scholarly journals The Principle of Continuous Biological Information Flow as the Fundamental Foundation for the Biological Sciences. Implications for Ageing Research

2021 ◽  
Author(s):  
Xavi Marsellach
Keyword(s):  
Biological Sciences ◽  
Biological Information ◽  
Biological Knowledge ◽  
Phenotypic Characteristics ◽  
Apparent Contradiction ◽  
Current State ◽  
The Face ◽  
Unique Definition ◽  
Definition Of ◽  
Flow Of Information

The current state of biological knowledge contains an unresolved paradox: life as a continuity in the face of the phenomena of ageing. In this manuscript I propose a theoretical framework that offers a solution for this apparent contradiction. The framework proposed is based on a rethinking of what ageing is at a molecular level, as well as on a rethinking of the mechanisms in charge of the flow of information from one generation to the following ones. I propose an information-based conception of ageing instead of the widely accepted damage-based conception of ageing and propose a full recovery of the chromosome theory of inheritance to describe the intergenerational flow of information. Altogether the proposed framework allows a precise and unique definition of what life is: a continuous flow of biological information. The proposed framework also implies that ageing is merely a consequence of the way in which epigenetically-coded phenotypic characteristics are passed from one generation to the next ones.

scholarly journals The Principle of Continuous Biological Information Flow as the Fundamental Foundation for the Biological Sciences. Implications for Ageing Research

2021 ◽  
Author(s):  
Xavi Marsellach
Keyword(s):  
Biological Sciences ◽  
Biological Information ◽  
Biological Knowledge ◽  
Phenotypic Characteristics ◽  
Apparent Contradiction ◽  
Current State ◽  
The Face ◽  
Unique Definition ◽  
Definition Of ◽  
Flow Of Information

The current state of biological knowledge contains an unresolved paradox: life as a continuity in the face of the phenomena of ageing. In this manuscript I propose a theoretical framework that offers a solution for this apparent contradiction. The framework proposed is based on a rethinking of what ageing is at a molecular level, as well as on a rethinking of the mechanisms in charge of the flow of information from one generation to the following ones. I propose an information-based conception of ageing instead of the widely accepted damage-based conception of ageing and propose a full recovery of the chromosome theory of inheritance to describe the intergenerational flow of information. Altogether the proposed framework allows a precise and unique definition of what life is: a continuous flow of biological information. The proposed framework also implies that ageing is merely a consequence of the way in which epigenetically-coded phenotypic characteristics are passed from one generation to the next ones.

scholarly journals The Principle of Continuous Biological Information Flow as the Fundamental Foundation for the Biological Sciences. Implications for Ageing Research

2020 ◽  
Author(s):  
Xavi Marsellach
Keyword(s):  
Biological Sciences ◽  
Biological Information ◽  
Biological Knowledge ◽  
Phenotypic Characteristics ◽  
Apparent Contradiction ◽  
Current State ◽  
The Face ◽  
Unique Definition ◽  
Definition Of ◽  
Flow Of Information

The current state of biological knowledge contains an unresolved paradox: life as a continuity in the face of the phenomena of ageing. In this manuscript I propose a theoretical framework that offers a solution for this apparent contradiction. The framework proposed is based on a rethinking of what ageing is at a molecular level, as well as on a rethinking of the mechanisms in charge of the flow of information from one generation to the following ones. I propose an information-based conception of ageing instead of the widely accepted damage-based conception of ageing and propose a full recovery of the chromosome theory of inheritance to describe the intergenerational flow of information. Altogether the proposed framework allows a precise and unique definition of what life is: a continuous flow of biological information. The proposed framework also implies that ageing is merely a consequence of the way in which epigenetically-coded phenotypic characteristics are passed from one generation to the next ones.

Biomarkers of Acromegaly and Growth Hormone Action

2020 ◽  
Vol 27 (12) ◽  
pp. 1231-1245
Author(s):  
Filippo Maffezzoni ◽  
Teresa Porcelli ◽  
Andrea Delbarba ◽  
Letizia Pezzaioli ◽  
Carlo Cappelli ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Biological Markers ◽  
Clinical Care ◽  
Hormone Deficiency ◽  
Surrogate Outcomes ◽  
Current State ◽  
Growth Hormone Action ◽  
Igf I ◽  
Definition Of

: Biological markers (biomarkers) play a key role in drug development, regulatory approval and clinical care of patients and are linked to clinical and surrogate outcomes. : Both acromegaly and Growth Hormone Deficiency (GHD) are pathological conditions related to important comorbidities that, in addition to having stringent diagnostic criteria, require valid markers for the definition of treatment, treatment monitoring and follow-up. GH and insulin-like growth factor-I (IGF-I) are the main biomarkers of GH action in children and adults while, in acromegaly, both GH and IGF-I are established biomarkers of disease activity. : However, although GH and IGF-I are widely validated biomarkers of GHD and acromegaly, their role is not completely exhaustive or suitable for clinical classification and follow-up. Therefore, new biological markers for acromegaly and GH replacement therapy are strongly needed. : The aim of this paper is to review and summarize the current state in the field pointing out new potential biomarkers for acromegaly and GH use/abuse.

