scholarly journals Toxicological Studies of popular eye cosmetic used world wide

2018 ◽  
Vol 18 (1) ◽  
pp. 118-123
Author(s):  
Tehmina Sohail ◽  
Atiq Ur Rahman ◽  
Hina Imran ◽  
Zahra Yaqeen ◽  
Nudrat Fatima ◽  
...  
Keyword(s):  
Medical Science ◽  
Research Work ◽  
Lead Toxicity ◽  
Experimental Period ◽  
Albino Rats ◽  
Experimental Animals ◽  
Toxicological Effects ◽  
Toxicological Studies ◽  
Liver And Kidney ◽  
Zinc Levels

Background and Objective: Present research work was designed and conducted to verify the safe use of kajal, a popular eye cosmetic, which is widely used to beautify eyes throughout the world especially in South Asia and Middle East region. Material and Method: The toxicological studies were conducted in experimental animals for a period of 90 days to clarify misleading thoughts associated with its long term use including lead toxicity. The study was carried out in Albino rats of Wister strain and New Zealand White rabbits. Hashmi kajal dibya (net weight 4.25g), an eye cosmetic manufactured by M/s A.Q. and company international Pakistan was used as source for study. The ingredients claimed by the manufacturer are zinc oxide, wax, cinnamonum camphora, processed carbon black and clarified butter. Result: The elemental analysis resulted in presence of zinc 9.56%, lead 0.09% and total ash 41.01%, while sulfur, antimony, mercury and arsenic were not detected in the sample. The sub-chronic toxicological studies revealed that no toxicological effects were found in experimental animals. All the animals of test and control groups exhibited normal physiological activities and an increase in body weights. Lead and Zinc levels remained constant throughout the experimental period and no mortality was recorded. Furthermore, liver and kidney function tests were normal, indicating non-toxic effect of the kajal on vital organs. Conclusion: So it can be assumed that this eye cosmetic is non-toxic and can be used safely in humans. Bangladesh Journal of Medical Science Vol.18(1) 2019 p.118-123

scholarly journals Biochemical and Toxicological Studies of Bridelia micrantha [Berth] and Mitracarpus villosus [Swartz] DC Extracts used as Biofumigant Against Stored Produce Insect Pests on Albino Rats

2019 ◽  
Vol 13 (4) ◽  
pp. 5-10
Author(s):  
Jacobs Mobolade Adesina ◽  
◽  
Thomas Inomisan Ofuya ◽  
Kayode David Ileke ◽  
Yallappa Rajashekar ◽  
...  
Keyword(s):  
Body Weight ◽  
Total Protein ◽  
Insect Pest ◽  
Petroleum Ether Extract ◽  
The Body ◽  
Albino Rats ◽  
Oral Toxicity ◽  
Plant Materials ◽  
Toxicological Studies ◽  
Liver And Kidney

Background: In recent years, plant materials have been widely explored as sources of insect pest control agents with little or no study on their toxicity. The present study aimed to detect the biochemical alterations in liver and kidney associated with acute oral toxicity of the extracts of B. micrantha and M. villosus in albino rats. Methods: Twenty seven albino rats, weighing between 150-180g were used and divided into nine groups of three rats each, administered with different doses of each extracts (0, 500, 1000, 1500 and 2000mg/kg). The plasma and homogenates of liver and kidney of the rats were investigated for the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALT), total protein, urea and creatinine, using standard laboratory kits. Results: The administration of either extract did not cause death or any hazardous symptoms of acute toxicity, nor resulted in any evident changes in the body weight. However, the extracts caused significant decreases in the levels of ALT, AST, ALP and total protein, urea and creatinine in biochemical parameters. They also caused a significant decrease in the serum parameters of treated rats’ liver and kidney at all doses. Conclusions: The results demonstrated that the oral administration of B. micrantha ethyl acetate extract and of M. villosus petroleum ether extract may be considered as moderately free of toxicity. This was based on our findings that two compounds were moderately safe with respects to their effects on the liver and kidney functions at concentrations of up to 2000 mg/kg body weight of the rats.

