scholarly journals Association of Thyroid Status with Metabolic Markers in Young Women of South Indian Origin - A Cross Sectional Study

2020 ◽  
Vol 7 (39) ◽  
pp. 2156-2160
Author(s):  
Kavita Rasalkar ◽  
Nagaraju K ◽  
Chandana G ◽  
Sindhu R ◽  
Badreesh C. Vastrad
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Lipid Profile ◽  
Cardiovascular Mortality ◽  
Anthropometric Measurements ◽  
Primary Study ◽  
Thyroid Status ◽  
Cross Sectional ◽  
Metabolic Markers ◽  
South Indian

BACKGROUND Thyroid hormone is known to regulate metabolisms which are an integral part of normal growth and development. It affects key metabolisms involved in energy storage and expenditure. We wanted to study the correlation of thyroid function test with metabolic markers. METHODS After appropriate clearance from Human Institutional Ethics Committee and proper permission from author of article by Dr Sindhu et al, the secondary, blinded data was adopted for this study. This is an observational, cross-sectional retrospective study. Anthropometric measurements were taken, and lipid and thyroid profile were analysed in overnight fasting sample. As per our inclusion and exclusion criteria 120 of 253 subjects included in primary study were recruited in our study. Statistical analysis was done in Microsoft Excel 2007 and SPSS software version 16.0. ATP III criteria were used as a benchmark for metabolic syndrome markers. RESULTS Our study suggests that prevalence of subclinical hypothyroidism was higher in young South Indian women and it significantly correlated with the markers of metabolic syndrome like BMI, waist circumference, Low Density Lipoprotein (LDL) and systolic blood pressure. TSH values strongly correlated with BMI and LDL values. FT4 values correlated well with LDL. CONCLUSIONS High TSH and lower thyroxine values in blood can be a marker associated with metabolic syndrome. Our study suggests routine screening for thyroid status and lipid profile in young females to categorize them as high risk for cardiovascular mortality and morbidity along with anthropometric measurements. The study can be continued by long term follow up of the study subjects and correlation of these study subjects into mid or old age can give significant information of their cardiac status at that age. Counseling on appropriate diet and lifestyle modification may be beneficial for young people categorized as high risk to reduce the cardiovascular mortality later in life. KEYWORDS Thyroid Stimulating Hormone, Free Thyroxine, BMI, Lipid Profile

scholarly journals Anthropometric validity of the lipid profile in patients at the heart clinic RSUD Budhi Asih East Jakarta

2020 ◽  
Vol 5 (1) ◽  
pp. 1-10
Author(s):  
Riva Octarina ◽  
Leni Sri Rahayu ◽  
Luthfiana Nurkusuma Ningtyas
Keyword(s):  
Waist Circumference ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Lipid Profiles ◽  
Anthropometric Measurements ◽  
Good Sensitivity ◽  
Cross Sectional ◽  
High Waist Circumference ◽  
Quota Sampling ◽  
Sensitivity Specificity

ABSTRACT                           Dyslipidemia is a major factor in cardiovascular disease which can cause atherosclerosis, ischemic stroke and peripheral arteries. Dyslipidemia can be predicted by anthropometric measurements. The purpose of this study was to determine the anthropometric measurements that have the highest validity in detecting lipid profiles compared to biochemical assessments in poly cardiac patients at Budhi Asih Regional Hospital, East Jakarta. Research conducted in cross sectional method with quota sampling. This study was conducted on 75 cardiac poly patients. Data was collected by anthropometric measurements of body weight, height, waist circumference and hip circumference. Data on lipid levels were obtained from hospital medical record data. The results showed the lipid profile of normal HDL patients (73.30%), Normal LDL (58.70%), Triglycerides normal (65.30%), Total cholesterol was not normal (52%). Anthropometric value of BMI Obesity (44%), high RLPP (85.3%) and high waist circumference (74.7%). The conclusion of the analysis showed that BMI had poor sensitivity and specificity values ​​for all lipid profiles (Se <60%). RLPP has a very good sensitivity value on all lipid profiles (se> 90%) but has an unfavorable specificity value (Sp <60%). Waist circumference has a relatively good sensitivity (Se> 70%) in LDL, Triglycerides and Total Cholesterol, whereas in HDL it is quite good (Se> 60%). But it has poor specificity (Sp <60%). The results of the three anthropometric measurements RLPP is the best measurement in detecting lipid profiles in cardiac poly patients compared with BMI and Waist Circumference. Keywords: Lipid Profile, BMI, RLPP, Waist Circumference, Sensitivity, Specificity  

scholarly journals Psoriasis and metabolic syndrome: hospital based cross sectional study of prevalence and correlation in a rural south Indian population

