The relationship between intestinal flora and the immunity of the intestinal tract

1989 ◽  
Vol 8 (2) ◽  
pp. 465-516 ◽  
Author(s):  
P. PORTER ◽  
W.D. ALLEN
Keyword(s):  
Intestinal Tract ◽  
Intestinal Flora ◽  
The Relationship

Relationship between Lactase Activity and Intestinal Flora Structure

2021 ◽  
Vol 7 (5) ◽  
pp. 3104-3109
Author(s):  
Ying Zhang ◽  
Mingjian Huang ◽  
Jianfeng Chen ◽  
Shuyuan Wang ◽  
Jian Xu
Keyword(s):  
Young Children ◽  
Intestinal Tract ◽  
Lactose Intolerance ◽  
Intestinal Flora ◽  
Control Group ◽  
Lactase Activity ◽  
Beneficial Bacteria ◽  
The Relationship ◽  
Experimental Group ◽  
Infants And Young Children

To analyze and explore the relationship between lactase activity and the structure of intestinal flora in infants under 1 year old. Method: Our hospital selected 60 infants and young children in the Haizhu Maternity and Child Health Hospital from August 2019 to September 2020 as the research objects. The infants in the experimental group were diagnosed as lactose intolerant infants, the control group were normal infants, and the experimental group and control group had 30 cases each. The relationship between lactase activity and intestinal flora structure. Result: The experimental group had fewer beneficial bacteria in the intestinal tract than the control group, but improved lactase activity by correcting the structure of the intestinal flora and alleviating symptoms of lactose intolerance. Conclusion: Infants and young children are prone to non-infectious diarrhea, and the causes are more complicated, but most of them are related to lactose intolerance. When infants and young children develop lactose intolerance, it is necessary to pay attention to the lack of beneficial bacteria in the intestinal tract. Targeted supplementation of probiotics (such as Lactobacillus reuteri, Clostridium butyricum, etc.) can correct the intestinal flora, improve lactase activity, and relieve symptoms of lactose intolerance.

scholarly journals The Role of Intestinal Flora in the Regulation of Bone Homeostasis

2021 ◽  
Vol 11 ◽  
Author(s):  
Chengxiang Li ◽  
Guofu Pi ◽  
Feng Li
Keyword(s):  
Intestinal Tract ◽  
Fecal Microbiota Transplantation ◽  
Relevant Literature ◽  
Intestinal Flora ◽  
Fecal Microbiota ◽  
Bone Homeostasis ◽  
Novel Target ◽  
And Function ◽  
The Relationship

Intestinal flora located within the intestinal tract comprises a large number of cells, which are referred to as the second gene pool of the human body and form a complex symbiotic relationship with the host. The knowledge of the complex interaction between the intestinal flora and various life activities of the host is a novel and rapidly expanding field. Recently, many studies are being conducted on the relationship between the intestinal flora and bone homeostasis and indicate that the intestinal flora can regulate bone homeostasis via the host immune, metabolic, and endocrine systems. What’s more, based on several clinical and preclinical pieces of evidence, changing the composition and function of the host intestinal flora through the application of probiotics, prebiotics, and fecal microbiota transplantation is being considered to be a potential novel target for the regulation of bone homeostasis. Here, we searched relevant literature and reviewed the role of the intestinal flora in the regulation of bone homeostasis and its modulating interventions.

scholarly journals Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Jun-meng Wang ◽  
Ming-xiao Yang ◽  
Qiao-feng Wu ◽  
Ji Chen ◽  
Shu-fang Deng ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Intestinal Microbiota ◽  
Antihypertensive Effect ◽  
Intestinal Flora ◽  
Hypertensive Patients ◽  
Healthy Group ◽  
Oscillometric Device ◽  
Intestinal Dysbiosis ◽  
Stage 1 ◽  
The Relationship

Abstract Background Increasing evidence have indicated the relationship between intestinal dysbiosis and hypertension. We aimed to evaluate the effect of the electroacupuncture (EA) on intestinal microbiota in patients with stage 1 hypertension. Methods 93 hypertensive patients and 15 healthy subjects were enrolled in this study. Applying a highly accurate oscillometric device to evaluate the antihypertensive effect of EA. 16S rRNA sequencing was used to profile stool microbial communities from Healthy group, Before treatment (BT) group and After treatment (AT) group, and various multivariate analysis approaches were used to assess diversity, composition and abundance of intestinal microbiota. Results In this study, EA significantly decreased the blood pressure (BP) of hypertensive patients. Higher abundance of Firmicutes and lower Bacteroidetes abundance were observed in the BT group compared to the Healthy group. And EA treatment significantly decreased the Firmicutes/Bacteroidetes ratio compared to the BT group. Moreover, at the genus level, there was an increased abundance of Escherichia-Shigella in patients with hypertension, while Blautia were decreased, and EA reversed these changes. Conclusions Our study indicates that EA can effectively lower BP and improve the structure of intestinal microbiota which are correlate with the alteration of blood pressure by electroacupuncture. Trial registration: Clinicaltrial.gov, NCT01701726. Registered 5 October 2012, https://clinicaltrials.gov/ct2/show/study/NCT01701726

