scholarly journals Pengaruh Susu Kedelai terhadap Ekspresi Reseptor Estrogen-Β Uterus pada Masa Reproduksi Awal Rattus Norvegicus Betina

2019 ◽  
Vol 5 (1) ◽  
pp. 17
Author(s):  
Vide Bahtera Dinastiti ◽  
Nurdiana Nurdiana ◽  
Pande Made Dwijayasa
Keyword(s):  
Rattus Norvegicus ◽  
Endocrine System ◽  
Reproductive Function ◽  
Potential Effect ◽  
Reproductive Period ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
Soy Milk ◽  
Control Group Design

 Receptors estrogen can also stimulated by other, namely by fitoestrogen. Fitoestrogen are the group of non steroid plants that have composition resembling the natural estrogen in the body. One of it is isoflavon, that can be binding with receptor estrogen, which affinity for RE-β is greater than RE-α and can make potential effect because receptors estrogen will blocked by isoflavon and cannot be occupied by estrogen.This compound can harm the endocrine system of the body because of the possible bad effects for reproductive function. Isoflavonoid is mostly found in soy. Soybean can be processed to soybean milk. The purpose of this study is demonstrate that administration of soy milk can affect the  expression of RE-β uterus at the early reproductive period of female Rattus norvegicus. The method used is an experimental design post test control group design. The sample in this study is 24 Rattus norvegicus females. Then divided into four groups: one control group and three treatment groups were given soy milk each dose of 2.5 mg/kg/weight; 5mg/kg/weight; 10mg/kg/weight. The  expression of RE-β uterus were measured by immunohistochemistry. Based on the analysis using ANOVA, was obtained p-value of 0.000, smaller than α = 0:05 (p <0.05). There is a significant influence on the administration of soy milk increase expression of RE-β and by LSD test obtained the results of differences from application of soy milk with different doses. 

scholarly journals Optimalisasi Pertumbuhan Bayi dengan Baby Massage and Spa

2019 ◽  
Vol 10 (2) ◽  
pp. 276
Author(s):  
Yusari Asih ◽  
I Gusti Ayu Mirah WS
Keyword(s):  
Body Length ◽  
Head Circumference ◽  
Intervention Group ◽  
Sampling Technique ◽  
Holistic Approach ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Significant Difference

<p><span>Baby Massage and Spa was a traditional effort that uses a holistic approach through comprehensive care using a combination of massage and water therapy methods that are carried out in an integrated manner to balance the body, mind, and feelings. Age 3-6 months is the right time for babies to do massage and spa. The purpose of this study was to determine the effect of baby massage and spa on the growth of infants aged 3-5 months in Pringsewu District in 2018. This study uses a quasi-experimental approach with research design pre and post-test with control group design. The purposive sampling technique was taken with a sample of 30 infants as the intervention group and 30 infants as the control group. Data were processed using computerization and analyzed using the T-Test. The results showed that there were significant differences between body weight, body length and baby head circumference in the pre and post-treatment. There was no significant difference in the average increase in infant weight between babies who were carried out by baby massage and spa with babies who were not carried out by baby massage and spa with p-value 0.116. There is a significant difference in the baby's body length and head circumference performed by baby massage and spa with those not carried out by baby massage and spa with p-value 0.000. Baby Massage and Spa has a significant effect on increasing the growth of babies aged 3-5 months.</span></p><p><span> </span></p>

scholarly journals EFFECT OF BACK EXERCISE TO DECREASE LOW BACK PAIN OF BATIK ARTISANTS IN KAUMAN VILLAGE, SOKARAJA

2019 ◽  
Vol 11 (1) ◽  
pp. 45
Author(s):  
Siti Harwanti ◽  
Budi Aji ◽  
Nur Ulfah
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Treatment Group ◽  
Exercise Therapy ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
Low Back ◽  
Control Group Design ◽  
And Control

