scholarly journals FILMS IN RUSSIAN MEDICINE AND COSMETOLOGY: DEVELOPMENT HISTORY, CLASSIFICATION, TECHNOLOGY

2020 ◽  
Vol 8 (2) ◽  
pp. 124-132
Author(s):  
Victoria M. Kishchenko ◽  
Vladislav V. Vernikovsky ◽  
Igor M. Privalov ◽  
Aleksander M. Shevchenko
Keyword(s):  
Systemic Effect ◽  
Biologically Active ◽  
Active Components ◽  
Application Form ◽  
State Register ◽  
History Of ◽  
State Of Research ◽  
The Moment ◽  
Pharmacologically Active ◽  
Active Substances

Since the moment of their appearance in the second half of the 20th century, application forms have attracted the attention of the specialists involved in the skin application of pharmacologically active agents. Herewith, both localized exposure to the external integuments and the possibility of achieving a systemic effect, are of interest. The range of products used in modern films, is also wide – from pharmaceutical substances to biologically active components of cosmetics.The aim of the present work is to study the current state of research in the field of the creation and improvement of medicinal and cosmeceutical films.Materials and methods. The study was conducted on the base of patent information (fips.ru, findpatent.ru) and information and search databases - the State register of medicines (grls.rosminzdrav.ru) and the data from the Federal accreditation service (www.fsa.gov.ru), as well as scientific libraries (Google Scholar, eLIBRARY, PubMed) and reference literature.Results. Native and foreign medicinal films have longer than a 50-year history of their existence in the pharmaceutical market. Modern scientists’ interest in this application form, does not fade away due to a great number of its positive characteristics. In addition to pharmaceutical applications, films are widely used in cosmetics in the form of masks applied to the skin. Biologically active substances are widely used in cosmetics which, in recent years, has led to the emergence of a group of cosmeceutical products that combine medical and cosmetic films. The article also discusses film manufacturing technology, active substances, as well as polymers used for medicinal and cosmetic films presented in the Russian market.Conclusion. The analysis of the literature data makes it possible to conclude that the development of films is promising in both medicine and cosmeceuticals.

scholarly journals STUDY OF TOXICOLOGICAL PROPERTIES AND LOCAL IRRITANT EFFECT OF THE DRUGS INSACAR TOTAL C PLUS AND INSACAR TOTAL K PLUS ON LABORATORY RATS

2021 ◽  
pp. 330-335
Author(s):  
Makhvatova
Keyword(s):  
Parasite Species ◽  
Systemic Effect ◽  
Single Application ◽  
Active Components ◽  
Cutaneous Toxicity ◽  
Laboratory Rats ◽  
Entire Observation Period ◽  
White Rats ◽  
Active Substances ◽  
Observation Period

The study of acute cutaneous toxicity and local irritant effect of the drugs Insacar Total C Plus and Insacar Total K Plus on mongrel white rats was conducted in doses of 5000 and 10 000 mg/kg of body weight (BW). When the drugs were applied to the skin of rats, no animal deaths were recorded during the entire observation period. Thus, the LD50 is more than 10 000 mg / kg of BW. A single application of the drugs to the skin in rats at a dose of 1 ml/100 g (10 000 units) in two experimental groups on the 7th and 9th day of the study showed the most pronounced irritant effect. In this regard, the drugs have an irritating effect – 1 point. The studied drugs Insacar Total C Plus and Insacar Total K Plus belong to the group of insectoacaricidal and anthelmintic agents. The substances included in its composition have a contact and systemic effect on ectoparasites and nematodes. They are complex medicines containing 4 active components – moxidectin, pyriproxifen, imidacloprid, praziquantel. Such a combination of active substances is characterized by effectiveness against a larger number of parasite species, stages of their development, and in addition, reduce the likelihood of developing resistance of pathogens to drugs.

scholarly journals The biography and scientific work of the Soviet microbiologist Z.V. Yermolyeva: historiographic characteristics of post-Soviet publications

2020 ◽  
Vol 9 (4) ◽  
pp. 268-271
Author(s):  
Aleksandr Vladimirovich Gorshenin
Keyword(s):  
Scientific Work ◽  
Research Direction ◽  
Biologically Active ◽  
Soviet Period ◽  
Woman Scientist ◽  
Scientific Biography ◽  
Russian Science ◽  
Wide Range ◽  
History Of ◽  
Active Substances