The Relationship Between Exclusive Breastfeeding And Diarrhea In Children Aged 6-24 Months At Aek Parombunan Public Health Center, South Sibolga 2019

2021 ◽  
Vol 4 (2) ◽  
Author(s):  
Tamara Lubis ◽  
Dwi Rita Anggraini
Keyword(s):  
Exclusive Breastfeeding ◽  
Intestinal Tract ◽  
Sampling Technique ◽  
Chi Square ◽  
Additional Food ◽  
Cross Sectional ◽  
Children Under Five ◽  
Under Five ◽  
Chi Square Test ◽  
The Relationship

Diarrhea is a symptom of infection in the intestinal tract with the second death rate in the world in children under five years of age. Risk factors for the incidence of diarrhea in children under five are host factors that increase susceptibility to diarrhea, not giving exclusive breastfeeding (ASI), not giving breastfeeding for 2 years, malnutrition, measles and immunodeficiency. Breastfeeding (ASI) contains the best nutrients that match the needs of the baby and exclusive breastfeeding is carried out from birth to the first six months without any additional food or drink. Several studies have shown that the immunity content of breastfeeding is able to coat the gastrointestinal mucosa and protect the digestive tract from incoming pathogens. The aim of this study is to find out the relationship between exclusive breastfeeding and the incidence of diarrhea in children aged 6-24 months at Puskesmas Aek Parombunan, Sibolga Selatan in 2019. The research design used was observational analytic cross-sectional with the criteria for the research sample of toddlers aged 6-24 months. The sampling technique in this study used total sampling. The research instrument was a medical record and data analysis used the chi-square test. Based on the results of the study, there was a relation between exclusive breastfeeding and the incidence of diarrhea.

scholarly journals Total Bilirubin Predicts Severe Progression of Diabetic Retinopathy and the Possible Causal Mechanism

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Yu Ding ◽  
Junmin Zhao ◽  
Gangsheng Liu ◽  
Yinglong Li ◽  
Jiang Jiang ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Total Bilirubin ◽  
Intestinal Flora ◽  
Intestinal Barrier ◽  
Vitreous Hemorrhage ◽  
Causal Mechanism ◽  
Stable Group ◽  
Loss Of Vision ◽  
Increased Risk ◽  
The Relationship

Early detection and treatment are key to delaying the progression of diabetic retinopathy (DR), avoiding loss of vision, and reducing the burden of advanced disease. Our study is aimed at determining if total bilirubin has a predictive value for DR progression and exploring the potential mechanism involved in this pathogenesis. A total of 540 patients with nonproliferative diabetic retinopathy (NPDR) were enrolled between July 2014 and September 2016 and assigned into a progression group (N=67) or a stable group (N=473) based on the occurrence of diabetic macular edema (DME), vitreous hemorrhage, retinal detachment, or other conditions that may cause severe loss of vision following a telephonic interview in August 2019. After further communication, 108 patients consented to an outpatient consultation between September and November 2019. Our findings suggest the following: (1) TBIL were significant independent predictors of DR progression (HR: 0.70, 95% CI: 0.54–0.89, p=0.006). (2) Examination of outpatients indicated that compared to stable group patients, progression group patients had more components of urobilinogen and LPS but a lower concentration of TBIL. The relationship between bilirubin and severe DR was statistically significant after adjusting for sex, age, diabetes duration, type of diabetes, FPG, and HbA1c (OR: 0.70, 95% CI: 0.912–0.986, p=0.016). The addition of serum LPS and/or urobilinogen attenuated this association. This study concludes that total bilirubin predicts an increased risk of severe DR progression. Decreasing bilirubin might be attributed to the increased levels of LPS and urobilinogen, which may indicate that the change of bilirubin levels is secondary to intestinal flora disorder and/or intestinal barrier destruction. Further prospective investigations are necessary to explore the causal associations for flora disorder, intestinal barrier destruction, and DR.

