scholarly journals Epidemiology and Molecular Identification of Mycoplasma pneumoniae associated respiratory tract, Zhejiang province, China, 2008-2017

2019 ◽  
Author(s):  
Qian Jiang ◽  
Zhao Zhao ◽  
Fangfang Yang ◽  
Yumei Ge
Keyword(s):  
Tract Infection ◽  
Early Diagnosis ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Mycoplasma Pneumoniae ◽  
Acute Respiratory Tract Infection ◽  
Zhejiang Province ◽  
Taqman Probe ◽  
Positive Rate ◽  
Tract Infections

Abstract Background Mycoplasma pneumoniae is a common cause of respiratory infections in humans. The aim of this study was to investigate the infection of Mycoplasma pneumoniae (MP) in patients with acute respiratory tract infections in Zhejiang Province from 2008 to 2017, and to provide evidence for the early diagnosis and prevention of MP pneumonia. Methods MP-DNA was detected in nasopharyngeal swabs of patients with acute respiratory tract infection by real-time fluorescent PCR (Taqman probe). Statistical analysis and epidemiological investigation were carried out on the test results. Results There were 10296 patients with acute respiratory tract infection in Zhejiang People's Hospital from 2008 to 2017, including 4387 females and 5909 males. A total of 1251 MP-DNA positive patients were detected, with a total positive rate of 12.2% (1251/10296). Among 1251 patients with M. pneumoniae infection, 571 were female positive, with an average positive rate of 13.0% (571/4387), 680 were male positive, with a positive rate of 11.5% (680/5909). From 2008 to 2017, the positive rates were 22.8% (33 cases), 20.9% (211 cases), 20.9% (350 cases), 5.5% (70 cases), 11.7% (136 cases), 15.2% (190 cases), 7.8% (94 cases), 5.9% (62 cases), 7.8% (56 cases) and 6.0% (49 cases), respectively. Of 1251 MP-DNA positive patients, 1243 (99.4%) were younger than 18 years old. Conclusions MP infection mainly occurs in the age below 18 years old, suggesting that early diagnosis and prevention of MP infection in adolescents should be emphasized.

scholarly journals The study of Mycoplasma pneumonia infection among children with respiratory tract infection in hospital in Chengdu from 2014 to 2020

2021 ◽  
Author(s):  
lei zhang ◽  
Meimei Lai ◽  
Tao Ai ◽  
Huilling Liao ◽  
Yijie Huang ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Incidence Rate ◽  
Respiratory Diseases ◽  
Hospitalized Children ◽  
Temperature And Humidity ◽  
Mycoplasma Pneumonia ◽  
Positive Rate ◽  
Tract Infections

Abstract Aim: The hospitalized children with Mycoplasma pneumonia (M. pneumonia) infection caused by respiratory tract infection in Chengdu were studied and analysis of the epidemiological characteristics was carried out to provide a theoretical basis for clinical diagnosis and treatment.Method: 22882 hospitalized children with respiratory tract infections between January 2014 and December 2020 were collected M. pneumonia IgM antibody was detected by indirect immunofluorescence method and passive agglutination method. Demographic characteristics, clinical diagnose and laboratory data of these children were analyzed.retrospectively.. Result : The 4213 specimens with M. pneumonia were tested positive, the total positive rate was18.41%(18.30% in male and 22.72% in female). Higher positive rates were found in female children,Look from the statistical analysis results, the consistency between the two sets of data is low（ｘ2=198.078、P＜0.01）. The results of different age patients with contrast different M. pneumonia infection degree were statistically significant（F=162.7532、P＜0.01）,there was higher M. pneumonia positive rate in Preschoolers and school-age children ,33.98% and 32.98%, respectively.The incidence rate of M. pneumonia in 2017 and 2019 was significantly higher than average （F=538.95, P＜0.01)The difference of incidence rate of M. pneumonia was not significant in different months in 2014, 2015 and 2020 (P>0.05). But the probability of M .pneumonia infection patients was much higher from April to May and September to October in2016,2017,2018 and 2019（P＜0.05）. There was no correlation about M. pneumonia infection with temperature and humidity( P＞0.05)，there was negative correlation with PM2.5（R=0.09362, P<0.01）and PM10.（R=0.1185, P<0.01）.There was no difference about constituent ratio of case of M. pneumonia infection between 2014 and 2019 (F=32.34,P>0.05).The Common respiratory diseases of M. pneumonia infection, bronchopneumonia accounts for the highest proportion,followed the exacerbation of asthma and severe pneumonia.There was significantly difference about constituent ratio of case of M. pneumonia infection between in 2020 and in other years (F=159.35,P<0.01) .The Common respiratory diseases of M. pneumonia infection, bronchopneumonia accounts for the highest proportion,followed the acute bronchitis and exacerbation of asthma.Conclusion:The distribution and epidemiological trend of M. pneumonia in patients with respiratory tract infection showed the risk of inflammation was connected with the gender, age, year and month, no relationship with temperature and humidity in Chengdu,.Higher M. pneumonia positive rate was shown in the children with bronchial pneumonia and exacerbation of asthma.The prevention measures which controlled the COVID-19 disease had effectively controlled the infection rate of M. pneumonia.

