scholarly journals Optimization of Intraperitoneal Aerosolized Drug Delivery: A Computational Fluid Dynamics (CFD) and Experimental Study

2021 ◽  
Author(s):  
Mohammad Rahimi-Gorji ◽  
Charlotte Debbaut ◽  
Ghader Ghorbaniasl ◽  
Sarah Cosyns ◽  
Wouter Willaert ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Drug Delivery ◽  
Computational Fluid Dynamics ◽  
Spatial Distribution ◽  
Droplet Size ◽  
Flow Rate ◽  
Liquid Flow ◽  
Liquid Flow Rate ◽  
Aerosol Distribution ◽  
Computational Fluid Dynamics Cfd

Abstract Intraperitoneal (IP) aerosolized anticancer drug delivery was recently introduced in the treatment of patients with peritoneal metastases. However, little is known on the effect of treatment parameters on the spatial distribution of the aerosol droplets in the peritoneal cavity. Here, computational fluid dynamics (CFD) modeling was used in conjunction with experimental validation in order to investigate the effect of droplet size, liquid flow rate and viscosity, and the addition of an electrostatic field on the homogeneity of IP aerosol. We found that spatial distribution is optimal with small droplet sizes (1-5 µm). Using the current clinically used technology (droplet size of 30 µm), the optimal spatial distribution of aerosol is obtained with a liquid flow rate of 0.6 mL s-1. Compared to saline, nebulization of higher viscosity liquids results in less homogeneous aerosol distribution. The addition of electrostatic precipitation significantly improves homogeneity of aerosol distribution, but no further improvement is obtained with voltages higher than 6.5 kV. The results of the current study will allow to choose treatment parameters and settings in order to optimize spatial distribution of IP aerosolized drug, with a potential to enhance its anticancer effect.

Characterisation of Cell Adhesion to Substrate Materials and the Resistance to Enzymatic and Mechanical Cell-Removal

2008 ◽  
Vol 1097 ◽  
Author(s):  
Helen Jane Griffiths ◽  
John G Harvey ◽  
James Dean ◽  
James A Curran ◽  
Athina E Markaki ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Cell Adhesion ◽  
Liquid Flow ◽  
Adhesive Strength ◽  
Cell Detachment ◽  
Shear Forces ◽  
Cfd Modelling ◽  
Computational Fluid Dynamics Cfd

AbstractCell-implant adhesive strength is important for prostheses. In this paper, an investigation is described into the adhesion of bovine chondrocytes to Ti6Al4V-based substrates with different surface roughnesses and compositions. Cells were cultured for 2 or 5 days, to promote adhesion. The ease of cell removal was characterised, using both biochemical (trypsin) and mechanical (accelerated buoyancy and liquid flow) methods. Computational fluid dynamics (CFD) modelling has been used to estimate the shear forces applied to the cells by the liquid flow. A comparison is presented between the ease of cell detachment indicated using these methods, for the three surfaces investigated.

scholarly journals Effect of hydraulic and geometric factors upon leakage flow rate in pressurized pipes

RBRH ◽  
2021 ◽  
Vol 26 ◽  
Author(s):  
Mayara Francisca da Silva ◽  
Fábio Veríssimo Gonçalves ◽  
Johannes Gérson Janzen
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Flow Rate ◽  
Leakage Flow ◽  
Cfd Simulations ◽  
Mean Velocity ◽  
Leakage Flow Rate ◽  
Geometric Factors ◽  
Leakage Area ◽  
Computational Fluid Dynamics Cfd

ABSTRACT Computational Fluid Dynamics (CFD) simulations of a leakage in a pressurized pipe were undertaken to determine the empirical effects of hydraulic and geometric factors on the leakage flow rate. The results showed that pressure, leakage area and leakage form, influenced the leakage flow rate significantly, while pipe thickness and mean velocity did not influence the leakage flow rate. With relation to the interactions, the effect of pressure upon leakage flow rate depends on leakage area, being stronger for great leakage areas; the effects of leakage area and pressure on leakage flow rate is more pronounced for longitudinal leakages than for circular leakages. Finally, our results suggest that the equations that predict leakage flow rate in pressurized pipes may need a revision.

Study of Gas Shortcut Flow Rate in Cyclone with Different Inlet Section Angles Using Response Surface Methodology

2009 ◽  
Vol 7 (1) ◽  
Author(s):  
Fuping Qian ◽  
Xingwei Huang ◽  
Mingyao Zhang
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Response Surface Methodology ◽  
Response Surface ◽  
Flow Rate ◽  
Numerical Solutions ◽  
Inlet Section ◽  
Statistical Software ◽  
Vortex Finder ◽  
Computational Fluid Dynamics Cfd