ABSTRACT Low back pain ( LBP ) is a musculoskeletal disorder that occurs in the lower back which can be caused by various diseases and  activity of the body being less good. One effort to overcome the LBP is back exercise. The research purpose is to find out the effect of back exercise therapy which concern to lowering painful complaint of batik artisants in Kauman village Sokaraja subsdistrict. This research is using Quasi Experiment technique phenomenological non equivalen control group design (pre -post test). Sample taking is using purposive sampling technique. Data analysis use Friedman experiment for treatment group and Repeated Annova experiment for control group. Experiment analysis is different between treatment group and control group with using Mann Whitney experiment. The result of Friedman experiment in treatment group shows that p-value=0,000(p<0,05), it means the therapy those given is effective to lowering painful complaint. The result of Repeated Annova experiment in control group shows that p-value=0,234(p>0,05), it means the painful complaint seems not different in control group. The result of Mann Whitney experiment shows that p-value=0,000(p<0,05) it means there are differences between painful complaint in treatment group and control group after doing back exercise. There is the effect by giving back exercise therapy which concern to lowering the complaint of low back pain for batik artisants in Kauman village Sokaraja subdistrict.   Key words: Handmade Batik, Low back pain, back exercise

scholarly journals Efektivitas Ekstrak Bawang Merah (Allium ascalonicum L) Terhadap Penurunan Suhu Tubuh Anak dengan Demam Pasca Imunisasi DPT Pentabio

2021 ◽  
Vol 11 (1) ◽  
pp. 6
Author(s):  
Setiawandari Setiawandari ◽  
Eka Deviany Widyawaty
Keyword(s):  
Body Temperature ◽  
Hepatitis B ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
Type B ◽  
Control Group Design ◽  
Group Design ◽  
Influenza Type ◽  
Post Test

The immunizations that must be given to children include the Diphtheria Pertussis Tetatus-Hepatitis B-Hemophilus Influenza type B vaccine or better known as Pentabio DPT. The DTwP / HB / HiB vaccine is given to babies in 3 doses at 1 month intervals. This immunization caused a systemic reaction, one of which was a fever of 0.85% in the first 30 minutes and increased to 14.03% on the day after immunization. The purpose of this study was to determine the effectiveness of shallots (Allium ascalonicum L) in reducing the body temperature of feverish children after Pentabio DPT immunization. This type of research was quasi-experimental study, with pre and post test with control group design. The sample in this study were babies who received DPT immunization as many as 20 respondents. DPT Pentabio immunization was given a dose of 0.5 ml in the intervention group and the control group. The statistical test used was the T test. The results showed that there was a significant effect of shallots on in reducing the body temperature of feverish children after Pentabio DPT immunization, with a p-value of 0.000. Keywords: shallots; body temperature; fever; Pentabio DPT immunization ABSTRAK Imunisasi yang wajib diberikan kepada anak-anak diantaranya adalah vaksin Diphtheria Pertusis Tetatus-Hepatitis B-Hemophilus Influenza type B atau lebih dikenal dengan DPT Pentabio. Vaksin DTwP/HB/HiB diberikan kepada bayi sebanyak 3 dosis dengan interval 1 bulan. Imunisasi ini menimbulkan reaksi sistemik salah satunya berupa demam 0,85% pada 30 menit pertama dan meningkat menjadi 14,03% pada satu hari pasca imunisasi. Tujuan dari penelitian ini adalah mengetahui efektifitas bawang merah (Allium ascalonicum L) terhadap penurunan suhu tubuh anak demam pasca imunisasi DPT Pentabio. Jenis penelitian quasi eksperimen dengan pre and post test with control group design. Sampel pada penelitian ini adalah bayi yang mendapat imunisasi DPT sebanyak 20 orang responden. Pemberian imunisasi DPT PENTABIO Pentabio dosis 0,5 ml pada kelompok intervensi dan kelompok kontrol. Uji statistik yang digunakan adalah Uji T. Hasil penelitian menunjukkan ada pengaruh yang signifikan dari bawang merah dalam menurunkan suhu tubuh anak demam pasca imunisasi DPT Pentabio, dengan p-value 0,000. Kata kunci: bawang merah; suhu tubuh; demam; imunisasi DPT Pentabio

scholarly journals Effects of Curcumin on Vascular Endothelial Growth Factor Expression on Rattus norvegicus Cervical Cancer Xenograft Model

