scholarly journals Carcinoma epidermoide de neovagina en paciente con síndrome de Mayer-Rokitansky-Küster-Hauser. Reporte de un caso y revisión de la literatura

2019 ◽  
Vol 70 (4) ◽  
pp. 266-276
Author(s):  
Marta Fernández-Ruiz ◽  
Manuel Pantoja-Garrido ◽  
Zoraida Frías-Sánchez ◽  
Inmaculada Rodríguez-Jiménez ◽  
María del Valle Aguilar- Martín
Keyword(s):  
Congenital Abnormalities ◽  
Squamous Carcinoma ◽  
Hpv Infection ◽  
Carcinoma Epidermoide ◽  
Vaginal Neoplasms

Objetivo: presentar el caso de una paciente con síndrome de Mayer-Rokitansky-Küster-Hauser, con diagnóstico de carcinoma escamoso en neovagina, y realizar una revisión de la literatura del tratamiento y pronóstico de las neoplasias o la infección por VPH de tejidos neovaginales en mujeres transgénero o con síndrome MRKH. Materiales y métodos: mujer de 56 años de edad que consulta en un hospital universitario regional de la ciudad de Sevilla (España). Tras la exploración clínica se aprecia una tumoración exofítica en fondo de vagina, con resultado de biopsia de carcinoma escamoso y cultivo positivo para virus del papiloma humano (VPH) tipo 16. Se realizó una búsqueda bibliográfica en la base de datos Medline vía PubMed, con los términos: “congenital abnormalities”; “mullerian aplasia”; “neovagina”; “vaginal neoplasms”; “squamous carcinoma”; “HPV infection”, de reportes y series de caso, y estudios observacionales publicados desde el año 2000 hasta octubre de 2019 en inglés y español. Resultados: se incluyeron 14 estudios; de estos, siete correspondieron a carcinoma escamocelular, tres a adenocarcinoma y cuatro informan infección solo por VPH. Todos los carcinomas escamocelulares presentaban estadios avanzados por compromiso local o linfático y recibieron radioterapia con quimioterapia concomitante o cirugía radical. El pronóstico fue malo en tres de los casos. Las pacientes con adenocarcinoma también presentaron lesiones avanzadas con compromiso local, el tratamiento fue quirúrgico, con quimioterapia concomitante en dos de los casos. Solo una paciente tuvo seguimiento mayor a cinco años. La infección por VPH es frecuente en mujeres sometidas a construcción de neovagina. Conclusiones: las pacientes con neovagina son susceptibles de desarrollar carcinomas escamosos si se utilizaron injertos cutáneos, o adenocarcinomas en aquellas en las que se reconstruyó la vagina a partir de injertos tisulares intestinales. Dado que al momento del diagnóstico presentan compromiso local, a menudo requieren tratamientos radicales o combinados. Se debe investigar cuáles son las mejores estrategias de tamizaje de VPH, cáncer escamoso y adenocarcinoma en este tipo de pacientes.

scholarly journals LncRNA WT1-AS up-regulates p53 to inhibit the proliferation of cervical squamous carcinoma cells

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yunxia Zhang ◽  
Renhua Na ◽  
Xinling Wang
Keyword(s):  
Cell Proliferation ◽  
Squamous Carcinoma ◽  
Cervical Squamous Cell Carcinoma ◽  
Hpv Infection ◽  
Carcinoma Cells ◽  
Over Expression ◽  
Squamous Carcinoma Cells ◽  
Measurement Cell ◽  
Cancer Tissues ◽  
Medical University