What Is A Chemical Element?

2020 ◽  
Keyword(s):  
Periodic Table ◽  
Chemical Element ◽  
Abstract Concept ◽  
International Union ◽  
Applied Chemistry ◽  
Educational Levels ◽  
Unique Position ◽  
Current State ◽  
Element Carbon ◽  
Definition Of

The term “element” is typically used in two distinct senses. First it is taken to mean isolated simple substances such as the green gas chlorine or the yellow solid sulphur. In some languages, including English, it is also used to denote an underlying abstract concept that subsumes simple substances but possesses no properties as such. The allotropes and isotopes of carbon, for example, all represent elements in the sense of simple substances. However, the unique position for the element carbon in the periodic table refers to the abstract sense of “element.” The dual definition of elements proposed by the International Union for Pure and Applied Chemistry contrasts an abstract meaning and an operational one. Nevertheless, the philosophical aspects of this notion are not fully captured by the IUPAC definition, despite the fact that they were crucial for the construction of the periodic table. This pivotal chemical notion remains ambiguous and such ambiguity raises problems at the epistemic, logical, and educational levels. These aspects are discussed throughout the book, from different perspectives. This collective book provides an overview of the current state of the debate on the notion of chemical element. Its authors are historians of chemistry, philosophers of chemistry, and chemists with epistemological and educational concerns.

Minority Presidents in a Coalitional World

2018 ◽  
Author(s):  
Paul Chaisty ◽  
Nic Cheeseman ◽  
Timothy J. Power
Keyword(s):  
Coalition Formation ◽  
Cost Minimization ◽  
Analytical Framework ◽  
System Level ◽  
Current State ◽  
Key Concepts ◽  
Definition Of

This chapter summarizes the main parameters of coalitional presidentialism and the key concepts, definitions, explanatory frameworks, indicators, and propositions. It summarizes our understanding of coalitional presidentialism; the distinction between coalition formation and maintenance; the definition of coalitions; the multidimensional understanding of coalition management (the ‘presidential toolbox’); and an analytical framework that emphasizes the motivation of presidents to achieve cost minimization under constraints determined by system-level, coalition-level, and conjunctural factors. It also summarizes our main empirical findings: (1) the characteristics of presidential tools, (2) the substantive patterns of their deployment, (3) the factors that shape the costs of using these tools, (4) the actual (observed) costs of using them, and (5) the potential for imperfect substitutability of these tools. Finally, it concludes with some reflections on the current state of the research on comparative presidentialism.

scholarly journals Likely Exacerbation of Psychological Disorders from Covid-19 Response

2021 ◽  
Vol 12 ◽  
pp. 215013272110167
Author(s):  
Tara Rava Zolnikov ◽  
Tanya Clark ◽  
Tessa Zolnikov
Keyword(s):  
Psychological Disorders ◽  
Emotional Reactions ◽  
Post Traumatic Stress ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Current State ◽  
The Face ◽  
Adults And Children ◽  
Post Traumatic ◽  
Anxiety Depression

Anxiety and fear felt by people around the world regarding the coronavirus pandemic is real and can be overwhelming, resulting in strong emotional reactions in adults and children. With depressive and anxiety disorders already highly prevalent in the general population (300 million worldwide), depression and/or anxiety specifically because of the pandemic response is likely. Moreover, the current state of panic in the face of uncertainty is apt to produce significant amounts of stress. While this situation has the potential to cause psychological disorders in previously unaffected populations, perhaps more impactful is the exacerbation of symptoms of many existing disorders including anxiety, depression, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD) and hoarding disorder.

scholarly journals Analysis of Educational Data in the Current State of University Learning for the Transition to a Hybrid Education Model

2021 ◽  
Vol 11 (5) ◽  
pp. 2068
Author(s):  
William Villegas-Ch. ◽  
Xavier Palacios-Pacheco ◽  
Milton Roman-Cañizares ◽  
Sergio Luján-Mora
Keyword(s):  
Online Education ◽  
Educational Model ◽  
Hybrid Education ◽  
Face To Face ◽  
Current State ◽  
Use Of Technology ◽  
Technological Advances ◽  
The World ◽  
The Face ◽  
Education Model