scholarly journals Recurrent Respiratory Tract Infection in an infant: Early Diagnosis by Clinical and Radiological Pearls

2021 ◽  
Vol 41 (1) ◽  
pp. 111-114
Author(s):  
Shatanik Sarkar ◽  
Chaitali Patra ◽  
Shibani Pal ◽  
Arkapriya Pramanik
Keyword(s):  
Tract Infection ◽  
Early Diagnosis ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Clinical Examination ◽  
Respiratory Tract Infections ◽  
Recurrent Respiratory Tract Infection ◽  
Organ Systems ◽  
Tract Infections ◽  
Recurrent Respiratory Tract Infections

Recurrent respiratory tract infections, a cause of concern for both parents and paediatricians, can have various etiologies entitled to different organ systems. Diagnosing the exact cause warrants both clinical acumen and timely investigations. Here, we are reporting an infant with recurrent respiratory tract infections, where adequate clinical examination prompted us to diagnose the extra-respiratory cause with simple investigations.

scholarly journals Clinical Value of Two Detection Methods for Mycoplasma Pneumoniae Antibody in the Diagnosis of Mycoplasma Pneumoniae Infection in North China

2021 ◽  
Author(s):  
Jupeng Wang ◽  
Lina Zhu ◽  
Mingkun Ma ◽  
Hui Chen ◽  
Suxiang Guo ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Mycoplasma Pneumoniae ◽  
North China ◽  
Detection Methods ◽  
Antibody Detection ◽  
Positive Rate ◽  
Adults And Children ◽  
Males And Females

Abstract Background: To analyze the detection of Mycoplasma pneumoniae in adults and children in North China using two antibody detection methods, and to guide prevention and treatment.Methods: A retrospective study was conducted from September 2017 to May 2021. Mycoplasma pneumoniae total antibody was detected using particle agglutination (PA). Anti-Mycoplasma pneumoniae IgM in patients with respiratory tract infection was detected by indirect immunofluorescence. All patients were divided into 9 groups according to age: ≤1, 2-3, 4-6, 7-14, 15-18, 19-39, 40-59, 60-79, ≥80,Results: The positive rate of Mycoplasma pneumoniae total antibody in 5,666 patients with community-acquired pneumonia was 40.13%. In adults and children, the positive rates were 19.92% and 77.3% (p<0.05), respectively. The positive rates in males and females was 37.89% and 42.40% (p<0.05), respectively. The positive rate for anti-Mycoplasma pneumoniae IgM in 5,746 patients with respiratory tract infection was 28.56%, and 10.37% and 36.82% in adults and children (p<0.05), respectively. In males and females, the positive rate for anti-Mycoplasma pneumoniae IgM was 24.56% and 33.38% (p<0.05). The highest positive rates for total antibody and anti-Mycoplasma pneumoniae IgM were recorded in autumn. Of the 1,975 patients tested for Mycoplasma pneumoniae antibody using both methods simultaneously, 26.71% were negative for total antibody and 8.63% had titers ranging between 1:40 and 1:80 when positive for IgM antibody. When negative for anti-Mycoplasma pneumoniae IgM, total antibody titer was ≥1:160 in 34.94% of the patients.Conclusion: Mycoplasma pneumoniae is the main cause of respiratory tract infection and its incidence is highest in autumn. Because Mycoplasma pneumoniae was more commonly detected in women and children, screening should be strengthened in these groups.

