scholarly journals A comparison of oral versus topical combination of glucosamine sulphate and diacerein in patients of grade 2 osteoarthritis

2021 ◽  
Author(s):  
Nikhil Tandon ◽  
Rajesh Paul ◽  
Gagandeep Kwatra
Keyword(s):  
P Value ◽  
Reactive Protein ◽  
Osteoarthritis Knee ◽  
Oral Group ◽  
Glucosamine Sulphate ◽  
The Difference ◽  
Efficacy Parameters ◽  
In The Beginning ◽  
A Prospective Study ◽  
And Function

<p class="abstract"><strong>Background:</strong> The study aimed to compare oral versus topical combination of glucosamine sulphate and diacerein in patients of grade 2 Osteoarthritis.</p><p class="abstract"><strong>Methods: </strong>This was a prospective study of 70 patients with grade 2 osteoarthritis knee, randomly divided into 2 groups of 35 each. The first group was given oral 1500mg of glucosamine and 100mg of diacerein per day and second group was given topical preparation of 10% w/w glucosamine sulphate and 1% w/w diacerein to be applied twice. Both the groups were followed up at 1, 3, 6 and 12 weeks. At each follow up, Visual Analog Scale (VAS) and Lequesne et al scores were used as efficacy parameters. C-Reactive Protein (CRP) level was measured in the beginning and at the end of 12 weeks.</p><p class="abstract"><strong>Results:</strong> Both the groups showed improvement in pain and joint function as depicted by VAS score and Lequesne index however the difference was not statistically significant. The decrease in CRP value was significant in oral group (p value&lt;0.001) but not in topical group (p value of 0.047). Paracetamol demand was slightly higher in topical group however the difference was not significant.</p><p class="abstract"><strong>Conclusions:</strong> Glucosamine sulphate and diacerein combination are effective in improving pain, stiffness and function in patients of grade 2 osteoarthritis knee. However, the efficacy of glucosamine sulphate and diacerein combination- oral as well as topical, in improving pain and stiffness is similar- there is no superiority of one over the other.</p>

scholarly journals A STUDY TO ASSESS PREDICTIVE ROLE OF C-REACTIVE PROTEIN IN EARLY PREGNANCY AMONG WOMEN

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Neeti Mahla ◽  
Mukesh Choudhary
Keyword(s):  
Early Pregnancy ◽  
Quantitative Estimation ◽  
First Trimester ◽  
Normal Pregnancy ◽  
P Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Predictive Role ◽  
The Difference

Background: To Assess Predictive Role of C-Reactive Protein In Early Pregnancy among Women Methods: Hospital based comparative analysis was conducted on Women with early pregnancy upto 14 weeks with either abdominal pain or vaginal bleeding or suspected extrauterine pregnancy. C-reactive protein (CRP) quantitative estimation is done by turbi-diametric method. Collected samples were sent to a designated lab of our hospital. Results: The mean c-reactive protein level in cases 2.31 with min-max value ranging from 0.80-3.91mg/dl while in controls mean c-reactive protein value came to be 9.12 with min-max range from 3.21-24.16 mg/dl. The difference between the two groups is significant as p value is less than 0.001. Conclusion: Our results of significantly increased CRP levels in normal pregnancy and a clear association between CRP and normal pregnancy, support the clinical application of this diagnostic tool in early pregnancy, especially as a predictor of abnormal first trimester pregnancies. Keywords: CRP, Pregnancy, Women

scholarly journals C-reactive protein/albumin ratio as a predictor of 28 day mortality in patients with sepsis

2020 ◽  
Vol 8 (2) ◽  
pp. 503
Author(s):  
Hamsa B. T. ◽  
Srinivasa S. V. ◽  
Raveesha A.
Keyword(s):  
Inotropic Support ◽  
Secondary Outcome ◽  
P Value ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Significant Difference ◽  
Life Threatening ◽  
Sepsis And Septic Shock ◽  
A Prospective Study

