scholarly journals Examination of the Missense Mutation (rs74653330, Ala481Thr) of the Oculocutaneous Albinism 2 Gene to the Facial Skin Characteristics

2021 ◽  
Author(s):  
Dasom Lee ◽  
Ja-Eun Choi ◽  
Da-Hyun Park ◽  
Kyung-Won Hong
Keyword(s):  
Missense Mutation ◽  
Middle Age ◽  
Skin Pigmentation ◽  
Oculocutaneous Albinism ◽  
P Value ◽  
Age Group ◽  
Facial Skin ◽  
Pathway Gene ◽  
Melanin Pathway ◽  
Sebum Secretion

Abstract ObjectiveA melanin pathway gene, oculocutaneous albinism 2 (OCA2) operates the first step of the melanin synthesis pathway and is known to associate with the albinism and pigmentation. Our previous study identified a significant association (p-value<5x10-8) between a OCA2 missense mutation (rs74653330, Ala481thr) and skin pigmentation. Since melanin pigment protects the skin from damage by ultraviolet light and we hypothesize that the rs74653330 SNP effect on the skin phenotypes not only the melanin, but also the other skin characteristics such as wrinkle formation, moisture level and sebum levels. We examined the association of the rs74653330 SNP to 19 skin characteristics consisting of wrinkle, moisture, melanin, erythema, brightness, and sebum using eight cosmetological instruments. ResultsThe rs74653330 SNP showed significant association with melanin phenotypes, specifically in young and middle groups. The melanin levels of pigmented area showed more melanin in middle age group but less in old group. Also, the rs74653330 SNP affect to wrinkle formation and sebum secretion. Conclusively, the analyses in this study clearly indicate that rs74653330 SNP affects to the melanin related skin phenotypes, and to the wrinkle formation or sebum secretion.

Influence of Ageing and Regional Differences on Draught Performance of Umblachery Cattle

2019 ◽  
Vol 15 (02) ◽  
pp. 42-45
Author(s):  
Devi M Kousalya ◽  
S.M K Karthickeyan ◽  
R Venkataramanan ◽  
S N Sivaselvam ◽  
K G Tirumurugaan
Keyword(s):  
Pulse Rate ◽  
Power Output ◽  
Regional Differences ◽  
Stride Length ◽  
South India ◽  
Middle Age ◽  
Age Group ◽  
Morphometric Traits ◽  
Maximum Power Output ◽  
Effects Of Aging

An attempt was made to assess the effects of aging, regional differences, and draught load applied on draught potential of Umblachery cattle, an important draught breed of South India. Age had a highly significant effect (p less than 0.01) on all morphometric traits, stride length, and significant effect (p less than 0.05) on pulse rate after work. The middle age group (5.0 to 7.5 years) with more substantial stride length was identified as the critical productive age group for draught ability. Regional differences had a highly significant (p less than 0.01) influence on stride length, horsepower, and a significant effect (p less than 0.05) on pulse rate after work. The optimum draught load with which Umblachery breed could give uniform and maximum power output was found to be around 75 to 78 kg.

scholarly journals To Establish A Normal Range of Inter-Incisal Opening - A Study of 756 Subjects of Age Group 20-50 Years in Yamunanagar City, Haryana.

2013 ◽  
Vol 01 (01) ◽  
pp. 001-003
Author(s):  
Aruna Singh ◽  
Nymphea Pandit ◽  
Monica Sharma
Keyword(s):  
Pearson Correlation ◽  
Mouth Opening ◽  
Clinical History ◽  
P Value ◽  
Age Group ◽  
Male Population ◽  
Female Population ◽  
Odontogenic Infections ◽  
Anterior Teeth ◽  
Average Maximum

Abstract Aim- 1. The aim of this study was to investigate the average maximum range of inter-incisal mouth opening in a representative sample of the adult subjects of Haryana. 2. To see any correlation between maximal inter-incisal opening with age. Methods- Maximum mouth opening was studied in 756 adult subjects with age range of 20-50 years in Yamunanagar, Haryana. Age limit was further divided into three groups (20-30, 31-40, 41-50). Those with clinical history of TMJ involvement, OSMF, any trauma, odontogenic and non-odontogenic infections, dental prosthesis on the anterior teeth, congenital anomalies in the maxillofacial region were excluded from this study. The measurements were recorded twice and mean of the two values were taken. Statistical Analysis- Independent sample t-test was calculated to compare age and mouth opening in both male and females respectively. Bivariate pearson correlation was used to see any relationship between age and mouth opening. P-value ≤ 0.05 and CI (confidence interval) at 95% were considered statistically significant. The Results- The average mouth opening of males (45.36±6.70 mm) subjects was higher as compared to female (41.27 ± 6.75 mm) with significant, p-value 0.000. The mean mouth opening ± SD for both sexes combined was 43.39 ± 7.02 mm. The corresponding values for mean inter-incisal opening in male population aged 20-30, 31-40, 41-50 were 45.52 ± 7.15, 46.16 ± 5.47, 42.96 ± 6.82 mm and in female population aged 20-30, 31-40, 41-50 were 41.40 ± 7.08, 41.60 ± 6.29 and 40.03 ± 6.38 mm respectively. Conclusion- Maximal mouth opening differ significantly with gender. There is a decrease in MMO with older age group.

