scholarly journals Keloids Profile in the Dermatovenerology Clinic of RSUP Dr. M. Djamil Padang Indonesia from January 2014 to December 2018

2020 ◽  
Vol 13 (4) ◽  
pp. 383-387
Author(s):  
Sherly Birawati ◽  
Ennesta Asri
Keyword(s):  
Risk Factors ◽  
Wound Healing ◽  
Medical Records ◽  
Healing Process ◽  
Descriptive Study ◽  
Wound Healing Process ◽  
Age Group ◽  
Skin Tension ◽  
Common Location ◽  
Using Data

Keloid is an abnormal scar that appears as an impact of the wound healing process. Trauma, skin tension, hormone, and genetics are the risk factors of keloid. This study was aimed to obtain the profile of keloid patients at Polyclinic of Dermatovenereology RSUP. Dr. M. Djamil Padang in the period 2014-2018. This was a retrospective descriptive study using data of medical records. The results showed that the incidence of keloid in the period 2014-2018 was 157 cases. Based on gender, females were the most (51.60%). The age group that had the highest in number was 15-24 years old (27.39%). Based on occupation, most were students (33 cases; 20,49%). The most common location of the lesion was on the chest, which accounted for 57 cases (36.31%). Seventy-six cases (48.41%) with interpretation big effect on patient life. Conclusion :Keloid was more common in females, age group 15-24 years old, and occupation as students. The most common location of the lesion was on the chest and a big effect on patient life.

scholarly journals Profil keloid di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2011-Desember 2015

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Rina D.S. Andisi ◽  
Pieter L. Suling ◽  
Marlyn G. Kapantow
Keyword(s):  
Risk Factors ◽  
Medical Records ◽  
Steroid Injection ◽  
Healing Process ◽  
Descriptive Study ◽  
Wound Healing Process ◽  
Age Group ◽  
Skin Tension ◽  
Common Location ◽  
Using Data

Abstract: Keloid is an abnormal scar that appears as an impact of wound healing process. Trauma, skin tension, hormone, and genetics are the risk factors of keloid. This study was aimed to obtain the profile of keloid patients at Polyclinic of Dermatology and Venereology Prof. Dr. R. D. Kandou Hospital in the period 2011-2015. This was a retrospective descriptive study using data of registration book and medical records. The results showed that the incidence of keloid in the period 2011-2015 was 93 cases (1.68%). Based on gender, females were the most (52.69%). The age group that had the highest in number was 15-24 years old (36.56%). Based on occupation, most were students (25 cases; 26,88%). The most common location of lesion was on the chest, which accounted for 48 cases (51.61%). Eighty-nine cases (90.70%) used intralesion steroid injection as the therapy. Conclusion: Keloid was more common in females, age group 15-24 years old, and occupation as students. The most common location of the lesion was on the chest, and the intraleson steroid injection was the most used therapy for keloid.Keywords: keloids, scar, profile Abstrak: Keloid adalah parut abnormal yang timbul sebagai akibat dari proses penyembuhan luka. Trauma, ketegangan kulit, hormon, dan genetik merupakan faktor penyebab terbentuknya keloid. Penelitian ini bertujuan untuk mengetahui profil penderita keloid yang berobat di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode tahun 2011-2015. Jenis penelitian ialah deskriptif retrospektif menggunakan data dari buku register dan catatan rekam medik. Hasil penelitian menunjukkan insidensi penderita keloid periode 2011-2015 sebanyak 93 kasus (1,68%). Distribusi kasus terbanyak pada perempuan (52,69%), kelompok umur 15-24 tahun (36,56%), pekerjaan sebagai pelajar dengan 25 kasus (26,88%). Lokasi lesi paling sering pada daerah dada yaitu sebanyak 48 kasus (51,61%). Sebanyak 89 kasus (90,70%) menggunakan terapi injeksi steroid intralesi. Simpulan: Berdasarkan hasil penelitian ini keloid lebih sering pada perempuan, kelompok umur 15-24 tahun, pekerjaan sebagai pelajar, dengan lokasi lesi paling sering pada daerah dada dan injeksi steroid intralesi merupakan terapi keloid yang paling banyak digunakan. Kata kunci: keloid, bekas luka, profil

scholarly journals Profil keloid di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2011-Desember 2015