scholarly journals THE EFFECT OF ENVIRONMENTAL FACTOR AND USE OF PERSONAL PROTECTIVE EQUIPMENT ON THE SYMPTOMS OF ACUTE RESPIRATORY TRACT INFECTIONS IN FURNITURE INDUSTRY WORKERS

2020 ◽  
Vol 2 (1) ◽  
pp. 42-49
Author(s):  
Merry Sunaryo
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Environmental Factor ◽  
Respiratory Tract Infections ◽  
Acute Respiratory Tract Infection ◽  
Dust Exposure ◽  
Wood Dust ◽  
Furniture Industry ◽  
Tract Infections

Dust is one type of potential hazardzs in the workplace that can affect the health of the workers. The occupation that are always exposed to dust is furniture industry workers so that they have higher risk of getting acute respiratory tract infection (ARI) disorder which can interfere with breathing. The wood dust is formed from some of the sawn wood and sanding that will lead to an acute respiratory tract infection. The study aimed to determine the effect of environmental factor and the use of Personal Protective Equipment (PPE) against the symptoms of acute respiratory infections in the furniture industry workers. The research method used was quantitative method with observational and cross-sectional research types and it was analysed by using logistic regression test. The population in this study was the workers of the furniture industry at Semarang street, Surabaya City, with a total of 57 people, of which 37 furniture workers as a sample. The results show that most of the workers has symptoms of acute respiratory tract infection. It could be influenced by the environmental factor such as dust exposure that produced wood dust in each manufacturing processes. Additionally, the use of PPE also affected the occurrence of acute respiratory tract infections symptoms in the workers. In conslusion, many factors can influence the occurrence of acute respiratory tract infection symptoms in the furniture industry workers. Therefore, it is necessary to minimize the dust exposure in workers by wearing PPE such as respirators.

scholarly journals Acute respiratory tract infection among preschool children in Western Maharashtra, India

2014 ◽  
Vol 5 (4) ◽  
pp. 34-38
Author(s):  
Mahesh B Tondare ◽  
VV Raje ◽  
Sachin Mumbare ◽  
MV Rayate ◽  
Sangamesh Tondare ◽  
...  
Keyword(s):  
Preschool Children ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Primary School ◽  
Respiratory Tract Infection ◽  
Urban Area ◽  
School Children ◽  
Urban Slum ◽  
Acute Respiratory Tract Infection ◽  
Tract Infections

Background: Malnutrition and infectious diseases both occur in the same unfortunate children and together they play a major role in causing the high morbidity and mortality in them.In developing countries, mortality from ARTI is 30?70 times higher than in developed countries and it has been estimated that up to 1/3rd of all deaths in children less than 5 years are attributed to ARTI. Aims & Objectives: This study aimed to find the attack rate of Acute Respiratory Tract infection and the socio?demographic variables of pre?school children suffering from Acute Respiratory Tract infections. Method: A Comparative Longitudinal study was carried out among preschool children (3?5 years) who were selected from Private pre?primary school of urban area (155)& Anganwadis (157) of urban slum area of karad town and followed for the period of one year. Mother/guardian/teacher was interviewed by using pre?tested proforma during this period. Results & Interpretation: out of all 97.4% of private pre?primary school children had 1.8 episodes/child/year of ARTI compared to Anganwadi children where all of them had 2.5 episodes/child/year of ARTI. Conclusion: Maximum number of children from private pre?primary schools from urban area also suffered with at least one episode of Acute Respiratory Tract Infection compared to Anganwadi children from urban slum areas. DOI: http://dx.doi.org/10.3126/ajms.v5i4.10044 Asian Journal of Medical Sciences 2014 Vol.5(4); 34-38

scholarly journals Features associated with SARS-COV-2 positivity among people presenting with acute respiratory tract infections to public Hospitals in Harari region, Ethiopia