scholarly journals Haematological profile of children with malaria in Sorong, West Papua, Indonesia

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Syilvia Jiero ◽  
Ayodhia Pitaloka Pasaribu
Keyword(s):  
Malaria Infection ◽  
Clinical Symptoms ◽  
Public Health Problem ◽  
Malaria Diagnosis ◽  
White Blood Count ◽  
P Value ◽  
Major Public Health Problem ◽  
Age Group ◽  
Haematological Profile ◽  
West Papua

Abstract Background Malaria remains a major public health problem in Indonesian Papua, with children under five years of age being the most affected group. Haematological changes, such as cytopenia that occur during malaria infection have been suggested as potential predictors and can aid in the diagnosis of malaria. This study aimed to assess the haematological alterations associated with malaria infection in children presenting with signs and symptoms of malaria. Methods A retrospective study was performed by collecting data from the medical records of malaria patients at Sorong Regional General Hospital, Sorong, West Papua, Indonesia, both from outpatient and inpatient clinics, from January 2014 until December 2017. The laboratory profile of children suffering from malaria was evaluated. Results One hundred and eighty-two children aged 1 month to 18 years old were enrolled. The subjects were mostly male (112, 61.5%) with a mean age of 6.45 years (SD = 4.3 years). Children below 5 years of age suffered the most from malaria in this study (77, 42.3%). One hundred two subjects (56%) were infected with Plasmodium falciparum. Half of the enrolled subjects (50%) had haemoglobin level (Hb) between 5.1 and 10 gr/dL. A total of 41 children (53.2%) less than 5 years old suffered from P. falciparum infection. In the age group of 5–10 years, there were 34 children (57.6%) who suffered from P. falciparum, and in the age group > 10 years, 27 children (58.7%) suffered from P. falciparum infection. Only 4 subjects (5.2%) in the less than 5 years old age group had mixed malaria infection. Among eight predictors of the haematological profile, there were five predictors that were significantly associated with the diagnostic criteria, namely haemoglobin, haematocrit, leukocytes, platelets and monocytes (p < 0.05). Generally, clinical symptoms are not significantly associated with a malaria diagnosis, and only one variable showed a significant relationship, pale, with a P value of 0.001. Conclusions Children with malaria had changes in some haematological markers, with anaemia, low platelet count, white blood count, and lymphocyte count being the most important predictors of malaria infection in the study area. These markers could be used to raise suspicion of malaria in children living in high endemic areas, such as West Papua.

scholarly journals Reliability and Validity of Facial Check Sheet (FCS): Checklist for Self-Satisfaction with Cosmetic Acupuncture

Medicines ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 18
Author(s):  
Hiroshi Kuge ◽  
Hidetoshi Mori ◽  
Tim Hideaki Tanaka ◽  
Ryouta Tsuji
Keyword(s):  
Reliability And Validity ◽  
Internet Survey ◽  
Age Group ◽  
Facial Skin ◽  
Moderate Correlation ◽  
Skin Rejuvenation ◽  
Facial Region ◽  
Practical Tool ◽  
Multiple Comparison Procedure ◽  
The Relationship

Background: In recent years, cosmetic acupuncture has gained popularity among individuals interested in improving their facial appearance. We have created an original facial check sheet (FCS) to obtain cosmetic acupuncture patients’ perspectives on treatment outcomes. This study examined the reliability and validity of FCS. Methods: We conducted an Internet survey on the appearance of the facial region among Japanese women. A reliability analysis was performed between each item of FCS. A multiple comparison procedure was used to determine the relationship between the age group, the FCS score, and the number of terms used in the open-ended question. Results: The most frequently stated concern was blotchiness and hyperpigmented spots (47.2%, n = 67). The FCS items showed reliability (Cronbach α = 0.871). The number of extracted terms and the FCS score showed a moderate correlation (r = 0.407; p < 0.001). There was a significant relationship between age and FCS score (p = 0.005, r2 = 0.255), which indicated that the FCS score increases with aging. Conclusions: The FCS can be used as a practical tool to evaluate facial appearances and assess satisfaction levels of patients who underwent cosmetic acupuncture or other facial skin rejuvenation procedures.

scholarly journals Trends of Stomach Cancer in Central Serbia

Medicina ◽  
2021 ◽  
Vol 57 (7) ◽  
pp. 665
Author(s):  
Miodrag M. Stojanovic ◽  
Natasa K. Rancic ◽  
Marija R. Andjelkovic Apostolovic ◽  
Aleksandra M. Ignjatovic ◽  
Mirko V. Ilic
Keyword(s):  
Stomach Cancer ◽  
Preventive Measures ◽  
Age Groups ◽  
Optimal Number ◽  
P Value ◽  
Age Group ◽  
Joinpoint Regression ◽  
Mortality Trends ◽  
Incidence Trend ◽  
Incidence And Mortality