2016 ◽  
Vol 2 (3) ◽  
pp. 49
Author(s):  
Dhanalakshmi Kathirvel ◽  
Vaishnavi Dhandapani ◽  
Baskaran R. ◽  
Gladius Jennifer H.
Keyword(s):  
Metabolic Syndrome ◽  
Lifestyle Modification ◽  
Normal Population ◽  
Cross Sectional Study ◽  
South Indian Population ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
South Indian ◽  
Chi Square Test

<p class="abstract"><strong>Background:</strong> Psoriasis is a chronic inflammatory skin disease that affects 1-3% of the population. Recent studies have reported that psoriasis is associated with metabolic disorders, including obesity, dyslipidaemia and diabetes. The aim of the present study was to investigate the prevalence of metabolic syndrome (MS) in psoriasis and to evaluate the association with severity and duration of psoriasis</p><p class="abstract"><strong>Methods:</strong> This was a hospital based cross sectional study that involved 60 patients with psoriasis evaluated for MS. Statistical analysis was done by SPSS version 16.0 software. Percentages, mean, standard deviation, correlation, chi-square test, t test were calculated at 5% level of significance.<strong></strong></p><p class="abstract"><strong>Results:</strong> 20% of patients had MS which is comparable to the normal population. 60% of the patients in our study are obese which is directly correlating with MS. There is significant increase in MS as age (p =0.01), duration of psoriasis (p =0.03), BMI (p =0.0001), waist circumference (p =0.0001) increases.</p><p><strong>Conclusions:</strong> There is 20% association of psoriasis with MS. There is no gender predisposition and no association between the severity of psoriasis and metabolic syndrome. There is minimal relationship between the duration of psoriasis and metabolic syndrome. Obesity is the commonest factor related to psoriasis, diabetes and MS which should be taken care of by diet, exercise and lifestyle modification. </p>

scholarly journals Associations between urinary hydration markers and metabolic dysfunction: a cross-sectional analysis of NHANES data, 2008–2010

2021 ◽  
Author(s):  
Tiphaine Vanhaecke ◽  
Alberto Dolci ◽  
Victor L. Fulgoni ◽  
Harris R. Lieberman
Keyword(s):  
Metabolic Syndrome ◽  
Urine Osmolality ◽  
Population Based ◽  
Urine Specific Gravity ◽  
Metabolic Dysfunction ◽  
Clinical Trial Registry ◽  
Cross Sectional ◽  
Metabolic Markers ◽  
Logistic Regression Models ◽  
The Metabolic Syndrome

Abstract Purpose Growing evidence suggests hydration plays a role in metabolic dysfunction, however data in humans are scarce. This study examined the cross-sectional association between hydration and metabolic dysfunction in a representative sample of the US population. Methods Data from 3961 adult NHANES (National Health and Nutrition Examination Survey) participants (49.8% female; age 46.3 ± 0.5 years) were grouped by quartile of urine specific gravity (USG, 2007–2008 cohort) or urine osmolality (UOsm, 2009–2010 cohort) as measures of hydration. Metabolic dysfunction was assessed by glycemic and insulinemic endpoints and by components of the metabolic syndrome. Multivariate-adjusted linear and logistic regression models were used. Results Increasing quartiles of USG but not UOsm was associated with higher fasting plasma glucose (FPG), glycated hemoglobin (all P < 0.01), HOMA-IR and elevated insulin (all P < 0.05). Compared with the lowest quartile, those with the highest USG but not UOsm had greater risk of metabolic syndrome (Q4 vs. Q1, OR (99% CI): 1.6 (1.0, 2.7), P = 0.01) and diabetes (Q4 vs. Q1, OR: 1.8 (1.0, 3.4), P < 0.05). Additionally, those with USG > 1.013 or UOsm > 500 mOsm/kg, common cut-off values for optimal hydration based on retrospective analyses of existing data, had less favorable metabolic markers. In a subset of participants free from diabetes mellitus, impaired kidney function, hypertension and diuretic medication, USG remained positively associated with FPG (P < 0.01) and elevated FPG (P < 0.05). Conclusion These analyses provide population-based evidence that USG as a proxy for hydration is associated with glucose homeostasis in NHANES 2007–2008. The same association was not significant when UOsm was used as a proxy for hydration in the 2009–2010 wave. Clinical trial registry Not applicable, as this was a reanalysis of existing NHANES data.

