scholarly journals Chromobacterium violaceum causing neonatal osteomyelitis – A case report from Kerala

2021 ◽  
Vol 7 (3) ◽  
pp. 213-214
Author(s):  
Rafeeda K M ◽  
Geethanjali M
Keyword(s):  
Case Report ◽  
Mortality Rates ◽  
Skin Infections ◽  
Stagnant Water ◽  
Gram Negative ◽  
First Case ◽  
Facultative Anaerobic ◽  
Life Threatening ◽  
Tract Infections ◽  
Human Infections

is facultative anaerobic, motile, oxidase positive gram negative bacilli which is a normal inhabitant of soil and stagnant water of the tropical and subtropical areas. Human infections caused by is very uncommon with only a few cases reported in the literature, the first case being described by JE Lesslarin in 1927 in Malaya. In humans, infections ranging from life threatening sepsis with metastatic abscesses to skin infections and urinary tract infections can be caused by . High mortality rates are associated with these infections. So it is very essential to diagnosis and treat with appropriate antibiotic at the earliest. Here we report a case of neonatal osteomyelitis by and could prevent sepsis by adequate antibiotic therapy and intensive treatment.

scholarly journals Chromobacterium violaceum Periareolar Infection, First Non-Lethal Case in Colombia: Case Report and Literature Review

2021 ◽  
Vol 13 (2) ◽  
pp. 571-581
Author(s):  
Diego Alejandro Cubides Diaz ◽  
Daniel Arsanios Martin ◽  
Nicolas Bernal Ortiz ◽  
Ana Lucia Ovalle Monroy ◽  
Valentina Hernandez Angarita ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Kidney Disease ◽  
Clinical Manifestations ◽  
Chromobacterium Violaceum ◽  
Polycystic Kidney ◽  
Gram Negative ◽  
Lethal Infection ◽  
Facultative Anaerobic ◽  
Human Infections

Chromobacterium violaceum is a facultative anaerobic, Gram-negative rod found in different ecosystems, especially tropical and subtropical areas. Human infections are rare, and just a few cases have been reported in literature. In this paper, we present the first non-lethal infection due to Chromobacterium violaceum, in an adult male with polycystic kidney disease in Colombia. Periareolar soft tissue infection was documented with isolation of Chromobacterium violaceum. Clinical manifestations, treatment, and outcome are shown.

scholarly journals The First Case Report of Endocarditis Caused by Serratia fonticola

2021 ◽  
Vol 9 ◽  
pp. 232470962110449
Author(s):  
Valerie Espinoza ◽  
Michael Valdez ◽  
Serghei Burcovschii ◽  
Isabel Fong ◽  
Greti Petersen ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Lower Extremity ◽  
Antibiotic Therapy ◽  
Uneventful Recovery ◽  
Review Of The Literature ◽  
Transesophageal Echocardiogram ◽  
First Case ◽  
Tract Infections ◽  
Human Infections

The cases of human infections caused by Serratia fonticola are relatively rare. The few cases that have been reported primarily describe skin and soft tissue, urinary, and biliary tract infections. We describe a case of a 59-year-old man with infected bilateral lower extremity wounds who developed endocarditis due to S fonticola confirmed with transesophageal echocardiogram. The patient was treated with 6 weeks of antibiotic therapy and had an uneventful recovery. After a thorough review of the literature using PubMed and Google Scholar, we concluded that this is the first reported case of endocarditis caused by S fonticola.

Adult Presentation of a Familial-Associated Vein of Galen Aneurysmal Malformation: Case Report

Neurosurgery ◽  
2010 ◽  
Vol 67 (6) ◽  
pp. E1845-E1851 ◽  
Author(s):  
David S Xu ◽  
Asad A Usman ◽  
Michael C Hurley ◽  
Christopher S Eddleman ◽  
Bernard R Bendok
Keyword(s):  
Case Report ◽  
Natural History ◽  
Vein Of Galen ◽  
Review Of The Literature ◽  
Time Resolved ◽  
Presenting Symptoms ◽  
First Case ◽  
Life Threatening ◽  
History Of ◽  
Asymptomatic Adult

Abstract BACKGROUND AND IMPORTANCE: Vein of Galen aneurysmal malformations (VGAMs) arise from persistent arteriovenous shunting from primitive choroidal vessels into the median prosencephalic vein of Markowski, the embryonic precursor of the vein of Galen. VGAMs rarely present past infancy, and their natural history in adults is unknown. We report the first case of a familial-associated VGAM in an asymptomatic adult female patient. The clinical features of this case are presented alongside a systematic review of the literature on adult VGAM cases to assess the natural history, clinical management, and genetic basis of this rare neurovascular lesion. CLINICAL PRESENTATION: A previously healthy 44-year-old woman with a family history of a VGAM in a stillborn presented with an 8-week onset of dizziness and vertigo that spontaneously resolved. Time-resolved magnetic resonance angiography identified a choroidal VGAM. No intervention was undertaken at this time because of the patient's asymptomatic status after 9 months of follow-up. CONCLUSION: Based on our review of the literature, this is the first case report of a familial-associated VGAM in an adult patient and suggests that VGAM development can be genetically linked. Of 15 adult VGAM cases previously reported, all patients were either symptomatic or treated, thus precluding determination of VGAM natural history in adults. Patient outcomes correlated with the severity of presenting symptoms, which ranged from asymptomatic to immediately life-threatening. We hypothesize that self-selection may render VGAMs to be more benign for them to persist past childhood. Further investigation of the molecular biology underlying VGAM development is warranted.