2019 ◽  
Vol 12 (3) ◽  
pp. 95
Author(s):  
Laili Muninggar ◽  
Widjiati Widjiati ◽  
Indra Yuliati ◽  
Brahmana Askandar ◽  
Poedjo Hartono
Keyword(s):  
Cervical Cancer ◽  
Rattus Norvegicus ◽  
Histopathological Examination ◽  
Xenograft Model ◽  
Control Group ◽  
P Value ◽  
Vegf Expression ◽  
Control Group Design ◽  
Significant Difference ◽  
Median Expression

Objective: To analyze the effect of curcumin in VEGF expression on Rattus norvegicus cervical cancer cell xenograft model.Methods: An experimental study with randomized post test only control group design. The subjects were Rattus norvegicus (Sprague Dawley), inoculated with He-la cervical cancer cells from American Type Culture Collection (ATCC) processed in stem cell laboratory Institute of Tropical Disease (ITD) Airlangga University. 5x106 of He-La cells were injected subcutaneously in dorsal flank area of Rattus norvegicus. After 30 days of observation we performed histopathological examination of xenograft tissue and randomized into 2 groups which were given curcumin orally 1000 mg/kg (curcumin group) vs. no therapy (control group). After another 30 days the xenograft tissue was dissected and underwent immunochemistry examination for VEGF expression.Results: 32 samples of Rattus norvegicus were divided into 2 groups, In curcumin group the VEGF median expression was 2,2 (0,3-7,6) and in control group the VEGF median expression was 6,6 (1,2-12). There was a statistically significant difference with p value =0,009 with Mann Whitney test (p<0,05).Conclusion: VEGF expression in Rattus norvegicus xenograft model of cervical cancer was suppressed by giving Curcumin 1000 mg/kgBB orally.

scholarly journals Short Communication: Effects of black soy phytoestrogens (Glycine soja) on elevated levels of estradiol in rat blood (Rattus novergicus) ovariectomy

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Dwi Yuliawati ◽  
WURI WIDI ASTUTI ◽  
FITRI YUNIARTI
Keyword(s):  
Group Treatment ◽  
Rattus Norvegicus ◽  
Glycine Soja ◽  
Negative Control ◽  
Female Rats ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Rat Blood

Abstract. Yuliawati D, Astuti WW, Yuniarti F. 2020. Effects of Black Soy phytoestrogens (Glycine soja) on elevated levels of estradiol in Rat Blood (Rattus norvegicus) ovariectomy. Nusantara Bioscience 12: 55-58. Menopause is the transition from productive to non-productive times due to reduced estrogen and progesterone and has an impact on improving cardiovascular problems. The fulfillment of estrogen needs in menopause can use a type of phytoestrogens from black soybeans. The purpose of research is to prove the administration of black soy extract (Glycine soja) can increase the levels of estradiol in the rat blood (Rattus norvegicus) ovariectomy. Design research uses post-test only control group design. Twenty-five female rats were randomly divided into 5 groups (n = 5 tails per group), negative controls, positive and 3 treatments. Ovariectomy was performed in a group of positive controls and treatment. Thirty-day post ovariectomy rats were given appropriate group treatment (negative control, positive, and treatment with the administration of black soy extract dose of 50, 100, 150 mg/200  g/day for 30 days). The estradiol test used the Enzyme-linked immunosorbent assay (ELISA). Anova's test results with a significant degree of α = 0.05 established that the p-value of 0.000 was less than α = 0.05, meaning there was a significant effect of giving black soy extract on increased levels of estradiol in the rat blood ovariectomy. Post - Hoc Tukey testing shows increased the highest estradiol levels in the dose treatment group 100 mg/200  g/day. This research proves that the administration of black soy extract (Glycine soja) can increase the levels of estradiol in the rat blood (Rattus norvegicus) ovariectomy.