Currently, the 2019 Coronavirus Disease pandemic has caused serious damage to health throughout the world. Its contagious capacity has forced the governments of the world to decree isolation and quarantine to try to control the pandemic. The consequences that it leaves in all sectors of society have been disastrous. However, technological advances have allowed people to continue their different activities to some extent while maintaining isolation. Universities have great penetration in the use of technology, but they have also been severely affected. To give continuity to education, universities have been forced to move to an educational model based on synchronous encounters, but they have maintained the methodology of a face-to-face educational model, what has caused several problems in the learning of students. This work proposes the transition to a hybrid educational model, provided that this transition is supported by data analysis to identify the new needs of students. The knowledge obtained is contrasted with the performance presented by the students in the face-to-face modality and the necessary parameters for the transition to this modality are clearly established. In addition, the guidelines and methodology of online education are considered in order to take advantage of the best of both modalities and guarantee learning.

WoCoVA consensus on the clinical use of in-line filtration during intravenous infusions: Current evidence and recommendations for future research

2021 ◽  
pp. 112972982198916
Author(s):  
Ton Van Boxtel ◽  
Mauro Pittiruti ◽  
Annemarie Arkema ◽  
Patrick Ball ◽  
Giovanni Barone ◽  
...  
Keyword(s):  
Potential Benefit ◽  
Scientific Evidence ◽  
Venous Access ◽  
Current Evidence ◽  
Future Research ◽  
Global Awareness ◽  
Current State ◽  
Intravenous Infusions ◽  
Proper Definition ◽  
Definition Of

The need for filtering intravenous infusions has long been recognized in the field of venous access, though hard scientific evidence about the actual indications for in-line filters has been scarce. In the last few years, several papers and a few clinical studies have raised again this issue, suggesting that the time has come for a proper definition of the type of filtration, of its potential benefit, and of its proper indications in clinical practice. The WoCoVA Foundation, whose goal is to increase the global awareness on the risk of intravenous access and on patients’ safety, developed the project of a consensus on intravenous filtration. A panel of experts in different aspects of intravenous infusion was chosen to express the current state of knowledge about filtration and to indicate the direction of future research in this field. The present document reports the final conclusions of the panel.

scholarly journals The Role of P-Selectin in COVID-19 Coagulopathy: An Updated Review

2021 ◽  
Vol 22 (15) ◽  
pp. 7942
Author(s):  
Chiara Agrati ◽  
Alessandra Sacchi ◽  
Eleonora Tartaglia ◽  
Alessandra Vergori ◽  
Roberta Gagliardini ◽  
...  
Keyword(s):  
Endothelial Activation ◽  
Cardiovascular Complications ◽  
Current State ◽  
Activated Platelets ◽  
Blood Clots ◽  
Severe Infections ◽  
Platelet Aggregates ◽  
Definition Of ◽  
Leucocyte Recruitment

In severe COVID-19, which is characterized by blood clots and neutrophil-platelet aggregates in the circulating blood and different tissues, an increased incidence of cardiovascular complications and venous thrombotic events has been reported. The inflammatory storm that characterizes severe infections may act as a driver capable of profoundly disrupting the complex interplay between platelets, endothelium, and leukocytes, thus contributing to the definition of COVID-19-associated coagulopathy. In this frame, P-selectin represents a key molecule expressed on endothelial cells and on activated platelets, and contributes to endothelial activation, leucocyte recruitment, rolling, and tissue migration. Briefly, we describe the current state of knowledge about P-selectin involvement in COVID-19 pathogenesis, its possible use as a severity marker and as a target for host-directed therapeutic intervention.

scholarly journals Defining and Quantifying Intermittency in the Power Sector

Energies ◽  
2020 ◽  
Vol 13 (13) ◽  
pp. 3366
Author(s):  
Daniel Suchet ◽  
Adrien Jeantet ◽  
Thomas Elghozi ◽  
Zacharie Jehl
Keyword(s):  
Power Source ◽  
Production Data ◽  
Power Sector ◽  
Predictive Capacity ◽  
The Public ◽  
Current State ◽  
Definition Of ◽  
Quantitative Definition ◽  
The Impact

The lack of a systematic definition of intermittency in the power sector blurs the use of this term in the public debate: the same power source can be described as stable or intermittent, depending on the standpoint of the authors. This work tackles a quantitative definition of intermittency adapted to the power sector, linked to the nature of the source, and not to the current state of the energy mix or the production predictive capacity. A quantitative indicator is devised, discussed and graphically depicted. A case study is illustrated by the analysis of the 2018 production data in France and then developed further to evaluate the impact of two methods often considered to reduce intermittency: aggregation and complementarity between wind and solar productions.

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