Somach cancer is the third most common cause of cancer-related deaths worldwide. The objective of the paper was to analyze the incidence and mortality trends of stomach cancer in Central Serbia in the period between 1999–2017. Materials and Methods: trends and annual percentage change (APC) of the incidence and mortality rate with corresponding 95% confidence intervals (CI) were calculated by joinpoint regression analyses. The optimal number of Joinpoints was identified using the Monte Carlo permutation method. The trend was considered to be significantly increasing (positive change) or decreasing (negative change) when the p-value was below 0.05 (p < 0.05). Results: the total number of new cases was 16,914 (10,873 males and 6041 females) and the total number of mortality cases was 14,790 (9348 in and 5442 in females). Almost one third (30.8%) of new cases were registered in the 60–69-year age group, and new cases were significantly more frequent in males than in females (30.8% vs. 29.02%, p < 0.001). Joinpoint regression analysis showed a significant decrease of incidence trend in females during the 2000–2015 period with APC of −2.13% (95% CI: −3.8 to −0.5, p < 0.001). An insignificant decrease in incidence trend was in males with APC of −0.72% (95% CI: −2.3 to 0.9, p = 0.30). According to the joinpoint analysis, a significant decrease of mortality trends both in males during 2000–2015 with APC of −2.21% (95% CI: −1.6 to −7.5, p ≤ 0.001 and in females, during the same period, with APC of −1.75% (95% CI: −2.9 to −0.6, p < 0.001) was registered. From 2015 to 2017, a significant increase of mortality was registered with APC of 44.5% (95% CI: from 24.2 to −68.1, p ≤ 0.001) in females and in males with APC of 53.15% (95% CI: 13.5 to −106.6, p ≤ 0.001). Conclusion: a significant decrease of stomach cancer incidence trend in females and insignificant decrease of incidence trend in males were determined in Central Serbia. Based on presented results, the mortality trend decreased significantly both in males and in females during 2000–2015, and from 2015 to 2017 we recorded a significant increase in mortality in both sexes. We found significantly more new cases in women than in men in the age group of 40–49, and the mortality of stomach cancer was significantly more frequent among females compared to males in the age groups 30–39, as well as in the 50–59 age group. There is a need for improving recording and registration of new cases of stomach cancer, especially in females. Urgent primary and secondary preventive measures are needed—introducing stomach cancer screening and early detection of premalignant changes. Urgent primary and secondary preventive measures are needed.

scholarly journals National Surveillance of Injury in the Republic of Korea: Increased Injury Vulnerability in the Late Middle Age

2021 ◽  
Vol 18 (3) ◽  
pp. 1210
Author(s):  
Hansol Chang ◽  
Ji Young Min ◽  
Dajeong Yoo ◽  
Se Uk Lee ◽  
Sung Yeon Hwang ◽  
...  
Keyword(s):  
Middle Age ◽  
Age Groups ◽  
Admission Rate ◽  
Age Group ◽  
National Surveillance ◽  
Early Prevention ◽  
Group 4 ◽  
Group 3 ◽  
Prevention Methods ◽  
Injury Outcomes

Surveillance of injury patterns and comparisons among different age groups help develop a better understanding of recent injury trends and early prevention. This study conducted a national surveillance of injury by age group. Data were collected retrospectively from Emergency Department-Based Injury In-Depth Surveillance (EDIIS) in South Korea, between January 2011 and December 2017. Patients were divided into the following four groups by age: Group 1–18 to 34 years, Group 2–35 to 49 years, Group 3–50 to 64 years, and Group 4—≥65 years. A total of 1,221,746 patients were included in the study. Findings revealed that, each year, the injury rate increased in the population aged ≥65 years. The place and mechanism of injury in Group 3 were similar to those in younger age groups, while injury outcomes and injured body parts were similar to those in Group 4. Further, hospital admission rate, ICU admission rate, hospital death, traumatic brain injury, and injury severity increased with an increase in age. In our study, each age group showed diverse characteristics pertaining to the mechanism, place, time, and outcomes of injuries. Interestingly, Group 3, which represented the late middle age, exhibited increased vulnerability to injury, and emerged as a gray zone between the young and old age groups. Therefore, different injury prevention methods are needed for each age group. Specifically, early prevention methods need to be implemented from the late middle age to improve the old age group’s injury outcomes.

Abstract P614: Effect Sizes of Vascular Risk Factors for Stroke Occurrence by Age Among West Africans

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Mayowa Owolabi ◽  
FRED S SARFO ◽  
Onoja Akpa ◽  
Joshua Akinyemi ◽  
Albert Akpalu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Middle Age ◽  
Meat Consumption ◽  
The Elderly ◽  
Vascular Risk Factors ◽  
Effect Sizes ◽  
Modifiable Risk Factors ◽  
Age Group ◽  
Vascular Risk ◽  
Elderly Age

Background: Age is a non-modifiable risk factor for stroke occurrence due its influence on vascular risk factor acquisition. In sub-Saharan Africa, the effect sizes of vascular risk factors for stroke occurrence by age is unknown. Objective: To quantify the magnitude and direction of the effect sizes of key modifiable risk factors of stroke according to three age groups: <50years(young), 50-65 years(middle age) and >65 years(elderly) in West Africa. