scholarly journals Genetic, environmental and microbiological causes of periodontal diseases

2021 ◽  
Author(s):  
Yazeed Abdullah Alhabdan ◽  
Abdulhameed G. Albeshr ◽  
Shoroq Mansour Alqahtani ◽  
Rudaina Saud Khallaf ◽  
Khadijah Mustafa Saidi ◽  
...  
Keyword(s):  
Literature Review ◽  
Periodontal Disease ◽  
Metabolic Disorders ◽  
Periodontal Diseases ◽  
Main Mechanism ◽  
Early Interventions ◽  
Developmental Genetic ◽  
Raising Awareness ◽  
Literature Evidence ◽  
Oral Conditions

Periodontal disease is a term that can be used to describe different oral conditions that occur to the gingiva, in addition to the bones and ligaments supporting the teeth. Periodontal diseases can develop secondary to inflammatory, developmental, genetic, traumatic, neoplastic, and metabolic disorders. In the present literature review, we aim to discuss the different genetic, environmental, and microbiological causes of periodontal diseases based on evidence from the current studies in the literature. Evidence regarding genetics is still not adequate, and further research is still needed to understand the main mechanism of this etiology furtherly. Different diseases and habitual factors can contribute periodontal diseases, mainly due to increased inflammation-induced pathological events. Further attention should be directed to preventing these events to intervene against the development of periodontal diseases adequately. Early interventions against these diseases can attribute to enhance the health and prognosis of the affected patients significantly. Microbiological causes are also important and usually develop mainly as a result of poor hygiene. Therefore, further interventional research should be directed towards raising awareness among individuals to reduce the incidence of the condition.

scholarly journals The relationship between periodontite and diabetes mellitus type ii facing the new classification of periodontal diseases: literature review

2020 ◽  
Vol 68 ◽  
Author(s):  
Lívia Maria Lopes de OLIVEIRA ◽  
Lívia Mirelle BARBOSA
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Literature Review ◽  
Periodontal Disease ◽  
Periodontal Diseases ◽  
New Classification ◽  
The Relationship

ABSTRACT Periodontal disease and type 2 diabetes mellitus are considered chronic diseases that at their core have a deep relationship with inflammation. It is assumed that there is a bidirectional relationship between periodontal disease and type 2 diabetes mellitus. It is estimated that approximately 10% of the world’s population is affected by periodontal disease, in its most severe form, almost the same percentage estimated for people with diabetes, which is considered a 21st century emergency. The World Workshop for the Classification of Periodontal and Peri-implant Diseases and Conditions took place from September 9-11, 2017. The aim of this study is to analyze the results of this workshop with regard to the relationship between periodontal diseases/conditions and diabetes mellitus, in addition to conducting an integrative review on the topic. A literature review was conducted, using the Medline electronic databases via Pubmed, Scientific Electronic Library Online, Scientific and Technical Literature of Latin America and the Caribbean and Virtual Health Library. A new classification of periodontal disease included tools for individual assessment of the patient and recognizing risk factors that might negatively interfere in response to treatment. The occurrence of metabolic lack of control in periodontal patients with type 2 diabetes mellitus is now considered a factor of great importance for the assessment of individual susceptibility to the progression of periodontitis. Diabetes is believed to promote a hyper inflammatory response to bacterial challenge by modifying the tissue response of periodontal tissues.

METHODS FOR TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS (LITERATURE REVIEW)

2021 ◽  
Vol 2 (5) ◽  
pp. 30-33
Author(s):  
Saloma Avezova ◽  
Keyword(s):  
Literature Review ◽  
Oral Cavity ◽  
Periodontal Disease ◽  
Oral Mucosa ◽  
Periodontal Diseases ◽  
Pathological Changes ◽  
Urgent Task ◽  
Immunological Changes