Numerical simulations of cyclones with various vortex finder dimensions and inlet section angles were performed to study the gas shortcut flow rate. The numerical solutions were carried out using commercial computational fluid dynamics (CFD) code Fluent 6.1. A prediction model of the gas shortcut flow rate was obtained based on response surface methodology by means of the statistical software program (Minitab V14). The results show that the length of the vortex finder insertion, the vortex finder diameter and the inlet section angle play an important role in influencing the gas shortcut flow rate. The gas shortcut flow rate decreases when increasing the inlet section angle, and increases when increasing the vortex finder diameter and decreasing the length of the vortex finder insertion. Compared with the effect of the length of the vortex finder insertion on the shortcut flow rate, the effect of the vortex finder diameter on the gas shortcut flow rate seems more pronounced. The effect of the vortex finder dimension on the gas shortcut flow rate is changed with the different inlet section angles, i.e., the effects of the vortex finder dimension of the conventional cyclone (the inlet section angle is 0º) on the gas shortcut flow rate is stronger than the cyclone with 30º and 45º inlet section angles.

scholarly journals A twin-fluid injector for FCC feed injection

2019 ◽  
Vol 4 (3) ◽  
pp. 109-115
Author(s):  
Deepak Kumar ◽  
Tushar Sikroria ◽  
Kushari A ◽  
Pramod Kumar ◽  
Sriganesh G
Keyword(s):  
Droplet Size ◽  
Flow Rate ◽  
Liquid Flow ◽  
Liquid Flow Rate ◽  
Air Flow ◽  
Product Yield ◽  
Droplet Velocity ◽  
Injection System ◽  
Airflow Rate ◽  
Air Flow Rate

In Fluidized Bed Catalytic Cracking (FCC) process, hydrocarbon feed undergoes vapour phase cracking in presence of hot regenerated catalyst to produce valuable products like LPG, Gasoline and Diesel. FCC feed injection system is most critical hardware component of FCC unit in order to get desired product yield by minimizing the undesirable dry gas and coke yield. Typically, twin-fluid nozzles (hydrocarbon and stream) are used to atomize the feed. In the present study, a twin-fluid injector, with an internal impactor to minimize the droplet size and velocity, is designed, developed and characterized. The performance of the feeding injector was evaluated using water and air as operating fluids and the droplet size and velocity were measured 150 mm downstream of the injector tip using a PDPA system for different water and air flow rates. The average droplet size (D32) showed an increase while the droplet velocity remained almost constant with the increase in the liquid flow rate for a given flow rate of air, consistent with the increase in droplet size with decreasing air-liquid ratio for twin–fluid atomizers. But, for a given liquid flow rate, the droplet SMD decreased and the droplet velocity increased with increasing airflow rate, which can be attributed to the increase in overall kinetic energy due to the increase in air flow rate. The flow rate of liquid was seen to be independent of air flow rate unlike conventional twin-fluid atomizers. The droplet size was found to be a function of ALR and the local volume flux of the droplets was found to be a function of the liquid flow rate.

Computational Study of Single-Sided Ventilation Through a 3-Dimensional Room With Rounded Edges

2013 ◽  
Author(s):  
A. Idris ◽  
B. P. Huynh
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Wind Speed ◽  
Flow Pattern ◽  
Flow Rate ◽  
Software Package ◽  
Computational Study ◽  
Ventilation Rate ◽  
3 Dimensional ◽  
Computational Fluid Dynamics Cfd

A commercial Computational Fluid Dynamics (CFD) software package is used to investigate numerically a 3-dimensional rectangular-box room with rounded edges. The room has all its window openings located on one wall only. The standard K-ε turbulence model is used. Air’s flow rate and flow pattern are considered in terms of wind speed and the openings’ characteristics, such as their number, location, size and shape. Especially, comparison with ventilation rate corresponding to when the room edges are sharp is made; and thereby the effects of the edges being rounded are examined.

Spray Droplet Size for Water and Paraffinic Oil Applied at Ultralow Volume

1993 ◽  
Vol 7 (4) ◽  
pp. 799-807 ◽  
Author(s):  
James E. Hanks ◽  
Chester G. McWhorter
Keyword(s):  
Droplet Size ◽  
Flow Rate ◽  
Liquid Flow ◽  
Liquid Flow Rate ◽  
Air Pressure ◽  
Water Droplets ◽  
Spray Droplet ◽  
Paraffinic Oil ◽  
Pressure Nozzle ◽  
Nozzle Type

Spray droplet size of water and paraffinic oil was affected by air pressure, nozzle type, and liquid flow rate when applied with an ultralow volume (ULV), air-assist sprayer. Volume median diameters of water were generally larger than oil at constant air pressure and liquid flow rate. Droplet size decreased as air pressure increased, but increased as liquid flow rate increased. Volume median diameters of water droplets ranged from 41 to 838μm and from 16 to 457μm with oil when atomized at air pressures ranging from 14 to 84 kPa. Relative spans ranged from 1.2 to 18.0 and 2.0 to 7.2 for water and oil, respectively.

