scholarly journals Inter-Eye Correlation Analysis of 24-hour IOPs and Glaucoma Progression

2021 ◽  
Author(s):  
Mohamad Dakroub ◽  
Raoul Verma-Fuehring ◽  
Vaia Agorastou ◽  
Julian Schön ◽  
Jost Hillenkamp ◽  
...  
Keyword(s):  
Disease Progression ◽  
Roc Curves ◽  
Bivariate Analysis ◽  
Progression Rate ◽  
Fiber Layer ◽  
Glaucoma Progression ◽  
Ocular Perfusion ◽  
Significant Difference ◽  
Relationship Of ◽  
The Relationship

Purpose: To determine whether 24-hour IOP monitoring can be a predictor for glaucoma progression and to analyze the inter-eye relationship of IOP, perfusion and progression parameters. Methods: We extracted data from manually drawn IOP curves with HIOP-Reader, a software suite we developed. The relationship between measured IOPs and mean ocular perfusion pressures (MOPP) to retinal nerve fiber layer (RNFL) thickness was analyzed. We determined the ROC curves for peak IOP (Tmax), average IOP (Tavg), IOP variation (IOPvar) and historical IOP cut-off levels to detect glaucoma progression (rate of RNFL loss). Bivariate analysis was conducted to check for various inter-eye relationships. Results: 217 eyes were included. The average IOP was 14.8±3.5 mmHg, with a 24-hour variation of 5.2±2.9 mmHg. 52% of eyes with RNFL data showed disease progression. There was no significant difference in Tmax, Tavg and IOPvar between progressors and non-progressors (all p>0.05). Except for Tavg and the temporal RNFL, there was no correlation between disease progression in any quadrant, Tmax, Tavg and IOPvar. 24-hour and outpatient IOP variables had poor sensitivities and specificities in detecting disease progression. The correlation of inter-eye parameters was moderate; correlation with disease progression was weak. Conclusion: In line with our previous study, IOP data obtained during a single visit (outpatient or inpatient monitoring) make for a poor diagnostic tool, no matter the method deployed. Glaucoma progression and perfusion pressure in left and right eyes correlated weakly to moderately with each other.

scholarly journals HIOP-Reader: Automated Data Extraction for the Analysis of Manually Recorded Nycthemeral IOPs and Glaucoma Progression

2021 ◽  
Author(s):  
Vaia Agorastou ◽  
Julian Schoen ◽  
Raoul Verma-Fuehring ◽  
Mohamad Dakroub ◽  
Jost Hillenkamp ◽  
...  
Keyword(s):  
Disease Progression ◽  
Perfusion Pressure ◽  
Data Extraction ◽  
Ocular Perfusion Pressure ◽  
Analysis Software ◽  
Fiber Layer ◽  
Glaucoma Progression ◽  
Image Analysis Software ◽  
Ocular Perfusion ◽  
The Relationship

Purpose: Nycthemeral (24-hour) glaucoma inpatient intraocular pressure (IOP) monitoring has been used in Europe for more than 100 years to detect peaks missed during regular office hours. Data supporting this practice is lacking, partially because it is difficult to correlate manually drawn IOP curves to objective glaucoma progression. To address this, we deployed automated IOP data extraction tools and tested for a correlation to a progressive retinal nerve fiber layer loss on spectral-domain optical coherence tomography (SDOCT). Methods: We created and deployed a machine-learning image analysis software to extract IOP data from hand-drawn, nycthemeral IOP curves of 225 retrospectively identified glaucoma patients. The relationship between demographic parameters, IOP and mean ocular perfusion pressure (MOPP) data to SDOCT data was analyzed. Sensitivities and specificities for the historical cut-off values of 15 mmHg and 22 mmHg in detecting glaucoma progression were calculated. Results: IOP data could be extracted efficiently. The IOP average was 15.2±4.0 mmHg, nycthemeral IOP variation was 6.9±4.2 mmHg, and MOPP was 59.1±8.9 mmHg. Peak IOP occurred at 10 AM and trough at 9 PM. Disease progression occurred mainly in the temporal-superior and -inferior SDOCT sectors. No correlation could be established between demographic, IOP, or MOPP parameters and SDOCT disease progression. The sensitivity and specificity of both cut-off points (15 and 22 mmHg) were insufficient to be clinically useful. Outpatient IOPs were non-inferior to nycthemeral IOPs. Conclusion: IOP data obtained during a single visit make for a poor diagnostic tool, no matter whether obtained using nycthemeral measurements or during outpatient hours.