scholarly journals Cedecea lapagei An Extremely Rare Uropathogen: A Case Report and Review of the Literature

2021 ◽  
Author(s):  
Abdikarim Hussein Mohamed ◽  
Hussein Ali Mohamud
Keyword(s):  
Renal Failure ◽  
Case Report ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Beta Lactam ◽  
Gram Negative ◽  
Beta Lactamases ◽  
Extended Spectrum ◽  
Extended Spectrum Beta Lactamases ◽  
Tract Infections

Abstract Background: Gram-negative enterobacteria are the most common cause of urinary tract infections. Cedecea is a new separate genus in the family enterobacteriaceae, and it is a very rare pathogen that was primarily found in the respiratory tract. Cedecea lapagei is a very rare pathogen of urinary tract infections. To the best of our knowledge, this is the first case report in the world reported in English literature. Case presentation: A 55 years old man with chronic renal failure, poorly controlled diabetes mellitus, and hypertension presented with acute exacerbations of renal failure and irritative voiding symptoms. After stabilization and empirical antibiotic therapy with Ceftriaxone, the patient’s condition was not improved and deteriorated progressively. After the request of urine culture, the culture was isolated, an extremely rare uropathogen recently recognized by the Centers for Disease Control and Prevention (CDC); the Cedecea lapagei. Cedecea lapagei identification had been done using Eosin methylene blue agar (EMB). Gram-negative lipase positive bacteria with bacillus in shape, motile in nature that is non-spore-forming, and non-encapsulated enterobacteria with the final result of >100,000 colony-forming units per ml of Cedecea lapagei were isolated. Mueller-Hinton agar had been used to perform antimicrobial sensitivity and resistance. The pathogen was extensively resistant to the extended-spectrum beta-lactamases antibiotics and extended-spectrum beta-lactam inhibitors while carbapenems, fluoroquinolones, aminoglycosides, and Trimethoprim-sulfamethoxazole showed a higher sensitivity rate. Conclusion: The treatment of Cedecea lapagei infections represents a challenging issue due to its multi-drug resistant and extensive drug resistance patterns to a variety of antimicrobial classes, such as extended-spectrum beta-lactamases, cephalosporins, and beta-lactam inhibitors. Antimicrobial treatment should be aligned with the culture findings once available.

Abacavir Hypersensitivity Reaction: The First Case Report in Thailand and Literature Review

2021 ◽  
Vol 104 (1) ◽  
pp. 159-163
Keyword(s):  
Developing Countries ◽  
Case Report ◽  
Hypersensitivity Reaction ◽  
Screening Test ◽  
Blood Test ◽  
Clinical Presentation ◽  
Health Security ◽  
First Case ◽  
Threatening Condition ◽  
Life Threatening

Abacavir-related hypersensitivity reaction (ABC-HSR) is a life-threatening condition. The incidence is low since it could have been prevented by screening with blood test for HLA-B*5701, which is strongly associated with this reaction. However, the affordability for the HLA-B*5701 screening test is still a challenging issue in many developing countries. Thai National Health Security Office (NHSO) recommends either using HLA-B*5701 as a screening test or monitoring clinical presentation for ABC-HSR after using it. Therefore, the clinical presentation of ABC-HSR should be acknowledged for the diagnosis of this condition and death prevention. This was the first reported case and literature reviewed of ABC-HSR associated with the presence of the HLA-B*5701 allele in Thailand. Keywords: Abacavir, Hypersensitivity reaction, HLA-B*5701, Clinical presentation, Thailand

Doxycycline-Induced Gastric Perforation

2021 ◽  
pp. 000313482110474
Author(s):  
Yeahwa Hong ◽  
Christopher Staniorski ◽  
Dean Pollack ◽  
Steven Evans
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Chest Pain ◽  
Adverse Effects ◽  
Diagnostic Criteria ◽  
Gastric Perforation ◽  
Mucosal Injury ◽  
First Case ◽  
Life Threatening

Esophageal and gastric mucosal injuries are well-documented adverse effects of doxycycline leading to odynophagia, chest pain, and abdominal pain. There are no clear diagnostic criteria for such adverse effects; hence, the diagnosis depends heavily on thorough history. There is a paucity of literature describing life-threatening complications from doxycycline-induced mucosal injury, such as hemorrhage and perforation. We present the first case report describing a gastric perforation from doxycycline use.

scholarly journals Whole genome sequencing provides genomic insights into three Morganella morganii strains isolated from bovine rectal swabs in Dhaka, Bangladesh