Fumigant Toxicity of Cleistopholis patens (Benth) Oil extracts on Plodia interpunctella (Hubner) and Its Toxicological Effects in Wistar Rats

2021 ◽  
Author(s):  
Sunday Tope Olorunsogbon ◽  
Joseph Akinneye ◽  
Eniola Olowu
Keyword(s):  
Wistar Rats ◽  
Plodia Interpunctella ◽  
Adult Mortality ◽  
Fumigant Toxicity ◽  
Toxicological Effects ◽  
Toxicological Studies ◽  
Liver And Kidney ◽  
Group A ◽  
Oil Extract ◽  
Toxic Potential

Abstract Background: The efficacy of root and stem barks oil of Cleistopholis patens as a fumigant agent on Plodia interpunctella infesting maize grains as well as its toxic potential in wistar rats were investigated. Both plant oils were used for fumigant bioassay while only the root oil extract was used for all toxicological studies due to its higher toxicity on P. interpunctella when compared to stem oil extract. Both insects and wistar rats were exposed to different concentrations (0.0, 5%, 10%, 15%, 20% and 25%) of the extract. 36 wistar rats were divided into Group A-F and each group received different concentrations of the oil extract except for Group A that received only Dimethyl sulphide saline and various toxicological tests were conducted. Results: Result shows that both stem and root extracts significantly evoked (p<0.05) higher larva and adult mortality in treated grains when compared to both controls except at 5% of both oil extracts. Ten percent root oil extract achieved 50% mortality in Plodia interpunctella within 48hrs and 25% achieved 100% mortality in larva and adult of Plodia interpunctella within 72hrs when compared to the amount needed to achieve 50% and 100% mortality in stem oil extract within 48hrs and 72hrs. Irrespective of the concentration administered to the animal, there were no significant alteration (p>0.05) in the toxicological test using both liver and kidney biochemical parameters.Conclusion: This study shows that root oil extract of C. patens is a very good fumigant poison to Plodia interpunctella with no toxic impact in wistar rats.

scholarly journals Impact of different doses of Malathion on the selected blood parameter in albino rats (Rattus norvegicus)

2021 ◽  
Vol 22 (1&2) ◽  
pp. 1-5
Author(s):  
C.D. Sharma ◽  
Geeta Bansal
Keyword(s):  
Blood Sugar ◽  
Biochemical Parameter ◽  
Abnormal Behavior ◽  
Albino Rats ◽  
Blood Parameter ◽  
Toxicological Effects ◽  
Blood Biochemical ◽  
Home Gardening ◽  
Liver And Kidney ◽  
Different Doses

Malathion is an organophosphate pesticides commonly used to eradicate the pest of agricultural crops. It is routinely used to protect the ornamental and home gardening plants. Malathion is found in market by its trade name called cythion. In Indian scenario farmers and spray men use pesticide in their fields ignoring its toxicological effects. The main target organs of any toxicant in human body are liver and kidney.Present study is based on the effects of different dose of Malathion on blood biochemical parameter like blood sugar, blood urea, creatinine and bilirubin. These four parameters are used to observe the behavior of liver and kidney in albino rats. Four doses of Malathion has been selected as 25 mg, 50mg, 75mg and 100mg per kilogram body weight per day for 7 days and 15 days of treatment. Findings indicate that at normal condition the value of sugar was 121.54 +14.44 mg/dl , blood urea  41.27 + 3.13 mg/dl , blood bilirubin 0.76 + 0.10 mg/dl and value of creatinine was observed as 0.85 + 00.52 mg/dl. with different doses of Malathion after 7 and 15 days the  value of blood sugar significantly decreases upto 78.52 + 10.25 mg/dl at higher dose while blood urea value significantly increased up to 50.88+4.8 mg/dl, the value of creatinine significantly increased 1.05 + 0.18 mg/dl and bilirubin also increased significantly 2.20 +0.64mg/ dl. The fluctuation in parameter represents the abnormal behavior of liver and kidney of albino rats due to the toxicity of pesticide.