scholarly journals MUC1 and MUC5AC Acting on Helicobacter pylori-Related Deficiency and Solid Syndrome of Spleen and Stomach

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Ling Hu ◽  
Wanqun Chen ◽  
Ming Cheng ◽  
Ting Zhang ◽  
Shaoyang Lan ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Dynamic Equilibrium ◽  
Deficiency Syndrome ◽  
Blue Staining ◽  
Significant Difference ◽  
Tai Ji ◽  
Hematoxylin And Eosin ◽  
Relationship Of ◽  
Heat Syndrome ◽  
The Relationship

To investigate the relationship of MUC1, MUC5AC, and the syndrome of spleen and stomach, 109 subjects (34 peptic ulcer (PU), 62 chronic gastritis (CG), and 13 healthy volunteers (CON)) were included. All the subjects included were surveyed with questionnaire to classify them into damp-heat syndrome of spleen and stomach (DHSS), spleen-qi deficiency syndrome (SQD), and CON, examined by gastric endoscope, and biopsied. Rapid urease and methylene blue staining (MBS) were performed on every subject to diagnose for Helicobacter pylori (Hp) infection, and both were defined as Hp-positive. Hematoxylin and eosin (HE) staining was performed on every specimen to explore the histomorphology, inflammatory degree, and inflammatory activity of different groups; then Elivision™ plus kit was used to test the expression of MUC1 and MUC5AC. All the results of digital images were reviewed by two experts blindly. The inflammatory degree with Hp infection was higher than those uninfected or CON, but no significant difference was found between DHSS and SQD. And the expressions of MUC5AC with positive Hp was higher than those with negative Hp or CON regardless of the deficiency and solid syndrome of spleen-stomach but not for MUC1. We speculate that the deficiency and solid syndrome of spleen-stomach is a condition like Tai Ji symbol of dynamic equilibrium, showing the higher expression of MUC5AC but no change of MUC1 in the circumstance of Hp infection.

scholarly journals Kejadian Hiperbilirubinemia Ditinjau dari Berat Badan Lahir

2020 ◽  
Vol 5 (1) ◽  
pp. 36-42
Author(s):  
Yeviza Puspitasari
Keyword(s):  
Random Sampling ◽  
Statistical Tests ◽  
Univariate Analysis ◽  
Bivariate Analysis ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Study Population ◽  
Relationship Of ◽  
The Relationship

Hyperbilirubinemia is one of the clinical phenomena most often found in neonates occurring in the first week of life, which is also one of the factors causing infant death is influenced by the immature liver function of the baby to process erythrocytes (red blood cells), resulting in the accumulation of bilirubin. The purpose of this study was to determine the relationship of birth weight of infants with the incidence of hyperbilirubinemia in RSUD dr. Ibnu Soetowo Baturaja Ogan Komering Ulu Regency in 2019. This study uses analytic methods with a cross-sectional approach. The study population was all infants aged 0-7 days in the neonatal room at RSUD dr. Ibnu Soetowo Baturaja Ogan Komering Ulu Regency in 2019, with a random sampling. Data analysis uses univariate analysis and bivariate analysis using distribution tables and Chi-Square statistical tests, with a 95% confidence level. In the univariate analysis, of 203 respondents found 26.5% had hyperbilirubinemia and those without hyperbilirubinemia 72.5%, 24.6% of infants with LBW and non-LBW infants 75.4%. Bivariate analysis showed that there was an LBW relationship with the incidence of hyperbilirubinemia (p-value 0,000).

scholarly journals Influence of publication year, add-on design, and geographical region on the progression of Alzheimer’s disease: a modeling analysis of literature aggregate data

2020 ◽  
Author(s):  
ningyuan zhang ◽  
Xijun Zheng ◽  
Hongxia Liu ◽  
Qingshan Zheng ◽  
Lujin Li
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Disease Assessment ◽  
Progression Rate ◽  
Progression Model ◽  
Geographical Regions ◽  
Significant Difference ◽  
Disease Progression Rate ◽  
Disease Progression Model