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Rina D.S. Andisi ◽  
Pieter L. Suling ◽  
Marlyn G. Kapantow
Keyword(s):  
Risk Factors ◽  
Medical Records ◽  
Steroid Injection ◽  
Healing Process ◽  
Descriptive Study ◽  
Wound Healing Process ◽  
Age Group ◽  
Skin Tension ◽  
Common Location ◽  
Using Data

Abstract: Keloid is an abnormal scar that appears as an impact of wound healing process. Trauma, skin tension, hormone, and genetics are the risk factors of keloid. This study was aimed to obtain the profile of keloid patients at Polyclinic of Dermatology and Venereology Prof. Dr. R. D. Kandou Hospital in the period 2011-2015. This was a retrospective descriptive study using data of registration book and medical records. The results showed that the incidence of keloid in the period 2011-2015 was 93 cases (1.68%). Based on gender, females were the most (52.69%). The age group that had the highest in number was 15-24 years old (36.56%). Based on occupation, most were students (25 cases; 26,88%). The most common location of lesion was on the chest, which accounted for 48 cases (51.61%). Eighty-nine cases (90.70%) used intralesion steroid injection as the therapy. Conclusion: Keloid was more common in females, age group 15-24 years old, and occupation as students. The most common location of the lesion was on the chest, and the intraleson steroid injection was the most used therapy for keloid.Keywords: keloids, scar, profile  Abstrak: Keloid adalah parut abnormal yang timbul sebagai akibat dari proses penyembuhan luka. Trauma, ketegangan kulit, hormon, dan genetik merupakan faktor penyebab terbentuknya keloid. Penelitian ini bertujuan untuk mengetahui profil penderita keloid yang berobat di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode tahun 2011-2015. Jenis penelitian ialah deskriptif retrospektif menggunakan data dari buku register dan catatan rekam medik. Hasil penelitian menunjukkan insidensi penderita keloid periode 2011-2015 sebanyak 93 kasus (1,68%). Distribusi kasus terbanyak pada perempuan (52,69%), kelompok umur 15-24 tahun (36,56%), pekerjaan sebagai pelajar dengan 25 kasus (26,88%). Lokasi lesi paling sering pada daerah dada yaitu sebanyak 48 kasus (51,61%). Sebanyak 89 kasus (90,70%) menggunakan terapi injeksi steroid intralesi. Simpulan: Berdasarkan hasil penelitian ini keloid lebih sering pada perempuan, kelompok umur 15-24 tahun, pekerjaan sebagai pelajar, dengan lokasi lesi paling sering pada daerah dada dan injeksi steroid intralesi merupakan terapi keloid yang paling banyak digunakan.Kata kunci: keloid, bekas luka, profil

scholarly journals GAMBARAN PASIEN INFARK MIOKARD DENGAN ELEVASI ST (STEMI) YANG DIRAWAT DI BLU RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JANUARI 2010 SAMPAI DESEMBER 2010

e-CliniC ◽  
2013 ◽  
Vol 1 (3) ◽  
Author(s):  
Edward August Wagyu
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Developing Countries ◽  
Risk Factor ◽  
Medical Records ◽  
Descriptive Study ◽  
Skin Tumor ◽  
St Elevation Myocardial Infarction ◽  
Age Group ◽  
St Elevation