2020 ◽  
Vol 367 (6) ◽  
Author(s):  
Aura Rahman ◽  
Omar Faruk Bhuiyan ◽  
Abdus Sadique ◽  
Tamanna Afroze ◽  
Mrinmoy Sarker ◽  
...  
Keyword(s):  
Metabolic Pathways ◽  
Anaerobic Bacterium ◽  
Opportunistic Pathogen ◽  
Genomic Islands ◽  
Morganella Morganii ◽  
Gram Negative ◽  
Facultative Anaerobic ◽  
Animal Hosts ◽  
Tract Infections ◽  
Ubiquitous Presence

ABSTRACT Morganella morganii, a gram negative, facultative anaerobic bacterium belonging to the Proteeae tribe of the Morganellaceae family, is an unusual opportunistic pathogen mainly responsible for nosocomial and urinary tract infections. While cattle have long been established as a source of a few zoonotic pathogens, no such data has been recorded for M. morganii despite its ubiquitous presence in nature and a number of animal hosts. In this study, draft genomes were produced of three M. morganii isolates from Bangladeshi cattle. The three isolates, named B2, B3 and B5, possessed an average genome size of 3.9 Mp, a GC% of ∼51% and pan and core genomes of 4637 and 3812 genes, respectively. All strains were bearers of the qnrD1 carrying plasmid Col3M and possessed roughly similar virulence profiles and prophage regions. The strains also carried genes that were unique when compared with other publicly available M. morganii genomes. Many of these genes belonged to metabolic pathways associated with adaptation to environmental stresses and were predicted in silico to be borne in genomic islands. The findings of this study expand on the current understanding of M. morganii’'s genomic nature and its adaptation in cattle.

scholarly journals Idarucizumab to revert the anticoagulant effect of dabigatran in traumatic acute subdural haematoma: a case report of first use in Latin America

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Raúl Izaguirre Ávila ◽  
José Eduardo Bahena López ◽  
Evelyn Cortina de la Rosa ◽  
Miguel Ángel Hernández Márquez
Keyword(s):  
Latin America ◽  
Case Report ◽  
Emergency Surgery ◽  
Subdural Haematoma ◽  
Vitamin K Antagonists ◽  
Attractive Alternative ◽  
Venous Disease ◽  
First Case ◽  
Increased Risk ◽  
Life Threatening

Abstract Background  Direct oral anticoagulants (DOAC) are an attractive alternative over vitamin K antagonists. They have several advantages in primary and secondary prevention of thromboembolisms due to atrial fibrillation, as well as in prevention and treatment of thromboembolic venous disease. They have fast onset action, do not need laboratory controls in patients with normal renal function, and they have practically no interference with the patient’s diet or medications. The strongest objection to their use was the lack of reversal agents that could be used in case of life-threatening haemorrhage or the need for emergency surgery. Dabigatran was the first DOAC to have its own specific reversal agent: idarucizumab, a monoclonal antibody. Case summary  We report here the case of a patient undergoing treatment with dabigatran that suffered an expansive subdural haematoma secondary to a cranial injury. The condition was life-threatening and required emergency surgery. Anticoagulation was successfully reversed with idarucizumab. Discussion  Emergency surgery in patients in treatment with DOAC is associated with an increased risk of bleeding. With the use of a specific antidote to block the action of the anticoagulant, as in the case of idarucizumab with dabigatran, the risk of complications during and after emergency surgery is reduced. This is the first case report with which the successful use of idarucizumab in Latin America is documented.

scholarly journals Idiopathic aplastic anemia: a rare case report in Jammu and Kashmir region, India

2019 ◽  
Vol 8 (6) ◽  
pp. 2559
Author(s):  
Smriti Sharma ◽  
Upma . ◽  
Deep Mani
Keyword(s):  
Case Report ◽  
Aplastic Anemia ◽  
Rare Case ◽  
Immunosuppressive Agents ◽  
Unknown Origin ◽  
Normal Incidence ◽  
Jammu And Kashmir ◽  
First Case ◽  
Rare Case Report ◽  
Life Threatening

Idiopathic aplastic anemia is a pancytopenia disorder that is a rare but life threatening for both mother and fetus during pregnancy. Association of aplastic anemia with pregnancy is unclear but considered to be interrelated. Bone marrow transplantation is the most effective treatment for adult aplastic anemia but is inadvisable to perform during pregnancy because of the teratogenic effect of immunosuppressive agents or radiation therapy to the growing fetus. Supportive care, withdrawal from offending drugs and involving erythrocytes and platelets transfusion is a promising way to save the life. Here author present a case report of 36-year-old lady with idiopathy aplastic anemia. In this case medical investigation revealed severe anemia of unknown origin. The patient was treated with hematinics, blood transfusion and glucocorticoids. A healthy baby was delivered without evidence of hemolysis at her eight month and one week of pregnancy, the patient recovered and discharged with normal incidence. Being a rare case, it becomes a necessity to report such life-threatening disorder and management. Moreover, to our knowledge this is the first case reported of its kind from Jammu and Kashmir Division of India.

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