Abstract Background Our objective was to develop a disease progression model for cognitive decline in Alzheimer’s disease (AD) and to determine whether disease progression of AD is related to the year of publication, add-on trial design, and geographical regions. Methods Placebo-controlled randomized AD clinical trials were systemically searched in public databases. Longitudinal placebo response (mean change from baseline in the cognitive subscale of the Alzheimer’s Disease Assessment Scale [ADAS-cog]) and the corresponding demographic information were extracted to establish a disease progression model. Covariate screening and subgroup analyses were performed to identify potential factors affecting the disease progression rate. Results A total of 142 publications (148 trials) were included in this model-based meta-analysis. The typical disease progression rate was 5.82 points per year. The baseline ADAS-cog score was included in the final model using an inverse-U type function. Age was found to be negatively correlated with disease progression rate. After correcting the baseline ADAS-cog score and the age effect, no significant difference in disease progression rate was found between trials published before and after 2008, and between trials using add-on design and those that did not use add-on design. However, a significant difference was found among different trial regions. Trials in East Asian countries showed the slowest decline rate and the largest placebo effect. Conclusions Our model successfully quantified AD disease progression by integrating baseline ADAS-cog score and age as important predictors. These factors and geographic location should be considered when optimizing future trial designs and conducting indirect comparisons of clinical outcomes.

scholarly journals Hubungan Karakteristik individu dan Perilaku Caring Perawat Dengan Kepuasan pasien di Ruang Rawat Inap RSUD Abdul Manap Jambi Tahun 2019

2020 ◽  
Vol 20 (3) ◽  
pp. 996
Author(s):  
Ernawati Ernawati ◽  
Bettywati E Tumanggor
Keyword(s):  
Nursing Care ◽  
Individual Characteristics ◽  
Bivariate Analysis ◽  
P Value ◽  
Caring Behavior ◽  
Nursing Services ◽  
Chi Square Analysis ◽  
Relationship Of ◽  
The Relationship

Nursing services have a big role to play in improving and determining the quality of health care. caring is an important component in nursing and is at the core of nursing practice because it contains humanistic values, respects human freedom of choice, emphasizes on improving ability and self-reliance, increasing knowledge and respecting every human being. Nurses who have value and caring spirit will have work behaviors that are in accordance with the principles of ethics due to the care of nurses who view clients as humanistic beings so motivated to provide high quality nursing services. This study is a quantitative study with a design description of correlation with a cross sectional approach to view the relationship of individual characteristics and caring behavior of nurses as independent variables and patient satisfaction as variable dependent. The goal is to know the relationship of individual characteristics and behavior of caring nurses with the satisfaction of inpatients of Abdul Manap Jambi Hospital. Samples of patients treated in the first and VIP inpatient rooms, how to take samples by accidental sampling. Data processing with chi-square analysis. Based on the results of the study the characteristics of individuals are mostly: male gender respondents (56.7%), low education (83.3%), age over 46 years (56.7%), and work (61.7%). Caring behavior of nurses is mostly well behaved (73.3%) and 70% of patients are satisfied with the services provided in the inpatient room of RsUD Abdul Manap Kota Jambi. The results of bivariate analysis there is no relationship of individual characteristics with the satisfaction of inpatients and there is a relationship of caring behavior of nurses with the satisfaction of inpatients in Abdul Manap Hospital Jambi City (p value 0.018). The results of the study are expected to improve the quality of nursing services, especially in providing nursing care by taking into account caring aspects to improve the satisfaction of inpatients. For nurses in the inpatient room consistently and further improve caring application in providing nursing care to patients especially in the fulfillment of basic needs and health education in the inpatient room.

scholarly journals The Relationship of Surgeon Handedness and Experience on Operative Duration and Hearing Improvement in Ipsilateral and Contralateral Otologic Surgeries

2020 ◽  
Vol 35 (2) ◽  
pp. 17
Author(s):  
Gillian Barzaga
Keyword(s):  
Hearing Improvement ◽  
Ear Surgery ◽  
Hearing Gain ◽  
Operative Duration ◽  
Left Handed ◽  
Significant Difference ◽  
Surgeon Experience ◽  
The Right ◽  
Relationship Of ◽  
The Relationship

