽

Lymph Node Biopsy ◽

Single Center ◽

Single Center Experience ◽

Node Biopsy

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Risk factors for severe outcomes in people with diabetes hospitalised for COVID-19: a cross-sectional database study

BMJ Open ◽

10.1136/bmjopen-2021-051237 ◽

2021 ◽

Vol 11 (7) ◽

pp. e051237

Author(s):

Emilio Ortega ◽

Rosa Corcoy ◽

Mònica Gratacòs ◽

Francesc Xavier Cos Claramunt ◽

Manel Mata-Cases ◽

...

Keyword(s):

Hospital Mortality ◽

Invasive Mechanical Ventilation ◽

The Elderly ◽

Cross Sectional Study ◽

Cross Sectional ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Male Sex ◽

Poor Outcomes ◽

The Relationship

AimThis study’s objective was to assess the risk of severe in-hospital complications of patients admitted for COVID-19 and diabetes mellitus (DM).DesignThis was a cross-sectional study.SettingsWe used pseudonymised medical record data provided by six general hospitals from the HM Hospitales group in Spain.Outcome measuresMultiple logistic regression analyses were used to identify variables associated with mortality and the composite of mortality or invasive mechanical ventilation (IMV) in the overall population, and stratified for the presence or absence of DM. Spline analysis was conducted on the entire population to investigate the relationship between glucose levels at admission and outcomes.ResultsOverall, 1621 individuals without DM and 448 with DM were identified in the database. Patients with DM were on average 5.1 years older than those without. The overall in-hospital mortality was 18.6% (N=301), and was higher among patients with DM than those without (26.3% vs 11.3%; p<0.001). DM was independently associated with death, and death or IMV (OR=2.33, 95% CI: 1.7 to 3.1 and OR=2.11, 95% CI: 1.6 to 2.8, respectively; p<0.001). In subjects with DM, the only variables independently associated with both outcomes were age >65 years, male sex and pre-existing chronic kidney disease. We observed a non-linear relationship between blood glucose levels at admission and risk of in-hospital mortality and death or IMV. The highest probability for each outcome (around 50%) was at random glucose of around 550 mg/dL (30.6 mmol/L), and the risks flattened above this value.ConclusionThe results confirm the high burden associated with DM in patients hospitalised with COVID-19 infection, particularly among men, the elderly and those with impaired kidney function. Moreover, hyperglycaemia on admission was strongly associated with poor outcomes, suggesting that personalised optimisation could help to improve outcome during the hospital stay.

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A PROSPECTIVE OBSERVATIONAL STUDY OF CLINICAL PROFILE IN ETIOLOGY OF ANEMIA IN ELDERLY-A HOSPITAL BASED STUDY IN A TERTIARY CARE CENTRE IN SOUTH INDIA

International Journal of Advanced Research ◽

10.21474/ijar01/13508 ◽

2021 ◽

Vol 9 (09) ◽

pp. 961-972

Author(s):

K. Shivaraju ◽

◽

Karanam Sai Arun ◽

Mandhala Saikrishna ◽

◽

...

Keyword(s):

Tertiary Care ◽

The Elderly ◽

Moderate Degree ◽

Care Hospital ◽

Tertiary Care Centre ◽

Total Study Population ◽

Study Population ◽

Poor Outcomes ◽

One Year ◽

Severe Degree

Background: Anemia is often considered as a normal physiological process that occurs with aging. but recently since past 2 decades anemia of any degree is being recognized as significant independent contributor to morbidity mortality and frailty in elderly patients. It is easy to overlook anemia in elderly as symptoms of anemia like fatigue, SOB etc are often attributed to aging process itself. many evidences accumulated states that anemia of any degree reflects poor health and increased vulnerability to poor outcomes. Materials and methods: This study was conducted in the department of internal medicine in a tertiary care hospital over a period of one year with sample size of 362 subjects satisfying the inclusion and exclusion criteria after taking the consent form. Results: Moderate degree anaemia was the commonest around, 65.6% followed by severe degree anemia 20.1%. Easy fatigability was the commonest symptom and pallor was the commonest sign of anaemia in elderly. Anemia is not always a consequence of aging. Anemia of unexplained etiology constituted 15.97% of total study population. Conclusion: Anaemia in elderly is a challenge and has to be approached in an organized manner for appropriate diagnosis and evaluation to look into its cause and plan management to improve the quality of life of the elderly persons.An effort should always be made to reach etiological diagnosis before instituting specific therapy.

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Coronary artery disease in the elderly

Reviews in Clinical Gerontology ◽

10.1017/s0959259899009120 ◽

1999 ◽

Vol 9 (1) ◽

pp. 13-21 ◽

Cited By ~ 2

Author(s):

SK Glen ◽

NA Boon

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Elderly Patients ◽

Treatment Guidelines ◽

Treatment Options ◽

The Elderly ◽

Elderly Subjects ◽

Younger Patients ◽

Artery Disease ◽

Morbid Conditions

Coronary artery disease is extremely common among elderly people and accounts for half of all deaths in those who are more than 65 years old. Although the condition is essentially the same as that encountered in younger patients, the management of coronary artery disease in elderly subjects can be difficult because the anticipated benefits and risks of the various treatment options are often altered by the presence of co-morbid conditions. Moreover, the results of the major outcome studies that underpin most treatment guidelines may not be relevant to the needs of many elderly patients for several reasons.

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Current Perspective: Vertigo in the Elderly

Gerontology & Geriatrics: Research ◽

10.26420/gerontolgeriatrres.2021.1049 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Yeolekar AM ◽

◽

Yeolekar ME ◽

Keyword(s):

Elderly Patient ◽

The Elderly ◽

Complex Condition ◽

Current Perspective ◽

One Year ◽

Bedside Tests ◽

Morbid Conditions

Vertigo is a relatively complex condition demanding a skilfully collected and analyzed history. When an elderly patient presents with vertigo, some conditions are most commonly considered highly possible and likely whereas others (prevalent more in young) tend to be excluded from the mental algorithm of the clinician. It also matters to whom the patient presents first-internist, neurologist or the otolaryngologist. An important feature in vertigo in the elderly is the probability of it being multifactorial because of co-morbid conditions that could contribute to the complexity of manifestations. Conducting and appropriately interpreting the bedside tests/maneuvers and thereafter selecting battery of tests/investigations in a sequential manner can clinch the issue of a fair diagnosis in most cases. The Covid Dimension: Any discussion on vertigo would be incomplete without noting the findings on vertigo reported abundantly over the last one year. The compounding COVID angle merits being duly and appropriately considered.

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