Background: Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis remains a major cause of morbidity and mortality worldwide. Important biomarkers that can be used as prognostic markers in sepsis are C Reactive Protein (CRP) and serum Albumin levels. CRP levels markedly elevate in response to infection whereas albumin levels decrease in response to acute phase infection. We want to ascertain the value of CRP/albumin ratio as an independent predictor of 28-day mortality in sepsis patients.Methods: A prospective study was conducted including 150 patients satisfying the criteria for sepsis according to SOFA score of more than 2. Initial CRP/Albumin ratio was assessed to determine its significance in assessing the 28-day mortality, primary end point of our study. Secondary end points assessed were length of ICU stay, need for inotropic support, need for ventilator support and renal replacement therapy.Results: In the analysis of CRP/Albumin ratio as a predictor of 28-day mortality, patients were followed up from day of admission till 28 days to assess primary outcome. Among study subjects survivors were 92 in whom mean CRP/ALB ratio was 0.1197 and non survivors were 58 patients with mean CRP/ALB ratio was 0.0426. p-value <0.001, there was statistically significant difference found between survivor and Non-Survivor with respect to CRP/Albumin ratio. In assessing secondary outcome statistically significant association was found for need for ventilator and inotropic support, whereas it was insignificant in assessing need for dialysis and length of ICU stay.Conclusions: CRP/albumin ratio, which indicates the extent of residual inflammation, could be used as a prognostic marker in predicting mortality in patients with sepsis and septic shock.

scholarly journals Abnormal Thyroid Function Is Associated With Lymphopenia in Bacterial Sepsis and COVID-19

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A835-A836
Author(s):  
Inge Grondman ◽  
Aline H de Nooijer ◽  
Nikolaos Antonakos ◽  
Nico A F Janssen ◽  
Maria Mouktaroudi ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Plasma Concentrations ◽  
P Value ◽  
Bacterial Sepsis ◽  
Reactive Protein ◽  
Inflammatory Parameters ◽  
Absolute Lymphocyte Counts ◽  
And Function ◽  
Lymphocyte Populations

Abstract Background: Lymphopenia is a key feature of immune dysfunction in bacterial sepsis and COVID-19 patients and is associated with poor clinical outcomes, but the cause is largely unknown. These severely ill patients may also present with thyroid function abnormalities, so-called non-thyroidal illness syndrome (NTIS), and several studies have suggested that TSH, thyroxin (T4) and triiodothyronine (T3) play a crucial role in the homeostatic regulation and function of lymphocyte populations. Aim: The purpose of this study was to test the hypothesis that abnormal thyroid function correlates with lymphopenia in severly ill patients with bacterial sepsis or COVID-19. Methods: Retrospective analysis of absolute lymphocyte counts and circulating TSH, T4, FT4, T3, albumin and inflammatory biomarkers was performed in two independent cohorts of bacterial sepsis (n=224) and hospitalized COVID-19 patients (n=35). Results: Only T3 correlated (rho=0.252, p-value: &lt;0.001) with lymphocyte counts in the bacterial sepsis population and lower concentrations were found in severe lymphopenic compared to non-lympopenic patients (p-value: &lt;0.001; n=56 per group). Severe lymphopenic COVID-19 patients (n=17) showed significantly lower plasma concentrations of TSH, T4, FT4 and T3 (p-value: 0.026, &lt;0.001, 0.001, &lt;0.001, respectively) compared to patients withouth lymphopenia (n=18), and demonstrated significantly increased values of the inflammatory parameters IL-6, C-reactive protein and ferritin (p-value: &lt;0.001, 0.023, and 0.008, respectively). Remarkable, after one week follow-up, the majority of (12/15) COVID-19 patients showed quantitative recovery of their lymphocyte numbers, while TSH and thyroid hormones remained mainly disturbed. Conclusions: Abnormal thyroid function correlates with low lymphocyte counts in severe sepsis and COVID-19 patients, but future studies need to establish whether a causal relationship is involved.