Abstract Background It has been reported that the development of cervical squamous cell carcinoma (CSCC) requires the involvement of a large number of lncRNAs. In a recent study lncRNA, WT1-AS was been characterized as a tumor-suppressive lncRNA in gastric cancer. In our study we aim to explore the involvement of WT1-AS in CSCC. Methods Seventy-six CSCC patients (20 to 63 years, 40.1 ± 6.1 year) from the 233 CSCC patients who were admitted by the Affiliated Tumour Hospital of Xinjiang Medical University between august 2010 and January 2014. RT-qPCR, cell proliferation rate measurement, cell transfection, and western blot were carried out to analyze the samples. Results We found that HPV infection failed to affect WT1-AS expression in CSCC tissues, while WT1-AS was down-regulated in CSCC tissues compared with non-cancer tissues. P53 was also down-regulated in CSCC tissues and positively correlated with WT1-AS. Analysis of the survival of CSCC patients revealed that low levels of WT1-AS were accompanied by poor survival. Significantly up-regulated p53 was observed after WT1-AS over-expression in CSCC cells, while p53 over-expression failed to affect WT1-AS. P53 and WT1-AS over-expression resulted in the inhibited proliferation of CSCC cells. Conclusion Therefore, WT1-AS is down-regulated in CSCC and it may inhibit CSCC cell proliferation at least partially by up-regulating p53.

scholarly journals FOXD1 expression in head and neck squamous carcinoma: a study based on TCGA, GEO and meta-analysis

2021 ◽  
Author(s):  
Junjie Huang ◽  
Bin Liang ◽  
Tianjiao Wang
Keyword(s):  
Head And Neck ◽  
Cell Lines ◽  
Plasma Cells ◽  
Immune Cell ◽  
Cox Regression ◽  
Meta Analysis ◽  
Squamous Carcinoma ◽  
Hpv Infection ◽  
Signal Pathways ◽  
Tcga Dataset

Forkhead box D1 (FOXD1) is a new member of FOX transcription factor family. FOXD1 has demonstrated multi-level roles during normal development and several diseases’ pathogenesis. However, litter is known about the role of FOXD1 in the progression of head and neck squamous cancer (HNSC). In the present study, we analyzed FOXD1 expression pattern using TCGA dataset, GEO datasets, HNSC cell lines and HNSC tissues. Then, we analyzed the correlation between FOXD1 expression and clinical characteristics, and evaluated the prognostic value of FOXD1 in HNSC. Moreover, we assessed the relationship between FOXD1 expression and tumor environment (TME) and immune cell infiltration using ESTIMATE and CIBERSORT algorithms. Finally, we predicted the FOXD1-related biological processes and signal pathways. FOXD1 was up-regulated in HNSC tissues in TCGA datasets, validated by GEO datasets, HNSC cell lines and HNSC tissues. FOXD1 expression was significantly associated with tumor site and HPV infection. Univariate and multivariate Cox regression analyses showed that FOXD1 expression was an independent prognostic factor. Moreover, we found that the proportions of naïve B cells, plasma cells, and resting dendritic cells were negatively correlated with FOXD1 expression, otherwise, the proportion of activated mast cells was positively correlated with FOXD1 expression using CIBERSORT algorithm. GSEA analyses revealed that FOXD1 was mainly involved in cancer-related signaling pathway and metabolism-related pathways. FOXD1 was a potential oncogene, and might represent an indicator for predicting overall survival of HNSC patients. Moreover, many cancer-related pathways and metabolism-related processes may be regulated by FOXD1.

The main differences between vulvar intraepithelial neoplasia and vulvar intraepithelial lesion

2020 ◽  
Vol 11 (5) ◽  
Author(s):  
Vivian de Oliveira Rodrigues Brum ◽  
Denise Gasparetti Drumond ◽  
Neila Maria de Góis Speck ◽  
Gabriel Duque Pannain ◽  
Giovana Moreira Bordim
Keyword(s):  
Vulvar Cancer ◽  
Gynecological Cancer ◽  
Squamous Carcinoma ◽  
Intraepithelial Neoplasia ◽  
Final Diagnosis ◽  
Hpv Infection ◽  
Vulvar Intraepithelial Neoplasia ◽  
Low Grade ◽  
Intraepithelial Lesion ◽  
The Difference