2021 ◽  
Vol 9 ◽  
pp. 205031212110627
Author(s):  
Abdi Birhanu ◽  
Galana Mamo Ayana ◽  
Miesso Bayu ◽  
Ahmed Mohammed ◽  
Yadeta Dessie
Keyword(s):  
Tract Infection ◽  
Severe Acute Respiratory Syndrome ◽  
Respiratory Tract ◽  
Marital Status ◽  
Respiratory Tract Infection ◽  
Acute Respiratory Tract Infection ◽  
Public Hospitals ◽  
Upper Respiratory Tract ◽  
Resource Limited ◽  
Tract Infections

Background: Despite investigating coronavirus among respiratory tract infected cases is a top priority to prevent further transmission, severe acute respiratory syndrome coronavirus 2 positivity among this group of patients remains unexplored in resource-limited settings. Therefore, this study intended to assess the severe acute respiratory syndrome coronavirus 2 positivity among patients presenting with acute respiratory tract infection from 1 July to 31 December 2020 in Harar Region, Ethiopia, from 15 February to 10 March 2021. Methods: A facility-based cross-sectional study design was used. Severe acute respiratory syndrome coronavirus 2 was tested by assaying oropharyngeal swabs using reverse transcriptase–polymerase chain reaction among patients presenting with acute respiratory tract infection in Harari Public Hospitals. A binary logistic regression was used to identify factors associated with severe acute respiratory syndrome coronavirus 2 positivity with an adjusted odds ratio at a 95% confidence interval. Results: Out of a total of 1692 study participants, 388 (22.9%) of them tested positive for severe acute respiratory syndrome coronavirus 2. Of these severe acute respiratory syndrome coronavirus 2 positive patients, 364 (21.6%) patients presented with lower respiratory tract infection, while the rest only 24 (1.4%) presented with upper respiratory tract infection. Independent variables included separated/divorced in marital status (AOR = 0.53, 95% CI: 0.29–0.95), presenting with cough, fever, and difficulty of breathing (AOR = 2.5, 95% CI: 1.22–4.7), age group of 30–39 years (AOR = 0.35, 95% CI: 0.15–0.79), 40–49 years (AOR = 0.37, 95% CI: 0.14–0.94), and 50–59 years (AOR = 0.31, 95% CI: 0.13–0.76) compared to patients with the age of ⩾ 60 years, had statistically significant association with severe acute respiratory syndrome coronavirus 2 positivity. Conclusion: Severe acute respiratory syndrome coronavirus 2 was positive among 388 (22.9%) acute respiratory tract infected people. Elder age, particular symptoms, such as cough, fever, and difficulty of breathing, and married marital status were associated with a severe acute respiratory syndrome coronavirus 2 positive test. In resource-limited setups, where a shortage of testing equipment is common, these findings could contribute to boosting targeted symptom-oriented screening schemes. Moreover, this study could have paramount clinical importance for further studies in the country.

scholarly journals Prediction model for pneumonia in primary care patients with an acute respiratory tract infection: role of symptoms, signs, and biomarkers

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
G. H. Groeneveld ◽  
J. W. van ’t Wout ◽  
N. J. Aarts ◽  
C. J. van Rooden ◽  
T. J. M. Verheij ◽  
...  
Keyword(s):  
Primary Care ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Prediction Model ◽  
Respiratory Tract Infection ◽  
Acute Respiratory Tract Infection ◽  
Clinical Model ◽  
X Ray ◽  
Chest X Ray ◽  
Tract Infections

Abstract Background Diagnosing pneumonia can be challenging in general practice but is essential to distinguish from other respiratory tract infections because of treatment choice and outcome prediction. We determined predictive signs, symptoms and biomarkers for the presence of pneumonia in patients with acute respiratory tract infection in primary care. Methods From March 2012 until May 2016 we did a prospective observational cohort study in three radiology departments in the Leiden-The Hague area, The Netherlands. From adult patients we collected clinical characteristics and biomarkers, chest X ray results and outcome. To assess the predictive value of C-reactive protein (CRP), procalcitonin and midregional pro-adrenomedullin for pneumonia, univariate and multivariate binary logistic regression were used to determine risk factors and to develop a prediction model. Results Two hundred forty-nine patients were included of whom 30 (12%) displayed a consolidation on chest X ray. Absence of runny nose and whether or not a patient felt ill were independent predictors for pneumonia. CRP predicts pneumonia better than the other biomarkers but adding CRP to the clinical model did not improve classification (− 4%); however, CRP helped guidance of the decision which patients should be given antibiotics. Conclusions Adding CRP measurements to a clinical model in selected patients with an acute respiratory infection does not improve prediction of pneumonia, but does help in giving guidance on which patients to treat with antibiotics. Our findings put the use of biomarkers and chest X ray in diagnosing pneumonia and for treatment decisions into some perspective for general practitioners.