Using Computational Fluid Dynamics (CFD) to Improve the Bi-Directional Nasal Drug Delivery Concept

2005 ◽  
Vol 83 (2) ◽  
pp. 107-117 ◽  
Author(s):  
M. Kleven ◽  
M.C. Melaaen ◽  
M. Reimers ◽  
J.S. Røtnes ◽  
L. Aurdal ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Drug Delivery ◽  
Computational Fluid Dynamics ◽  
Nasal Drug Delivery ◽  
Computational Fluid Dynamics Cfd

Characteristics of Mean Droplet Size Produced by Spinning Disk Atomizers

2012 ◽  
Vol 134 (7) ◽  
Author(s):  
Mahmoud Ahmed ◽  
M. S. Youssef
Keyword(s):  
Droplet Size ◽  
Flow Rate ◽  
Liquid Flow ◽  
Liquid Flow Rate ◽  
Sauter Mean Diameter ◽  
Disk Diameter ◽  
Downstream Distance ◽  
Spinning Disk ◽  
Mean Diameter ◽  
The Mean

Characteristics of mean droplet size of spray produced by spinning disk atomizers were experimentally investigated. The phase-doppler particle analyzer (PDPA) was used to measure the droplet size of water spray in the downstream distance along the spray trajectory. Effects of various operating conditions on the mean diameter had been studied. The studied variables were: the rotational speed in the range of 838 to 1677 rad/s (8,000–16,000 rpm), the liquid flow rate in the range of 0.56 to 2.8 × 10−6 m3/s (2–10 L/h), the disk diameter in the range of 0.04 to 0.12 m, and the downstream tangential distance along the spray trajectory of up to 0. 24 m. The Sauter mean diameter (d32) was used to represent the mean of generated spray droplet sizes. The results indicated that the Sauter mean diameter can be correlated with dimensionless groups, such as the Reynolds number, Weber number, flow coefficient, and the ratio of downstream distance to disk diameter. Based on this correlation, it was found that the Sauter mean diameter (d32) increases as the downstream tangential distance, and liquid flow rate increase. Similarly, a decrease of rotational speed and disk diameter results in an increase in the Sauter mean diameter (d32). A comparison between the developed correlation and correlations obtained by other researchers has been presented and discussed in detail.

scholarly journals COMPUTATIONAL INVESTIGATION ON CSF FLOW ANALYSIS IN THE THIRD VENTRICLE AND AQUEDUCT OF SYLVIUS

2011 ◽  
Vol 12 (3) ◽  
Author(s):  
Edi Azali Hadzri ◽  
Kahar Osman ◽  
Mohamed Rafiq Abdul Kadir ◽  
Azian Abdul Aziz
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Cerebrospinal Fluid ◽  
Flow Rate ◽  
Third Ventricle ◽  
Region Of Interest ◽  
Csf Flow ◽  
The Third ◽  
Aqueduct Of Sylvius ◽  
Computational Fluid Dynamics Cfd

In this study, a three dimensional (3D) model of the third ventricle and aqueduct of Sylvius derived from MRI scans was constructed by using Computational Fluid Dynamics (CFD) modeling. Cerebrospinal fluid(CSF) can be modeled as a Newtonian Fluid and its flow through the region of interest (ROI) was visualized using Engineering Fluid Dynamics (EFD).The constructed ROI was regarded as rigid walled and only steady state flow was able to be defined due to the limitations of current software. Different flow rate was simulated at the Foramen of Monro and a small stenosis was modeled at the middle of the aqueduct of Sylvius at a fixed location. This was made corresponding to normal patients with variation of CSF flow rate physiologically and abnormal patients with tumor causing obstruction to or within the aqueduct of Sylvius, respectively. Due to the small dimensions of the ROI geometry, gravity and complex external gravity that acted upon it was considered to be neglected. The results show as the flow rate increase, the pressure drop of CSF in the ROI proportionally increased. For normal CSF flow rate, the presence of stenosis in the aqueduct demonstrates a significant increased pressure drop.ABSTRAK-Dalam kajian ini, model tiga dimensi (3D) untuk ventrikel ketiga dan akueduk Sylvius, yang terhasil daripada pengimejan resonans magnetik telah dikonstruksi menggunakan Permodelan Perkomputeran Dinamik Bendalir (Computational Fluid Dynamics (CFD)). Cecair serebrospinal (Cerebrospinal fluid (CSF)) dimodelkan sebagai bendalir Newtonan dan alirannya melalui kawasan kepentingan (region of interest (ROI)) digambarkan menggunakan Dinamik Bendalir Kejuruteraan (Engineering Fluid Dynamics (EFD)). Kawasan kepentingan yang dikonstruksi dianggap sebagai dinding tegar dan hanya aliran keadaan tunak yang dapat ditakrifkan berdasarkan pengehadan perisian komputer terkini. Kadar aliran yang berbeza disimulasikan di foramen monro dan laluan stenosis yang kecil dimodelkan di tengah-tengah akueduk Sylvius di satu lokasi yang telah ditetapkan. Kaedah ini dijalankan terhadap pesakit normal dengan variasi pada kadar aliran CSF, serta pesakit abnormal yang mempunyai tumor, penyebab sekatan terhadap atau melinkungi akueduk Sylvius. Disebabkan oleh ukuran geometri ROI kecil, tarikan graviti dan graviti luar kompleks yang bertindak ke atasnya diabaikan. Keputusan menunjukkan bahawa apabila kadar aliran meningkat, susutan tekanan CSF di dalam ROI meningkat dengan berkadar. Untuk kadar aliran CSF yang normal, kehadiran stenosis di dalam akueduk membuktikan pertambahan susutan tekanan yang ketara.

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