The article provides data on the methods used for the treatment of generalized periodontitis. Most researchers believe that periodontitis is a polyetiological disease, the development of which is based on a complex of pathological changes occurring in the oral cavity associated with microbiological and immunological changes. Improving the effectiveness of treatment of inflammatory periodontal diseases is an urgent task in modern dentistry.Keywords:dentistry, diseases of the oral mucosa, periodontal disease, chronic generalized periodontitis, etiology, treatment

scholarly journals Periodontal Diseases in Diabetes Melitus - A Two Way Link? A Review of Literature

2020 ◽  
Vol 25 (4) ◽  
pp. 77-79
Author(s):  
Ovidiu Boitor ◽  
Carmen Natea Sitterli ◽  
Mihăilă Romeo
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Periodontal Disease ◽  
Metabolic Disorders ◽  
Periodontal Diseases ◽  
Review Of Literature ◽  
Diabetes Melitus

Abstract Numerous studies in the last decades report a frequent association of marginal periodontal disease with some systemic metabolic disorders, such as diabetes or obesity. The prevalence of these diseases is growing alarmingly both globally and in our country. Recent data from the literature confirm that advanced forms of periodontal disease can influence the evolution of type 2 diabetes. This may provide a premise for better glycemic control.

scholarly journals Study of physicochemical properties of oral fluid in persons with periodontal disease on the background of metabolic syndrome

2021 ◽  
Vol 105 (1) ◽  
pp. 44-47
Author(s):  
T. Glushchenko ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Oral Cavity ◽  
Periodontal Disease ◽  
Physicochemical Properties ◽  
Metabolic Disorders ◽  
Oral Fluid ◽  
Periodontal Diseases ◽  
Acid Base Balance ◽  
Leading Role ◽  
The Metabolic Syndrome

Topicality. Over the past few years, scientists have attracted the attention of the problem of studying the relationship between metabolic syndrome and periodontal disease. Topics of risks associated with the association with various metabolic disorders have become one of the most important research topics in periodontology. Oral fluid plays a leading role in the proper functioning and maintenance of homeostasis of the entire periodontal tissue complex, is a mediator of the combination of its structures with the environment and an important nutrient substrate for the microflora of the oral cavity. The aim of the study. In order to study the quantitative and qualitative changes of oral fluid in periodontal diseases on the background of the metabolic syndrome, the rate of secretion of mixed saliva, its viscosity and acid-base balance were studied. 2 groups were formed for research: basic and comparative. Materials and methods. The main group included 30 people with inflammatory-dystrophic lesions of the periodontium on the background of metabolic syndrome, the comparison group consisted of 30 people with periodontal disease without endocrinological pathology. Results and discussion. The results of the study revealed homeostatic shifts in the oral biosystem of persons with periodontal disease on the background of metabolic syndrome: a decrease in salivation may indicate a violation of the secretory function of the salivary glands on the background of metabolic disorders, which naturally affected the increase in saliva viscosity. Conclusions. The predominance of acidosis in the oral cavity and the reduction of the protective properties of saliva becomes an important factor in creating a periodontopathogenic situation in the oral cavity and aggravating the course of periodontal disease in this category of patients. Key words: metabolic syndrome, periodontal disease, oral fluid, physicochemical properties.

scholarly journals КЛІНІЧНІ АСПЕКТИ ЗАХВОРЮВАНЬ ТКАНИН ПАРОДОНТА (ОГЛЯД ЛІТЕРАТУРИ)

2018 ◽  
Author(s):  
M. М. Shevchuk
Keyword(s):  
Periodontal Disease ◽  
Metabolic Disorders ◽  
Clinical Symptoms ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
The Body ◽  
Periodontal Tissue ◽  
Internal Organs ◽  
Dental Tissues ◽  
Periodontal Tissues

