scholarly journals Aplikasi dan Tinjauan Kinetika Hasil Fraksinasi Produk Pirolisis Cangkang Biji Jambu Mete Uji sebagai Antijamur Candida albicans

2019 ◽  
Vol 2 (2) ◽  
pp. 47-53
Author(s):  
Ustamuni Ustamuni ◽  
Laily Nurliana ◽  
Rustam Musta
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Chemical Kinetics ◽  
Reaction Order ◽  
Fractional Distillation ◽  
Clear Zone ◽  
Pyrolysis Products ◽  
Activity Rate ◽  
Cashew Nut ◽  
Cashew Nut Shell

Research on application and kinetics study of fractionation pyrolysis product from cashew nut shell as antifungal of Candida albicans has been carried out. This study aims to determine the constituent compounds, antifungal activity and chemical kinetics including order and rate constants antifungal activity C. albicans from fractional distillation results of cashew nut shell pyrolysis products. Cashew nuts were hydrolyzed and purified using a fractional distillation device. The results of the antifungal activity test C. albicans from fractional distillation results of cashew nut shell pyrolysis products showed that the inhibitory power varied from each concentration variation of 12.5%, 25%, 50%, 75%, and 100%. The concentration of 100% was the highest inhibitory characterized by the formation of a clear zone of 18.23 mm which indicates that the inhibitory force is a strong category. The clear zone that has been formed was calculated in terms of its chemical kinetics including the reaction order and the activity rate constant. The reaction order of antifungals C. albicans from the results of fractional distillation of cashew nut shell pyrolysis products is 0.15 with a constant activity rate of 8.74.

scholarly journals Kinetika Kimia Antibakteri Fraksi Alkana Alifatik Hasil Pirolisis Cangkang Biji Jambu Mete (CNS)

2020 ◽  
Vol 7 (2) ◽  
pp. 170-176
Author(s):  
Rustam Musta ◽  
Laily Nurliana ◽  
Andraysno Andraysno
Keyword(s):  
Chemical Kinetics ◽  
Reaction Order ◽  
Fractional Distillation ◽  
Pyrolysis Products ◽  
E Coli ◽  
Activity Rate ◽  
Cashew Nut ◽  
Activity Test ◽  
Inhibitory Power ◽  
Cashew Nut Shell

Chemical kinetics research antibacterial of aliphatic alkane fraction from the results of pyrolysis Cashew Nut Shell (CNS) (Annacardium occidentale L.) on Eschericia coli have been carried out. Cashew nuts are prepared by separating the shell and seeds for pyrolysis and purifying using a fractional distillation device. The results of E. coli anti-bacterial activity test from aliphatic alkane fractional distillation results of cashew nut shell pyrolysis products showed that the inhibitory power was different from each concentration variation of 100%, 75%, 50%, 25%, and 12.5%, with inhibitor zone: 8.02; 7.16; 5.56; 4.52 dan 4.26 mm which indicates that the inhibition is weak category for 12.5% and 25%, medium category for 50%, 75% and 100%. The clear zone that has been formed are calculated in terms of its chemical kinetics including the reaction order and the activity rate constant. The reaction order (n) antibacterial of aliphatic alkane fraction from the results of pyrolysis CNS on E. coli was 0.3145 with a constant activity rate of (k) = 1,7791. 

scholarly journals Studi Kinetika Antibakteri dari Hasil Pirolisis Cangkang Biji Jambu Mete terhadap Staphylococcus aureus

2019 ◽  
Vol 6 (2) ◽  
pp. 74-80
Author(s):  
Laily Nurliana ◽  
Rustam Musta
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Response Inhibition ◽  
Pyrolysis Product ◽  
Test Results ◽  
Pyrolysis Products ◽  
Cashew Nut ◽  
Activity Test ◽  
Inhibitory Power ◽  
Cashew Nut Shell