This paper provides a brief analysis of works that consider the main stages of the scientific biography of the famous Soviet scientist-microbiologist, academician of medicine Zinaida Vissarionovna Yermolyeva (18981974). Among the most famous achievements of the scientist are the receipt of the first Soviet penicillin and the prevention of the cholera epidemic in Stalingrad during the Great Patriotic War. Her scientific interests had a fairly wide range: from cholera and antibiotics to lysozyme, interferon and other biologically active substances. Speaking about Z.V. Yermolyeva, the famous Soviet microbiologist and epidemiologist, academician N.F. Gamaleya noted that she as a researcher is characterized by a desire to work in the area that is currently the most urgent for socialist health care. Indeed, getting acquainted with the biography of this amazing woman scientist, it becomes clear why she switched from one research direction into another this was her ability to quickly respond to the needs of the country and the challenges of the time. Given a great importance to the figure of Z.V. Yermolyeva in the history of Russian science, it seems relevant to establish a degree of study of this problem. The author of this paper has already carried out a brief analysis of the historiography of the works in the Soviet period on the history of Zinaida Yermolyevas scientific activities; therefore this paper is its logical continuation.

scholarly journals Brown algae of the orders Laminariales and Fucales from the Sakhalin-Kuril region: stocks, extraction, use

Trudy VNIRO ◽  
2020 ◽  
Vol 181 ◽  
pp. 235-256
Author(s):  
A.V. Podkorytova ◽  
◽  
A.N. Roshchina ◽  
N.V. Evseeva ◽  
A.I. Usov ◽  
...  
Keyword(s):  
Brown Algae ◽  
Raw Materials ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Active Components ◽  
Industrial Processing ◽  
Forced Air ◽  
Far Eastern ◽  
Air Circulation ◽  
Active Substances

Data on distribution, stocks of commercial and potentially commercial brown algae in the Sakhalin-Kuril region, their extraction, industrial processing, and chemical composition are presented. It is shown that for the preservation of biologically active substances and technically valuable components of laminaria, the use of an IR dryer for its preservation at LLC FIG «BINOM», Aniva, Island Sakhalin was an innovative technological solution. The products that are produced at this enterprise, in particular, dried shredded laminaria (IR drying), dried thalloms in heat dryers equipped with gas air heaters with forced air circulation are high — quality products containing all the biologically active components of natural brown alga. Expanded quality indicators of dried products from the laminaria of Sakhalin-Kuril region are presented. Based on the obtained data, recommendations were developed for the integrated use of algae as an annually renewable aquatic biological resource, traditionally extracted and used as raw materials in the production of food products and biologically active substances. It is shown that, despite the significant reserves of kelp in the far Eastern seas of Russia, they are currently poorly developed by fishing, with the exception of the coastal zone of Western Sakhalin.

Research biologically active substances Atragene speciose Weinm.

2002 ◽  
Vol 1 (2) ◽  
pp. 55-59
Author(s):  
I. V. Shilova
Keyword(s):  
Oleanolic Acid ◽  
Pharmacological Activity ◽  
Triterpene Glycosides ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Active Fraction ◽  
Overground Part ◽  
Pharmacologically Active ◽  
Active Substances ◽  
Nootropic Effect

From the overground part of Atragene speciosa Weinm. family Ranunculaceae, we obtained a fraction possessing a marked nootropic effect from which 3,4-dihydroxyphenylethanol-2, its 2-O-β-D-glucopyranoside, and a sum of glycosides of dihydroxybutane acid were isolated. In addition to the foregoing substances, in the pharmacologically active fraction we revealed the presence of triterpene glycosides (whose sapogenins are hederagenine and oleanolic acid), aminoacids and microelements. For the frist time the obtained data about the biologically active substances and their pharmacological activity give us the possibility of development of a new phytopreparation with the nootropic effect on the basis of Atragene speciose Weinm.

scholarly journals Chemical profile and antimicrobial activity of extractable compounds of Betula litwinowii (Betulaceae) buds

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Valery A. Isidorov ◽  
Róża Bagan ◽  
Lech Szczepaniak ◽  
Izabela Swiecicka
Keyword(s):  
Antimicrobial Activity ◽  
Folk Medicine ◽  
Biologically Active ◽  
Chemical Profile ◽  
Active Components ◽  
Volatile Elements ◽  
Gram Positive Bacteria ◽  
History Of ◽  
Extractable Compounds

AbstractIn spite of the long history of therapeutic use of buds from different birch species in folk medicine the existing information on their chemical composition is insufficient. The main goal was to develop a method for GC-MS determination of the chemical profile of birch buds as well as their antimicrobial activity. 150 substances of different classes were identified in Betula litwinowii buds. The volatile elements of the buds were mainly represented by sesquiterpene compounds. Ether extracts also contained other biologically active components such as flavonoids and triterpenoids. However, a particular feature of this fraction was the high content of sesquiterpene phenylpropenoids, including esters of ferulic and caffeic acids with caryophyllene-type alcohols that had not been previously found in any biological samples. Apart from carbohydrates, a series of free amino acids were detected in methanol extracts. The antimicrobial activity of the ether extracts of the buds was observed against all of the microorganisms tested, with MIC values from 0.04 to 0.08 mg mL-1 for Gram-positive bacteria and Candida albicans. However, their inhibitory activities against tested Gram-negative bacteria were rather occasional.

scholarly journals The influence of antioxidant postharvest treatment on content of biologically active substances during storage of cucumbers

2017 ◽  
Vol 11 (4) ◽  
Author(s):  
O. Priss ◽  
V. Yevlash ◽  
V. Zhukova ◽  
I. Ivanova
Keyword(s):  
Ascorbic Acid ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Ascorbate Oxidase ◽  
Control Groups ◽  
Slowing Down ◽  
Phenolic Substances ◽  
The Moment ◽  
And Control ◽  
Active Substances

The influence of heat treatment with antioxidant compositions on the content of biologically active substances during storage of cucumbers is investigated. It was found that the use of the proposed treatment inhibits the activity of ascorbate oxidase by 15–18%, which allows to slow down the decomposition of ascorbic acid by 1.5 times. The content of ascorbic acid in the experimental fruit after storage for 28 days is 1.4 times higher than in the control after 21 days of storage. It was found that in the cucumbers 11–14 sm long, the synthesis of polyphenols continued in the period of storage.  The intensity of accumulation of phenolic substances proved to be different in the treated and control groups. It was shown that thermal treatment with antioxidants slowed the growth rate of total polyphenols by 20% relative to control, indicating inhibition of maturation processes. It was revealed that the activity o polyphenol oxidase during the storage of treated fruits was slowing down. It has been established that the application of said treatment substantially inhibits the degradation of chlorophylls. Rapid loss of chlorophyll caused yellowing and loss of consumer properties in the control groups after 2 weeks of storage. In processed cucumbers only 21 days of storage revealed a decrease in the concentration of chlorophyll in relation to the moment of laying. At day 28 the amount of chlorophylls in the experimental fruit is at the same level as in the control after a week of storage. It has been found that the use of the proposed treatment slows the degradation of carotenoids. The quantity of carotenoids in experimental cucumbers at the end of storage is 21–23% higher than in the control ones. The compensatory function of ascorbic acid, carotenoids and phenolic substances during storage of cucumber fruits is proved.

scholarly journals Viral diseases of cacti (Cactaceae Juss.)

2016 ◽  
Author(s):  
T. Mudrak ◽  
G. Koroteeva ◽  
V. Polishchuk
Keyword(s):  
Pharmaceutical Industry ◽  
Genetic Differentiation ◽  
Viral Infections ◽  
Biologically Active ◽  
Raw Material ◽  
Viral Diseases ◽  
Protective Measures ◽  
Modern Methods ◽  
History Of ◽  
Active Substances

There are about 220 genera and 3000 species in Cactaceae family. Since its discovery in XV cacti gained much popularity among botanists, gardeners and collectors because of unusual and highly decorative appearance. Cactus viruses are known for about a century now. The first definitive indication came in 1951 in Europe. Currently, 13 viruses are known to infect plants of Cactaceae family: five members of the genus Potexvirus (CVX, OpVX, SchVX, ZyVX and PiVX), four members of the genus Tobamovirus (SOV, TMV, CMMoV and RCNaV), one representative of the Carlavirus (CV-2), one representative of the Carmovirus (SgCV) and two representatives of the genus Tospovirus (TSWV and INSV). Potexviruses are best described among the viruses infecting Cactaceous plants. Some infections are mostly symptomless, when others demonstrate both external and internal symptoms. Externally symptoms include chlorotic rings and spots on the pads of Opuntia sp., reddening of the fronds of the Zygocactus sp., etc. Occasionally more severe symptoms, such as bending, marked yellowing and dieback of stems occur. The article discusses the viruses infecting Cactaceae family members, their biological characteristics, geographical distribution and history of their discovery. It covers the problem of genetic differentiation between some Asian and European isolates of potexviruses, and describes peculiarities of mono- and co-infections in different species of cacti. The article also considers the practical value of cacti for the gardening and exemplifies the use of their biologically active substances in medicine and pharmaceutical industry. Viral infections can damage cacti rendering raw material inapplicable for practical use. Hence it is necessary to apply not only technical protective measures, but also timely application of modern methods of diagnosis and the establishment of diversity of viruses circulating in the collections.

scholarly journals FEATURES OF THE COMPOSITION MACRO ELEMENTS AND TRACE ELEMENTS OF THE EXTRACT OF ALFREDIA CERNUA (L.) CASS., POSSESSING PSYCHOTROPIC EFFECT

2019 ◽  
pp. 191-198
Author(s):  
Inessa Vladimirovna Shilova ◽  
Natal'ya Vladimirovna Baranovskaja ◽  
Rustam Niyazovich Mustafin ◽  
Nikolay Innokent'yevich Suslov
Keyword(s):  
Trace Elements ◽  
Aerial Part ◽  
Organometallic Compounds ◽  
Ethanol Extract ◽  
Biologically Active ◽  
Cobalt Chromium ◽  
Macro Elements ◽  
Ultra Trace ◽  
Pharmacologically Active ◽  
Active Substances

