scholarly journals Cutaneous fungal infections in subjects with diabetes mellitus

2017 ◽  
Vol 3 (1) ◽  
pp. 55
Author(s):  
Thilak S. ◽  
Anbumalar M. ◽  
Sneha Priya M.
Keyword(s):  
Diabetes Mellitus ◽  
Fungal Infections ◽  
Communicable Disease ◽  
Diabetic Control ◽  
Systematic Screening ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
High Prevalence ◽  
Common Skin ◽  
Tinea Versicolor

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Diabetes mellitus is a chronic non-communicable disease causing an increase in blood glucose levels due to an ineffectiveness or insufficiency of secreted insulin. Infections have also been shown to be the most common skin changes in diabetics. In our study we aim to assess the susceptibility of diabetics to various superficial fungal infections. We will study candidiasis, tinea versicolor and dermatophytic infections in diabetics.</span></p><p class="abstract"><strong>Methods:</strong> 400 diabetic individuals who gave consent were chosen at random from the patients attending the OPD. They were subjected to thorough clinical evaluation. Routine hematological investigations were done. FBS, PPBS, and HBA1C were done to assess diabetic control. Fungal infections were confirmed by KOH mounts.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Of the 400 subjects 220 were male and 180 were female. 52.5% of the subjects had some fungal infections. 55.2% of the fungal infections were candidiasis. 27.6% of the fungal infections were dermatophytic infections. 17.1% of the fungal infections were tinea versicolor infections. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">The study has analysed the epidemiology of cutaneous fungal infections in diabetics. A little over half the diabetics studied proved to have cutaneous fungal infections. Candidiasis was the most frequent form of cutaneous fungal infections accounting for 57% of the fungal infections. Dermatophytic infections were seen in 28% of infections and pityriasis versicolor for 17% of the infections. This high prevalence of cutaneous fungal infections among diabetics merits systematic screening for the same among this target group.</span></p>

scholarly journals Efek Pemberian Buah Naga Merah (Hylocereus Polyrhizus) Terhadap Penurunan Kadar Glukosa Darah Pada Penderita Diabetes Tipe 2

2021 ◽  
Vol 5 (2) ◽  
pp. 97-103
Author(s):  
Yhurike Diah Pitaloka ◽  
Siti Juwariyah
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Communicable Disease ◽  
Public Health Problem ◽  
The Body ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Dragon Fruit ◽  
Reduce Blood Glucose

Diabetes Mellitus is a non-communicable disease and is an important public health problem. Diabetes mellitus is a chronic disease in which the pancreas does not produce enough insulin or when the body is ineffective in using it (WHO, 2016). One of the non-pharmacological management of diabetes mellitus is the administration of red dragon fruit. Dragon fruit is rich in antioxidants and contains many substances such as calcium, beta-carotene, vitamin B1, vitamin B2, vitamin C, phosphorus and flavonoid substances so that it can be used as a therapy to reduce blood glucose levels by preventing apoptosis due to oxidative reactions. The purpose of this case study is to compile a resume of nursing care in giving red dragon fruit to reduce blood glucose levels. This type of research is descriptive with a case study method in the form of a one group pretest posttest design. The subject of this study was 1 patient with diabetes mellitus. The results of the study showed that there was a change in the patient's condition after being given red dragon fruit for 10 days. Conclusion Dragon fruit has the effect of lowering blood glucose levels in people with type 2 diabetes mellitus because it contains fiber that is able to bind water in the intestines, and contains antioxidants and bioactive compounds and is able to inhibit free radical compounds. Keywords: diabetes mellitus, adults, red dragon fruit

scholarly journals Pencegahan Penyakit Diabetes Mellitus melalui Pelatihan Pembuatan Jamu Saintifik bagi Warga Kecamatan Wonokromo Surabaya

2021 ◽  
Vol 4 (1) ◽  
pp. 104
Author(s):  
Devyana Dyah Wulandari ◽  
Hotimah Masdan Salim ◽  
Andreas Putro Ragil Santoso ◽  
Endah Budi Permana Putri
Keyword(s):  
Diabetes Mellitus ◽  
Herbal Medicine ◽  
Communicable Disease ◽  
Public Understanding ◽  
Average Value ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Training Event ◽  
Treatment Of Diabetes ◽  
Community Development Team

