scholarly journals Advanced Materials in Cancer Therapy

2021 ◽  
Vol 7 (2) ◽  
pp. 01-17
Author(s):  
Ritika Sahajwani ◽  
Manish Srivastava ◽  
Anamika Srivastava ◽  
Chanchal Parashar ◽  
Agrima Singh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Cancer Therapy ◽  
Silver Nanoparticle ◽  
Medical Science ◽  
Chemotherapeutic Agents ◽  
The Body ◽  
Medicinal Uses ◽  
Pharmaceutical Industries ◽  
Different Shapes

The overview of this review article depends on the various techniques of formation of silver nanoparticles and different application take place in medicinal point of view. The branch of nanotechnology plays an important role in medical science research. In this different nanoparticle is synthesized which have various application in gene delivery, drug delivery and reduce the toxic effect of drugs in the human body and also act as an antibacterial in pharmaceutical industries. In recent days silver nanoparticles have had an important role due to their optical and catalytic properties. A large number of different particles or methods are used to prepare the different shapes of silver nanoparticles used in drug delivery. Different shapes of nanoparticles have increased their demand in various researches depend on medicinal uses. Silver nanoparticle preparation can be studied by 3 techniques related to irradiations, chemicals, bacteria, fungi, and plants.  Nanomedicine have a large number of advantages in treating various chronic diseases by using biological agents, chemotherapeutic agents, and used to deliver the drug to a specific site of the body. A silver nanoparticle is prepared for detection tool to detect the adverse effect of diseases on the target cell. Nanoparticles are used in cancer therapy to remove the damaged cell of the body. 

Studies on drug-assisted silver nanoparticles to reduce granulocytopenia and improve drug delivery for cancer therapy

2021 ◽  
Vol 127 (5) ◽  
Author(s):  
Chetan Chavan ◽  
Saniya Prabhune ◽  
Siddhi Shedge ◽  
Rajashree Patwardhan ◽  
Sagar Kamble ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Cancer Therapy ◽  
Improve Drug Delivery

scholarly journals Liposomal drug delivery system as an effective treatment approach for lung cancer

2020 ◽  
Vol 10 (3-s) ◽  
pp. 367-370
Author(s):  
Kinjal Patel ◽  
Devanshi Patel
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Drug Loading ◽  
Chemotherapeutic Agents ◽  
The Body ◽  
Therapeutic Interventions ◽  
Target Delivery ◽  
Liposomal Drug ◽  
Cancer Management ◽  
Important Field

Worldwide, cancer is one of the leading causes of mortality and cancer rates are set to increase at alarming rate globally. There are various types of cancer in which the leading type is the lung cancer.   In recent years lipid-based carriers, such as liposomes, have successfully encapsulated chemotherapeutic agents ameliorating some toxicity issues, while enhancing the overall therapeutic activity in cancer patients. In addition to this, nanomaterials can help to improved half-life in the body, morphology, for increased drug loading and many other ways. The survey discussed in this review will lead the anticancer therapy and cancer management which will provide the platform to the next generation.  Therefore, this critical review includes the therapeutic interventions, liposomes target delivery, active and passive drug loading. Finally, we attempt to summarize the current challenges in nanotherapeutics and provide an outlook on the future of this important field. Keywords: Drug Delivery, Liposomes target Delivery, Nanostructures, Drug loading

scholarly journals Applications of Nanomaterials for Theranostics of Melanoma

2020 ◽  
Vol 1 (1) ◽  
pp. 39-55
Author(s):  
Guanqiao Jin ◽  
Pohlee Cheah ◽  
Jing Qu ◽  
Lijuan Liu ◽  
Yongfeng Zhao
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Early Diagnosis ◽  
Real Time ◽  
Treatment Plan ◽  
Chemotherapeutic Agents ◽  
The Body ◽  
Diagnostic Methods ◽  
Therapeutic Drug

Melanoma is an aggressive form of skin cancer with a very high mortality rate. Early diagnosis of the disease, the utilization of more potent pharmacological agents, and more effective drug delivery systems are essential to achieve an optimal treatment plan. The applications of nanotechnology to improve therapeutic efficacy and early diagnosis for melanoma treatment have received great interest among researchers and clinicians. In this review, we summarize the recent progress of utilizing various nanomaterials for theranostics of melanoma. The key importance of using nanomaterials for theranostics of melanoma is to improve efficacy and reduce side effects, ensuring safe implementation in clinical use. As opposed to conventional in vitro diagnostic methods, in vivo medical imaging technologies have the advantages of being a type of non-invasive, real-time monitoring. Several common nanoparticles, including ultrasmall superparamagnetic iron oxide nanoparticles, silica nanoparticles, and carbon-based nanoparticles, have been applied to deliver chemotherapeutic agents for the theranostics of melanoma. The application of nanomaterials for theranostics in molecular imaging (MRI, PET, US, OI, etc.) plays an important role in targeting drug delivery of melanoma, by monitoring the distribution site of the molecular imaging probe and the therapeutic drug in the body in real-time. Hence, it is worthwhile to anticipate the approval of these nanomaterials for theranostics in molecular imaging by the US Food and Drug Administration in clinical trials.

