scholarly journals Fourier analysis of corneal Scheimpflug imaging: clinical use in keratoconus

2021 ◽  
Vol 14 (12) ◽  
pp. 1963-1969
Author(s):  
Dorukcan Akincioglu ◽  
◽  
Onder Ayyildiz ◽  
Gokcen Gokce ◽  
Umut Karaca ◽  
...  
Keyword(s):  
Fourier Analysis ◽  
Predictive Accuracy ◽  
Area Under The Curve ◽  
Binary Logistic Regression ◽  
Binary Logistic Regression Analysis ◽  
Diagnostic Model ◽  
Clinical Use ◽  
Ocular Surgery ◽  
Model Combining ◽  
History Of

AIM: To evaluate the clinical use of Fourier analysis of videokeratography data in the diagnosis and follow-up of keratoconus (KC). METHODS: We conducted a chart review of consecutive patients presented to our cornea clinic. A team of two experienced cornea specialists divided the patients into three groups: normal cornea, forme fruste KC (FFKC), and clinical KC. The exclusion criteria were a history of previous ocular surgery, any accompanying corneal pathology other than KC, high myopia (>6.00 diopters), amblyopia, pregnancy, breastfeeding, or any current autoimmune disease. The data of Fourier series harmonic analysis were evaluated for their diagnostic capacity using the receiver operating characteristic (ROC) curve. A binary logistic regression analysis was also conducted to construct a diagnostic model. A total of 259 eyes showed progression in the clinical KC group and underwent a combination of accelerated corneal collagen cross-linking and topography-guided customized treatment with an excimer laser. RESULTS: The study included 1262 eyes (618 normal, 530 KC, and 114 FFKC) of 1262 patients. We observed that maximum decentration (MaxDec) was almost as good as maximum keratometry (Kmax) in detecting progressive KC. The area under the curve (AUC) was 0.95 for KC [95% confidence interval (CI): 0.93-0.96] and 0.84 for FFKC (95%CI: 0.79-0.88). Higher predictive accuracy was obtained using a model combining the spherical component, MaxDec, irregularity, and regular astigmatism in the center of the cornea (AUC: 0.97; sensitivity: 89%, and specificity: 96%). CONCLUSION: Decentration, Kmax, and posterior radii of curvatures from a 3.0-mm optical zone centered on the thinnest point of the cornea provide the highest accuracy with low reproducibility of Kmax.

Clinical Factors Associated with the Diagnosis of Granulomatosis with Polyangiitis

2017 ◽  
Vol 156 (3) ◽  
pp. 484-488 ◽  
Author(s):  
Erdem Eren ◽  
Toygar Kalkan ◽  
Seçil Arslanoğlu ◽  
Mustafa Özmen ◽  
Kazım Önal ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Nasal Mucosa ◽  
Odds Ratio ◽  
Granulomatosis With Polyangiitis ◽  
Univariate Analysis ◽  
Binary Logistic Regression ◽  
Binary Logistic Regression Analysis ◽  
Significant Difference ◽  
History Of

Objective To determine the predictive value of nasal endoscopic findings and symptoms in the diagnosis of granulomatosis with polyangiitis (GPA). Study Design A cross-sectional study. Setting A tertiary university hospital. Subjects and Methods A total of 116 adults were enrolled in the study: 19 patients with GPA, 29 patients with other rheumatic diseases, and 68 healthy volunteers. All patients were examined with a flexible endoscope, and nasal endoscopic images were recorded and evaluated blindly. The medical history of each patient was taken by a physician blinded to the patient’s diagnosis. Results Univariate analysis indicated a statistically significant difference in rhinorrhea ( P = .002), postnasal drip ( P = .015), epistaxis ( P < .001), and saddle nose ( P = .017). However, binary logistic regression analysis demonstrated that only history of epistaxis ( P = .012; odds ratio, 5.6) was statistically significant in predicting GPA. Univariate analysis showed a statistically significant difference in nasal secretion ( P = .028), nasal septal perforation ( P < .017), nasal crusting ( P < .001), nasal adhesion ( P < .001), nasal granuloma ( P = .017), and hemorrhagic fragile nasal mucosa ( P < .001). A binary logistic regression analysis demonstrated that only hemorrhagic fragile nasal mucosa ( P < .001; odds ratio, 52.9) was a statistically significant predictor of GPA. Conclusions Given the results of this study, we believe that hemorrhagic fragile nasal mucosa and history of recurrent epistaxis may put patients at risk for GPA and should be investigated accordingly.