Diabetes mellitus is a chronic disease caused by the pancreas not being able to produce enough insulin so that glucose levels in the blood cannot be controlled. Symptoms of this disease are characterized by polyuria, polydipsia, polyphagia and elevated blood glucose levels. Diabetes mellitus is a non-communicable disease that ranks 7th in the world's cause of death and Indonesia is a country with diabetes which is ranked 4th in the world. Prevention and treatment of diabetes mellitus patients can be done through various efforts, one of which is traditional herbal medicine. Therefore, the community development team held a training event for preparation scientific herbs in the context of preventing diabetes mellitus for residents of Wonokromo Surabaya. The results showed that there was an increase in public understanding about the dangers of diabetes mellitus with an increase in the average value from 45% to 90% and an increase in skills in preparation scientific herbal medicine from 40% to 95%. So it can be concluded that this activity brings very good benefits for the residents of Wonokromo Surabaya.

scholarly journals Effect of Flaxseed Extract on the Liver Histological Structure in Streptozotocin Induced Diabetic Rats

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Imad M. Al-Ani ◽  
Ahmed N. Abired ◽  
Basma E. Mustafa ◽  
Emad N. Abdel Wahab ◽  
Marwan S. Azzubaidi
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Liver Weight ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Histological Structure ◽  
Sprague Dawley ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Flaxseed Extract

Introduction: Diabetes mellitus has become a serious warning to mankind health all over the world. The management goal of diabetes is to keep blood glucose levels as close as possible to healthy individuals. Medications used to treat diabetes are usually associated with complications and may cause different side effects. Many traditional anti-diabetic plants have become popular in the management of diabetes mellitus. Flaxseed has been used as traditional medicine for centuries. Objective: This study aimed to evaluate the hepatoprotective effects of flaxseed extract in streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes mellitus was induced in Sprague-Dawley rats using a single injection of streptozotocin (60 mg/kg i.p.). The rats were divided into five groups of 8 rats each. Group NC, normal control rats; Group NF, normal rats treated with flaxseed extract (400 mg/kg); Group DC, diabetic control rats; Group DG, diabetic rats treated with glibenclamide (0.6 mg/kg); Group DF, diabetic rats treated with flaxseed extract (400 mg/kg); for 4 weeks. Results: There were significant increase in relative liver weight, blood glucose levels in DC group comparing to NC group (p<0.05). The disturbance of these parameters was ameliorated in DF and DG groups. Histological observation revealed congestion of central veins, degeneration of hepatocytes, and reduced glycogen granules in DC group. These pathological changes were ameliorated in the flaxseed extract and glibenclamide treated rats. Conclusion: Flaxseed extract may represent a candidate alternative treatment to control diabetes mellitus and its related hepatopathy.

Efeitos dos Programas de Treinamento Aeróbio, de Força e Combinado na Glicose Sanguínea em Diabéticos do Tipo 2: uma Revisão Sistemática/ Effects of Aerobic, Strength and Combined Programs Training on Blood Glucose in Type 2 Diabetic: a Systematic Review.

1970 ◽  
Vol 5 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Alexandre de Souza E Silva ◽  
Maria Paula Gonçalves Mota
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Training Program ◽  
Aerobic Training ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Pubmed Database

O trabalho tem como objetivo analisar os estudos que avaliaram os efeitos dos programas de treinamento aeróbio, força e combinado nos níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Foi utilizado o método de revisão sistemática, sendo utilizada a base de dados PubMed. As palavras chaves utilizadas para pesquisa foram training and diabetes. Foram identificados 484 artigos originais. Apenas 17 estudos respeitaram os critérios de inclusão. Os resultados evidenciam que os programas de treinamento aeróbio diminuíram os níveis de glicose. O programa de treinamento de força também foi favorável à diminuição dos níveis de glicose sanguínea. Já o programa de treinamento combinado não demonstrou efeitos favoráveis no controle da glicose sanguínea. Conclui-se que o programa de treinamento aeróbio e de força ajudam a controlar os níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Palavras-chave: diabetes mellitus, treinamento, glicose.ABSTRACTThe study aims to analyze the studies that evaluated the effects of aerobic, strength and combined programs training in blood glucose levels in people with type 2 diabetes. We used a systematic review method and is used to PubMed database. The key words used for searching were training and diabetes. We identified 484 original articles. Only 17 studies complied with the inclusion criteria. The results show that aerobic training programs decreased glucose levels. The strength training program was also favorable to decrease in blood glucose levels. But the combined training program has not shown favorable effects on blood glucose control. We conclude that the aerobic training and strength helps control blood glucose levels in individuals with type 2 diabetes. Keywords: diabetes mellitus, training, glucose.

scholarly journals Pharmaceutical hit of anti type 2 Diabetes mellitus on the phenolic extract of Malaka (Phyllanthus emblica L.) flesh