scholarly journals 683. Molecular Detection of Enterovirus D68 among Children with Acute Respiratory Tract Infection in Ghana

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S395-S395
Author(s):  
Joyce Appiah-Kubi
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Real Time ◽  
Respiratory Infections ◽  
Acute Respiratory Tract Infection ◽  
Influenza Viruses ◽  
Viral Origin ◽  
Enterovirus D68 ◽  
Tract Infections

Abstract Background Acute respiratory tract infections of viral origin remain a leading cause of morbidity, mortality and economic loss regardless of age or gender. A small number of acute respiratory tract infection cases caused by enterovirus D68 (EV-D68) have been reported regularly to Centers for Disease Control and Prevention since 1987 by countries in North America, Europe and Asia. However, in 2014 and 2015, the number of reported confirmed EV-D68 infections was much greater than in previous years. The National Influenza Centre (NIC), Ghana carries out surveillance of respiratory infections, focusing on those caused by influenza virus; however, there is inadequate information on other viruses causing respiratory infections in Ghana, including EV-D68. Objectives To investigate the association of EV-D68 with Severe Acute Respiratory Infections (SARI) and Influenza-Like Illness (ILI) in Ghana. Methods This was a retrospective cross-sectional study which involved archived human respiratory specimens stored at -80ºC at the NIC from 2014 to 2015. Using a random sampling method, oropharyngeal and nasopharyngeal swabs from patients with SARI and ILI that were negative by real-time PCR for human influenza viruses were screened for EV-D68 using real-time reverse transcription-polymerase chain reaction (rRT-PCR). Results Enterovirus D68 was detected in 4 (2.2%) out 182 SARI samples tested. EV-D68 was detected in children younger than 5 years (4-100% of positives) and was not detected in children older than 5 years. Enterovirus D68 was detected more frequently in SARI cases (3%) than in ILI cases (1.2%). Conclusion This study has shown for the first time the presence of EV-D68 in acute respiratory infection in Ghana. The results confirmed minimal EV-D68 circulation in the Ghanaian population. Disclosures All Authors: No reported disclosures

scholarly journals Detection and phylogenetic analysis of Human bocavirus in children diagnosed with acute respiratory tract infection

2020 ◽  
Vol 69 (9) ◽  
pp. 1197-1202
Author(s):  
Rania Abozahra ◽  
Sarah M. Abdelhamid ◽  
Karim Khairy ◽  
Kholoud Baraka
Keyword(s):  
Phylogenetic Analysis ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Acute Respiratory Tract Infection ◽  
University Hospital ◽  
Genetic Lineage ◽  
Human Bocavirus ◽  
Igm Antibodies ◽  
Tract Infections

Introduction. Human bocavirus (HBoV) is a recently discovered parvovirus; it has been shown to be a common cause of respiratory infections and gastroenteritis in children. Since its identification, HBoV has been detected worldwide in nasopharyngeal swabs, serum and stool samples particularly those obtained from young children suffering from respiratory or gastrointestinal tract infections. Aim. The aim of this work was to determine HBoV prevalence among children with acute respiratory tract infection in Egypt, to detect the most prevalent HBoV genotype and to compare PCR and ELISA as diagnostic techniques for HBoV infection. Methods. Nasopharyngeal swabs and blood samples were obtained within the first day of admission from 75 children diagnosed with acute respiratory tract infection in El-Shatby University Hospital for Children in Alexandria, Egypt from October 2018 to March 2019. Conventional PCR was used to detect HBoV DNA, ELISA was used to detect HBoV IgM antibodies and sequencing of the VP1/2 genes was used for genotyping. Results. Seven (9.3%) of the 75 nasopharyngeal swabs obtained from patients with acute respiratory tract infection were positive for HBoV by PCR, while 5 (6.7 %) of the 75 serum samples were positive for HBoV IgM antibodies using ELISA. The correlation between PCR and ELISA results showed a highly significant association between PCR and ELISA techniques (X 2=52.041, P<0.01) and a highly significant agreement between the two methods (Kappa=81.9 %, P<0.01). Phylogenetic analysis showed that all positive samples were related to the HBoV-1 genotype. Conclusion. Human bocavirus was detected at 9.3 % prevalence in nasopharyngeal swabs obtained from children with acute respiratory tract infection. The HBoV-1 genotype was the only genotype detected, suggesting that a single genetic lineage of HBoV is circulating in Egypt. PCR and ELISA are two reliable methods for detection and diagnosis of HBoV.