Periodontal disease is one of the most complex problems of modern dentistry. It is known that in the development of periodontal disease, a prominent role belongs to local factors, but systemic processes, which lead to profound changes in the internal environment of the organism and structural damage to the periodontal tissues, play an important role. It is proved that generalized periodontitis is pathogenetically closely associated with the pathology of internal organs, and inflammatory and dystrophic-inflammatory lesions of parodontium are largely secondary to systemic processes in the body that underlie a number of diseases of the internal organs. Scientists from all over the world believe that periodontal diseases are etiological and pathogenetic factors to heterogeneous diseases, in which the etiology and pathogenesis of a complex of immunological, biochemical, structural and other pathological changes in mechanisms of inflammatory alteration around dental tissues is observed, and metabolic disorders in the body are accompanied by pathochemical , morphological, immune and biological changes in parodontium. In this regard, promising directions for studying the etiology and pathogenesis of periodontal diseases include the identification of factors that affect the entire human body and periodontal tissue in particular. In the body of the patient with generalized periodontitis there are numerous processes, the interaction of which depends on the nature of the course of the disease and the peculiarities of the formation of a local pathological center. The most important is the association of the endocrine and immune system, the violation of the functional state which promotes the development of deep metabolic disorders in the periodontal tissues. As a result of the review of scientific publications and own observations, the most common clinical symptoms and pathogenesis in inflammatory diseases of periodontal tissues have been analyzed. Clinical symptoms of inflammatory diseases are considered as sublimation of their pathogenetic bases, as clinical manifestations of basic for pathology of processes. The conclusion is made on the need for an integrated approach in the treatment of periodontal diseases. The aim of the study – familiarization of broad medical public with the modern views on the etiology, pathogenesis and clinical symptoms in patients with periodontal tissue diseases.

scholarly journals Evaluation of the Adjuvant Effect of Antimicrobial Photodynamic Therapy in the Treatment of Periodontal Disease: Literature Review

2019 ◽  
Vol 21 (3) ◽  
pp. 274
Author(s):  
Maria das Graças Barbosa da Silva ◽  
Karla Dos Santos Menezes ◽  
Thamyres Maria Silva Simões ◽  
José De Alencar Fernandes Neto ◽  
Ana Luzia Araújo Batista ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Photodynamic Therapy ◽  
Literature Review ◽  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Conventional Treatment ◽  
Web Of Science ◽  
Periodontal Diseases ◽  
Antimicrobial Photodynamic Therapy ◽  
Clinical Protocols

AbstractIntroduction: Antimicrobial Photodynamic Therapy (aPDT) is a promising approach with several clinical applications, including the treatment of periodontal diseases, by acting as an adjuvant to the conventional treatment of periodontal disease by allowing reduction of periodontopathogens, with no systemic side effects and minimal possibilities of bacterial resistance. Objective: To verify, through the scientific literature, the effectiveness of Antimicrobial Photodynamic Therapy associated with conventional periodontal treatment. Methodology: The literature review was conducted in the MEDLINE databases - PubMed, Scopus and Web of Science. The articles were selected through the analysis of titles and abstracts published in the period from 2007 to 2018. Selected articles were published in their entirety and with free or controlled access, of the type clinical trial on the subject, without restriction of languages. The terms used were: “Periodontal diseases”; “Chronic Periodontitis” and “Photochemotherapy.” Results: 84 articles were found, and 20 clinical trials that met the inclusion criteria were analyzed. There were different clinical protocols for the association of aPDT with the conventional treatment of periodontal disease. a number of different clinical outcomes were found for each of the proposed clinical protocols. Conclusion: Considering the clinical trials investigated, conflicting results regarding the efficacy of aPTD as an adjuvant treatment of the conventional treatment of periodontal disease are observed. and lack of standardization of clinical parameters and protocols.Keywords: Chronic Periodontitis. Periodontal Diseases. Photochemotherapy.ResumoA terapia fotodinâmica antimicrobiana (aPDT) é uma abordagem promissora com várias aplicações clínicas, incluindo o tratamento das doenças periodontais, ao atuar como um adjuvante ao tratamento convencional da doença periodontal por permitir redução de periodontopatógenos, com ausência de efeitos sistêmicos colaterais e mínimas possibilidades de resistência bacteriana. O objetivo deste estudo é verificar, por meio da literatura científica, a eficácia da terapia fotodinâmica antimicrobiana associada ao tratamento periodontal convencional. A revisão de literatura foi conduzida nas bases de dados MEDLINE – PubMed, Scopus e Web of Science. Os artigos foram selecionados através da análise de títulos e de resumos publicados no período de 2007 a 2018. Foram selecionados artigos publicados na íntegra e com acesso livre e gratuito, ou controlado, do tipo ensaio clínico sobre o tema, sem restrição de idiomas. Os termos utilizados foram: Periodontal diseases; Chronic Periodontitis e Photochemotherapy. Foram encontrados 84 artigos, e 20 ensaios clínicos que atenderam os critérios de inclusão, foram analisados. Observou-se diferentes protocolos clínicos para a associação da aPDT com o tratamento convencional da doença periodontal. Também foram encontrados diferentes desfechos clínicos para cada um dos protocolos clínicos propostos. Conclusão: Considerando os ensaios clínicos pesquisados, observa-se resultados conflitantes frente à eficácia da aPDT como tratamento adjuvante do tratamento convencional da doença  periodontal. Observa-se, ainda, uma produção literária escassa e a falta de uma padronização dos parâmetros e dos protocolos clínicos.Palavras-chaves: Periodontite Crônica. Doença Periodontal. Fotoquimioterapia.