Vulvar cancer is a recurrent subject in gynecological cancer. Vulvar Intraepithelial Neoplasia is known for being a precursor lesion of vulvar cancer and can be divided in three different subtypes: Low-grade Vulvar Intraepithelial Lesion (vulvar LSI), High-grade Vulvar Intraepithelial Lesion (vulvar HSIL) and Differentiated Vulvar Intraepithelial Neoplasia (dVIN). These subtypes differ in several aspects, and this article aims to present those differences in order to facilitate its treatment and the final diagnosis. The HSIL is the most associated with cronic Human Papilloma Virus (HPV) infection and can be related to other environment factors. As for dVIN, it’s more frequent in post-menopausal women with sclerosis lichen and it has a higher rate of progression to vulvar squamous carcinoma. The difference must be made in order to choose what is the best treatment, once there are various modalities, such as simple excision, CO2 ablation and topical application of imiquimod or fluoracil. This differences is also important for the development of measures that seek specific prevention, such as HPV vaccine for the HSIL and the proper treatment of vulvar conditions for the dVIN.

scholarly journals Analysis of the p53 gene and papillomavirus detection in smears from cervical lesions

2002 ◽  
Vol 120 (1) ◽  
pp. 20-22 ◽  
Author(s):  
Ledy do Horto dos Santos Oliveira ◽  
André de Paula Fernandez ◽  
Brunno Lessa Saldanha Xavier ◽  
Eliana de Vasconcelos Machado Rodrigues ◽  
Silvia Maria Baeta Cavalcanti
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Cellular Response ◽  
Squamous Carcinoma ◽  
P53 Gene ◽  
Suppressor Gene ◽  
Hpv Infection ◽  
Cervical Lesions ◽  
Cervical Intraepithelial Neoplasia Grade ◽  
Damage Initiation

CONTEXT: Alterations of the p53 tumor suppressor gene are correlated with a critical step in the development of many human cancers.The tumor suppressor gene functions include regulation of the cell cycle and the cellular response to DNA damage, initiation of DNA repair and replication, induction of apoptosis and promotion of cell differentiation. CASE REPORT: Smears from ten cases of cervical lesions were analyzed for status of exons 5-8 of the p53 gene using PCR/SSCP. HPV infection was also screened by the PCR method using two PCR primer sets. Changes in the p53 gene were observed in a case of squamous carcinoma and a case of asymptomatic cervical intraepithelial neoplasia grade III (CIN III). High-risk HPV was detected in both cases showing that HPV infection and p53 mutation are not exclusive events.

Direction of human papilloma virus (HPV) infection in patients with squamous carcinoma of the oesophagus

1993 ◽  
Vol 2 (Supplement) ◽  
pp. 11 ◽  
Author(s):  
P Chaves ◽  
M Cravo ◽  
P Fidalgo ◽  
F Costa Mira ◽  
C Nobre Leitao ◽  
...  
Keyword(s):  
Human Papilloma Virus ◽  
Squamous Carcinoma ◽  
Hpv Infection ◽  
Papilloma Virus

scholarly journals Invasive Squamous Carcinoma and Adenocarcinoma of an Unreconstructed Exstrophic Bladder with HPV Infection

2015 ◽  
Vol 9 (2) ◽  
pp. 109-112
Author(s):  
Mesut Altan ◽  
Burak Çıtamak ◽  
Hakan Bahadır Haberal ◽  
Emrullah Söğütdelen ◽  
Ali Cansu Bozaci ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Bladder Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Bladder Exstrophy ◽  
Squamous Carcinoma ◽  
Hpv Infection ◽  
Squamous Cell Carcinomas ◽  
Early Years ◽  
Increased Risk

Bladder exstrophy is a complex abnormality and is traditionally treated within the early years of life. It is associated with an increased risk of bladder cancer, with 95% of the arising tumors being adenocarcinomas and 3 to 5% being squamous cell carcinomas. HPV infections are also associated with an increased risk of bladder cancer. This case represents a patient with bladder exstrophy that gave rise to coinciding squamous cell carcinoma and adenocarcinoma. Final pathology results showed an infection with HPV. We presented the management of the case and discussed the diagnosis and treatment methods for this patient.