scholarly journals Peresepan Obat “Off-Label” Pada Anak Dengan Penyakit Infeksi Saluran Pernapasan Akut

2021 ◽  
Vol 2 (1) ◽  
pp. 94
Author(s):  
Oki Nugraha Putra ◽  
Eri Destin Anggraini ◽  
Ana Khusnul Faizah
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Prescription Drugs ◽  
Acute Respiratory Tract Infection ◽  
Off Label Use ◽  
Cross Sectional ◽  
Off Label ◽  
Tract Infections ◽  
Label Use

ABSTRAKInfeksi Saluran Pernapasan Akut (ISPA) termasuk penyakit yang banyak terjadi di Indonesia terutama pada usia anak. Pada populasi anak berisiko mendapatkan peresepan obat off-label dikarenakan terbatasanya data efikasi obat untuk anak. Penggunaan obat off-label meningkatkan risiko efek yang tidak dikehendaki. Penelitian ini bertujuan untuk mengevaluasi penggunaan obat secara off-label pada peresepan pasien ISPA anak. Penelitian ini merupakan penelitian deskriptif observasional dengan menggunakan desain cross-sectional. Pengumpulan data menggunakan peresepan obat dengan diagnosis ISPA  pada anak usia 0-18 tahun. Penelitian ini dilakukan pada bulan November 2019 sampai dengan Februari 2020. Pada` penelitian ini didapatkan 124 resep dengan diagnosis ISPA. Penggunaan obat off-label pada peresepan penyakit infeksi saluran pernapasan akut untuk pasien anak sebesar 23% dengan kategori off-label usia (15,67%), off-label dosis (5,70%), off-label rute pemberian (1,22%) dan off-label indikasi (0,40%). Jenis obat off-label paling banyak diresepkan untuk ISPA anak adalah antihistamin klorfeniramin maleat. Berdasarkan hasil penelitian yang telah dilakukan dapat disimpulkan bahwa penggunaan obat off-label pada penyakit ISPA anak cukup tinggi. Farmasis dan dokter dapat berkolaborasi untuk pemantauan penggunaan obat yang tergolong off-label. Penelitian lanjutan diperlukan untuk melihat korelasi atau faktor risiko yang berpotensi meningkatkan penggunaan off-label pada ISPA anak. Kata kunci : Obat off-label; ISPA; Peresepan; Anak. ABSTRACTAcute respiratory tract infections (ARTI) is a disease that often occurs in Indonesia, especially in children. The population of children is high risk of receiving off-label prescription drugs. The use of off-label drugs increases the risk of undesirable effects. This study was aimed to evaluate the off-label use of drugs in prescribing with acute respiratory tract infection. This research is a descriptive observational study using a cross-sectional design. Data was collected by the prescription in children aged 0-18 years old with acute respiratory tract infection. This study was conducted from November 2019 to February 2020. In this study, 124 prescriptions were obtained with a diagnosis of ARTI. The use of off-label drugs was 23% with the off-label age category (15.67%), off-label dose (5.70%), off-label route of administration (1.22%) and off-label indication (0.40%). The type of off-label drug most commonly prescribed in children with ARTI is chlorpheniramine maleate. It can be concluded that the use of off-label drugs in children with ARTI disease is quite high. Pharmacists and clinicians should collaborate each other to monitor the use of drugs that are classified as off-label. Further research is needed to analyze   correlations or risk factors that potentially may increase off-label use in children with ARTI.Keywords : Off-label drugs; Acute Respiratory Tract ; Infection; Prescribing; Children.

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