scholarly journals Dyslipidemia and oxidative stress are causative factors for atherosclerosis changes in hemodialysis patients

2019 ◽  
Vol 6 (5) ◽  
pp. 1383
Author(s):  
B. H. V. K. Praveen Varma ◽  
T. Madhusudhana Rao ◽  
D. S. S. K. Raju
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Lipid Profile ◽  
Cardiovascular Mortality ◽  
General Medicine ◽  
Hemodialysis Patients ◽  
Serum Triglycerides ◽  
Cross Sectional ◽  
And Oxidative Stress

Background: Cardiovascular disease is one of the leading cause of death in chronic kidney disease. The increased cardiovascular mortality observed in all stages of Chronic kidney disease patients.  In hemodialysis cardiovascular mortality is more than 60%. In hemodialysis dyslipidemia contribute for the triggering of atherosclerosis.  Endothelial dysfunction and oxidative stress are serves as main precursor for the progression of atherosclerosis. So the present study was aimed at studying lipid profile and oxidative stress in hemodialysis patients.Methods: A cross sectional study carried out over a 2 year period in Department Nephrology and General Medicine OPD, MIMS, Vizianagaram, Andhra Pradesh, India. A total of 60 hemodialysis patients are included. In all the participants Lipid profile, SOD, MDA and Serum Nitrate was measured.   Results: There is a significantly increased levels of serum triglycerides and VLDL in hemodialysis patients when compared with Control. The HDL-C was significant Lower in hemodialysis patients when compared with control. The serum total cholesterol and LDL-C not shown any significant change. The Serum MDA and Serum Nitrate was significantly higher in hemodialysis patients compared with Control and it is statistically significant (p<0.001). Whereas the serum SOD value was significantly decreased in hemodialysis patients when compared with control and it is statistically significant (p<0.001).Conclusion: Present study finding suggested that the incidence of atherosclerosis changes are higher in hemodialysis patients. Early detection and correction of atherosclerosis changes can help us to reducing the deleterious effects.

scholarly journals THE ASSOCIATION OF INSULIN RESISTANCE AND LIPID PROFILE RATIO IN METABOLIC SYNDROME

2019 ◽  
Vol 25 (1) ◽  
pp. 21
Author(s):  
Rini Rahmayani ◽  
Adi Koesoema Aman ◽  
Santi Safril
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Serum Glucose ◽  
Lipid Concentration ◽  
Cross Sectional ◽  
Serum Lipid Concentration

The cause of metabolic syndrome is still not known for sure, but it is suspected that the pathophysiology of metabolic syndrome is associated with insulin resistance and central obesity. Researchers have attempted to evaluate insulin resistance using various serum lipid concentration ratio. This study was to observe the association between insulin resistance and lipid profile ratio using HOMA-IR in metabolic syndrome patients. This study was a cross-sectional that was conducted in Inpatient and Outpatient Adam Malik Hospital during March 2016 - April 2016. Subjects were patients with metabolic syndrome criteria according to the International Diabetic Federation 2005. All samples were examined for their waist circumference, weight, height, blood pressure, insulin, serum glucose, total cholesterol, HDL cholesterol, LDL cholesterol, Triglycerides. Among sixty-six patients in the study 40 (60.6%) were male and 26 (39.4%) female. In this study, there was a significant correlation between HOMA-IR with CT/HDL ratio (r: 0.244 p <0.05); and there was no correlated HOMA-IR, and TG/HDL ratio (r: 0.086 p > 0.05) and there was no correlation between HOMA-IR and LDL/HDL (r: 0.336 p > 0.05). There was a significant relationship between insulin resistance and ratio CT/HDL

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