scholarly journals Effect of Giving Mahkota Dewa Fruits (Phaleria Macrocarpa) Extract to Epithelialization In Incision Wound of White Rats (Rattus Norvegicus)

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Idola Perdana Sulistyoning Suharto
Keyword(s):  
Treatment Group ◽  
Rattus Norvegicus ◽  
Male Rats ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
White Rats ◽  
Significant Difference ◽  
Phaleria Macrocarpa ◽  
Incision Wound

The research purpose was to analysis effect of giving mahkota dewa fruits (Phaleria macrocarpa) extract to epithelialization in incision wound of white rats (Rattus norvegicus). The method was randomized posted-only control group design. There were 30 male rats (Rattus norvegicus) grouped on control and treatment group. Control group divided into three groups (KK1, KK2, KK3) and also treatment group divided into three groups (KP1, KP2, KP3). Control group just given CMC 1% peroral without mahkota dewa fruits extract, the treatment group given mahkota dewa fruits extract 22.5 mg/kg body weight. The data was analyzed by Kruskall Wallis. Based on Kruskall Wallis test, obtained result that there was a significant difference (p<0.05) epithelialization variable with p value p = 0.000 between control and treatment group. And based on One-way Anova test, obtained result that there was a significant difference (p<0.05) with p value p =0.000 between control and treatment group. The conclusion of this research was giving mahkota dewa fruits (Phaleria macrocarpa) extract can increase epithelialization in incision wound of white rats (Rattus norvegicus). Keywords : Mahkota Dewa Fruits (Phaleria Macrocarpa) Extract, Epithelialization, Incision Wound 

scholarly journals Pengaruh Kitosan Terhadap Jumlah Osteoklas dan Osteoblas Pada Tikus Galur Wistar Model Menopause

2017 ◽  
Vol 1 (2) ◽  
pp. 76-87
Author(s):  
Muhammad Nur
Keyword(s):  
Treatment Group ◽  
Total Sample ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Positive Control Group ◽  
Control Group ◽  
Control Group Design ◽  
White Rats ◽  
Significant Difference

Chitosan is one of the most abundant and dispersed polymers in nature. It has a rapid healing effect for tissues and has an effect on bone remodeling. The purpose of this study was to prove that giving chitosan influenced the decrease of osteoclast number and increasing number of osteoblasts in female mice of wistar strain of ovariectomy menopause model.This study used a posttest only control group design. The total sample of 30 rats divided into three groups was randomized, osteoporosis was made with the menopausal model which was performed ovariectomy in the positive control group and the treatment group then in the treatment group was given chitosan extract of single dose of 45 mg / day via Nasogastric Tube (NGT). K1 was a negative control group (without ovariectomy and without chitosan), K2 was a positive control group (with no chitosan ovariectomy), K3 was the treatment group (ovariectomy and chitosan 45 mg / day).The results showed significant differences in the number of osteoblasts between K1 and K3, K2 with K3, and no significant differences were found in the K1 group with K2. While the number of osteoclasts showed that there were significant differences in K1 group with K2 and no significant difference was found in K1 group with K3, K2 with K3.Conclusions in this study showed that 45 mg / day of chitosan doses could significantly increase osteoblast counts in menopause female white rats and decrease the number of osteoclasts performed by ovariectomy with chitosan administration.

scholarly journals Effects of Curcumin on Vascular Endothelial Growth Factor Expression on Rattus norvegicus Cervical Cancer Xenograft Model

2019 ◽  
Vol 12 (3) ◽  
pp. 95
Author(s):  
Laili Muninggar ◽  
Widjiati Widjiati ◽  
Indra Yuliati ◽  
Brahmana Askandar ◽  
Poedjo Hartono
Keyword(s):  
Cervical Cancer ◽  
Rattus Norvegicus ◽  
Histopathological Examination ◽  
Xenograft Model ◽  
Control Group ◽  
P Value ◽  
Vegf Expression ◽  
Control Group Design ◽  
Significant Difference ◽  
Median Expression

