Fumigant Toxicity of Cleistopholis patens (Benth) Oil extracts on Plodia interpunctella (Hubner) and Its Toxicological Effects in Wistar Rats

2021 ◽  
Author(s):  
Sunday Tope Olorunsogbon ◽  
Joseph Akinneye ◽  
Eniola Olowu
Keyword(s):  
Wistar Rats ◽  
Plodia Interpunctella ◽  
Adult Mortality ◽  
Fumigant Toxicity ◽  
Toxicological Effects ◽  
Toxicological Studies ◽  
Liver And Kidney ◽  
Group A ◽  
Oil Extract ◽  
Toxic Potential

Abstract Background: The efficacy of root and stem barks oil of Cleistopholis patens as a fumigant agent on Plodia interpunctella infesting maize grains as well as its toxic potential in wistar rats were investigated. Both plant oils were used for fumigant bioassay while only the root oil extract was used for all toxicological studies due to its higher toxicity on P. interpunctella when compared to stem oil extract. Both insects and wistar rats were exposed to different concentrations (0.0, 5%, 10%, 15%, 20% and 25%) of the extract. 36 wistar rats were divided into Group A-F and each group received different concentrations of the oil extract except for Group A that received only Dimethyl sulphide saline and various toxicological tests were conducted. Results: Result shows that both stem and root extracts significantly evoked (p<0.05) higher larva and adult mortality in treated grains when compared to both controls except at 5% of both oil extracts. Ten percent root oil extract achieved 50% mortality in Plodia interpunctella within 48hrs and 25% achieved 100% mortality in larva and adult of Plodia interpunctella within 72hrs when compared to the amount needed to achieve 50% and 100% mortality in stem oil extract within 48hrs and 72hrs. Irrespective of the concentration administered to the animal, there were no significant alteration (p>0.05) in the toxicological test using both liver and kidney biochemical parameters.Conclusion: This study shows that root oil extract of C. patens is a very good fumigant poison to Plodia interpunctella with no toxic impact in wistar rats.

scholarly journals Toxicological Studies of popular eye cosmetic used world wide

2018 ◽  
Vol 18 (1) ◽  
pp. 118-123
Author(s):  
Tehmina Sohail ◽  
Atiq Ur Rahman ◽  
Hina Imran ◽  
Zahra Yaqeen ◽  
Nudrat Fatima ◽  
...  
Keyword(s):  
Medical Science ◽  
Research Work ◽  
Lead Toxicity ◽  
Experimental Period ◽  
Albino Rats ◽  
Experimental Animals ◽  
Toxicological Effects ◽  
Toxicological Studies ◽  
Liver And Kidney ◽  
Zinc Levels

Background and Objective: Present research work was designed and conducted to verify the safe use of kajal, a popular eye cosmetic, which is widely used to beautify eyes throughout the world especially in South Asia and Middle East region. Material and Method: The toxicological studies were conducted in experimental animals for a period of 90 days to clarify misleading thoughts associated with its long term use including lead toxicity. The study was carried out in Albino rats of Wister strain and New Zealand White rabbits. Hashmi kajal dibya (net weight 4.25g), an eye cosmetic manufactured by M/s A.Q. and company international Pakistan was used as source for study. The ingredients claimed by the manufacturer are zinc oxide, wax, cinnamonum camphora, processed carbon black and clarified butter. Result: The elemental analysis resulted in presence of zinc 9.56%, lead 0.09% and total ash 41.01%, while sulfur, antimony, mercury and arsenic were not detected in the sample. The sub-chronic toxicological studies revealed that no toxicological effects were found in experimental animals. All the animals of test and control groups exhibited normal physiological activities and an increase in body weights. Lead and Zinc levels remained constant throughout the experimental period and no mortality was recorded. Furthermore, liver and kidney function tests were normal, indicating non-toxic effect of the kajal on vital organs. Conclusion: So it can be assumed that this eye cosmetic is non-toxic and can be used safely in humans. Bangladesh Journal of Medical Science Vol.18(1) 2019 p.118-123

scholarly journals Clinico-toxicological effects of ceftriaxone after intramuscular administration of graded doses in Basenji dogs

2021 ◽  
Vol 20 (10) ◽  
pp. 2089-2097
Author(s):  
Ukamaka U. Eze ◽  
Ifeanyi G. Eke ◽  
Aruh O. Anaga ◽  
Elias Abah ◽  
Ikechukwu J. Udeani ◽  
...  
Keyword(s):  
Haemoglobin Concentration ◽  
Intramuscular Administration ◽  
Toxicological Effects ◽  
Hind Limbs ◽  
Liver And Kidney ◽  
Group A ◽  
Red Blood Cell Count ◽  
Kidney Functions ◽  
Group D ◽  
Haematological Indices