scholarly journals Colonization resistance of the digestive tract in conventional and antibiotic-treated mice

1971 ◽  
Vol 69 (3) ◽  
pp. 405-411 ◽  
Author(s):  
D. Van der Waaij ◽  
J. M. Berghuis-de Vries ◽  
J. E. C. Lekkerkerk-van der Wees
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Intestinal Tract ◽  
Normal Values ◽  
Anaerobic Bacteria ◽  
Intestinal Flora ◽  
Treated Animal ◽  
Housing Conditions ◽  
Colonization Resistance ◽  
Germ Free

SUMMARYThe effect of oral administration of antibiotics on the intestinal flora of conventional mice and their resistance to colonization by orally introducedEscherichia coli, Klebsiella pneumoniaeandPseudomonas aeruginosawas studied. Colonization resistance (CR) was expressed as the log of the oral bacterial dose followed by a persistent take in 50 % of the contaminated animals. The intestinal flora was virtually eliminated by the antibiotics and this elimination was accompanied by a precipitous fall of CR. CR gradually returned to normal values during the period of repopulation of the intestinal tract by the organisms surviving the treatment. Antibiotic treatment resulted in the disappearance of Enterobacteriaceae, enterococci, staphylococci and yeasts and, under appropriate housing conditions, the animals remained free of these organisms indefinitely. Germ-free mice contaminated with the intestinal flora of an antibiotic-treated animal and their offspring housed in a germ-free isolator showed high values of CR. Their intestinal flora consisted of anaerobic bacteria only. Apparently, these anaerobes are responsible for CR in these and in conventional mice.

PCR-DGGE Analysis of Bacterial Diversity of Intestinal System in Hyperlipidemia Rats

2013 ◽  
Vol 726-731 ◽  
pp. 898-901
Author(s):  
Ri Na Wu ◽  
Xiao Meng Pang ◽  
Xi Yan Wang ◽  
Jun Rui Wu
Keyword(s):  
Bacterial Diversity ◽  
Denaturing Gradient Gel Electrophoresis ◽  
Intestinal Flora ◽  
Intestinal Bacteria ◽  
Control Group ◽  
Rrna Gene ◽  
Dgge Analysis ◽  
Gradient Gel Electrophoresis ◽  
The Relationship ◽  
Insight Into

Denaturing gradient gel electrophoresis (DGGE) analysis of 16S rRNA gene has been regarded as one of powerful tools for gaining insight into the bacterial diversity of intestinal system. In the present study, hyperlipidemia model was constructed in rat according to the tests of blood lipids. Fecal samples of rats were collected after 60d feeding, and DGGE was used to investigate the diversities of intestinal bacteria in the artificially-induced hyperlipidemia rats and normal rats. The results showed that two patterns had similarities, but there were also some different bacteria communities. Moreover, control group had much more bands than model group on gel, showing species in intestinal of model rats might be deduced by hyperlipidemia. It will be helpful to explore the relationship between hyperlipidemia and intestinal flora.

scholarly journals Gut–Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections

2021 ◽  
Vol 12 ◽  
Author(s):  
Wenxia Zhu ◽  
Yilin Wu ◽  
Hui Liu ◽  
Caini Jiang ◽  
Lili Huo
Keyword(s):  
Gut Microbiota ◽  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Respiratory Infections ◽  
Intestinal Flora ◽  
Intestinal Microbes ◽  
Important Regulator ◽  
Tract Infections ◽  
The Relationship ◽  
Gut Microbiota Composition

The gut microbiota is an important regulator for maintaining the organ microenvironment through effects on the gut-vital organs axis. Respiratory tract infections are one of the most widespread and harmful diseases, especially in the last 2 years. Many lines of evidence indicate that the gut microbiota and its metabolites can be considered in therapeutic strategies to effectively prevent and treat respiratory diseases. However, due to the different gut microbiota composition in children compared to adults and the dynamic development of the immature immune system, studies on the interaction between children’s intestinal flora and respiratory infections are still lacking. Here, we describe the changes in the gut microbiota of children with respiratory tract infections and explain the relationship between the microbiota of children with their immune function and disease development. In addition, we will provide perspectives on the direct manipulation of intestinal microbes to prevent or treat pediatric respiratory infections.

scholarly journals Effect of intestinal flora on the formation of endometritis of sow