Objective: To analyze the effect of curcumin in VEGF expression on Rattus norvegicus cervical cancer cell xenograft model.Methods: An experimental study with randomized post test only control group design. The subjects were Rattus norvegicus (Sprague Dawley), inoculated with He-la cervical cancer cells from American Type Culture Collection (ATCC) processed in stem cell laboratory Institute of Tropical Disease (ITD) Airlangga University. 5x106 of He-La cells were injected subcutaneously in dorsal flank area of Rattus norvegicus. After 30 days of observation we performed histopathological examination of xenograft tissue and randomized into 2 groups which were given curcumin orally 1000 mg/kg (curcumin group) vs. no therapy (control group). After another 30 days the xenograft tissue was dissected and underwent immunochemistry examination for VEGF expression.Results: 32 samples of Rattus norvegicus were divided into 2 groups, In curcumin group the VEGF median expression was 2,2 (0,3-7,6) and in control group the VEGF median expression was 6,6 (1,2-12). There was a statistically significant difference with p value =0,009 with Mann Whitney test (p<0,05).Conclusion: VEGF expression in Rattus norvegicus xenograft model of cervical cancer was suppressed by giving Curcumin 1000 mg/kgBB orally.

scholarly journals Pengaruh Pemberian Ekstrak Rumput Laut Cokelat (Sargassum duplicatum) terhadap Peningkatan Kadar Hematokrit pada Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Anemia yang di Induksi NaNO2

2020 ◽  
Vol 3 (2) ◽  
pp. 38
Author(s):  
Ayu Mayang A. P. ◽  
Liliawanti Liliawanti ◽  
Wachjudi Kurnia
Keyword(s):  
Rattus Norvegicus ◽  
White Male ◽  
Brown Seaweed ◽  
Negative Control ◽  
Laboratory Method ◽  
The Body ◽  
Male Rats ◽  
Control Group ◽  
Control Group Design ◽  
Significant Difference

<p>Anemia is still a high prevalence disease in Indonesia, caused by a lack of iron in the body. The components from brown seaweed such as cobalamin (vitamin B12), pyridoxine (vitamin B6), chlorophyll and iron (Fe) can increase red blood cells in the body. The purpose of this research was to determine the effect of brown seaweed (<em>Sargassum duplicatum</em>) which can increase hematocrit levels in the blood of white male wistar strain rat (<em>Rattus norvegicus</em>) suffered from anemia in induction NaNO<sub>2</sub>.</p><p>            This research uses an experimental laboratory method with a post test only control group design. The samples were 30 male rats divided into 3 treatment groups, the negative control group (K<sub>0</sub>) without treatment, the positive control (K<sub>1</sub>) be treated anemia given NaNO<sub>2</sub> for 18 days without <em>Sargassum duplicatum </em>extract and treatment group (K<sub>2</sub>) treated with anemia given NaNO<sub>2</sub> for 18 days without <em>Sargassum duplicatum </em>extract at a dose of 2,45gr / kgBB. On the 40<sup>th</sup> day, a blood sample was taken, then measured the hematocrit level.</p><p>            The results showed that the mean number of blood hematocrit levels in K<sub>2</sub> was higher than K<sub>1</sub>, it showed a significant difference descriptively. Based on the Kruskal-Wallis test, a value of 0.260 was obtained that p &gt; 0,05 showed that there were no statistically significant differences between groups of experimental animals.</p><p>            From the results of this research, the conclusion is the administration of brown seaweed extract (<em>Sargassum duplicatum</em>) descriptively increased, but not statistically significant.</p><p> </p><p><strong>Keywords :</strong> Anemia, hematocrit, <em>Sargassum duplicatum</em>, NaNO<sub>2</sub></p>

scholarly journals INTERVENSI EMOTIONAL FREEDOM TECHNIQUE (EFT) UNTUK MENGURANGI NYERI POST OPERASI SECTIO CAESARIA (SC)

2018 ◽  
Vol 1 (1) ◽  
pp. 53
Author(s):  
Lutfatul Latifah ◽  
Dian Ramawati
Keyword(s):  
Treatment Group ◽  
Rating Scale ◽  
Numeric Rating Scale ◽  
Pain Scale ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Significant Difference ◽  
Before And After ◽  
Mother And Child