Research on kinetics antibacterial from pyrolysis product of cashew nut shell againts Staphylococcus aureus have been carried out. Cashew nuts are prepared by separating the shell and seeds for pyrolysis. The results of S. aureus antibacterial activity test results pyrolysis pyrolysis products shell cashew nut showed inhibition is different for each variation of the concentration of 12.5%, 25%, 50%, 75% and 100% with inhibition of successive 0.87; 0.97; 1.38; 1.47 and 1.61 (cm). Based on these results it can be said that the result of the pyrolysis of cashew nut shells provide a response inhibition that were at concentrations of 12.5 and 25%. While the concentration of 50%, 75%, and 100% response inhibitory power is included in the strong category on the growth of S. aureus. Order the reaction of the antibacterial activity of S. aureus from the pyrolysis products obtained cashew nut shell 0,3 with activity rate constant of 0.38. The concentration of pyrolysis products of pyrolysis results cashew nut shell the minimum recommended for use as an antibacterial S.aureus.

scholarly journals Microwave-Assisted Pyrolysis of Cashew Nut Shell

2021 ◽  
Vol 16 (2) ◽  
pp. 227-232
Author(s):  
Novriany Amaliyah ◽  
Andi Erwin Eka Putra
Keyword(s):  
Pyrolysis Product ◽  
Volatile Matter ◽  
Fixed Carbon ◽  
Pyrolysis Products ◽  
Microwave Assisted ◽  
Cashew Nut ◽  
Bio Oil ◽  
Ft Ir ◽  
Proximate And Ultimate Analysis ◽  
Cashew Nut Shell

This research examines the characteristics of microwave assisted pyrolysis products of cashew nutshell waste (CNS). The pyrolysis process of CNS conducted with microwave heating of 400 W for 60 minutes. Pyrolysis product such as bio-gas, bio-oil and bio-char were identified using proximate and ultimate analysis, scanning electron microscope (SEM), thermogravimetric analysis (TGA/DTG), gas chromatograph-mass spectrometer (GC-MS) and Fourier Transform InfraRed (FTIR) Method. There is a significant increasing in volatile matter and fixed carbon of derived bio-char and the porous structure was observed in a range of macropore after pyrolysis. The TGA profile reveals CNS sample lost about 71.25% of mass before reached 750℃. The highest decomposition rate on the DTG profile was 0.57 mg/min and 0.56 mg/min as observed at about 261.2℃ and 340.3℃. Bio-oil yield has density of 1.036 gr/ml, viscosity of 19.5 cst after water removing, flash point of 138℃ and HHV of 21.7 MJ/kg. The GC-MS of the bio-oil shows about 53% phenol, 19% palmitic and oleic acid, 11% cyclobutene, 14% ethyl and methyl ester, and cyclopentene and cyclohexane in small amounts in accordance with FT-IR results.

Antifungal activity analysis of 3 essential oils (thyme, ajwainand orange) on candida albicans

2017 ◽  
Vol 6 (3) ◽  
pp. 2948-2950
Author(s):  
Vaishnavi Sivakali Subramanian ◽  
◽  
R.V Geetha ◽  
Anitha Roy ◽  
◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Essential Oils ◽  
Activity Analysis

Aktivitas Antifungi Air Perasan Bawang Merah (Allium ascalonicum L.) Terhadap Candida albicans Secara In Vitro

2017 ◽  
Vol 9 (2) ◽  
pp. 71
Author(s):  
Nurhasanah Nurhasanah ◽  
Fauzia Andrini ◽  
Yulis Hamidy
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Allium Sativum ◽  
Fungicidal Activity ◽  
Positive Control ◽  
Negative Control ◽  
Randomized Design ◽  
Significant Difference ◽  
Completely Randomized Design