Periodontopathogens: a new view. Systematic review. Part 2

2020 ◽  
Vol 20 (2) ◽  
pp. 160-167
Author(s):  
E. S. Slazhneva ◽  
E. A. Tikhomirova ◽  
V. G. Atrushkevich
Keyword(s):  
Systematic Review ◽  
Periodontal Disease ◽  
Pathogenic Bacteria ◽  
Periodontal Diseases ◽  
Oral Microbiome ◽  
Controlled Trials ◽  
New Paradigm ◽  
Microbial Composition ◽  
Randomized Controlled ◽  
The Past

Relevance. The modern view of periodontitis as a dysbiotic disease that occurs as a result of changes in the microbial composition of the subgingival region is considered in a systematic review.Purpose. To study a new paradigm of development of generalized periodontitis.Materials and methods. Randomized controlled trials (RCTS) were selected for the study, including cluster RCTS, controlled (non-randomized) microbiological and clinical studies of the oral microbiome in adult patients with generalized periodontitis over the past 10 years.Results. The transition from a symbiotic microflora to a dysbiotic pathogenic community triggers the host's inflammatory response, which contributes to the development of periodontal diseases. Modern ideas about periodontal pathogenic bacteria dictate new requirements for the treatment of periodontal diseases. The second part of the review examines the microbial profiles of periodontal disease in various nosological forms, the mechanisms of the immune response and approaches to the treatment of periodontal disease from the perspective of biofilm infection.Conclusions. As follows from modern literature periodontitis is to a certain extent caused by the transition from a harmonious symbiotic bacterial community to a dysbiotic one. Recent scientific studies have shown that not single microorganism is not able to cause disease but the microbial community as a whole leads to the development of pathology.

Comparison of Sampling Techniques For qPCR Quantification of Periodontal Pathogens

2018 ◽  
Vol 68 (12) ◽  
pp. 2853-2856 ◽  
Author(s):  
Igor Jelihovschi ◽  
Cristian Drochioi ◽  
Aida Corina Badescu ◽  
Raoul Vasile Lupusoru ◽  
Alexandra Elena Munteanu ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Periodontal Diseases ◽  
Pcr Analysis ◽  
Treponema Denticola ◽  
Subgingival Plaque ◽  
Periodontal Pathogens ◽  
Radiographic Evidence ◽  
Gingival Bleeding ◽  
As Species ◽  
Qpcr Quantification