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Musri Musman ◽  
Mauli Zakia ◽  
Ratu Fazlia Inda Rahmayani ◽  
Erlidawati Erlidawati ◽  
Safrida Safrida
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Phyllanthus Emblica ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Phenolic Extract

Abstract Background Ethnobotany knowledge in a community has shaped local wisdom in utilizing plants to treat diseases, such as the use of Malaka (Phyllanthus emblica) flesh to treat type 2 diabetes. This study presented evidence that the phenolic extract of the Malaka flesh could reduce blood sugar levels in the diabetic induced rats. Methods The phenolic extract of the P. emblica was administrated to the glucose-induced rats of the Wistar strain Rattus norvegicus for 14 days of treatment where the Metformin was used as a positive control. The data generated were analyzed by the two-way ANOVA Software related to the blood glucose level and by SAS Software related to the histopathological studies at a significant 95% confidence. Results The phenolic extract with concentrations of 100 and 200 mg/kg body weight could reduce blood glucose levels in diabetic rats. The post hoc Dunnet test showed that the administration of the extract to the rats with a concentration of 100 mg/kg body weight demonstrated a very significant decrease in blood glucose levels and repaired damaged cells better than administering the extract at a concentration of 200 mg/kg weight body. Conclusion The evidence indicated that the phenolic extract of the Malaka flesh can be utilized as anti type 2 Diabetes mellitus without damaging other organs.

Searching for Utopia, the Challenge of Standardized Medical Nutrition Therapy Prescription in Gestational Diabetes Mellitus Management: A Critical Review

2021 ◽  
Author(s):  
Nina Meloncelli ◽  
Shelley A. Wilkinson ◽  
Susan de Jersey
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Lifestyle Modification ◽  
Nutrition Therapy ◽  
Medical Nutrition Therapy ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Medical Nutrition

AbstractGestational diabetes mellitus (GDM) is a common pregnancy disorder and the incidence is increasing worldwide. GDM is associated with adverse maternal outcomes which may be reduced with proper management. Lifestyle modification in the form of medical nutrition therapy and physical activity, as well as self-monitoring of blood glucose levels, is the cornerstone of GDM management. Inevitably, the search for the “ultimate” diet prescription has been ongoing. Identifying the amount and type of carbohydrate to maintain blood glucose levels below targets while balancing the nutritional requirements of pregnancy and achieving gestational weight gain within recommendations is challenging. Recent developments in the area of the gut microbiota and its impact on glycemic response add another layer of complexity to the success of medical nutrition therapy. This review critically explores the challenges to dietary prescription for GDM and why utopia may never be found.

scholarly journals Degradation of Incretins and Modulation of Blood Glucose Levels by Periodontopathic Bacterial Dipeptidyl Peptidase 4

2017 ◽  
Vol 85 (9) ◽  
Author(s):  
Yuko Ohara-Nemoto ◽  
Manami Nakasato ◽  
Yu Shimoyama ◽  
Tomomi T. Baba ◽  
Takeshi Kobayakawa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Dipeptidyl Peptidase ◽  
Oral Glucose ◽  
Content Type ◽  
Dipeptidyl Peptidase 4 ◽  
Glucose Levels ◽  
Flight Mass Spectrometry ◽  
Blood Glucose Levels ◽  
Molecular Events

ABSTRACT Severe periodontitis is known to aggravate diabetes mellitus, though molecular events related to that link have not been fully elucidated. Porphyromonas gingivalis, a major pathogen of periodontitis, expresses dipeptidyl peptidase 4 (DPP4), which is involved in regulation of blood glucose levels by cleaving incretins in humans. We examined the enzymatic characteristics of DPP4 from P. gingivalis as well as two other periodontopathic bacteria, Tannerella forsythia and Prevotella intermedia, and determined whether it is capable of regulating blood glucose levels. Cell-associated DPP4 activity was found in those microorganisms, which was effectively suppressed by inhibitors of human DPP4, and molecules sized 73 kDa in P. gingivalis, and 71 kDa in T. forsythia and P. intermedia were immunologically detected. The k cat/Km values of recombinant DPP4s ranged from 721 ± 55 to 1,283 ± 23 μM−1s−1 toward Gly-Pro-4-methylcoumaryl-7-amide (MCA), while those were much lower for His-Ala-MCA. Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) analysis showed His/Tyr-Ala dipeptide release from the N termini of incretins, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide, respectively, with the action of microbial DPP4. Moreover, intravenous injection of DPP4 into mice decreased plasma active GLP-1 and insulin levels, accompanied by a substantial elevation in blood glucose over the control after oral glucose administration. These results are the first to show that periodontopathic bacterial DPP4 is capable of modulating blood glucose levels the same as mammalian DPP4; thus, the incidence of periodontopathic bacteremia may exacerbate diabetes mellitus via molecular events of bacterial DPP4 activities.