Abstract :Introduction : ST Elevation Myocardial Infarction disease is the leading cause of death in some advance and developing countries. This disease caused by several risk factor, including unhealthy life style, have diabetic history before, uncontrol hypertension, ages, genders and stress.Objective: This study aims to determine how the image of patients with ST elevation myocardial infarction (STEMI) who were treated in the department of Prof.. DR. R.D. Kandou Manado for 1 year (1st January 2010 - 31st December 2010). A descriptive study of benign skin tumor of the medical records of new patients based on gender, age, location of the occurrence of myocardial infarction, myocardial infarction risk factors, onset of an attack, myocardial infarction complications occurring levels and TIMI risk stratification based on TIMI Risk Score.Results: There were 83 patients of ST Elevation Myocardial Infarction in this hospital. Highest age group is 60-69 years. This disease was almost found in men patients than women. Most risk factor was found in this study is uncontrolled hypertension.Conclusion: ST Elevation Myocardial Infarction is the most dangerous diseases in world that found in Heart and Cardiovascular department Dr Prof Dr. R. D. Kandou Manado. Highest age group is 60-69 years. ST Elevation Myocardial Infarction was more common in men. Most risk factor for this disease is uncontrol hypertension.Keyword: ST Elevation Myocardial Infarction disease, HeartAbstrak :Pendahuluan : ST Elevation Myocardial Infarction penyakit adalah penyebab utama kematian di beberapa muka dan negara-negara berkembang . Penyakit ini disebabkan oleh beberapa faktor risiko , termasuk gaya hidup yang tidak sehat , memiliki sejarah diabetes sebelumnya , hipertensi terkendali , usia , jenis kelamin dan stres Tujuan: Penelitian ini bertujuan untuk mengetahui bagaimana gambaran pasien dengan ST elevasi miokard infark ( STEMI ) yang dirawat di departemen Prof . DR . RD Kandou Manado selama 1 tahun ( 1 Januari 2010 - 31 Desember 2010) .Sebuah penelitian deskritif dari rekam medis pasien baru berdasarkan jenis kelamin, usia , lokasi terjadinya infark miokard , faktor risiko infark miokard , timbulnya serangan , komplikasi infark miokard terjadi tingkat dan TIMI stratifikasi risiko berdasarkan TIMI Skor Risiko.Hasil: Ada 83 pasien dari ST Elevation Myocardial Infarction di rumah sakit ini . Kelompok umur tertinggi adalah 60-69 tahun . Penyakit ini hampir ditemukan pada pria daripada wanita pasien . Kebanyakan faktor risiko ditemukan dalam penelitian ini adalah hipertensi yang tidak terkontrol .Kesimpulan : ST Elevation Myocardial Infarction adalah penyakit yang paling berbahaya di dunia yang ditemukan di Jantung dan Kardiovaskular departemen Dr Prof Dr RD Kandou Manado . Kelompok umur tertinggi adalah 60-69 tahun . ST Elevation Myocardial Infarction lebih sering terjadi pada pria . Kebanyakan faktor risiko untuk penyakit ini adalah hipertensi terkendali .Kata kunci : Penyakit Infark Miokard dengan Elevasi segmen ST, Jantung

scholarly journals Gambaran jumlah leukosit pada pasien infark miokard akut di RSUP Prof. Dr. R. D.Kandou Manado periode Januari-Desember 2015

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Ade M. Sitepu ◽  
Dewi U. Djafar ◽  
Agnes L. Panda
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Medical Records ◽  
Leukocyte Count ◽  
Descriptive Study ◽  
Blood Stream ◽  
Age Group ◽  
Inclusion Criteria ◽  
Using Data ◽  
Observational Descriptive Study