scholarly journals Study of Blood Glucose and SGPT lowering effect of Eucalyptus Lanceolata Linn. in Induced Diabetic Rabbits

2015 ◽  
pp. 152-158
Author(s):  
MINGYUE YAOA
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
The Body ◽  
Antidiabetic Activity ◽  
Medicinal Uses ◽  
Diabetic Rabbit ◽  
Pharmaceutical Industries ◽  
Diabetic Rabbits ◽  
Plants Extract

The part of the plant to curing the diabetes mellitus and improves available data on plants with hypoglycemic effects. Antidiuretic potential of eucalyptus extracts has been evaluated in alloxan-induced diabetic rabbit. Here we used, plants extract about 256 kg were mix with 1000 ml methanol and keep in Flask. After filtering the extracts were exposed to rotary evaporator machine that methanol separated from plant extract. In the Nine rabbit were divided into three different groups. The body weight was recorded on every 6 days interval. The data obtained revealed that eucalyptus extracts reduced the glucose level effectively. Such treatment with extracts decreased the SGPT level. Therefore, it is concluded that the eucalyptus possesses significant antidiabetic activity. And finally, we recommend this plant for medicinal uses and for pharmaceutical industries to isolate pure drugs.

scholarly journals Advances of Microneedles in Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5912
Author(s):  
Jie Xu ◽  
Danfeng Xu ◽  
Xuan Xuan ◽  
Huacheng He
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Minimally Invasive ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Wound Repair ◽  
Delivery Systems ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Different Shapes

A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical therapy such as drug delivery systems, diagnoses of disease, as well as wound repair and cancer therapy are overviewed. Finally, the safety and the vision of the future of MNs are discussed.

scholarly journals Fenofibrate Niosomes by Modified Ether Injection Method- of Proper Diet to Help Lower “Bad

2018 ◽  
Vol 2 (1) ◽  
pp. 01-03
Author(s):  
Garrepalli Samatha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Forms ◽  
Chemotherapeutic Agents ◽  
The Body ◽  
Therapeutic Window ◽  
Prolonged Release ◽  
Site Of Action ◽  
Active Entity

The quest never ends. From the very beginning of the human race the quest is going on for newer and better alternatives and in case of drugs it will continue till we find a drug with maximum efficacy and no side effects. Many drugs, particularly chemotherapeutic agents, have narrow therapeutic window and their clinical uses are limited and compromised by dose limiting toxic effect. Thus, the therapeutic effectiveness of the existing drugs is improved by formulating them in an advantageous way. In the past few decades, considerable attention has been focused on the development of new drug delivery system (NDDS). The NDDS should ideally full fill two prerequisites. Firstly, it should deliver the drug at a rate directed by the needs of the body, over the period of treatment. Secondly, it should channel the active entity to the site of action. Conventional dosage forms including prolonged release dosage forms are unable to meet none of these. At present, no available drug delivery system behaves ideally, but sincere attempts have been made to achieve them through various novel approaches in drug delivery1. Approaches are being adapted to achieve this goal, by paying considerable attention either to control the distribution of drug by incorporating it in a carrier system, or by altering the structure of the drug at the molecular level, or to control the input of the drug into the bio environment to ensure an appropriate profile of distribution.

Plant Mediated Silver Nanoparticles and Mode of Action in Cancer Therapy: A Review

2020 ◽  
Vol 21 ◽  
Author(s):  
Rama Sharma ◽  
Nancy Srivastava
Keyword(s):  
Silver Nanoparticles ◽  
Side Effects ◽  
Cancer Therapy ◽  
Mode Of Action ◽  
The Body ◽  
Fatal Disease ◽  
Abnormal Growth ◽  
Wide Range ◽  
Research Opportunity ◽  
Shape And Size

Background: Cancer is a widespread fatal disease that is associated with abnormal growth of cells in the body. Objectives: This article represent, applications of biologically synthesized silver nanoparticles and their mode of action in cancer therapy. Methods: Nanomedicines have been proved to be an effective therapy in the treatment of the disease because of a wide range of applications. Due to the small shape and size, these nanoparticles are emerging to be of novel importance. They are abundantly found in various resources with easy extraction Results: Biologically synthesized silver nanoparticles are safe for humans as well as for the environment. These may replace the use of these harmful therapies like chemotherapy etc. using in cancer treatment because these have severe side effects. Sometimes patient may die because of these side effects. Conclusion: These green nanoparticles have great potential to treat and diagnose different cancers. This article laid a research opportunity for the diagnosis and treatment of cancer.