ABSTRACT Objective: To determine the relationship of the surgeon handedness and operative site laterality on operative duration and hearing improvement in otologic surgery, and to further explore whether this relationship may be related to surgeon experience. Methods:Design: Retrospective CohortSetting: Tertiary Private Teaching HospitalParticipants: Seventy-three (73) patients aged 18 to 65 years old who underwent primary ear surgery under general anesthesia between January 2016 and December 2019 were retrospectively divided into two groups: 39 contralateral and 34 ipsilateral. The operative durations and hearing improvements were compared using independent t-tests, with consideration of surgeon experience in years further stratifying patients. Results: There was no significant difference in operative duration, t(71) = 1.14, p = .26, between the contralateral (M = 281.95 minutes, SD = 71.82) and ipsilateral (M = 261.15, SD = 79.26) groups. This same pattern was more pronounced among surgeons with 10+ years of experience although there was also no significant difference in operative time, t(33) = 1.31, p = .19 for both ipsilateral and contralateral surgeries There was no statistically significant difference, t(36) = -0.72, p = .47, in overall mean hearing gain among patients in the contralateral (M = +2.22 dB, SD = 10.54) and ipsilateral (M = +5.12 dB, SD = 14.26) groups. Although the difference was also not statistically significant, t(16) = -1.94, p = .07 for contralateral (M = 0.00, SD = 5.43) and ipsilateral (M = +7.95 dB, SD = 11.52) procedures performed by surgeons with experience of 10 years or more, a mean hearing gain of +7 dB in the ipsilateral group compared to 0 dB in the contralateral group was notable. Conclusion: This study did not prove that regardless of surgeon experience, right-handed surgeons operating on the right ear and left-handed surgeons operating on the left ear have better ear surgery outcomes of operative duration and hearing improvement compared to right- handed surgeons operating on the left ear and left-handed surgeons operating on the right ear. Future studies on larger samples with more complete data may yet demonstrate this effect.

scholarly journals Glaucoma Optic Neuropathy Progression: the Results of Long-Term Follow-Up

2019 ◽  
Vol 16 (1S) ◽  
pp. 96-101
Author(s):  
N. I. Kurysheva ◽  
V. N. Trubilin ◽  
E. O. Shatalova ◽  
L. V. Lepeshkina
Keyword(s):  
Risk Factors ◽  
Optic Neuropathy ◽  
Glaucomatous Optic Neuropathy ◽  
Progression Rate ◽  
Channel Blockers ◽  
Fiber Layer ◽  
Glaucoma Progression ◽  
Prostaglandin Analogues ◽  
Long Term Follow Up

Purpose: to investigate the average speed and risk factors for the glaucomatous optic neuropathy (GON) progression during longterm observation. Patients and methods. The 10-year data of 750 patients were analyzed. The average GON progression rate was calculated on the basis of perimetry and optical coherent tomography data. Further, according to inclusion and exclusion criteria 128 patients were included into the group of retrospective analysis. Resultes. The following risk factors were established: initial cornealcompensated IOP (IOPcc) > 23.6 mm Hg (AUC 0.7), IOPcc after 5 years > 19.8 mm Hg (AUC 0.83), age > 69.5 years (AUC 0.6), corneal hysteresis < 9.9 mm Hg (AUC 0.6) and retinal nerve fiber layer < 92 μm (AUC 0.6). Patients with pseudoexfoliation syndrome, and patients taking systemic calcium channel blockers (p = 0.01) also had the higher risk of GON progression. Its rate was lower in patients with arterial hypertension (p = 0.015), and in patients who received prostaglandin analogues (risk was 5 times reduced, p = 0.04) and fixed combinations (risk was 2 times reduced, p = 0.018). IOPcc of higher than 17.6 mm Hg in the long-term period is the most pronounced risk factor for the progression of GON. It was determined that the average ROP of glaucoma progression among the patients was 0.6 dB/year for ROP1, 0.62 ± 1.09 μm/year for ROP2 and 0.95 ± 3.28 μm/year for ROP3, also each 1 dB/year decrease in photosensitivity (in group with glaucoma progression) was associated with further loss of RNFL (3.9 µm/year). Conclusion. The use of prostaglandin analogues and fixed combinations reduces this risk.