Purpose: The recent ceftriaxone-induced anaemia and mortalities at the dose of 50 mg/kg in Veterinary Teaching Hospital, University of Nigeria prompted this study which sought to assess the clinicotoxicological effects of ceftriaxone (CFZ) after intramuscular administration of graded doses in Basenji dogs.Methods: The effects of CFZ on the haematological indices, physiological parameters, liver and kidney functions were assessed in 4 group of dogs (n = 4) designated A – D. They were given CFZ intramuscularly for 21 days at doses of 12, 25 and 50 mg/kg for groups A, B, C, respectively, while thecontrol (group D) received the diluent (lignocaine 0.2 mL)Results: The mean pulse and heart rate of dogs in group C were significantly (p < 0.05) higher than those of group A, B and D. Significant (p < 0.05) decrease in red blood cell count (RBC), haemoglobin concentration (Hb) and packed cell volume (PCV) was observed in group C on days 7 and 14, while on day 21, these parameters were significantly (p < 0.05) higher in group D than in the treated groups. On day 14 of CFZ administration, the alanine transaminase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities of dogs in group C was significantly (p < 0.05) elevated than the control group.Conclusion: These findings suggest that CFZ, at the doses of 12.5 - 25 mg/kg, appears safe in dogs as most of the adverse effects observed are reversed following the withdrawal of the drug on day 28. However, CFZ at 50 mg/kg causes anaemia, tachycardia and bilateral paralysis of the hind limbs which did not revert to normal after one week; hence, it is not recommended for use in dogs at this dose.

scholarly journals Interaction of Environmental Pollutants with Microplastics: A Critical Review of Sorption Factors, Bioaccumulation and Ecotoxicological Effects

Toxics ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 40 ◽  
Author(s):  
Albert Menéndez-Pedriza ◽  
Joaquim Jaumot
Keyword(s):  
Environmental Pollutants ◽  
Potential Harm ◽  
Toxicological Assessment ◽  
Environmental Threats ◽  
Toxicological Effects ◽  
Toxicological Studies ◽  
Principal Factors ◽  
Persistent Organic Compounds ◽  
Toxic Potential ◽  
New Generation

Microplastics have become one of the leading environmental threats due to their persistence, ubiquity and intrinsic toxic potential. The potential harm that microplastics impose on ecosystems varies from direct effects (i.e., entanglement and ingestion) to their ability to sorb a diversity of environmental pollutants (e.g., heavy metals, persistent organic compounds or pharmaceuticals). Therefore, the toxicological assessment of the combined effects of microplastics and sorbed pollutants can produce in biota is one of the hottest topics on the environmental toxicology field. This review aims to clarify the main impacts that this interaction could have on ecosystems by (1) highlighting the principal factors that influence the microplastics sorption capacities; (2) discussing the potential scenarios in which microplastics may have an essential role on the bioaccumulation and transfer of chemicals; and (3) reviewing the recently published studies describing toxicological effects caused by the combination of microplastics and their sorbed chemicals. Finally, a discussion regarding the need for a new generation of toxicological studies is presented.

scholarly journals Assessment of Environmental Factors on Secondary Metabolites and Toxicological Effects of Datura metel Leaves Extracts

2018 ◽  
Vol 3 (2) ◽  
pp. 8-19
Author(s):  
Modinah A.O. Abdul Raheem ◽  
Faoziyat A. Sulaiman ◽  
Halimat A. Abdulrahim ◽  
Olatunde Ahmed ◽  
Kamil O. Yusuf ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Wistar Rats ◽  
Physicochemical Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Leaf Extracts ◽  
Toxicological Effect ◽  
Toxicological Effects ◽  
Datura Metel ◽  
Significant Difference ◽  
Liver And Kidney

AbstractThis study evaluated the chemical composition, physicochemical properties, toxicological and environmental potentials of the Datura metel (D. metel) leaves extracts. Fresh leaves of D. metel were harvested at three different times of the day (morning, afternoon and evening), extraction done in succession using n-hexane and ethanol solvents respectively. Preliminary phytochemical screening, physicochemical analysis for specific gravity, pH, colour, total ash and moisture contents of the dried extracts were determined. The characterisation of the bioactive compounds using Gas Chromatography-Mass Spectrometry, showed the presence of different compounds at the three different times of the day, out of which phytol and 9,12,15-octadecatrienoic acid were present at all times. These results confirmed that some bioactive compounds present in this plant are dependent on environmental factor , time of harvest and the choice of solvent used while the presence of others are independent on these factors. Each extract was administered orally to Wistar rats for two weeks. There were significant difference (p < 0.05) in activities of AST (serum and heart), ALT (liver and serum) and ALP (Serum, liver and kidney), as well as the concentrations of albumin and protein in the liver and serum and urea in the serum of experimental rats given n-hexane and ethanolic extracts of D. metel. Generally it also suggest that the leaf extracts collected at three different times of the day had some significant toxicological effect, thus may not be totally safe for consumption at the dosage indicated since tissues membranes integrity of the Wistar rats were not potentially preserved.