Abstract: Coronary heart disease (CHD) is the leading cause of death in the world and marked by the existence of atherosclerotic plaque at the coronary artery that progressively blocks the blood stream to myocardium resulting in myocardial infarction. Elevated of leukocyte count typically indicates an infection or inflammation, and has a role in vascular injury and atherogenesis that is a development of an atherosclerotic ruptured plaque and trombosis. This study was aimed to obtain the profile of leukocyte count in patient with acute myocardial infarction (AMI) at Prof. Dr. R. D. Kandou Hospital Manado from January to December 2015. This was an observational descriptive study with a retrospective approach using data of medical records of AMI patients who came to Prof. Dr. R. D. Kandou Hospital Manado from January to Desember 2015. The results showed that of totally 63 medical records of patients with AMI, there were 45 samples that fulfilled the inclusion criteria. The majority patients were in the age group 46-60 years, males, the risk factor was a combination of several major risks, and NSTEMI as the type of type of infarction. There were 57,77% of leukocyte count results ranged 10,000-14,900/mm3 and 8,88% were ≥15,000/mm3. Conclusion: There was an increase in the leukocytes count in more than half of the samples. Keywords: acute myocardial infarction, leukocyte, inflammation Abstrak: Penyakit jantung koroner (PJK) merupakan penyebab kematian tersering di dunia dan ditandai adanya plak aterosklerosis pada arteri koroner yang secara progresif menghalangi aliran darah ke miokardium yang berakibat terjadinya infark miokard. Peningkatan jumlah leukosit secara tipikal mengindikasikan adanya suatu infeksi dan peradangan, serta juga berperan pada cedera vaskular dan aterogenesis yang merupakan perkembangan dari suatu ruptur plak aterosklerosis dan trombosis. Penelitian ini bertujuan untuk mengetahui gambaran jumlah leukosit pada pasien IMA di RSUP Prof. Dr. R. D. Kandou periode Januari sampai Desember 2015. Jenis penelitian ialah deskriptif observasional dengan pendekatan retrospektif menggunakan data rekam medik pasien IMA yang berobat di RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Desember 2015 dengan eksklusi riwayat infeksi minimal 2 minggu sebelum masuk rumah sakit. Hasil penelitian mendapatlan 45 sampel dengan mayoritas kelompok usia 46-60 tahun, jenis kelamin laki-laki, faktor risiko kombinasi beberapa faktor risiko mayor, dan jenis infark NSTEMI. Sebanyak 57,77% hasil pemeriksaan leukosit berkisar 10.000-14.900/mm3 dan 8,88% pada ≥15.000/mm3. Simpulan: Lebih dari setengah jumlah sampel mengalami peningkatan jumlah leukosit.Kata kunci: infark miokard akut, leukosit, peradangan

HUBUNGAN MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST OPERASI SECTIO CESARIA

2019 ◽  
Vol 2 (1) ◽  
pp. 14-17
Author(s):  
Nurul Aini Siagian ◽  
Syafira Nusaibah ◽  
Andayani Boang Manalu
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Early Mobilization ◽  
Sectio Caesarea ◽  
Wound Healing Process ◽  
P Value ◽  
Cross Sectional ◽  
Care Services ◽  
Healing Wound ◽  
Rapid Healing

Early mobilization includes factors that can affect the process of wound healing after surgery. Immediate mobilization in stages is very useful for the process of healing wounds and preventing infection and venous thrombosis. The purpose of this study was to determine whether there is a relationship between early mobilization and the process of healing wound post operative sectio caesarea at Sinar Husni General Hospital Medan Helvetia. The research design used was analytic survey with cross sectional approach. The sample in this study used the Consecutive Sampling method of data collection using a checklist sheet conducted on a sample of 19 respondents. The results of the study in this study are the majority of respondents who did early mobilization and who experienced rapid wound healing process as many as 4 people (21%) while the minority of respondents who did early mobilization and who experienced slow wound healing process were 1 person (5.3%). The majority of respondents who did not mobilize early and who experienced a slow wound healing process were 11 people (57.9%) and a minority who did not mobilize early and who experienced rapid healing as many as 4 people (21.1%). Statistical test results obtained p value = 0.046 <0.005. The conclusions of the results of this study indicate there is a relationship between early mobilization and the process of healing post operative sectio of caesarea. Suggestions The results of this study can be applied as a reference to improve nursing care services, especially in providing counseling and assistance to patients.

Hubungan Status Gizi Dengan Proses Penyembuhan Luka Di Rsud H. Andi Sulthan Daeng Radja Kabupaten Bulukumba

2017 ◽  
Vol 2 (1) ◽  
pp. 20-28
Author(s):  
Fitriani ◽  
Tenriwati
Keyword(s):  
Wound Healing ◽  
Nutritional Status ◽  
Healing Process ◽  
Data Retrieval ◽  
Observational Research ◽  
Wound Healing Process ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