2020 ◽  
Author(s):  
Ling Zhang ◽  
Linkang Wang ◽  
Yimin Dai ◽  
Tianyu Tao ◽  
Jingqi Wang ◽  
...  
Keyword(s):  
Relative Abundance ◽  
Intestinal Flora ◽  
Intestinal Bacteria ◽  
Experimental Result ◽  
Intestinal Microbes ◽  
Birth Canal ◽  
Significant Difference ◽  
Vaginal Secretions ◽  
Fresh Feces ◽  
The Relationship

Abstract Background Aberration of birth canal microbiota is one of the most important factors in the etiology of sow endomentritis. Nevertheless, reports about the structure and composition of birth canal microbiota in endomentritis sow and their relationship with intestinal microbes is limited. Therefore, understanding the relationship between birth canal microbiota and intestinal microbiota of the host has become exceedingly crucial. Results In this study, 4 healthy and 4 endomentritis sows were selected basing on whether the sow had endometritis or not in a farm of China. The microflora of their birth canal secretions and fresh feces were analyzed via sequencing the V3 + V4 region of bacterial 16S rDNA gene. The results showed that the significant difference between endometritis and healthy sows birth canal flora in the composition and abundance. Sow endomentritis was associated with increasing in the relative abundance of Porphyromonas, Clostridium_sensu_stricto_1, Streptococcus, Ezakiella, Fusobacterium, Actinobacillus, Bacteroides, and Prevotella as well as Anaerococcus. On the contrary, the majority of beneficial bacteria that belonging to Firmicutes phylum (e.g., Lactobacillus and Enterococcus ) declined in endomentritis sow. The increased relative abundance of Porphyromonas in the vaginal secretions might correlate with the decrease of Lactobacillusin the feces of endometritis sows. Moreover, the experimental result also found that some intestinal bacteria (such as Escherichia-Shigella and Bacteroides) may be bound up with the onset of sow endometritis. Conclusion Sow endometritis is closely related to the microbiota of birth canal, and that some intestinal bacteria may promote the onset of endometritis. The above results can supply a theoretical basis to research the pathogenesis of endometritis and the microbiota of sow's birth canal and gut.

scholarly journals Association Between Breastmilk Microbiota and Food Allergy in Infants

2022 ◽  
Vol 11 ◽  
Author(s):  
Shuo Wang ◽  
Yuan Wei ◽  
Luyan Liu ◽  
Zailing Li
Keyword(s):  
Food Allergy ◽  
Infant Health ◽  
Intestinal Flora ◽  
16S Rrna Gene Sequencing ◽  
Allergic Diseases ◽  
Food Allergies ◽  
Infant Food ◽  
Rrna Gene ◽  
Protective Effects ◽  
The Relationship

Regulating the composition of human breastmilk has the potential to prevent allergic diseases early in life. The composition of breastmilk is complex, comprising varying levels of oligosaccharides, immunoactive molecules, vitamins, metabolites, and microbes. Although several studies have examined the relationship between different components of breastmilk and infant food allergies, few have investigated the relationship between microorganisms in breastmilk and infant food allergy. In the present study, we selected 135 healthy pregnant women and their full-term newborns from a cohort of 202 mother–infant pairs. Among them, 69 infants were exclusively breastfed until 6 mo after birth. At follow-up, 11 of the 69 infants developed a food allergy in infancy while 22 showed no signs of allergy. Thirty-three breastmilk samples were collected within 1 mo after delivery, and 123 infant fecal samples were collected at five time points following their birth. These samples were analyzed using microbial 16S rRNA gene sequencing. The abundance and evenness of the milk microbiota and the number of differential bacteria were higher in the breastmilk samples from the non-allergy group than in those from the food allergy group. The non-allergy group showed relatively high abundance of Bifidobacterium, Akkermansia, Clostridium IV, Clostridium XIVa, Veillonella, and butyrate-producing bacteria such as Fusobacterium, Lachnospiraceae incertae sedis, Roseburia, and Ruminococcus. In contrast, the abundance of Proteobacteria, Acinetobacter, and Pseudomonas in breastmilk was higher in the food allergy group. A comparison of the changes in dominant differential breastmilk microbiota in the intestinal flora of the two groups of infants over time revealed that the changes in Bifidobacterium abundance were consistent with those in the breastmilk flora. Functional pathway prediction of breastmilk microflora showed that the enhancement of the metabolic pathways of tyrosine, tryptophan, and fatty acids was significantly different between the groups. We suggest that changes in the breastmilk microbiota can influence the development of food allergies. Breastmilk contains several microbes that have protective effects against food allergies, both by influencing the colonization of intestinal microbiota and by producing butyrate. This study may provide new ideas for improving infant health through early intervention with probiotics.

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