scholarly journals Effect of Giving Mahkota Dewa Fruits (Phaleria Macrocarpa) Extract to Epithelialization In Incision Wound of White Rats (Rattus Norvegicus)

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Idola Perdana Sulistyoning Suharto
Keyword(s):  
Treatment Group ◽  
Rattus Norvegicus ◽  
Male Rats ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
White Rats ◽  
Significant Difference ◽  
Phaleria Macrocarpa ◽  
Incision Wound

The research purpose was to analysis effect of giving mahkota dewa fruits (Phaleria macrocarpa) extract to epithelialization in incision wound of white rats (Rattus norvegicus). The method was randomized posted-only control group design. There were 30 male rats (Rattus norvegicus) grouped on control and treatment group. Control group divided into three groups (KK1, KK2, KK3) and also treatment group divided into three groups (KP1, KP2, KP3). Control group just given CMC 1% peroral without mahkota dewa fruits extract, the treatment group given mahkota dewa fruits extract 22.5 mg/kg body weight. The data was analyzed by Kruskall Wallis. Based on Kruskall Wallis test, obtained result that there was a significant difference (p<0.05) epithelialization variable with p value p = 0.000 between control and treatment group. And based on One-way Anova test, obtained result that there was a significant difference (p<0.05) with p value p =0.000 between control and treatment group. The conclusion of this research was giving mahkota dewa fruits (Phaleria macrocarpa) extract can increase epithelialization in incision wound of white rats (Rattus norvegicus). Keywords : Mahkota Dewa Fruits (Phaleria Macrocarpa) Extract, Epithelialization, Incision Wound 

scholarly journals Pengaruh Pemberian Ekstrak Rumput Laut Cokelat (Sargassum duplicatum) terhadap Peningkatan Kadar Hematokrit pada Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Anemia yang di Induksi NaNO2

2020 ◽  
Vol 3 (2) ◽  
pp. 38
Author(s):  
Ayu Mayang A. P. ◽  
Liliawanti Liliawanti ◽  
Wachjudi Kurnia
Keyword(s):  
Rattus Norvegicus ◽  
White Male ◽  
Brown Seaweed ◽  
Negative Control ◽  
Laboratory Method ◽  
The Body ◽  
Male Rats ◽  
Control Group ◽  
Control Group Design ◽  
Significant Difference

<p>Anemia is still a high prevalence disease in Indonesia, caused by a lack of iron in the body. The components from brown seaweed such as cobalamin (vitamin B12), pyridoxine (vitamin B6), chlorophyll and iron (Fe) can increase red blood cells in the body. The purpose of this research was to determine the effect of brown seaweed (<em>Sargassum duplicatum</em>) which can increase hematocrit levels in the blood of white male wistar strain rat (<em>Rattus norvegicus</em>) suffered from anemia in induction NaNO<sub>2</sub>.</p><p>            This research uses an experimental laboratory method with a post test only control group design. The samples were 30 male rats divided into 3 treatment groups, the negative control group (K<sub>0</sub>) without treatment, the positive control (K<sub>1</sub>) be treated anemia given NaNO<sub>2</sub> for 18 days without <em>Sargassum duplicatum </em>extract and treatment group (K<sub>2</sub>) treated with anemia given NaNO<sub>2</sub> for 18 days without <em>Sargassum duplicatum </em>extract at a dose of 2,45gr / kgBB. On the 40<sup>th</sup> day, a blood sample was taken, then measured the hematocrit level.</p><p>            The results showed that the mean number of blood hematocrit levels in K<sub>2</sub> was higher than K<sub>1</sub>, it showed a significant difference descriptively. Based on the Kruskal-Wallis test, a value of 0.260 was obtained that p &gt; 0,05 showed that there were no statistically significant differences between groups of experimental animals.</p><p>            From the results of this research, the conclusion is the administration of brown seaweed extract (<em>Sargassum duplicatum</em>) descriptively increased, but not statistically significant.</p><p> </p><p><strong>Keywords :</strong> Anemia, hematocrit, <em>Sargassum duplicatum</em>, NaNO<sub>2</sub></p>

scholarly journals Effect of Dates Consumption On Bleeding, Duration, And Types of Labor