Relationship of Psychological well-being with Depression and Anxiety among Heart Patients

2021 ◽  
Vol 15 (11) ◽  
pp. 3101-3102
Author(s):  
Babar Javaid ◽  
Abrar Ahmed ◽  
Gohar Ali Arshad ◽  
M Shoaib Akhtar ◽  
Shazia Taj ◽  
...  
Keyword(s):  
Null Hypothesis ◽  
Well Being ◽  
Military Hospital ◽  
P Value ◽  
Depression And Anxiety ◽  
Psychological Well Being ◽  
Heart Patients ◽  
Significant Difference ◽  
Relationship Of ◽  
The Relationship

The study was designed to investigate the relationship of psychological well-being with depression and anxiety among heart patients.1 For this purpose, a sample of 200 patients was taken, including 100 men and 100 women, educated uneducated, employed and unemployed volunteers. The sample was taken from Nishtar Hospital, Combined military hospital and other private hospitals in Multan. The age range from 25 to 60 (mean age 43.085).2,3 Objective: To observe the effect of demographic variables (age, education, gender and source of finance) on psychological well-being and depression, anxiety in heart patients. Methods: 1. Low psychological well-being would be positively correlated with depression and anxiety. 2. Older age (above 50) heart patients would have low sense of psychological well-being as compared to younger age (above 35) heart patients. Results: Different statistical procedures were used to determine the relationship of psychological well-being with depression and anxiety among heart patients. Correlation was computed to see the relationship among variables. It was found that there is negative correlation between psychological well-being with depression and anxiety. Since the p-value in less than α (p-value < 0.01), so we reject null hypothesis Ho, and conclude that low psychological well-being is positively correlated with depression and anxiety. Conclusion: This study also finds out important findings on the role of stresses, feeling of worthlessness in depression and anxiety disorder. It is concluded that psychological well-being, depression and anxiety are not significant correlated with each other. Source of income or job and sex of the heart patients have significant effect on psychological well being. However there is no significant difference between men and women regarding the rate of depression and anxiety. Keywords: P-Value, Correlation, Null Hypothesis , Depression

Effects of decoupling on spectra of seismic waves

1962 ◽  
Vol 52 (1) ◽  
pp. 123-131
Author(s):  
D. E. Willis ◽  
James T. Wilson
Keyword(s):  
Seismic Waves ◽  
High Explosive ◽  
Atomic Energy Commission ◽  
University Of Michigan ◽  
Frequency Spectra ◽  
Spherical Cavities ◽  
Significant Difference ◽  
The University ◽  
Relationship Of ◽  
The Relationship

Abstract A series of controlled high explosive shots were conducted by the Atomic Energy Commission in a salt mine near Winnfield, Louisiana, to investigate seismic decoupling theories. Two recording stations were used by the University of Michigan at various distances between 1.1 and 14.7 kilometers for a majority of these shots. Frequency analyses of the magnetic tape recordings were made and the results are presented showing the relationship of the frequency spectra as a function of charge size, distance from the source, and coupled vs decoupled shots. The smaller decoupled shots detonated in the large spherical cavities were observed to have somewhat higher predominate frequencies than the equivalent size coupled shots. A change in cavity size produced no significant difference in the shape of the spectra of the large decoupled shots.

The Effect of two different protein sources in the diet upon the incidence and prevalance of lameness in dairy cattle

1989 ◽  
Vol 1989 ◽  
pp. 66-66
Author(s):  
D N Logue ◽  
A Lawson ◽  
D J Roberts ◽  
E A Hunter
Keyword(s):  
Dairy Cattle ◽  
Crude Protein ◽  
Economic Consequences ◽  
Relative Importance ◽  
The West ◽  
Significant Difference ◽  
Series Of Experiments ◽  
Relationship Of ◽  
The Relationship ◽  
Locomotion Score

The importance of lameness in dairy cattle in UK in terms of its economic consequences and welfare considerations is well documented (Russel and others, 1982). While such epidemiological work has identified factors of importance in the aetiology of the various conditions associated with lameness it has been less successful in apportioning their relative importance, particularly for those conditions affecting the hoof. A series of experiments has been conducted at the West of Scotland College over the period 1983 to 1989 mainly investigating the relationship of nutrition and lameness. In one of these Manson and Leaver (1988) found a significant difference in the prevalence of lameness between two groups of cattle fed complete diets containing either 16.1 or 19.8% crude protein. They also found a significant increase in mean locomotion score (LS) and commented that further studies were needed to understand the dietary processes by which the hoof of the cow was predisposed to such problems.The objective of this experiment was to investigate the influence of the type of protein source in the concentrate upon the locomotion of the cows, the incidence and prevalence of lameness and finally on hoof hardness, shape, growth and wear.

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