A PROSPECTIVE STUDY OF INTRAOPERATIVE DIFFICULTIES DURING LAPAROSCOPIC CHOLECYSTECTOMY IN DIABETIC PATIENTS

2021 ◽  
pp. 16-18
Author(s):  
Zayd Ashok Rahman ◽  
Harsh Agarwal
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
General Surgeon ◽  
P Value ◽  
Diabetic Patients ◽  
Equal Proportion ◽  
Independent Factor ◽  
Abdominal Adhesions ◽  
Northern India ◽  
The Difference ◽  
A Prospective Study

Introduction: Gall stones are one of the most common problems affecting the digestive tract requiring hospitalization. The disease frequently 1 occurs in young , otherwise healthy people with a prevalence of 11-36% on autopsy report . The reported prevalence of gallstones in northern India is 6.12%. Elective Laparoscopic Cholecystectomy (LC) is one of the most common minimum access surgery performed by General Surgeon. It is 2 indicated for patients with sufcient symptoms from gallstones . In more than 90% of patients, cholecystectomy is curative, leaving them symptom free. Sometimes the procedure is difcult, challenging, time consuming due to various intraoperative difculties. Aims And Objectives: Determine whether or not diabetes as an independent factor can lead to intraoperative difculties during LC. Material And Methods: Study design- ARandomized Prospective Cohort type of study period – September, 2018 to March, 2020 (18 months) Study Area- Ramakrishna Mission Seva Pratishthan hospital, Kolkata, West Bengal. Inclusion Criteria: Patients who are admitted for elective LC in department of General Surgery. Exclusion Criteria: LC performed with other laparoscopic (Ex- with CBD exploration) or open procedures, previous abdominal surgeries, post ERCPpatients. Results: Our study showed that intra-abdominal adhesions (46.7%) and higher proportion of intraoperative bleeding (11%) when compared to non-diabetic patients which had 34.7% patients with intra-abdominal adhesions and only 1.1% patients with intra-operative bleeding but these results were not found to be statistically signicant , in our study dense adhesions around GB was found to be present in equal proportion (3.8%) in both the groups.(P value - 0.999) and haemorrhage from GB fossa was observed in 1.9% of cases in diabetics and 3.8% in non-diabetics , here also the difference was not signicant.(p value 0.6494). Summary And Conclusion: Thus, it can be concluded that diabetes as an independent factor cannot lead to a difcult laparoscopic cholecystectomy. We also found that diabetic patients did not have increased conversion to open surgeries, we also conclude that intra-operative difculties encountered were present in bothdiabetes and non-diabetic patients, the difference in occurrence was not signicant and diabetes is often thought to be a major factor contributing to a difcult LC.

scholarly journals Endometrioma and ART: Does the Needle Work?

2011 ◽  
Vol 2 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Madhuri Patil ◽  
Rashmi P Hagargi
Keyword(s):  
Pregnancy Rates ◽  
P Value ◽  
Gnrh Analog ◽  
Gnrh Analogs ◽  
Significant Difference ◽  
Reproductive Techniques ◽  
Cyst Aspiration ◽  
The Difference ◽  
Group B ◽  
A Prospective Study