Recurrent anal squamous carcinoma: Is HPV a risk factor?

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e15094-e15094
Author(s):  
Caroline Letendre ◽  
Francine Aubin ◽  
Jean-Pierre M. Ayoub ◽  
Richard Letourneau ◽  
Rasmy Lougnarath ◽  
...  
Keyword(s):  
Risk Factor ◽  
Hpv Vaccination ◽  
Eligible Patient ◽  
Cancer Recurrence ◽  
Squamous Carcinoma ◽  
Patient Characteristics ◽  
Hpv Infection ◽  
First Year ◽  
Hpv Status ◽  
High Prevalence

e15094 Background: Anal squamous carcinoma (ASC) is a rare cancer, representing only 1.5 to 2% of all gastrointestinal (GI) malignancies. Combined chemo-radiotherapy therapy (CRT) is the treatment of choice with a response rate of 80% and recurrence rate of 10 to 15%. HPV is a risk factor for anal cancer but its role in cancer recurrence is less clear. We conducted a retrospective study to analyze clinical outcome of ASC patients in function of their HPV status. Methods: Patients with non-metastatic ASC treated between 2005-2011 at the Centre Hospitalier de l’Université de Montréal were eligible. Patient characteristics, clinical outcomes, and tumoral HPV status were retrospectively identified. Results: Seventy patients (M:31; F:39) were included in the analysis. The median age of patients was 51 years. Patient and tumor characteristics are shown in the Table. CRT was done in 57 patients. Median follow-up was 37.6 months. Eleven patients had recurrence of whom 10 were HPV-positive. Median TTR was 13.2 months. The 3 deaths related to cancer occurred during the first year of diagnosis. The 3 year overall survival was 90.08%. In multivariate analysis neither the advanced stage of disease nor the HPV-positive status had a statistically significant impact on relapse. Conclusions: In this small cohort, we found a high prevalence of HPV positivity in ASC but HPV infection couldn’t be identified as a risk factor for ASC relapse. Inclusion of men in the HPV vaccination program may help in reducing HPV related ASC. [Table: see text]

Expression CMTM6 and PD-L1 and Their Significance in Cervical Squamous Cell Carcinomas

2021 ◽  
Author(s):  
Hongyan Ma ◽  
Shuai Shi ◽  
Zhigang Zhang ◽  
Zhihong Ma ◽  
honggang liu
Keyword(s):  
Squamous Cell ◽  
Transmembrane Domain ◽  
Squamous Carcinoma ◽  
Cervical Squamous Cell Carcinoma ◽  
Hpv Infection ◽  
Squamous Cell Carcinomas ◽  
Chi Square ◽  
Squamous Mucosa ◽  
Chi Square Test ◽  
The Difference

Abstract Background: This study aimed to investigate the expression levels of chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 (CMTM6) and PD-L1 in cervical squamous cell carcinoma and their clinical significance. Methods: We used immunohistochemistry to detect the expression of CMTM6 and PD-L1 in 41 cases of normal cervical squamous mucosa tissue and 76 cervical squamous cell carcinomas. Chi-square test was used to analyze the difference of CMTM6 between cervical squamous carcinoma and normal squamous mucosa. Results: The results showed that the expression of CMTM6 and PD-L1 in cervical squamous carcinoma was significantly higher than that in normal squamous mucosa (p<0.05). There is a positive correlation between the expression of CMTM6 and PD-L1 in cervical squamous carcinoma (p<0.05). There is no correlation between CMTM6 and HPV infection in cervical squamous carcinoma. In addition, CMTM6 expression is positively correlated with lymph node metastasis and nerve invasion for cervical squamous carcinoma (p<0.05). PD-L1 expression is positively correlated with the differentiation of cervical squamous carcinoma. Conclusions: The expression of CMTM6 and PD-L1 is closely correlated in cervical squamous carcinoma , and may be used as a molecular target for cervical cancer in the future.

Sign in / Sign up

Export Citation Format

Share Document