scholarly journals Heteroxenia Ghardaqensis Extract Protects Against DNA Damage in Streptozotocin-Induced Experimental Diabetes

2019 ◽  
Vol 12 (1) ◽  
pp. 71-78 ◽  
Author(s):  
Abdel Razik Farrag ◽  
Mahmoud Nassar ◽  
Zakaria El-Khayat ◽  
Jihan Hussein ◽  
Nadia Ahmed Mohammed ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Dna Damage ◽  
Body Weight ◽  
Experimental Period ◽  
Reversed Phase ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Liver And Kidney

DNA damage is correlated to type-2 diabetes mellitus (T2DM) and its complications via oxidative stress. This study aimed to evaluate the anti-diabetic effect of Heteroxenia ghardaqensis extract on streptozotocin (STZ) induced-diabetes and how far can this extract attenuate DNA damage in this model. Forty male albino rats (160-180 g) were used in this study and divided into four groups: control, diabetic, diabetic rats received H. ghardaqensis extract (30 mg/kg body weight/day) orally for four weeks and diabetic rats received H. ghardaqensis extract (60 mg/kg body weight/day) orally for four weeks. After the experimental period, fasting blood sugar and serum cholesterol were determined. Urinary 8-hydroxyguanosine (8-OHdG) as a marker of DNA damage was estimated by reversed phase (HPLC). Liver and kidney nitic oxide (NO) and malondialdehyde (MDA) were estimated. Pancreatic tissues were histopathologicaly examined. Our results suggested that diabetes mellitus is accompanied by elevation of DNA damage that enhances the tendency to mutagens and reduce the efficacy of DNA repair. H. ghardaqensis extract appeared to be effective against the oxidative stress induced by STZ which may be due to sesquiterpenoids and diterpenes compounds that scavenge free radicals and increase the antioxidant enzymes as appeared in attenuation of DNA damage.

Effects of Dihydroquercetin on Behavior of Albino Rat Offspring with Transgenerational Chemical Body Burden

2020 ◽  
pp. 38-41
Author(s):  
E.A. Kapustina ◽  
L.G. Lisetskaya
Keyword(s):  
Physical Activity ◽  
Open Field ◽  
Antioxidant Properties ◽  
Body Burden ◽  
Statistical Processing ◽  
Lead Toxicity ◽  
Absorption Spectrometry ◽  
Albino Rats ◽  
Albino Rat ◽  
Rat Offspring

Introduction. Lead pollution is a common environmental problem. Having no physiological functions, this toxicant has a negative polytropic impact on a body, including neurotoxic, reproductive, and transgenerational effects. The mechanism of lead toxicity is oxidative stress. Flavonoids have active antioxidant properties. They are widely represented in plant foods, are able to restore protective capabilities of cells and have chelating properties with respect to lead. One of the representatives of this group of substances is dihydroquercetin. The objective was to study the effect of dihydroquercetin on behavior of rats with hereditary chemical body burden exposed to lead at 60 mg/kg during 25 days. Materials and methods. We studied the behavior of rat offspring in an open field and established their blood lead levels by electrothermal atomization atomic absorption spectrometry. For statistical processing the U-Mann – Whitney test was used. Results. In the present experiment, the effect of lead on the offspring of male albino rats exposed to 60 mg/kg of lead for 25 days caused changes in the activity of animals in the open field. The severity of changes was more pronounced in animals with a hereditary chemical body burden. These animals showed a decrease in orientation and physical activity and increased anxiety. In rats with a hereditary burden, changes in behavior were detected when administering dihydroquercetin. The activity of animals demonstrated a positive dynamics: we observed a statistically significant increase in physical activity and orientation. The number and duration of behavioral acts approached control values. Conclusions. The revealed effects of lead on the offspring of albino rats with a transgenerational chemical body burden require further study to understand the mechanism of the phenomenon.

scholarly journals Nutritional and toxicological analysis of phoenix dactylifera (date palm) powder used as a drink