scholarly journals Menopause and Metabolic Syndrome in Tunisian Women

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Samir Ben Ali ◽  
Hanen Belfki-Benali ◽  
Hajer Aounallah-Skhiri ◽  
Pierre Traissac ◽  
Bernard Maire ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Plasma Lipids ◽  
Fasting Glucose ◽  
Menopausal Status ◽  
Premenopausal Women ◽  
Binary Logistic Regression ◽  
Binary Logistic Regression Analysis ◽  
Mean Values ◽  
History Of

Objectives. This study aimed to evaluate the effect of menopausal status on the risk of metabolic syndrome (MetS) in Tunisian women.Methods. We analyzed a total of 2680 women aged between 35 and 70 years. Blood pressure, anthropometric indices, fasting glucose, and lipid profile were measured. The MetS was assessed by the modified NCEP-ATPIII definition.Results. The mean values of waist circumference, blood pressure, plasma lipids, and fasting glucose were significantly higher in postmenopausal than in premenopausal women, a difference that was no longer present when adjusting for age. Except for hypertriglyceridaemia, the frequency of central obesity, hyperglycemia, high blood pressure, and high total cholesterol was significantly higher in postmenopausal than in premenopausal women. After adjusting for age, the significance persisted only for hyperglycemia. The overall prevalence of MetS was 35.9%, higher in postmenopausal (45.7% versus 25.6%) than in premenopausal women. A binary logistic regression analysis showed that menopause was independently associated with MetS (OR = 1.41, 95% CI 1.10–1.82) after adjusting for age, residence area, marital status, family history of cardiovascular disease, education level, and occupation.Conclusions. The present study provides evidence that the MetS is highly prevalent in this group of women. Menopause can be a predictor of MetS independent of age in Tunisian women.

scholarly journals Declined ELABELA plasma levels in hypertension patients with atrial fibrillation: a case control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zheng Ma ◽  
Lei Zhao ◽  
Ye-ping Zhang ◽  
Jiu-chang Zhong ◽  
Xin-chun Yang
Keyword(s):  
Atrial Fibrillation ◽  
Heart Disease ◽  
Plasma Levels ◽  
Left Atrial ◽  
Binary Logistic Regression ◽  
Binary Logistic Regression Analysis ◽  
Related Factors ◽  
History Of ◽  
Underlying Risk Factor ◽  
Laboratory Examinations

Abstract Background Atrial fibrillation (AF) is a common arrhythmia in patients with hypertension. ELABELA, which has cardioprotective effects, is decreased in the plasma of patients with hypertension and might be associated with AF in the hypertensive population. This study aims to measure the ELABELA plasma levels in hypertension patients with and without AF and to analyse the related factors. Methods A total of 162 hypertension patients with or without AF were recruited for our monocentric observational study. Subjects were excluded if they had a history of valvular heart disease, rheumatic heart disease, cardiomyopathy, thyroid diseases, or heart failure. The patients’ histories were recorded, and laboratory examinations were conducted. Plasma ELABELA was detected by immunoassay. Echocardiographs were performed, and parameters were collected by two experienced doctors. Binary logistic regression analysis was used to identify the association between ELABELA plasma level and AF in patients with hypertension. Results Plasma ELABELA levels were lower in hypertension patients with AF than in those without AF (2.0 [1.5, 2.8] vs. 4.0 [3.4, 5.0] ng/ml, P < 0.001). ELABELA levels were correlated with age, heart rate, BNP levels and left atrial dimension. In addition to the left atrial dimension, ELABELA plasma levels were associated with AF in patients with hypertension (OR 0.081, 95% CI 0.029–0.224, P < 0.001). ELABELA levels were further decreased in the persistent AF subgroup compared with the paroxysmal AF subgroup (1.8 [1.4, 2.5] vs. 2.2 [1.8, 3.0] ng/ml, P = 0.012) and correlated with HR, BNP and ESR levels. Conclusions ELALABELA levels were decreased in hypertension patients with AF and further lowered in the persistent AF subgroup. Decreased ELABELA plasma levels were associated with AF in hypertension patients and may be an underlying risk factor.