ABSTRACT Aim and Objectives The aim of this study was to see if the fertility outcome improved when IVF/ICSI was done after administration of GnRH analogs and cyst aspiration in comparison with patients in whom either only cyst aspiration or only GnRh analogs were administered. Materials and methods This was a prospective study done in a tertiary level ART center which included 30 patients over a span of 5 years from 2004 to 2009. All of them had endometriomas and underwent assisted reproductive techniques (ART) either after cyst aspiration with or without GnRH analog pretreatment or only GnRH analog pretreatment. Depending on the pretreatment received, they were classified into three groups: • Group B: Both GnRH analog and cyst aspiration • Group C: Only cyst aspiration • Group G: Only GnRH analog. The patients were not randomized. The number of days required for stimulation, total dose of stimulation required, number of oocytes obtained, quality of embryos, and the pregnancy rates for each group were tabulated for comparison. Statistical analysis The significance of the difference in ART outcome after the different modalities of pretreatment, which was estimated in terms of pregnancy rates was evaluated by calculating the p-value. Observations and results Significant difference was observed between the pregnancy rates in the three groups, with the maximum pregnancy rate in group B, followed by the group G and then the group C. The p-value showed a trend, though not statistically significant, indicating the need for larger prospective studies with greater number of subjects. Conclusion Pretreating endometriomas by aspirating the cysts and administering three doses of GnRH analog depot preparation prior to IVF/ICSI seems to be better than administering GnRH analog depot preparation alone or aspirating the cysts alone in terms of the number of days required for stimulation, the number of oocytes obtained, and the clinical pregnancy rates.

scholarly journals Teaching Glasgow Coma Scale Assessment by Videos: A Prospective Interventional Study among Surgical Residents

2020 ◽  
Vol 11 (03) ◽  
pp. 381-384
Author(s):  
Jitin Bajaj ◽  
Sanjay Rathore ◽  
Vijay Parihar ◽  
Pawan Agarwal ◽  
Yad Ram Yadav ◽  
...  
Keyword(s):  
Glasgow Coma Scale ◽  
General Surgery ◽  
P Value ◽  
Chi Square ◽  
Coma Scale ◽  
Maximum Benefit ◽  
Before And After ◽  
Chi Square Test ◽  
The Difference ◽  
A Prospective Study

Abstract Objective Glasgow Coma Scale (GCS) assessment is vital for the management of various neurological, neurosurgical, and critical care disorders. Learning GCS scoring needs good training and practice. Due to limitation of teachers, the new entrants of the clinical team find it difficult to learn and use it correctly. Training through videos is being increasingly utilized in the medical field. This study aimed to evaluate the efficiency of video teaching of GCS scoring among general surgery residents. Materials and Methods A prospective study was done utilizing the freely available video at glasgowcomascale.org. The participants (general surgery residents, 1st–3rd year) were asked to assess and record their responses related to GCS both before and after watching the video. A blinded neurosurgeon recorded the correct responses separately. Statistical Analysis The difference between correct responses of the residents before and after watching the video was calculated using the “chi-square test.” p-Value ≤ 0.05 was taken as significant. Results There was a significant improvement in GCS scoring by residents after watching the videos (p < 0.05). On estimating the responses separately, all the three responses (eye, verbal, and motor) improved significantly for 1st-year residents while only the motor response improved significantly for 2nd- and 3rd-year residents. The mode subjective improvement for the 1st-, 2nd-, and 3rd-year residents was 5, 4, and 3, respectively. Conclusion Training GCS scoring through videos is an effective way of teaching the surgery residents with maximum benefit to the junior-most ones.

scholarly journals Evaluation esthetic and functional outcomes after rhinoplasty

2020 ◽  
Vol 6 (2) ◽  
Author(s):  
Falah Abdulla Hussein Hawrami ◽  
Zanyar M. Amin ◽  
Muhammad Mahmood ◽  
Rebwar A. Hama
Keyword(s):  
Outcome Evaluation ◽  
P Value ◽  
Open Rhinoplasty ◽  
Public And Private ◽  
Validated Questionnaire ◽  
Before And After ◽  
Post Operation ◽  
The Mean ◽  
A Prospective Study ◽  
And Function