2019 ◽  
Vol 4 (1) ◽  
pp. 85
Author(s):  
Kuswati Kuswati ◽  
Rohmi Handayani
Keyword(s):  
Treatment Group ◽  
Pregnant Women ◽  
Design Research ◽  
Sampling Technique ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
Fisher Exact Test ◽  
Control Group Design ◽  
Exact Test

Dates are a good source of nutrition for the body if consumed regularly both in the form of dried fruit, wet, as well as in the form of palm juice extracts, especially for pregnant and maternal mothers. Pregnant women who are going to give birth are in desperate need of drinks and foods that are rich in sugar, this is because of the many contractions of the uterine muscles when it comes to removing the baby, especially if it takes a long time. Dates contain potuchin hormone which functions to bind the uterus and muscles of the uterus so that it can help reduce postpartum bleeding. Besides, there is the hormone oxytocin which can help stimulate contractions in the muscles of the uterus so as to facilitate labor. The purpose of this study was to determine the effect of consumption of dates on bleeding, length of labor and type of labor. This type of research is a Pre experiment with a post-test Only Control Group Design research design. The population in this study were all pregnant women in the working area of South Klaten Public Health Center with estimated deliveries from July to September 2018. While the sample size was 60 samples consisting of 30 treatment group respondents and 30 control group respondents. The sampling technique used in this study was Quota sampling. Data analysis using Fisher Exact test and Mann-Whitney U test with p-value considered significant is p = 0.05. The results of the study of bleeding showed that there were no significant differences in the estimation of blood loss and during labor and type of delivery between the treatment group and the control group (p-value = 0.5). The results of the study about the length of labor showed that there was an effect of date consumption on the length of labor, with a value of p = 0,000

scholarly journals Pengaruh Latihan Renang Teratur dan Latihan Renang Tidak Teratur Terhadap Kadar Trigliserida Plasma pada Rattus norvegicus

2018 ◽  
Vol 2 (1) ◽  
pp. 24-40
Author(s):  
Adi Wijayanto
Keyword(s):  
Rattus Norvegicus ◽  
Exercise Program ◽  
The Body ◽  
Control Group ◽  
Regular Exercise ◽  
Control Group Design ◽  
Group Design ◽  
Significant Difference ◽  
Post Test ◽  
And Control

Triglycerides are source of energy in the body, but triglyceride deposits that exceed the threshold will cause health problems, so triglycerides should be lowered to normal. The reduction of triglycerides can be done through physical activity, therefore this study aims to reveal the effect of regular swimming exercises and irregular exercises against triglyceride levels. This research is an experimental research using The Post Test Only Control Group Design design. Subjects of the study were male of Rattus Norvegicus Wistar, 39 subjects was divided into 3 groups with Matched Subject Design technique, which consisted of 2 groups of treatment that is regular and irregular group, and control group. The exercise program was given a swimming with a 3% weight of body weight and was tied 5 cm from the tip of the tail which was performed 3 times per week consistently for regular exercise and 0 to 5 times per week inconsistently for irregular exercise for 12 weeks, While the control group was not given training. In the last week before the blood was taken, the first three groups were given swimming treatment exercises. Based on the results of the anava test, there was a significant difference in the reduction of triglyceride levels among white mice who were given regular exercise with irregular exercise. These results suggest that regular exercise has a better impact on triglyceride reduction than irregular exercise, due to the higher adaptation process of regular exercise.