scholarly journals Aggravation of Aluminum Phosphide Induced Liver Damage and Hematotoxicity in Adult Wistar Rat: The Role of Allium Sativum

2021 ◽  
Vol 2 (2) ◽  
pp. 51-59
Author(s):  
E. U. Eric ◽  
V. E. Boloya ◽  
A. E. Osuamkpe
Keyword(s):  
Wistar Rats ◽  
Mesangial Cells ◽  
Garlic Extract ◽  
Medical Laboratory ◽  
Aluminum Phosphide ◽  
Male Adult ◽  
Ameliorative Effect ◽  
Liver And Kidney ◽  
Group A ◽  
Animal House

Objectives: To investigate the ameliorative effect of garlic extract on Aluminum Phosphide induced toxicity on the liver and kidney of adult Wistar rats. Materials: Thirty six (36) male adult Wistar rats weighing 180±20 – 250±30 g were purchased from Dantom Farms, Swali, Bayelsa State and moved to the animal house of the department of Medical Laboratory Science, Niger Delta University. The animals were assigned into six (6) major groups with six (6) animals in each group after the period of acclimatization: Animals in Group A (Control): received pelleted growers mash (feed) and water. Group B (Positive Control received 0.014 mg of Aluminum Phosphide only. Group C: received 0.014 mg of Aluminum Phosphide and 250 g of garlic extract. Group D: received 0.014 mg of Aluminum Phosphide and 500 mg of garlic extract. Group E: received 500 mg of garlic extract, Group F: received 0.6 ml of oil at the end of the treatment, the liver and the kidney of each sacrificed rat were processed for paraffin sectioning and stained with Harris hematoxylin and eosin. Result: Photomicrograph of the liver of animals in Groups B, C and D show central venous congestion, degeneration, hemorrhage, sinusoidal dilation, bile stasis, centrilobular necrosis, Kupffer cell hyperplasia, inflammatory cells and fat infiltration which are features of hepatic injury also photomicrograph of the kidney of animals in Groups B, C and D shows membranous defect, contracted glomeruli with marked presence of mesangial cells, areas of tubular necrosis with mesangial cells proliferation. while the other groups (Group A, E, F) did not show any histological change in comparison with control. Conclusion: The present study proves that the oral ingestion of Aluminum Phosphide induces hepatotoxicity and inflammation of the liver and kidney. It also shows that the use of garlic at various concentrations (250 mg/l and 500 mg/l) aggravates the tissue damage even more, and also garlic extract does not have ameliorative effect on aluminum phosphide toxicity on the liver and kidney of albino wistar rats.

scholarly journals Methyl Benzoate Is Superior to Other Natural Fumigants for Controlling the Indian Meal Moth (Plodia interpunctella)

Insects ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 23
Author(s):  
Md Munir Mostafiz ◽  
Errol Hassan ◽  
Rajendra Acharya ◽  
Jae-Kyoung Shim ◽  
Kyeong-Yeoll Lee
Keyword(s):  
Insect Pests ◽  
Insect Pest ◽  
Plodia Interpunctella ◽  
Methyl Benzoate ◽  
Management Tool ◽  
Contact Toxicity ◽  
Fumigant Toxicity ◽  
Indian Meal Moth ◽  
Indian Meal ◽  
Food Commodities