The 95% ethanol extract of Alfredia drooping Alfredia cernua (L.) Cass. (Asteraceae) aerial part exhibits pronounced antidepressant, nootropic and anxiolytic activity. The aim of the work was the qualitative and quantitative analysis of macro-, trace and ultra trace elements of the pharmacologically active extract of the aerial part of the plant. The study of the elemental composition of the extract was performed after ashing using instrumental neutron activation analysis with irradiation with thermal neutrons. The study found 26 elements, of which eight are (conditionally) essential, two macro elements and four trace elements. The obtained results indicate the prevalence of Alfredia cernua of calcium, zinc, sodium, strontium, bromine, as well as iron, barium, cobalt, chromium and lanthanum in the pharmacologically active extract. The extract concentrates a specific group of elements (zinc, cobalt, thorium, hafnium, bromine, chromium, lutetium, lanthanum, strontium, samarium) in comparison with the feedstock, which can be explained by the formation of strong organometallic compounds and chelate complexes. Macro-, trace and ultra trace elements can have a significant impact on metabolic processes, nervous, immune, endocrine, cardiovascular systems, they are an integral part of enzymes, give other biologically active substances an easily digestible form and potentiate their effects.

scholarly journals Review on Pharmacologically Active Metabolites from Yarsagumba (Ophiocordyceps sinensis), an Epitome of Himalayan Elixir

2014 ◽  
Vol 14 (2) ◽  
pp. 49-58 ◽  
Author(s):  
S Shrestha ◽  
AK Shrestha ◽  
JH Park ◽  
DY Lee ◽  
JG Cho ◽  
...  
Keyword(s):  
Biological Activities ◽  
Biologically Active ◽  
Active Components ◽  
Active Metabolites ◽  
Traditional Use ◽  
Nitrogenous Compounds ◽  
Entomogenous Fungus ◽  
Ophiocordyceps Sinensis ◽  
Pharmacologically Active ◽  
Effective Drugs

Yarsagumba (Ophiocordyceps sinensis (Berk.) Sung et al.) is a well-known entomogenous fungus native to alpine nival terrain of trans-Himalaya and Tibetan Plateau. The traditional use of O. sinensis in Ayurvedic medicine as well as in traditional Chinese medicine for range of human health requirements with well documented evidences are themselves testimony of its value. It is regarded as winter worm, summer grass due to its association with Thitarodes (Hepialus) larvae. The extremities of habitat condition and endurance of fungus to sustain adversaries by production of metabolites has led to unique profile of metabolites including nucleosides, proteins and nitrogenous compounds, polysaccharides, sterols, fatty acids and their derivatives, as well as some vitamins and inorganics. There are wide ranges of biological activities that have been reported from O. sinensis including anti-inflammatory, antioxidant, anti-tumor, anti-metastatic, immunomodulatory, antimicrobial, insecticidal, hypolipidaemic, hypoglycemic, antiageing, lipolytic, neuroprotective, renoprotective effects, etc. Although several components can be responsible for activity of compounds, understanding ultimate compounds which fit with biomolecular target is crucial to combat diseases and development of new class of effective drugs. In this review a concise evaluation of pharmacological activities of metabolites reported for O. sinensis are done to provide insight into its biologically active components. DOI: http://dx.doi.org/10.3126/njst.v14i2.10415   Nepal Journal of Science and Technology Vol. 14, No. 2 (2013) 49-58

scholarly journals Encapsulation of plant and animal oils used in dairy industry: A review

2016 ◽  
Vol 20 (1) ◽  
pp. 21-40
Author(s):  
Georgi Kostov ◽  
Vesela Shopska ◽  
Rositsa Denkova ◽  
Mihaela Ivanova ◽  
Tatyana Balabanova ◽  
...  
Keyword(s):  
Food Product ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Food Science ◽  
Food Matrix ◽  
Active Components ◽  
Natural Oils ◽  
The Impact ◽  
Encapsulation Methods ◽  
Active Substances

Abstract The development of new food products enriched with biologically active components is a topical issue for modern food science and practice. Many of these substances are unstable when being incorporated into the food matrix, which demands a study on the possibilities to stabilize them before use. Encapsulation of biologically active substances is a method which provides stability of the substance in the food product. The principles for implementing encapsulation of biologically active substances, especially natural oils, the matrices and the encapsulation methods are discussed in the present review. Data on the impact of key process parameters of encapsulation, the biological value of oils and the opportunities for application of the encapsulated systems in different groups of dairy products are presented.

Sign in / Sign up

Export Citation Format

Share Document