Introduction: Every woman who undergo Sectio Caesaria (SC) surgery for delivery their babies often complain about pain after the surgery and it become very distrubing. The effect of the pain cause mobilisation limitation, interrupting bonding attachment between mother and child, and postponning breastfeeding inititation. This study conduct EFT or tapping as the pain management in women post SC surgery.The aim of this study is to identify the effect of EFT or tapping for reducing pain after SC surgery. Methods: Quasy experimental with pre-post non randomized control group design was used in this study. The data been colleted using Numeric Rating Scale (NRS) to measure the pain in participants before and after EFT or tapping treatment. The number of participants was 30 mothers with 15 women in control and treatment group respectively. The t-test was used to analize the effect of the EFT. Results: The mean of pain scale before treatment in control group was 5.20 dan 6.20 for the treatment group. The pain scale after treatment in control group was 5.00 and 4.27 in treatment group. There was a significant difference between the reducing pain scale in treatment group with p value = 0,000 (α = 0.05). Discussion: EFT or tapping can be one of many non farmacologic treatment as complementer therapy to reduce pain after SC surgery. Keywords: post SC pain, EFT, pain scale decline, non farmacologic therapy

scholarly journals THE EFFECTIVENESS OF CORIANDER (Coriandrum sativum L.) EXTRACTS ON REDUCING THE BLOOD SUGAR LEVELS OF ALLOXAN INDUCED WISTAR MALE RATS (Rattus norvegicus L.)

2020 ◽  
Vol 6 (1) ◽  
pp. 36-44
Author(s):  
Kalvin Dersing
Keyword(s):  
Blood Sugar ◽  
Rattus Norvegicus ◽  
Water Extract ◽  
Coriandrum Sativum ◽  
Male Rats ◽  
Control Group ◽  
Control Group Design ◽  
White Rats ◽  
Wistar Strain ◽  
Sugar Levels

AbstractBackground : Diabetes mellitus is the most common metabolic syndrome in the whole world with an incidence of 1-8%. This disease arises when insufficient insulin is produced or insulin cannot function properly.The ability of coriander juice water extract is expected to reduce blood glucose levels because the action is similar to insulin and can stimulate insulin release. Purpose : Knowing effectiveness coriander extract (Coriandrum sativum L.)to decline blood sugar levels in male white rats (Rattus norvegicus L.) wistar strain induced by alloxan. Method : This is a pure experimental study (true-experiment) using a pre and post test design with control group design using subjects namely white rats (Rattus norvegicus L.) male Wistar strain aged 10-12 weeks with a weight of 150-200 grams. By looking at changes in blood sugar levels during administration of alloxan and administration of coriander extract. Results : There were significant changes in some groups induced alloxan (p <0.05), but the effect of coriander extract was not very significant (p> 0.05). Conclusion : Coriander extract can control blood sugar levels to be stable or normal, but it takes longer and more research.  Keywords : coriander extract, blood sugar levels, alloxan

scholarly journals Default sequence of Mozart’s compositions during pregnancy gave higher dendritic density in the cerebrum and cerebellum of Rattus norvegicus offsprings compared with reversed sequence and control

2019 ◽  
Vol 27 (1) ◽  
pp. 5
Author(s):  
Harry Mangasi Binsar Panjaitan ◽  
Hermanto Tri Joewono ◽  
Widjiati Widjiati
Keyword(s):  
Experimental Study ◽  
Treatment Group ◽  
Rattus Norvegicus ◽  
Control Group ◽  
Exposure Group ◽  
Control Group Design ◽  
Group Design ◽  
Significant Difference ◽  
Post Test ◽  
And Control