Abstract P315: Vascular AT1 Angiotensin Receptors Do Not Contribute to Albuminuria or Hyperfiltration in Diabetes

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Matthew A Sparks ◽  
Stacy Johnson ◽  
Rishav Adhikari ◽  
Edward Diaz ◽  
Aaron Kupin ◽  
...  
Keyword(s):  
Kidney Injury ◽  
Renin Angiotensin System ◽  
Diabetic Control ◽  
Angiotensin Receptors ◽  
Mrna Levels ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference ◽  
Akita Mice ◽  
The Impact

Blockade of the renin angiotensin system (RAS) reduces albuminuria, attenuates hyperfiltration, and slows the progression of diabetic nephropathy (DN) by preventing vasoconstriction and subsequent increases in glomerular hydrostatic pressure. Since RAS blockade disrupts Ang II signaling in all tissues, the specific contribution of vascular actions of AT1 receptors in DN has been difficult to delineate. Therefore, we generated 129 SvEv mice with cell-specific loss of AT1A from VSMCs (SMKOs) using Cre-loxp . To eliminate AT1R from VSMCs, we crossed the SMKO mice with AT1BR -/- mice, lacking the minor AT1B isoform. To study the impact of vascular AT1R in DN, we crossed the AT1B- null SMKOs with mice having the Ins2 C96Y AKITA mutation, which develop DM1 early. To enhance kidney injury, mice underwent uninephrectomy (UNX) at 11wks. Blood glucose levels were elevated (~500mg/dL) and similar at 10, 16 and 24wks between the two groups. Prior to UNX, albuminuria was similar between Control AKITA and AT1B- null SMKO AKITA (62±10 Control AKITA versus 107±27 μg/24hrs SMKO AKITA, P=NS). Albuminuria increased with age in both Control Akita and AT1B- null SMKO AKITA but without significant differences between the groups at 16wks (307±106 vs 313±117 μg/24hrs; P=NS) or 24wks (494±236 versus 730±217 μg/24hrs; P=NS), despite a trend toward higher albuminuria in AT1B- null SMKO AKITAs. There was no significant difference in GFR (using FITC-inulin) between non-diabetic Control and AT1B- null SMKO (15.6±1.2 vs 14.8±0.8 μl/min/g BW), and hyperfiltration was observed in both Control AKITA (23.7±2.4 μl/min/g BW; P=0.003) and AT1B- null SMKO AKITA mice (20.7±1.7 μl/min/g BW; P=0.01) relative to their non-diabetic comparators. However, there was no significant difference in GFR between ControlAKITA and AT1B- null SMKO AKITA (P=NS). Finally we measured mRNA levels of putative kidney injury markers by RTqPCR and found no differences in levels of Col1A1 , NGAL , or TGFB1 mRNA between Control AKITA and AT1B null SMKO AKITA. Our studies indicate that the absence of vascular AT1R responses is not sufficient to reduce albuminuria and prevent hyperfiltration in a mouse model of DN. This suggests that blockade of AT1R in other cell lineages may contribute to beneficial actions of ARBs in DN.

Association of Acrochordons with Diabetes Mellitus - A Hospital based Case Control Study

2021 ◽  
Vol 4 (1) ◽  
pp. 51-60
Author(s):  
Sunita Karki ◽  
Anjan Rai ◽  
Manish Pradhan
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Postprandial Glucose ◽  
Early Screening ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Increased Risk ◽  
Skin Tags ◽  
And Gender ◽  
Control Study

Introduction Acrochordons or skin tags are common benign cutaneous tumors that occur especially over the neck and major flexures. A possible association between diabetes mellitus and dyslipidemia is observed in numerous past studies with varying results. We aim to find out the association of diabetes mellitus with acrochordons Methods: One hundred patients were enrolled in our study. Among them, 50 (27 males and 23 females) with skin tags were selected as cases and 50 with other dermatologic diseases after matching age and gender were taken as controls. Blood glucose levels including both fasting and postprandial glucose levels were determined for both cases and controls and compared. Results: There was a higher frequency of Diabetes Mellitus and impaired glucose tolerance in patients with skin tags in comparison to controls (p<0.001). Moreover, there were higher odds of acquiring skin tags in patient with abnormal blood glucose levels. Conclusions: There is an increased risk of developing DM in patients with skin tags. It is highly recommended that suspicion for Diabetes Mellitus is to be done in patients with skin tags for early screening and diagnosis of Diabetes.

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