The diagnosis of periodontal disease is mainly based on use of clinical and radiographic evidence. In this study we employed a quantitative PCR analysis of Aggregatibacter actinomycetemcomitans and Treponema denticola as species strongly involved in periodontal diseases, burden in periodontal pockets to detect the main sampling factors that interfere with qPCR results. From 22 patients with advanced periodontal disease, subgingival plaque was comparatively collected by paper points and periodontal Gracey curettes. Samples were collected from the same situs in presence of gingival bleeding and absence of bleeding. The concordance and agreement of results between samples were assessed. The present study demonstrates that subgingival plaque sampling with sterile absorbable paper points is often accompanied by gingival bleeding resulting in quantification biases of periodontal pathogens.

scholarly journals The occurrence of Entamoeba gingivalis among patients with periodontal disease

2016 ◽  
Vol 29 (2) ◽  
pp. 86-89 ◽  
Author(s):  
Joanna Luszczak ◽  
Michal Bartosik ◽  
Jolanta Rzymowska ◽  
Agnieszka Sochaczewska-Dolecka ◽  
Ewa Tomaszek ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Periodontal Disease ◽  
Periodontal Diseases ◽  
Age Groups ◽  
Healthy People ◽  
Gingival Tissue ◽  
Pathological Changes ◽  
Oral Diseases

AbstractAccording to some studies, the Entamoeba gingivalis colonizing the gingival tissue is an important agent in bringing about periodontitis. Other studies, however, deem it an opportunist that is able to survive in the medium induced by periodontal disease. The aim of this study was to investigate the prevalence of Entamoeba gingivalis infection in patients from the Department of Periodontology, and compare this population with that of healthy people, so as to analyze the relationships between infection and patient sex and age. The result of this work is that in both groups, a correlation (p = 0,19) has been noted between the occurrence of amoebae and other diseases in the oral cavity. Indeed, 81,4% of all patients with some periodontal disease showed the presence of amoeba. Among those who are not afflicted with oral diseases, the presence of amoeba was indicated in 62,5% of the total. In addition, a correlation between the person's age and the presence of protozoa (p = 0,15) was strongly marked among women (p = 0,19). In the three age groups of women in this study (40-49, 60-69, and above 80 years), we observed a 100% presence of protozoa.Our study leads us to the conclusion that infections with Entamoeba gingivalis should be regarded as an factor that is associated with the pathological changes occurring in patients with periodontal diseases.

scholarly journals BANA-Positive Plaque Samples Are Associated with Oral Hygiene Practices and Not CD4+ T Cell Counts in HIV-Positive Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Cathy Nisha John ◽  
Lawrence Xavier Graham Stephen ◽  
Charlene Wilma Joyce Africa
Keyword(s):  
T Cell ◽  
Periodontal Disease ◽  
Oral Hygiene ◽  
Periodontal Diseases ◽  
Cd4 T Cell ◽  
Hiv Positive ◽  
Hygiene Practices ◽  
Cell Counts ◽  
Probing Depth ◽  
Clinical Indices

Background. The “red complex” microorganisms, namely,Porphyromonas gingivalis,Treponema denticola, andTannerella forsythiaare considered as potential pathogens causing HIV-associated periodontal diseases. Moreover, it has been recognized that an association exists between CD4+ T cell counts and periodontal disease progression.Objective. To establish whether CD4+ T cell counts or oral hygiene plays a greater role in producing BANA-positive results in HIV-associated periodontal disease.Materials and Methods. One hundred and twenty HIV-positive patients participated in the study, and their CD4+ T cell counts were obtained from their medical records. The six Ramfjord teeth were used for evaluating periodontal clinical indices and subgingival plaque sampling. BANA test was used for the detection and prevalence of the “red complex” bacteria in plaque samples.Results. A majority of 69.17% HIV-positive patients were BANA-positive. No significant associations were found between BANA and CD4+ T cell counts. A highly significant association was found between BANA with probing depth and clinical attachment level (P≤0.0001) and between BANA and the use of interdental aids (P=0.0168).Conclusion. HIV-associated periodontal diseases are strongly related to oral hygiene practices rather than the effect of CD4+ T cell counts, and the use of interdental aids was marked as a significant predictor of BANA-negative plaque samples.

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