scholarly journals Antigen evolution from D614, to G614, and to Delta subtype of SARS-CoV-2

2022 ◽  
Author(s):  
Peijun Zuo ◽  
Liping Li
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Initial Data ◽  
Corona Virus ◽  
The Common ◽  
The Way

Abstract Since 2019, the antigens from Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) are keeping in evolution from initial D614, to G614, to Delta, and to Omicron. Seven of the peptides from SARS-CoV-2 are analyzed. The finding is that, the rule or route for the evolution of their antigens are exactly from “rough” status to “precise”. In this paper, we would like to show the initial data how the antigens from initial D614, conducted evolution to G614, to Delta of SARS-CoV-2. This finding can help the development of reagents for detecting the both “rough” and “precise” antigens, or even help for the development of the vaccines against SARS-CoV-2. And finally, to help the control of epidemic covid-19. According to such rule or route, the “common precise” antigens of the SARS-CoV-2 can be designed in silicon, developed in laboratory, and confirmed in animals. The way should be very tough and long.

scholarly journals An inhaler, syrup, drug and a vaccine for curing COVID-19

2020 ◽  
Vol 6 (2) ◽  
pp. 43-43
Author(s):  
S. Kalimuthu ◽  
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Common Cold ◽  
Infected Patient ◽  
Close Contact ◽  
Specific Treatment ◽  
Large Family ◽  
Corona Virus ◽  
The Common ◽  
Corona Viruses

Corona viruses are a large family of viruses that are known to cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). A novel corona virus (Co V) is a new strain of corona virus that has not been previously identified in humans. Corona viruses can be transmitted from person to person, usually after close contact with an infected patient. There is no specific treatment for disease caused by a novel corona virus. In this Hypothesis, the author proposes an alternative herbal inhaler, syrup, drug and a vaccine for curing Covid-19.

scholarly journals AN APPRAISAL OUTLINE ON CORONA VIRUS

2021 ◽  
Vol 12 (1) ◽  
pp. 118-123
Author(s):  
Onkar Doke ◽  
Anagha Kaldhone ◽  
Rupali Karkar ◽  
Raisa Shaikh ◽  
Salani Sahani
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Common Cold ◽  
Virus Disease ◽  
World Health ◽  
Corona Virus ◽  
The Common ◽  
Health Organization ◽  
Respiratory Droplets ◽  
Corona Viruses

A respiratory infection owing to a novel corona virus was first identified in Wuhan, China in December 2019. World health organization declared name for this novel corona virus as “COVID-19” is now a worldwide pandemic and has been recognized in more than 200 countries. Corona viruses are virus that is known to cause infection varying from the common cold to more critical diseases like Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). It is known to transmit by respiratory droplets released when corona virus patient coughs, sneezes or talks and if another person inhales the droplets or touches these surfaces and further touches his face, eyes or mouth can get an infection. Currently there are no specific vaccines or medicines for Corona virus disease and treatment given based on symptoms. But many vaccines are under investigation.

Causality Then and Now

1993 ◽  
Vol 10 (2) ◽  
pp. 165-177
Author(s):  
Karen Harding
Keyword(s):  
Quantum Theory ◽  
Common Sense ◽  
Mechanical Model ◽  
Physical World ◽  
Scientific Data ◽  
The World ◽  
The Common ◽  
The Universe ◽  
The Way