Shallot (Allium ascalonicum L.) has been known as traditional medicine. Shallot which has same genus with garlic(Allium sativum L.) contains allicin that is also found in garlic and has been suspected has fungicidal activity toCandida albicans. It is supported by several researches. Therefore, shallot is suspected has antifungal activity too.The aim of this research was to know antifungal activity of shallot’s water extortion againsts Candida albicans invitro. This was a laboratory experimental research which used completely randomized design, with diffusion method.Shallot’s water extortion was devided into three concentrations, there were 50%, 100% and 200%. Ketoconazole 2%was positive control and aquadest was negative control. The result of this research based on analysis of varians(Anova), there was significant difference between several treatments and was confirmed with Duncan New MultipleRange Test (DNMRT) p<0,05, there was significant difference between 100% shallot’s water extortion with othertreatments, but there was no significant difference between 50% shallot’s water extortion with 200% shallot’s. Theconclusion was shallot’s water extortion had antifungal activity againsts Candida albicans with the best concentration100%, but it was lower than ketoconazole 2%.

Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity

2019 ◽  
Vol 70 (10) ◽  
pp. 3603-3610
Author(s):  
Madalina Mihalache ◽  
Cornelia Guran ◽  
Aurelia Meghea ◽  
Vasile Bercu ◽  
Ludmila Motelica ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Biological Activity ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Copper Complexes ◽  
Substrate Adhesion ◽  
Inert Substrate

The three copper complexes having a-ketoglutaric acid (H2A) and 1- (o-tolyl) biguanide (TB) ligands have been synthesized and characterized. The proposed formulas for these complexes are: [Cu(TB)(HA)]Cl (C1), [Cu(TB)(HA)CH3COO]�H2O (C2) and [Cu(TB)(HA)](NO3) (C3) where HA represents deprotonated H2A. The complexes obtained were tested for antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853, antifungal activity on Candida albicans ATCC 10231 and antitumor activity on HeLa tumor cells. Due to the antitumor, antifungal, antimicrobial activity and inhibition of inert substrate adhesion, complexes synthesized could be used for potential therapeutic applications.

Efficacy of Novel Schiff base Derivatives as Antifungal Compounds in Combination with Approved Drugs Against Candida Albicans

2019 ◽  
Vol 15 (6) ◽  
pp. 648-658 ◽  
Author(s):  
Manzoor Ahmad Malik ◽  
Shabir Ahmad Lone ◽  
Parveez Gull ◽  
Ovas Ahmad Dar ◽  
Mohmmad Younus Wani ◽  
...  
Keyword(s):  
Schiff Base ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Fungal Infections ◽  
Total Sterol ◽  
Antifungal Drugs ◽  
New Drugs ◽  
Ergosterol Biosynthesis ◽  
Dependent Manner ◽  
Schiff Base Derivatives

Background: The increasing incidence of fungal infections, especially caused by Candida albicans, and their increasing drug resistance has drastically increased in recent years. Therefore, not only new drugs but also alternative treatment strategies are promptly required. Methods: We previously reported on the synergistic interaction of some azole and non-azole compounds with fluconazole for combination antifungal therapy. In this study, we synthesized some non-azole Schiff-base derivatives and evaluated their antifungal activity profile alone and in combination with the most commonly used antifungal drugs- fluconazole (FLC) and amphotericin B (AmB) against four drug susceptible, three FLC resistant and three AmB resistant clinically isolated Candida albicans strains. To further analyze the mechanism of antifungal action of these compounds, we quantified total sterol contents in FLC-susceptible and resistant C. albicans isolates. Results: A pyrimidine ring-containing derivative SB5 showed the most potent antifungal activity against all the tested strains. After combining these compounds with FLC and AmB, 76% combinations were either synergistic or additive while as the rest of the combinations were indifferent. Interestingly, none of the combinations was antagonistic, either with FLC or AmB. Results interpreted from fractional inhibitory concentration index (FICI) and isobolograms revealed 4-10-fold reduction in MIC values for synergistic combinations. These compounds also inhibit ergosterol biosynthesis in a concentration-dependent manner, supported by the results from docking studies. Conclusion: The results of the studies conducted advocate the potential of these compounds as new antifungal drugs. However, further studies are required to understand the other mechanisms and in vivo efficacy and toxicity of these compounds.

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