2018 ◽  
Vol 17 (2) ◽  
pp. 263-269
Author(s):  
Tehmina Sohail ◽  
Nida Saleem ◽  
Hina Imran ◽  
Zahra Yaqeen ◽  
Atiq Ur Rehman ◽  
...  
Keyword(s):  
Medical Science ◽  
Phoenix Dactylifera ◽  
High Energy ◽  
Oral Route ◽  
Fresh Fruit ◽  
Oral Toxicity ◽  
Nutritional Values ◽  
Wistar Strain ◽  
Toxicological Studies ◽  
Observation Period

Objective: Phoenix dactylifera fruit widely used in Muslim countries.They have religious attachment to it and also it had many health benefits. It is essential to investigate nutritional values of Phoenix dactylifera fruit in dried powder form and to find out any toxicological changes during processing of this dried powder drink.Method: Dried date powder was prepared from fresh fruit by drying it and its nutritional value and toxicological studies were carried out. The acute oral toxicity study of date powder was conducted on wistar strain rats by oral route in a dose of 0.5g/kg body weight and 0.1g/kg body weight.Result: The results of biochemical analysis of dehydrated date powder exhibited that it possesses high energy value of 311 Kcal, carbohydrate 70.5%, dietary fiber 7.3%, fat content 2.1%, protein 2.6%, and mineral content 2.2%. Whereas, total sugar was found to be as 63.2% and moisture content 2.3%. The test drink showed no sign of toxicity or death during the whole observation period (fourteen days) in rats. No group of animal showed any unusual change in behavior or in locomotors activity. The macroscopic studies of vital organs i.e. heart, liver, spleen, lungs and kidneys exhibited that they were normal.Conclusion: As a result of these studies it can be concluded that from processing of fresh fruit to dried powder along with its nutritional and toxicological studies no hazardous material like toxins were produced. So it can be used safely.Bangladesh Journal of Medical Science Vol.17(2) 2018 p.263-269

scholarly journals Synthesis of Some 3d Metal Complexes of Quinine and their Toxicological Studies

1970 ◽  
Vol 25 ◽  
pp. 19-28 ◽  
Author(s):  
Adedibu C. Tella ◽  
Joshua A. Obaleya
Keyword(s):  
Stability Constant ◽  
Metal Complexes ◽  
Chemical Society ◽  
Cinchona Alkaloids ◽  
Albino Rats ◽  
Spectroscopic Techniques ◽  
Tetrahedral Geometry ◽  
Toxicological Studies ◽  
3D Metal Complexes ◽  
The Stability

Four metal complexes of antimalarials cinchona alkaloids; [Co(Quin)Cl3]-1,[Fe(Quin)Cl2H2O]SO3H2O-2, [Cu(Quin)ClSO4]∞-3 and [Cd(Quin)ClSO4]∞-4 have beensynthesized and characterized by elemental analysis, conductivity, magnetic moment, IR,UV-Vis and mass spectroscopic techniques. The tetrahedral geometry is assigned for all thefour complexes and the quinine ligand is protonated at quinuclidine N atom with thecoordination of the metal at quinoline N atom for all the complexes. Complexes 1 and 2have zwitterionic structures while complexes 3 and 4 are polymeric in nature with zig-zagextended chains (MCl- O -SO2- O -MCl- O –SO2---).Stability constant of the complexes were evaluated for the metal salts. The value of thestability constant (β) was found to be log 10.48, 9.92, 7.98 and 7.81 for Cu(II), Fe(III),Co(II) and Cd(II), respectively and the order of β was found to beCu(II)>Fe(III)>Co(II)>Cd(II). The stability constant data revealed that concomitantlyadministration of quinine with preparation containing these metals may reduce theirefficacy. Toxicological study was carried out by investigating the effect of administration ofthe complexes on alkaline phosphatase activity of kidney, liver and serum of Albino rats. Allthe examined four metal complexes were found to be non-toxic.Keywords: Quinine, stability constant, FTIR, MS, phosphates activity.DOI:  10.3126/jncs.v25i0.3280Journal of Nepal Chemical Society Volume 25, 2010 pp 19-28

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