Objective: The aim of this study was to determine patient satisfaction in regard to nose appearance and function with the use of a validated questionnaire, before and after rhinoplasty surgery. Methods: A prospective study was conducted of all adult patients that underwent open rhinoplasty including other nasal procedures like septoplasty or turbinoplasty between September 2018 and August 2019 in both public and private hospital (Sulaimani Surgical Teaching Hospital and Faruk Medical City).The Rhinoplasty Outcome Evaluation (ROE) questionnaire was used to study the patients' view. Results: 100 patients participated in this study by completing the questionnaires and the follow-up period. The main reasons for rhinoplasty in our patients were: aesthetic 54% (n=54), functional 2 %( n=2), and a combination of both in 44% (n=44) patients The mean ROE score of all patients pre operation was 51.8 (males: 49.04, females 54.74.) and the mean score post operation was 75.22(males 75.64, females 74.81) at six months with no statistically significant gender differences p value=0.79 However, both genders showed a statistically significant improvement between the preoperative and postoperative scores (mean difference = 23.42, P<0.017).In the pre-operative stage, patients recorded worse score for anxious and insecure (p < 0.05). There were no difference for gender, age, cause or literacy level in the mean post-operative scores (p > 0.05). Conclusions: We found that patients who consider themselves anxious before surgery were less satisfied with the result of the procedure. Additionally Rhinoplasty surgery significantly improved patient quality of life regarding nose shape and function.

Motivasi dan kepuasan kerja pegawai puskesmas BLUD dan non-BLUD Kabupaten Semarang

2018 ◽  
Vol 2 (3) ◽  
pp. 111
Author(s):  
Aswindar Adhi Gumilang ◽  
Tri Pitara Mahanggoro ◽  
Qurrotul Aini
Keyword(s):  
Public Health ◽  
Job Satisfaction ◽  
Financial Management ◽  
Work Motivation ◽  
P Value ◽  
The Public ◽  
The Status ◽  
The Difference ◽  
Demand For Health ◽  
Public Demand

The public demand for health service professionalism and transparent financial management made some Puskesmas in Semarang regency changed the status of public health center to BLUD. The implementation of Puskesmas BLUD and non-BLUD requires resources that it can work well in order to meet the expectations of the community. The aim of this study is to know the difference of work motivation and job satisfaction of employees in Puskesmas BLUD and non-BLUD. Method of this research is a comparative descriptive with a quantitative approach. The object of this research are work motivation and job satisfaction of employees in Puskesmas BLUD and non-BLUD Semarang regency. This Research showed that Sig value. (P-value) work motivation variable was 0.019 smaller than α value (0.05). It showed that there was a difference of work motivation of employees in Puskemas BLUD and non-BLUD. Sig value (P-value) variable of job satisfaction was 0.020 smaller than α value (0.05). It showed that there was a difference of job satisfaction of BLUD and non-BLUD. The average of non-BLUD employees motivation were 76.59 smaller than the average of BLUD employees were 78.25. The average of job satisfaction of BLUD employees were 129.20 bigger than the average of non-BLUD employee were 124.26. Job satisfaction of employees in Puskesmas BLUD was higher than non-BLUD employees.

Perbedaan Penggunaan Antikoagulan K2EDTA DAN K3EDTA Terhadap Hasil Pemeriksaan Indeks Eritrosit

2018 ◽  
Vol 1 (2) ◽  
pp. 114
Author(s):  
Wahdaniah Wahdaniah ◽  
Sri Tumpuk
Keyword(s):  
Screening Test ◽  
Venous Blood ◽  
The Body ◽  
Ethylene Diamine ◽  
P Value ◽  
Cross Sectional ◽  
Significant Difference ◽  
Ethylene Diamine Tetra Acetate ◽  
The Difference ◽  
Index Value