scholarly journals AFP and CA-125 as an accurate risk factor to predict eye metastasis in hypertension patients with liver Carcinoma： A STROBE-compliant article

2021 ◽  
Author(s):  
Jing Tang ◽  
Li-Juan Zhang ◽  
Yan-Cheng Huang ◽  
Rong Huang ◽  
Hui-Ye Shu ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Liver Cancer ◽  
Cancer Metastasis ◽  
Binary Logistic Regression ◽  
Receiver Operating Curve ◽  
Ca 125 ◽  
Liver Carcinoma ◽  
Binary Logistic Regression Analysis ◽  
History Of ◽  
Ocular Metastasis

Abstract Purpose Primary liver carcinoma is a common malignant tumor. In this study, we analyzed the differences between hypertension patients with ocular metastasis of liver cancer and those with metastases to other sites, the correlation between history of HBV and liver cancer metastasis, and independent risk factors for ocular metastasis. METHODS We used treatment records from 488 patients with metastases of primary liver cancer from August 2001 to May 2015, divided into two groups based on metastatic sites: OM (ocular metastasis) and NOM (non-ocular, other sites of metastasis) groups. The Student’s t-test and Chi-square test were used to assess the significance of differences between the groups and define the relationship between history of HBV and ocular metastasis of liver cancer. Binary logistic regression analysis was used to identify indicators of ocular metastasis of liver cancer and receiver operating curve (ROC) analyses to estimate their diagnostic value. RESULTS No significant differences in sex, age, tumor stage, pathological type, or treatment were identified between the OM and NOM groups, while the prevalence of HBV was higher in the former than that in latter, confirming the association between history of HBV and ocular metastasis. Binary logistic regression demonstrated that AFP and CA-125 were independent indicators of liver metastasis (both P < 0.001). ROC curve analyses generated cut-off values for AFP and CA-125 of 957.2 ng/ml and 114.25 U/ml, respectively, with corresponding AUC values of 0.739 and 0.810. The specificity of the combination of AFP and CA-125 was higher than either factor separately.

scholarly journals Clinical Observation of the Correlation Between Overactive Bladder and Atopic Constitution in Children

2021 ◽  
Vol 9 ◽  
Author(s):  
Yue Zheng ◽  
Zhou Zhang ◽  
Ling Hou ◽  
Xiuli Wang ◽  
Kailei Jiang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Allergic Rhinitis ◽  
Overactive Bladder ◽  
Statistical Significance ◽  
Binary Logistic Regression ◽  
Binary Logistic Regression Analysis ◽  
Total Blood ◽  
Before And After ◽  
History Of ◽  
The Difference

Objective: The present study aimed to analyze the risk factors correlated with overactive bladder (OAB), observe the effects of desloratadine in the treatment of OAB, and explore the correlation between OAB and atopic constitution in children.Methods: Correlation and binary logistic regression analysis of the medical data from 447 children clinically diagnosed with OAB from June 2019 to June 2020 were conducted. The data included a history of urticaria, eczema, itchy skin, and allergic rhinitis or allergic cough. The OABSS scores before and after treatment with desloratadine were compared to evaluate the effectiveness of desloratadine for OAB.Results: The risk factors for OAB in children included eczema, allergic rhinitis or allergic cough, itchy skin, and the levels of total blood IgE. Desloratadine was 96.5% effective in treating cases with risk factors including eczema, allergic rhinitis or allergic cough, and itchy skin. There existed statistical significance in the difference in OABSS scores before and after the treatment of desloratadine (P &lt; 0.05).Conclusion: OAB in children was correlated with atopic manifestations such as eczema, itchy skin, allergic rhinitis, or allergic cough. Desloratadine was safe and effective in the treatment of OAB in children with atopic manifestations.

scholarly journals Mycoplasma pneumoniae and Recurrent Respiratory Tract Infection Within One Year After Treatment in Infants: Risk Factors and Prevalence

