A cross-sectional, non-interventional study of the correlation between insight and adherence in schizophrenia in Nepal
Abstract Background: There is a significant lack of research in the Nepalese study population on adherence in patients with schizophrenia. This cross-sectional, non-interventional study aims to re-examine the recognised correlation between insight and adherence in this population, whilst exploring the association between patient demographics and adherence to help bring understanding to how familial and environmental factors may impact adherence. Methods: Patients were recruited upon attendance to outpatient’s appointments and admission to the psychiatry department of Manipal Teaching Hospital. A self-report questionnaire was used to collect data on patient demographics, including age, ethnicity, religion, employment status, current living arrangements and education level; the Birchwood Insight Scale (BIS); and the Drug Attitude Inventory (DAI-10) score. Descriptive statistics on the demographics, BIS and DAI-10 were collated using SPSS. An analysis of variance of DAI-10 scores according to participant demographics was performed using a one-way ANOVA analysis. Correlation between the BIS and BIS subscales and the DAI-10 was tested using Pearson’s 2-tailed analysis at 0.01 significance level.Results: 19 participants consented to participate in this study with 100% data obtained. 57.9% unemployed, 63.2% living with parents and 47.4% had only a basic education. 36.8% of participants had poor insight; 84.2% of participants had poor insight into their symptoms; 78.9% of participants had poor insight into their illness and 36.8% had poor insight into their need for treatment. 52.7% of participants were poor adherers. No significant differences in DAI-10 scores were found between demographic groups. A positive correlation was found between the total BIS score and DAI-10 score (Pearson correlation coefficient of 0.585; P value = 0.009). Furthermore, the awareness of need for treatment subscale score and the DAI-10 score found a correlation coefficient of 0.609 (P value = 0.006). Conclusions: In conclusion, this study found prevalent non-adherence to medication and demonstrated that insight correlates with adherence. Although study findings did not suggest that patient demographics were associated with non-adherence, it is important to consider the possibility that these high rates of non-adherence have other contributing factors; overcoming rural health inequality, cultural beliefs regarding psychiatric illness and unaffordability remain the great challenges for the Nepalese population.