Abstract: Routine blood examination is the earliest blood test or screening test to determine the diagnosis of an abnormality. Blood easily froze if it is outside the body and can be prevented by the addition of anticoagulants, one of which Ethylene Diamine Tetra Acetate (EDTA). Currently available vacuum tubes containing EDTA anticoagulants in the form of K2EDTA and K3EDTA. K3EDTA is usually a salt that has better stability than other EDTA salts because it shows a pH approaching a blood pH of about 6.4. The purpose of this research is to know the difference of erythrocyte index results include MCH, MCV and MCHC using K3EDTA anticoagulant with K2EDTA. This research is a cross sectional design. This study used venous blood samples mixed with K2EDTA anticoagulant and venous blood mixed with K3EDTA anticoagulants, each of 30 samples. Data were collected and analyzed using paired different test. Based on data analysis that has been done on MCH examination, p value <0,05 then there is a significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value. Then on the examination of MCV and MCHC obtained p value <0.05 then there is no significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value.Abstrak: Pemeriksaan darah rutin merupakan pemeriksaan darah yang paling awal atau screening test untuk mengetahui diagnosis suatu kelainan. Darah mudah membeku jika berada diluar tubuh dan bisa dicegah dengan penambahan antikoagulan, salah satunya Ethylene Diamine Tetra Acetate (EDTA). Dewasa ini telah tersedia tabung vakum yang sudah berisi antikoagulan EDTA dalam bentuk  K2EDTA dan  K3EDTA. K3EDTA  biasanya berupa garam yang mempunyai stabilitas yang lebih baik dari garam EDTA yang lain karena menunjukkan pH yang mendekati pH darah yaitu sekitar 6,4. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan hasil indeks eritrosit meliputi MCH, MCV dan MCHC menggunakan antikoagulan K3EDTA dengan K2EDTA. Penelitian ini merupakan penelitian dengan desain cross sectional. Penelitian ini menggunakan sampel darah vena yang dicampur dengan antikoagulan K2EDTA dan darah vena yang dicampur dengan antikoagulan K3EDTA, masing-masing sebanyak 30 sampel. Data dikumpulkan dan dianalisis menggunakan uji beda berpasangan. Berdasarkan analisis data yang telah dilakukan pada pemeriksaan MCH didapatkan nilai p < 0,05 maka ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit. Kemudian pada pemeriksaan MCV dan MCHC didapatkan nilai p < 0,05 maka tidak ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit.

EFEITOS DO DEEP RUNNING SOBRE A AMPLITUDE DE MOVIMENTO E A CAPACIDADE FUNCIONAL DOS MEMBROS SUPERIORES DE MULHERES MASTECTOMIZADAS: RELATO DE CASOS

2019 ◽  
pp. 121-131
Keyword(s):  
Range Of Motion ◽  
Upper Limb ◽  
Functional Capacity ◽  
External Rotation ◽  
Treatment Protocol ◽  
Range Of Movement ◽  
Flexion Extension ◽  
Before And After ◽  
In The Beginning ◽  
And Function

Introduction: Breast cancer is the most common type of cancer among women in Brazil and in the worl. The surgical treatment procedure may cause severe morbidity in the upper limb homolateral to surgery, including the reduction of the range of motion, with consequent impairment of function. A physiotherapeutic approach has an important role in the recover range of motion and the functionality of these women, guaranteeing the occupational, domestestic, familiar and conjugated activities, and, in this way, also improving the quality of life. Objectives: To analyse chances in the shoulder's range of motion and the functional capacity of the upper limbs, promoted by the deep running procedure in women with late postoperative mastectomy. Methods: All the patients were submitted to an evaluation in the beginning and end of the treatment, including: goniometry of flexion, extension, abduction, adduction, internal and external rotation of the shoulder joint; and function capacity analysis in activities that involve the upper members by DASH questionnaire. The treatment protocol includes twelve sessions of deep running, realized twice a week, in deep pool, for 20-minute during six weeks. Results: Were submitted to treatment a total of 4 patients. Despite the improvement in the numerical values, statistically significant differences were not found on the range of movements and in the functional capacity of upper members before and after the deep running sessions in post-mastectomy women. Conclusion: Deep running had effects on the numerical values of range of movement and upper limb functionality in women in the late postoperative period of the mastectomy procedure, but without statistically significant differences.

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