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Cheng-Yi Wang ◽  
Chao-Min Song ◽  
Guang-Hua Liu
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Respiratory Tract ◽  
Mycoplasma Pneumoniae ◽  
Significant Risk ◽  
Binary Logistic Regression ◽  
Binary Logistic Regression Analysis ◽  
History Of ◽  
One Year ◽  
Tract Infections

Background: Mycoplasma pneumoniae pneumonia (MPP) is common in pediatric patients. Many studies showed that recurrent respiratory tract infections (RRTIs) are common in the year following treatment of MPP in infants, but the factors associated with the occurrence of RRTIs are rarely reported. Therefore, the present study aimed to identify these factors. Methods: This retrospective observational study included infants (< one year) who were clinically treated for MPP from January 2015 to December 2018. Clinical features and relevant data were collected on admission. The cases of the occurrence of RRTIs and the presence of related factors after one year of follow-up were investigated by questionnaires. The questionnaires contained the number of upper respiratory infections, tracheobronchitis, and pneumonia, the titers and course of MP-IgG and positive IgM antibody, eczema, pet ownership, interior decoration, inhaled or ingested allergens, exposure to environmental tobacco smoke, and gastrointestinal function. Independent significant risk factors for RRTIs were identified using binary logistic regression. Results: A total of 300 MPP cases were included, among which RRTIs occurred in 134 (44.7%) cases in the year following MPP treatment. Binary logistic regression analysis showed that a history of prematurity (OR = 6.336, 95% CI: 2.337 - 17.116, P ≤ 0.001), a history of exposure to inhaled or ingested allergens (OR = 2.527, 95% CI: 1.289 - 4.956, P = 0.007), and co-infection involving Chlamydia pneumoniae (OR = 2.787, 95% CI: 1.145 - 6.784, P = 0.024) were significantly and positively associated with RRTIs after MPP, while age (OR = 0.894, 95% CI: 0.825 - 0.970, P = 0.007) showed a negative correlation with RRTIs. Conclusions: RRTIs in the year following clinical treatment of MPP in infants are relatively common and significantly associated with the patient’s age, history of prematurity, history of exposure to inhaled or ingested allergens, and C. pneumoniae co-infection. Thus, these factors should be carefully assessed in pediatric MPP cases to predict the risk of RRTIs and appropriately manage the patient.

scholarly journals ADL Recovery Trajectory after Discharge and its Predictors among Baseline-Independent Older Inpatients

2019 ◽  
Author(s):  
Xiuyue Li ◽  
Tingting Zheng ◽  
Yaqi Guan ◽  
Hui Li ◽  
Kexin Zhu ◽  
...  
Keyword(s):  
Recovery Rate ◽  
Older Patients ◽  
Area Under The Curve ◽  
Binary Logistic Regression ◽  
Binary Logistic Regression Analysis ◽  
Cluster Sampling ◽  
Roc Curve Analysis ◽  
Post Discharge ◽  
Chi Square ◽  
Recovery Trajectory

Abstract Background Among the previous studies about the ADL recovery and its predictors,the researches and resources used to study and protect the baseline-independent older patients from being permanently ADL-dependent was few. We aimed to describe the level of activities of daily living (ADL) at discharge and ADL change within 6 months after discharge in older patients who were ADL-independent before admission but became dependent because of acute illness, and to identify the predictors of early rehabilitation,so as to provide the basis to early intervention. Methods Stratified cluster sampling was used to recruit 520 hospitalised older patients who were ADL-independent from departments of internal medicine at two tertiary hospitals from August 2017 to May 2018. Demographics, clinical data, and ADL status at 1, 3, and 6 months after discharge were collected. Data were analysed using descriptive statistics, Student’s t-test,Pearson’s chi-square test,Spearman’s correlation analysis, binary logistic regression analysis, and receiver operating characteristic (ROC) curve analysis. Results There were 403 out of 520 patients completing the 6-month follow-up, and 229 (56.8%) regained independence at 6 months after discharge. There was an overall increasing trend in ADL with time. The recovery rate was the highest within the first month after discharge, gradually declined after 1 month, and changed less obviously from 3 to 6 months after discharge (P<0.001). ADL score at discharge (OR=1.034, P<0.001), age (OR=0.269, P=0.001), post-discharge residence (OR=0.390, P<0.05), and cognition status at discharge(OR=1.685, P<0.05) were predictors of ADL recovery. The area under the curve of the four predictors combined was 0.763 (P<0.001). Conclusion Studying ADL recovery rate and its predicting indicators of the baseline independent inpatients at different time points provide a theoretical reference for the formulation of nursing plans and allocation of care resources.