Ate appearances deceiving? Do objects behave the way they do becauseGod wills it? Ate objects impetmanent and do they only exist becausethey ate continuously created by God? According to a1 Ghazlli, theanswers to all of these questions ate yes. Objects that appear to bepermanent are not. Those relationships commonly tefemed to as causalare a result of God’s habits rather than because one event inevitably leadsto another. God creates everything in the universe continuously; if Heceased to create it, it would no longer exist.These ideas seem oddly naive and unscientific to people living in thetwentieth century. They seem at odds with the common conception of thephysical world. Common sense says that the universe is made of tealobjects that persist in time. Furthermore, the behavior of these objects isreasonable, logical, and predictable. The belief that the univetse is understandablevia logic and reason harkens back to Newton’s mechanical viewof the universe and has provided one of the basic underpinnings ofscience for centuries. Although most people believe that the world is accutatelydescribed by this sort of mechanical model, the appropriatenessof such a model has been called into question by recent scientificadvances, and in particular, by quantum theory. This theory implies thatthe physical world is actually very different from what a mechanicalmodel would predit.Quantum theory seeks to explain the nature of physical entities andthe way that they interact. It atose in the early part of the twentieth centuryin response to new scientific data that could not be incorporated successfullyinto the ptevailing mechanical view of the universe. Due largely ...

scholarly journals Comparison of Five Serological Assays for the Detection of SARS-CoV-2 Antibodies

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 78
Author(s):  
Anja Dörschug ◽  
Julian Schwanbeck ◽  
Andreas Hahn ◽  
Anke Hillebrecht ◽  
Sabine Blaschke ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Blood Donor ◽  
Immunoglobulin G ◽  
The Other ◽  
Specific Antibodies ◽  
Diagnostic Assays ◽  
Immunoglobulin Class ◽  
Corona Virus ◽  
Immunoglobulin Subclass

Serological assays can contribute to the estimation of population proportions with previous immunologically relevant contact with the Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) virus. In this study, we compared five commercially available diagnostic assays for the diagnostic identification of SARS-CoV-2-specific antibodies. Depending on the assessed immunoglobulin subclass, recorded sensitivity ranged from 17.0% to 81.9% with best results for immunoglobulin G. Specificity with blood donor sera ranged from 90.2% to 100%, with sera from EBV patients it ranged from 84.3% to 100%. Agreement from fair to nearly perfect was recorded depending on the immunoglobulin class between the assays, the with best results being found for immunoglobulin G. Only for this immunoglobulin class was the association between later sample acquisition times (about three weeks after first positive PCR results) and positive serological results in COVID-19 patients confirmed. In conclusion, acceptable and comparable reliability for the assessed immunoglobulin G-specific assays could be shown, while there is still room for improvement regarding the reliability of the assays targeting the other immunoglobulin classes.

Covid-19 And Sudden Death with Pulmonary Manifestations- A Case Report

2021 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Sudden Death ◽  
Common Cold ◽  
Respiratory Symptoms ◽  
Transmission Dynamics ◽  
Pulmonary Manifestations ◽  
The Family ◽  
The Common ◽  
Virus Strains

Covid 19 being a pandemic has uniformly and bizarrely affected the globe in a most unpredictable manner. So it becomes very important to unravel the transmission dynamics and the effect of the virus which has made it a deadly virus so far. Covid 19 is a member of coronavirus family, which also includes the SARS virus (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Symptoms) virus. The family of Coronavirus includes virus strains that the common cold and flu are caused [1].

Voices of Spectators and Audience Power

Pólemos ◽  
2015 ◽  
Vol 9 (2) ◽  
Author(s):  
Christian Biet
Keyword(s):  
Social Relationship ◽  
The Other ◽  
Long Period ◽  
The Social ◽  
The Common ◽  
Dramatic Action ◽  
The Law ◽  
The Voice ◽  
The Way

AbstractTheatre and law are not so different. Generally, researchers work on the art of theatre, the rhetoric of the actors, or the dramaturgy built from law cases or from the questions that the law does not completely resolve. Trials, tragedies, even comedies are close: everybody can see the interpenetration of them on stage and in the courts. We know that, and we know that the dramas are made with/from/of law, we know that the art the actors are developing is not so far from the art of the lawyers, and conversely. In this paper, I would like to have a look at the action of the audience, at the session itself and at the way the spectators are here to evaluate and judge not only the dramatic action, not only the art of the actors, not only the text of the author, but also the other spectators, and themselves too. In particular, I will focus on the “common judgment” of the audience and on its judicial, aesthetic and social relationship. The spectators have been undisciplined, noisy, unruled, during such a long period that theatre still retains some prints of this behaviour, even if nowadays, the social and aesthetic rule is to be silent. But uncertainty, inattention, distraction, contradiction, heterogeneity are the notions which characterise the session, and the judgments of the spectators still depend on them. So, what was and what is the voice of the audience? And with what sort of voice do spectators give their judgments?