Objectives: This study aim to determine sequence of Mozart songs in the analyzing differences in dendritic density of cerebellum and cerebellum of new born Rattus novergicusMaterials and Methods: Experimental study randomized post test only control group design using Rattus norvegicus. Animal subjects were divided into three groups which were control group, and the treatment group that were given exposure to default sequence and reversed sequence of Mozart's music from gestation day 10. We used a comparison test in the analysis expression of BDNF.Results: In the cerebrum there was a significant difference in the Mozart group in reverse rather than with Mozart standard sequence and in standard Mozart group with no exposure group, with p=0.003 and p=0.000. In the cerebellum there was a significant difference in the group in reverse rather than with standard Mozart and in the standard Mozart group with the control group, with p=0.000 and p=0.000. However, there was no significant difference between control group and Mozart group upside down in cerebrum and cerebellum with p=0.109 and p=0.077Conclusion: The density of dendrites in the cerebrum and cerebellum of Rattus norvegicus newborn exposed to Mozart's music during pregnancy with standard Mozart sequence was higher than that in those receiving reverse order and without exposure. There were no significant differences between the density of the cerebrum and cerebellum dendrites between groups exposed to reversed sequence of Mozart composition and those without exposure.

scholarly journals Increased Brain Derived Neurothropic Factor in the cerebrum and cerebellum of Rattus norvegicus newborn with exposure to Mozart's music in default sequence compared with the reversed sequence and without exposure during gestation

2018 ◽  
Vol 26 (2) ◽  
pp. 67
Author(s):  
Agustina Hidayati ◽  
Hermanto Tri Joewono ◽  
Widjiati Widjiati
Keyword(s):  
Animal Models ◽  
Rattus Norvegicus ◽  
Control Group ◽  
P Value ◽  
Sequence Group ◽  
Bdnf Expression ◽  
Control Group Design ◽  
Significant Difference ◽  
Reverse Sequence ◽  
And Control

Objectives: To analyze the differences in the expression of Brain Derived Neurothropic Factor (BDNF) in Rattus norvegicus cerebrum and cerebellum of newborn between those exposed to Mozart's music composition in default sequence, reverse sequence, and without exposure in the womb.Materials and Methods: Analytical laboratory experimental study with randomized post test only control group design using animal models Rattus norvegicus. The animal models were divided into three groups: control group without any exposure, the treatment groups with exposure to Mozart's music in default sequence and another group in reverse sequence since day 10 of gestation. We used a comparison test in the analysis of BDNF expression.Results: We found significant difference in BDNF expression with p value 0.004 (mean 8.98±1.31 default sequence group, 5.58±3.08 reverse sequence group, 6.80±1.95 control) in the cerebrum. We found significant difference of BDNF expression with p value 0.003 (mean 9.48±1.41 default sequence group, 6.02±3.25 reverse sequence group, 7.14±2.54 control) in the cerebellum. In cerebrum dan cerebellum we found significant difference between standard Mozart’s music and control (cere-brum p=0.018, cerebellum p=0.001), and we found significant difference between standard Mozart’s music and reverse Mozart’s music (cerebrum p=0.001, cerebellum p=0.008) and no significant difference in reverse Mozart and control (cerebrum p=0.264, cerebellum p=0.490)Conclusion: Sequence in Mozart’s music is very important in increase expression of BDNF.

scholarly journals Pengaruh Terapi Komplementer Massage Punggung Terhadap Tekanan Darah pada Lansia dengan Hipertensi

2021 ◽  
Vol 8 (1) ◽  
pp. 40
Author(s):  
IGA Ari Rasdini ◽  
Ni Made Wedri ◽  
VM Endang SP Rahayu ◽  
IDP Putrayasa
Keyword(s):  
Blood Pressure ◽  
Treatment Group ◽  
Massage Therapy ◽  
The Elderly ◽  
Wilcoxon Test ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Significant Difference ◽  
Back Massage