The Indian meal moth, Plodia interpunctella (Hübner) (Lepidoptera: Pyralidae), is an insect pest that commonly affects stored and postharvest agricultural products. For the control of insect pests and mites, methyl benzoate (MBe) is lethal as a fumigant and also causes contact toxicity; although it has already been established as a food-safe natural product, the fumigation toxicity of MBe has yet to be demonstrated in P. interpunctella. Herein, we evaluated MBe as a potential fumigant for controlling adults of P. interpunctella in two bioassays. Compared to the monoterpenes examined under laboratory conditions, MBe demonstrated high fumigant activity using a 1-L glass bottle at 1 μL/L air within 4 h of exposure. The median lethal concentration (LC50) of MBe was 0.1 μL/L air; the median lethal time (LT50) of MBe at 0.1, 0.3, 0.5, and 1 μL/L air was 3.8, 3.3, 2.8, and 2.0 h, respectively. Compared with commercially available monoterpene compounds used in pest control, MBe showed the highest fumigant toxicity (toxicity order as follows): MBe > citronellal > linalool > 1,8 cineole > limonene. Moreover, in a larger space assay, MBe caused 100% mortality of P. interpunctella at 0.01 μL/cm3 of air after 24 h of exposure. Therefore, MBe can be recommended for use in food security programs as an ecofriendly alternative fumigant. Specifically, it provides another management tool for curtailing the loss of stored food commodities due to P. interpunctella infestation.

Spontaneous pineal body tumours (pinealomas) in Wistar rats; a histological and ultrastructural study

1984 ◽  
Vol 18 (3) ◽  
pp. 224-229 ◽  
Author(s):  
A. J. Al Zubaidy ◽  
W. Malinowski
Keyword(s):  
Ultrastructural Study ◽  
Wistar Rats ◽  
Pineal Body ◽  
Related Literature ◽  
Toxicological Studies

The pathology of 5 cases of pinealomas in Wistar rats used in long-term toxicological studies is described both grossly, microscopically and ultrastructurally, together with a review of the related literature.

scholarly journals The effects of Roux-en-Y limb length on gastric emptying and enterogastric reflux in rats

2008 ◽  
Vol 23 (2) ◽  
pp. 179-183 ◽  
Author(s):  
Robson Azevedo Dutra ◽  
Wemberton Martins Araújo ◽  
José Ivan de Andrade
Keyword(s):  
Gastric Emptying ◽  
Wistar Rats ◽  
Limb Length ◽  
Roux Limb ◽  
Short Limb ◽  
Male Wistar Rats ◽  
Group A ◽  
Group B ◽  
Enterogastric Reflux

PURPOSE: To assess the effects of Roux-en-Y jejunal limb length on gastric emptying and enterogastric reflux. METHODS: Seventy male Wistar rats were submitted to antrectomy with Roux-en-Y reconstruction and then were divided into two groups of 35 animals. Group A, short limb (7.5 cm) and Group B, standard limb (15 cm). Group A and B were subdivided into five subgroups each in order to study enterogastric reflux at 30 and 60 minutes and to evaluate gastric emptying at 5, 10 and 15 minutes. In order to measure gastric emptying and enterogastric reflux, radiotracers 99m Tc-Phytate and 99m Tc-DISIDA were respectively used. RESULTS: For gastric emptying, the radiotracer concentration was lower in Group A than in Group B after five minutes. The enterogastric reflux was present, but there were no significant differences between enterogastric reflux indexes concerning both A and B Groups. CONCLUSION: A standard Roux limb, besides being unable to protect the stomach from the enterogastric reflux, may become a functional barrier for gastric emptying.

scholarly journals Biochemical Evaluation of Silver Nanoparticles in Wistar Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Oluyomi Stephen Adeyemi ◽  
Ifeoluwa Adewumi
Keyword(s):  
Silver Nanoparticles ◽  
Biomedical Applications ◽  
Wistar Rats ◽  
Biochemical Analysis ◽  
Significant Loss ◽  
Male Rats ◽  
Rat Serum ◽  
Show Evidence ◽  
Group A ◽  
Biochemical Evaluation

Background. Silver nanoparticles have found wider and increasing biomedical applications due to their broad antimicrobial characteristics. However, toxicity of nanoparticles is a subject of continued controversy, thus necessitating further studies in this direction. Objectives. This study investigated the biochemical effects of silver nanoparticles in Wistar rats. Materials and Methods. Forty male rats were randomly distributed into eight experimental groups of five. Group A served as the control and received distilled water. Groups B to H were orally exposed to varying concentrations of silver nanoparticles (AgNPs) at 100, 1000, and 5000 mg/kg daily for 7, 14, and 21 days alternately. Following cessation of treatments, rats were sacrificed and the blood and other vital organs were collected and prepared as specimens for biochemical analysis. Results. Administration of AgNPs to rats did not produce significant loss in feed intake and body weight. However, rat exposure to AgNPs caused significant alterations to levels of serum and tissue AST, ALT, and ALP. At the 100 mg/kg AgNPs exposure, rat serum and tissue AST and ALT levels were significantly decreased (P < 0.05). In contrast, AgNPs administration elevated (P < 0.05) ALP levels in rat serum and tissues. Conclusion. We show evidence that AgNPs administration to Wistar rats altered some biochemical parameters.

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