At present, the incidence of injuries in Indonesia is quite high, as seen from data on traffic accidents in the general public. There are several factors that affect wound healing, one of which is nutritional status. Based on the preliminary data retrieval conducted by researchers in the seruni surgery room in the last 1 month namely in March, it was found that the number of wounded patients was 109 patients, where the number of men was 78 (71.56%) while the number of women was 31 ( 28.44%) The purpose of this study was to determine the relationship between nutritional status and the wound healing process in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. This research uses the type of design of this research is quantitative research. This type of research uses analytic observational research with cross sectional approach. The sample of this study were 41 respondents taken by purposive sampling method. Data analysis in this study used the chi-square test (chi square test). The results of the analysis used the chi-square statistical test with a confidence level (α = 0.05). Based on the results of this test, the p value is 0.001, thus p <α (0.001 <0.05), then Ho is rejected and Ha is accepted. The conclusion of this study is that there is a relationship between nutritional status and the process of wound healing in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. Researchers suggest that this study be used as a material consideration in the fulfillment of nutrition in wound care patients in RSUD.H.A. Sulthan Daeng Radja Kab. Bulukumba and this research can be continued by conducting research related to the wound healing process and linking it with other variables.

Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

2020 ◽  
Vol 26 (36) ◽  
pp. 4551-4568
Author(s):  
Mohammad Kashif Iqubal ◽  
Sadaf Saleem ◽  
Ashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Growth Factors ◽  
Combination Therapy ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Site ◽  
Synthetic Drugs ◽  
Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

Scientific aspect on Diet explained by Susrutha in Wound Healing

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Manoj Kumar ◽  
Amareshappa . ◽  
Anjali Bharadwaj ◽  
Shailaja S. V.
Keyword(s):  
Wound Healing ◽  
Mineral Metabolism ◽  
Healing Process ◽  
Surgical Techniques ◽  
The Body ◽  
Wound Healing Process ◽  
Human Being ◽  
Different Sources ◽  
Scientific Aspect ◽  
Important Branch

Wound healing has been the burning problem in a surgical practice because of a remarkable increase in the number of traumatic cases. A wound causes a number of changes in the body that can affect the healing process, including changes in energy, protein, carbohydrate, fat, vitamin and mineral metabolism. Various Ayurveda literatures, particularly, Sushruta Samhita, which is said to be an ancient textbook of surgery in Ayurveda, has mentioned about the diet for the person suffering from the wound, and the author said that diet plays a very important role in the wound healing process. Sushruta - The father of surgery has scientifically classified it in a systemic manner, whose wealth of clinical material and the principles of management are valid even today. Shalya Tantra (surgical branch in Ayurveda Science) is one of the important branch of Ayurveda, in which surgical and para-surgical techniques has described for management of various diseases. Vrana is the most important and widely described chapter of Shalya Tantra. Vrana (wound) is one of them, which have been managed by human being from starting of civilization. Under the circumstances, the first thing which the men came across was the injury from different sources which caused him the Vrana. Vrana is seen as debilitating and scaring disorder, usually seen affecting the human being at any age. Well balanced nutrition plays an essential role in the wound healing.

PENGARUH MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST SECTIO CAESAREA

2017 ◽  
Vol 11 (1) ◽  
pp. 109
Author(s):  
Reni Heryani ◽  
Ardenny Denny
Keyword(s):  
Wound Healing ◽  
Placenta Previa ◽  
Healing Process ◽  
Early Mobilization ◽  
Sectio Caesarea ◽  
Uterine Action ◽  
Wound Healing Process ◽  
P Value ◽  
Post Test ◽  
Development Goals