Sekitar 90% usia dewasa dengan tekanan darah normal akan berkembang menjadi hipertensi pada usia lanjut.  Hipertensi pada usia lanjut mempunyai beberapa kekhususan, umumnya disertai dengan faktor resiko yang lebih berat. Masage punggung  bermanfaat melancarkan peredaran darah dan memberikan efek tenang sehingga tekanan darah menjadi stabil. Penelitian ini bertujuan untuk mengetahui pengaruh  terapi  masase punggung terhadap tekanan darah  pada lansia dengan hipertensi. Rancangan penelitian menggunakan quasy experiment dengan desain pretest-posttest control group design, jumlah sampel 20 orang tiap kelompok, dengan  tehnik random sampling. Hasil penelitian menunjukkan rata rata  kelompok perlakuan berusia 73 tahun dan kontrol berusia 75 tahun, jenis kelamin tiap kelompok 10 orang laki laki dan 10 orang perempuan. Pada kelompok perlakuan nilai systole pre-post (164-148.5 mmHg), diastole pre-post (85-80 mmHg).  Kelompok control rata rata nilai systole pre-post  (167,7 - 151.2 mmHg), diastole (87.5-77.5 mmHg). Uji Wilcoxon test didapatkan ada perbedaan yang signifikan tekanan darah pada kelompok perlakuan dengan p value systole adalah 0.000, p value diastole 0.025. Tidak ada perbedaan yang signifikan tekanan darah pada kelompok kontrol baik systole dengan p value 0.086 dan p value diastole 0.140. Ada pengaruh yang signifikan terapi komplementer massage punggung  terhadap tekanan darah systole dengan p value 0.000 dan  p value diastole adalah 0,028. Direkomendasikan terapi massage punggung sebagai terapi non farmakologi untuk menstabilkan tekanan darah guna mencegah komplikasi kardiovaskuler Kata Kunci : massage punggung; tekanan darah; hipertensi; lansia. THE INFLUENCE OF COMPLEMENTER THERAPY ON BLOOD PRESSURE IN ELDERLY WITH HYPERTENSION AT GIANYAR SUKAWATI II HEALTH CENTRE ABSTRACT  Approximately 90% of adults with normal blood pressure will develop hypertension in old age. Hypertension in the elderly has several characteristics, generally accompanied by more severe risk factors. Back massage is useful for blood circulation and provides a calming effect so that blood pressure becomes stable. This study was aimed to determine the effect of back massage therapy on blood pressure in the elderly with hypertension. The research design used a quasi-experimental design with a pretest-posttest control group design, the number of samples were 20 people per group, with random sampling technique. The results showed that the average age of the treatment group was 73 years old and the control group was 75 years old, the sexes of each group were 10 men and 10 women. In the treatment group the value of pre-post systole (164-148.5 mmHg), pre-post diastole (85-80 mmHg). The control group averaged pre-post systole values (167.7 - 151.2 mmHg), diastole (87.5-77.5 mmHg). The Wilcoxon test showed that there was a significant difference in blood pressure in the treatment group with p-value of systole being 0.000, p-value of diastolic 0.025. There is no significant difference in blood pressure in the control group, both systole with p value 0.086 and p value diastole 0.140. There is a significant effect of complementary back massage therapy on systolic blood pressure with a p value of 0.000 and a diastolic p value of 0.028. Back massage therapy is recommended as a non-pharmacological therapy to stabilize blood pressure to prevent cardiovascular complications Key Ward ; back massage; blood pressure; hypertension; elderly

scholarly journals PENGARUH LUMATAN DAUN PLETEKAN (Ruellia Tuberosa L) TERHADAP LAMA PENUTUPAN LUKA PADA TIKUS PUTIH (Rattus Novergicus)

2017 ◽  
Vol 4 (2) ◽  
pp. 104
Author(s):  
Ria Susana ◽  
Rismia Agustina ◽  
Abdurahman Wahid
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Random Sampling ◽  
Wound Closure ◽  
Simple Random Sampling ◽  
Male Rats ◽  
Control Group ◽  
P Value ◽  
Closure Time ◽  
Significant Difference