The Positive State

2019 ◽  
pp. 129-137
Author(s):  
Judith N. Shklar
Keyword(s):  
Welfare State ◽  
Social Norms ◽  
Common Good ◽  
Industrial Capitalism ◽  
The Common Good ◽  
Positive Rights ◽  
The Common ◽  
Positive State ◽  
The Way

In this chapter Shklar identifies the problems that arise with the development of industrial capitalism. She traces the emergence of social obligations to fellow citizens and the new concerns this raised, paying particular attention to the way the English idealist T.H. Green addressed these issues. She discusses the thinking behind the new welfare state and the rising popularity of social norms and obligations, often also expressed in terms of “the common good,” “positive rights,” and “the obligation to be just.”

scholarly journals Emerging pandemic COVID-19: myths and facts

2020 ◽  
Vol 6 (7) ◽  
pp. 283
Author(s):  
Rohit Vadala ◽  
Isabella Princess
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Presentation ◽  
Surface Protein ◽  
Respiratory Viruses ◽  
The Novel ◽  
Nucleocapsid Proteins ◽  
The World ◽  
The Common ◽  
Human Infections ◽  
Relationship Of

<p>The first theory which has established itself across the world is that COVID-19 is a “new virus”. It is rather wise to call it a “new strain” of a pre-existing coronavirus since history clearly denotes cases of coronavirus surfacing the world in past years beginning as early as mid-1960s.Including this novel strain of the virus, seven strains of coronaviruses have been commonly associated with human infections. Coronaviruses are primarily respiratory viruses causing infections ranging from mild to severe involvement of the respiratory tract. The common cold strains of coronavirus are 229E alpha coronavirus, NL63 alpha coronavirus, OC43 beta coronavirus and HKU1 beta coronavirus.The acute respiratory distress causing strains are severe acute respiratory syndrome (SARS) beta CoV causing SARS, MERS beta CoV causing Middle East respiratory syndrome (MERS) and the very novel COVID-19. Researchers and molecular biologists have confirmed phylogenetic relationship of COVID-19 with a 2015 Chinese bat strain of SARS CoV.<sup> </sup>Mutations to the surface protein as well as nucleocapsid proteins were demonstrated. These two mutations predicts the characteristics such as higher ability to infect as well as enhanced pathogenicity of COVID-19 as compared to older SARS strain. For this reason and with similarities in clinical presentation the novel strain has been named as SARS-CoV-2.</p>

scholarly journals RT-PCR for COVID-19: Diagnosis Made Easy

BioMedica ◽  
2020 ◽  
Vol 36 (2S) ◽  
pp. 115-120
Author(s):  
Osheen Sajjad ◽  
Aiman Shahzad ◽  
Saqib Mahmood
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Real Time ◽  
Detection Method ◽  
Current Knowledge ◽  
Detection Methods ◽  
Rt Pcr ◽  
Corona Virus ◽  
Positive Sense ◽  
Affected Person ◽  
Sampling Procedures

<p>Coronavirus disease COVID-19, caused by Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV2), is highly contagious and has been a pandemic since March 2020. The SARS-CoV-2 is an enveloped, single-stranded, positive-sense RNA viruswhich spreadsthrough air droplets by sneezing and coughing from affected person. The diagnosis of the COVID-19 remains a challenge to the scientists since the genome of the SARS-CoV-2 was novel and varying. Various studies have reported the validated procedures for sampling and the detection method of SARS-CoV-2. This mini-review provides a brief introduction of the SARS-CoV-2 features and the current knowledge for the recommended COVID19 detection methods including sampling procedures and real time SARS-CoV-2 genome detection.</p>

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