<p align="center"><strong>A</strong><strong>BSTRAK</strong><strong></strong></p><p align="center"> </p><p>Salah satu tujuan pembangunan era <em>Millenium Development goals (MDG’s)</em> 2015 adalah perbaikan kesehatan maternal. Salah satu cara di dalam persalinan atau mengeluarkan bayi secara patologis yaitu dengan sectio caesarea. Menurut  statistik 3.509 kasus sectio caesarea, indikasi terbanyak adalah disproporsi cephalo pelvik (21%), sedangkan indikasi lain adalah gawat janin (14%), plasenta previa (11%), pernah sectio caesarea (11%), incoordinate uterine action (9%), preeklamsi dan hipertensi (7%). Penelitian ini menggunakan desain penelitian <em>Quasy Experiment</em> dengan <em>post test only with control.</em> Hasil penelitian menunjukkan bahwa umumnya responden memiliki umur tidak berisiko terhadap tindakan operasi yati sebanyak 15 orang (75%), sebagian responden pertama kali dilakukan operasi caesarea yaitu sebanyak 10 orang (50,0%), sebagian responden mengalami penyembuhan luka yang normal yaitu sebanyak 13 orang (65,0%), dan sebagian responden responden melakukan mobilisasi dini yaitu sebanyak 14  orang (70,0%). Secara statistik terdapat pengaruh mobilisasi dini terhadap penyembuhan luka post sectio caesarea di RSUD Arifin Achmad Pekanbaru (p value = 0.007). Disarankan bagi respnden dapat meningkatkan kesadarannya dalam meningkatkan derajat kesehatan melalui latihan mobilisasi dini untuk mempercepat proses penyembuhan luka akibat operasi.</p><p><em> </em></p><p><em>Kata Kunci      : </em><em>sectio </em><em>caesarea, mobilisasi, penyembuhan luka</em></p><p><em> </em></p><p align="center"><strong><em>ABSTRACT</em></strong></p><p><em> </em></p><p><em>One of the goals of development era of Millennium Development Goals (MDG's) in 2015 is the improvement of maternal health.</em><em> </em><em>One way in the delivery or the baby out with the pathological ie sectio caesarea. According to 3509 statistics compiled case sectio caesarea, an indication of cephalo pelvic disproportion is the highest (21%), while the other is an indication of fetal distress (14%), placenta previa (11%), never sectio caesarea (11%), incoordinate uterine action (9%), preeclampsia and hypertension (7%).</em><em> </em><em>This study research design quasy Experiment with post test only with control. The results showed that respondents generally have a lifespan of no risk for surgery yati many as 15 people (75%), the majority of respondents were first performed caesarea operation as many as 10 people (50.0%), the majority of respondents experienced a normal wound healing as many as 13 people (65.0%), and the majority of respondents respondents did early mobilization as many as 14 people (70.0%). There is a statistically significant relationship between early mobilization on wound healing post sectio caesarea (p value = 0.007). Suggested for respnden can increase awareness in improving health status through early mobilization exercises to accelerate the wound healing process as a result of the operation.</em></p><p><em> </em></p><em>Keywords: sectio caesarea, mobilization, wound healing</em>

scholarly journals Development of a Topical Insulin Polymeric Nanoformulation for Skin Burn Regeneration: An Experimental Approach

2021 ◽  
Vol 22 (8) ◽  
pp. 4087
Author(s):  
Maria Quitério ◽  
Sandra Simões ◽  
Andreia Ascenso ◽  
Manuela Carvalheiro ◽  
Ana Paula Leandro ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
In Vitro Release ◽  
Peptide Hormone ◽  
Plga Nanoparticles ◽  
Wound Healing Process ◽  
Target Area ◽  
Encapsulation Process

Insulin is a peptide hormone with many physiological functions, besides its use in diabetes treatment. An important role of insulin is related to the wound healing process—however, insulin itself is too sensitive to the external environment requiring the protective of a nanocarrier. Polymer-based nanoparticles can protect, deliver, and retain the protein in the target area. This study aims to produce and characterize a topical treatment for wound healing consisting of insulin-loaded poly-DL-lactide/glycolide (PLGA) nanoparticles. Insulin-loaded nanoparticles present a mean size of approximately 500 nm and neutral surface charge. Spherical shaped nanoparticles are observed by scanning electron microscopy and confirmed by atomic force microscopy. SDS-PAGE and circular dichroism analysis demonstrated that insulin preserved its integrity and secondary structure after the encapsulation process. In vitro release studies suggested a controlled release profile. Safety of the formulation was confirmed using cell lines, and cell viability was concentration and time-dependent. Preliminary safety in vivo assays also revealed promising results.

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