Characterization and Anticancer Activities of Green Synthesized CuO Nanoparticles, A Review

2020 ◽  
Vol 20 ◽  
Author(s):  
Seyedeh R. Alizadeh ◽  
Mohammad A. Ebrahimzadeh
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Copper Oxide ◽  
Medical Science ◽  
Copper Oxide Nanoparticles ◽  
Cuo Nanoparticles ◽  
Oxide Nanoparticles ◽  
Anticancer Activities

Background: Cancer is defined as an abnormal/uncontrolled cell growth that shows rapid cell division. This disease is annually recognized in more than ten million people. Nanomaterials can be used as new strategies for cancer therapy. Nanostructured devices have developed for drug delivery and controlled release and created novel anticancer chemotherapies. Nanomaterials were taken into consideration because of their new properties, containing a large specific surface area and high reactivity. Copper oxide nanoparticles (CuONPs) have potential applications in many fields like heterogeneous catalysis, antibacterial, anticancer, antioxidant, antifungal, antiviral, imaging agents, and drug delivery agents in biomedicine. CuONPs display different physical properties, such as hightemperature superconductivity, electron correlation effects, and spin dynamics. NPs can be synthesized using different methods like physical, chemical, and biological methods. Methods: Copper oxide nanoparticles (CuONPs) have been suggested for its broad usage in biomedical applications. In this review, we tried to exhibit the results of significant anticancer activity of green synthesized CuONPs and their characterization by different analytical techniques such as UV-Vis, FT-IR, XRD, EDAX, DLS, SEM, and TEM. Results: The green method for the synthesis of CuO nanoparticles as eco-friendly, cost-effective, and facile method is the more effective method. Synthesized CuONPs from this method have an appropriate size and shape. The Green synthesized CuONPs exhibited high potential against several breast cancer (AMJ-13, MCF-7, and HBL-100 cell lines), cervical cancer (HeLa), colon cancer (HCT-116), gastric cancer (human adenocarcinoma AGS cell line), lung cancer (A549), leukemia cancer, and other cancers with the main toxicity approach of increasing ROS production. Conclusion: The present review confirms the importance of green synthesized CuO nanoparticles in medical science especially cancer therapy that exhibited high activity against different cancer in both in vitro and in vivo. The main toxicity approach of CuONPs is increasing the production of reactive oxygen species (ROS). It needs to perform more studies about in vivo cancer therapy and following clinical trial testing in the future. We believe that green synthesized CuO nanoparticles can be used for the improvement of different diseases.

Synthesis of silver nanoparticles for the dual delivery of doxorubicin and alendronate to cancer cells

2015 ◽  
Vol 3 (36) ◽  
pp. 7237-7245 ◽  
Author(s):  
F. Benyettou ◽  
R. Rezgui ◽  
F. Ravaux ◽  
T. Jaber ◽  
K. Blumer ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Silver Nanoparticle ◽  
Intracellular Delivery

We present the synthesis of a silver nanoparticle (AgNP) based drug-delivery system that achieves the simultaneous intracellular delivery of doxorubicin (Dox) and alendronate (Ald) and improves the anticancer therapeutic indices of both drugs.

scholarly journals Biosynthesised Drug-Loaded Silver Nanoparticles: A Vivid Agent for Drug Delivery for Human Breast Carcinoma

2021 ◽  
Vol 14 (4) ◽  
pp. 1839-1846
Author(s):  
Pradeepa Varadharajaperumal
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Drug Carriers ◽  
The Body ◽  
Human Breast ◽  
Drug Bioavailability ◽  
Resonance Band

The use of nanoparticles as drug carriers has been investigated, and it offers various benefits, including the controlled and targeted release of loaded or associated drugs, as well as enhanced drug bioavailability. They do, however, have certain disadvantages, such as in vivo toxicity, which affects all organs, including healthy ones, and overall disease treatment improvement, which might be undetectable or limited. Silver nanoparticles are being studied more and more due to their unique physical, chemical, and optical properties, which allow them to be used in a variety of applications, including drug delivery to specific targets in the body. Given the constraints of traditional cancer treatment, such as low bioavailability and the resulting usage of high doses that produce side effects, attempts to address these challenges are essential. In this work, Biocompatible Silver nanoparticles (AgNps) loaded with tamoxifen have been prepared using the gelation process. Tamoxifen-loaded green synthesized AgNps are reported to be amorphous. The phytochemicals present in the extract of Hemionitis arifolia leaf were responsible for the reduction of silver nitrate to AgNPs. The functional groups existing in the particles were identified with FT-IR analysis. XRD analysis state that the particles were crystalline in nature and arranged in quartzite crystal. Particle size and shape were illustrated from SEM analysis and revealed that the particles were amorphous in nature. UV-visible spectrophotometer showed the band around 440nm which was identified as “surface Plasmon resonance band”. The synthesized AgNps loaded with tamoxifen were significantly effective against Human breast cancer cells. The silver nanoparticle loaded with tamoxifen was found to be inducing apoptotic signals in the selected cells. It inhibits the breast cancer cells even at the lower concentration of AgNPs and TAM-AgNPs. Further apoptotic studies (AO/EtBr and DAPI) reveal that cell death is due to the fragmentation of nuclear material of the treated cells.

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