scholarly journals Seroprevalence and risk factors of brucellosis in livestock in the wildlife and livestock interface area of Similipal Biosphere Reserve, India

2020 ◽  
Vol 13 (3) ◽  
pp. 465-470
Author(s):  
Sujit Kumar Behera ◽  
Deepanker Das ◽  
K. Balasubramani ◽  
Savitha Chellappan ◽  
Kaushik Rajaram ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Biosphere Reserve ◽  
Binary Logistic Regression ◽  
Farm Animals ◽  
Bivariate Analysis ◽  
Binary Logistic Regression Analysis ◽  
History Of ◽  
Wildlife Reserve ◽  
Shed Light

Background and Aim: Brucellosis is an important zoonotic disease that affects fertility in farm animals. The risk factors of brucellosis have not been well studied. This study aimed to understand the seroprevalence and risk factors of brucellosis among livestock in Bangriposi block of Mayurbhanj district in Odisha, a region that borders Similipal wildlife reserve. Materials and Methods: Rose Bengal plate test (RBPT) was carried out to estimate the seroprevalence of the livestock in this region. Bivariate analysis was carried out to analyze the association between the variables and brucellosis. Binary logistic regression was performed to assess the risk factors associated with brucellosis in the livestock. Results: Based on RBPT, the seroprevalence of brucellosis among cattle and goats was estimated to be 1.1% and 11.2%, respectively. Binary logistic regression analysis indicates that study area, age, goats, animals with a history of abortion, and rearing practices were the major risk factors in this region. Conclusion: This is one of the first studies in India to shed light on risk factors of brucellosis, an important neglected disease that affects the health of animals and humans and nation's economy.

scholarly journals ADL Recovery Trajectory after Discharge and its Predictors among Baseline-Independent Older Inpatients

2020 ◽  
Author(s):  
Xiuyue Li ◽  
Tingting Zheng ◽  
Yaqi Guan ◽  
Hui Li ◽  
Kexin Zhu ◽  
...  
Keyword(s):  
Recovery Rate ◽  
Older Patients ◽  
Area Under The Curve ◽  
Binary Logistic Regression ◽  
Binary Logistic Regression Analysis ◽  
Cluster Sampling ◽  
Roc Curve Analysis ◽  
Post Discharge ◽  
Chi Square ◽  
Recovery Trajectory

Abstract Background Among the previous studies about the ADL recovery and its predictors, the researches and resources used to study and protect the baseline-independent older patients from being permanently ADL-dependent was few. We aimed to describe the level of activities of daily living (ADL) at discharge and ADL change within 6 months after discharge in older patients who were ADL-independent before admission but became dependent because of acute illness, and to identify the predictors of early rehabilitation,so as to provide the basis to early intervention.Methods Stratified cluster sampling was used to recruit 520 hospitalised older patients who were ADL-independent from departments of internal medicine at two tertiary hospitals from August 2017 to May 2018. Demographics, clinical data, and ADL status at 1, 3, and 6 months after discharge were collected. Data were analysed using descriptive statistics, Student’s t-test, Pearson’s chi-square test,Spearman’s correlation analysis, binary logistic regression analysis, and receiver operating characteristic (ROC) curve analysis.Results There were 403 out of 520 patients completing the 6-month follow-up, and 229 (56.8%) regained independence at 6 months after discharge. There was an overall increasing trend in ADL with time. The recovery rate was the highest within the first month after discharge, gradually declined after 1 month, and changed less obviously from 3 to 6 months after discharge (p<0.001). ADL score at discharge (OR=1.034, p<0.001), age (OR=0.269, p=0.001), post-discharge residence (OR=0.390, p<0.05), and cognition status at discharge (OR=1.685, p<0.05) were predictors of ADL recovery. The area under the curve of the four predictors combined was 0.763 (p<0.001). Conclusion Studying ADL recovery rate and its predicting indicators of the baseline independent inpatients at different time points provide a theoretical reference for the formulation of nursing plans and allocation of care resources.

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