scholarly journals EFEKTIVITAS PEPPERMINT DAN POMELO DALAM MENURUNKAN INTENSITAS MUAL DAN MUNTAH PADA IBU HAMIL

2020 ◽  
Vol 6 (4) ◽  
pp. 435-441
Author(s):  
Nora Veri ◽  
Nila Suci Ramadhani ◽  
Alchalidi Alchalidi
Keyword(s):  
Pregnant Women ◽  
The Body ◽  
Nausea And Vomiting ◽  
Control Group ◽  
P Value ◽  
Average Intensity ◽  
Control Group Design ◽  
Group Design ◽  
Significant Difference ◽  
Quasi Experimental

ABSTRACT Background: Emesis gravidarum can get worse into hyperemesis gravidarum which causes the body to become weaker, paler, and the frequency of urination decreases. As a result, decreased body fluids and hemoconcentration of blood can cause tissue damage. Non pharmacological treatment is very important because it reduces the pharmacological effects that appear in pregnant women. The herbal therapy that has been proven to be beneficial is the administration of peppermint, but research on the effects of Pamelo fruit related to nausea and vomiting in pregnant women is still rare.Objective: To determine the comparison of the effectiveness of peppermint and Pomelo orange on the intensity of nausea and vomiting in pregnant womenMethods: The research design was a quasi experimental study with a pretest posttest control group design approach. The number of samples was 24 pregnant women who were grouped into 3 groups.Results: The average intensity of nausea and vomiting in the peppermint group at pretest was 2.38 and decreased at posttest to 1 with P-value 0.004. The intensity of nausea and vomiting in the Pomelo group at pretest was 6.38, falling to 1.75 at posttest with P-value 0.000. The result of further test showed that there was no significant difference in the intensity of nausea and vomiting between the two groups with Sig. 0.428.Conclusion: Peppermint and pomelo are effective in reducing the intensity of nausea and vomiting in trimester I pregnant women.Suggestion : This research needs to be refined by enlarging the research sample and measuring the intensity of nausea and vomiting can be done every day during the study considering that this study only measured twice the number of 24 respondents. Keywords : Nausea, Vomiting, Pregnancy, Peppermint, Pomelo ABSTRAK Latar Belakang : Emesis gravidarum dapat bertambah berat menjadi hiperemesis gravidarum yang mengakibatkan tubuh semakin lemah, pucat, dan frekuensi buang air kecil menurun. Akibatnya cairan tubuh berkurang dan hemokonsentrasi darah yang dapat menimbulkan kerusakan jaringan. Pengobatan non farmakolgis sangat penting karena mengurangi efek farmakologis yang muncul pada ibu hamil. Terapi herbal yang sudah terbukti bermanfaat adalah pemberian peppermint, namun penelitian efek buah Pamelo yang berkaitan dengan mual muntah pada ibu hamil masih jarang.Tujuan Penelitian : Untuk mengetahui  perbandingan efektifitas pemberian peppermint dan Jeruk Pomelo terhadap intensitas  mual dan  muntah pada ibu hamilMetode Penelitian : Rancangan penelitian ini adalah quasi experimental dengan pendekatan pretest posttest control group design. Jumlah sampel  adalah sebanyak 24 orang ibu hamil yang dikelompokkan kedalam 3 kelompok.Hasil Penelitian : Rata-rata intensitas mual muntah pada kelompok peppermint saat pretest adalah 2,38 dan menurun pada saat posttest menjadi 1 dengan P-value 0,004. Intensitas mual muntah kelompok Pomelo pada pretest adalah 6.38 turun menjadi 1,75 pada saat posttest dengan P-value 0,000. Hasil uji lanjut didapatkan tidak ada perbedaan bermakna intensitas mual muntah antara kedua kelompok dengan Sig. 0,428.Kesimpulan : Pemberian Peppermint dan pomelo efektif dalam menurunkan intensitas mual dan muntah pada ibu hamil trimester I.Saran : Penelitian ini perlu disempurnakan dengan memperbesar sampel penelitian dan pengukuran intensitas mual muntah dapat dilakukan setiap hari selama penelitian mengingat penelitian ini hanya mengukur sebanyak dua kali pada 24 responden. Kata kunci : Mual, Muntah, Kehamilan, Peppermint, Pomelo 

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