ABSTRAKLuka didefinisikan sebagai gangguan pada fungsi dan integritas jaringan tubuh. Penyembuhan luka merupakan proses yang kompleks dari perbaikan dan remodeling jaringan sebagai respon terhadap cedera. Pletekan (ruellia tuberosa l) mengandung flavonoid, glikosida, phenol, saponin dan nutrisi yang diharapkan mempercepat penyembuhan luka. Tujuan penelitian ini adalah mengidentifikasi pengaruh  lumatan daun pletekan (ruellia tuberosa l) terhadap lama penutupan luka pada tikus putih (rattus novergicus). Penelitian ini merupakan studi eksperimental dengan rancangan posttest only control, menggunakan teknik simple random sampling. Sampel yang digunakan sebanyak 40 ekor tikus jantan dengan luka insisi bersih sepanjang 3 cm yang dibagi menjadi 2 kelompok yaitu kelompok kontrol dan kelompok perlakuan. Data yang diukur adalah rata-rata lama penutupan luka. Data yang diperoleh dianalisis menggunakan uji mann-whitney dengan derajat kepercayaan 95% menunjukkan perbedaan yang signifikan rata-rata lama penutupan luka antara kelompok kontrol (8,45) dan kelompok perlakuan (3,75) dengan p-value 0,000 (p<0,05). Kesimpulan penelitian ini adalah terdapat pengaruh lumatan daun  pletekan (ruellia tuberosa l) terhadap lama penutupan luka pada tikus putih (rattus novergicus).Kata-kata kunci: luka insisi bersih, pletekan (ruellia tuberosa l), lama penutupan luka.ABSTRACTWounds is defined as disruption of the function and integrity of body tissues. Wound healing isa complex process of tissue repair and remodelling in response to injury. Pletekan (ruellia tuberosa l) contains flavonoids, glycosides, phenols, saponins and nutritive value that suppose to accelerate wound healing. The purpose of this study was to identify the effect of pletekan leaves (ruellia tuberosa) to wound closure time in rats (rattus novergicus). This research was an experimental study with post- test design using the simple random sampling technique. The samples were 40 male rats with a clean incision wound along 3 cm which were divided into two groups, control group and treatment group. The measured data were the average of wound closure time. Data were analyzed using the mann- whitney test with 95 % confidence level showed a significant difference between the control group (8,45) and the treatment group (3,75) with p-value 0,000 (p<0,005). There was significant effect of ruellia tuberosa l to wound closure time in rattus novergicus.Keywords: wounds, ruellia tuberosa , wound closure time.

scholarly journals EFEK EKSTRAK MELON (Cucumis melo) dan GliadinTERHADAP KADAR Hb DAN HbCO TIKUS WISTAR JANTAN YANG DIPAPAR ASAP ROKOK

2017 ◽  
Vol 11 (1) ◽  
pp. 78
Author(s):  
Yuyun Erlina Susanti ◽  
Bambang Wirjatmadi
Keyword(s):  
Treatment Group ◽  
Cigarette Smoke ◽  
Cucumis Melo ◽  
Wistar Rats ◽  
Cigarette Smoke Exposure ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Significant Difference ◽  
Male Wistar Rats

The exposure of cigarette smoke produce CO bond in hemoglobin. Melon (Cucumis melo) and gliadin contains of antioxidants that prevent tissue damage. The aim of this study was to analyze the difference of hemoglobin and carboxyhemoglobin concentration in male Wistar rats were exposed  to cigarette smoke and had been treated melon extract (Cucumis melo) and gliadin. The study was a laboratory experimental design, using Post Test Control Group Design Research and RAL method (Complete Randomize Design). The sample in this study were 25 male Wistar rats aged 3 months. The research was divided into 5 groups with 5 different treatment : control group, the treatment group were given exposure to cigarette smoke, the treatment group were given of cigarette smoke exposure and melon extract (Cucumis melo) and gliadin dose of 3 IU / day, 4.5 IU / day, and 9 IU / day.The subject were divided into 5 groups each treated for 28 day. The sample size used Federer formula. The collection of data was obtained from the results of laboratory tests to hemoglobin and Carboxyhemoglobin. Hb and HbCO data collected and analyzed by Manova test at 95% confidence level. The results showed significant difference in average Hb and HbCO concentration (p-value = 0.000) between male Wistar rats treated and not treated with melon extract (Cucumis melo) and gliadin. Melon extract has an effect on the decline of HbCO concentration due to exposure to cigarette smoke.Keywords:smoke, melon extract, Hb, HbCO

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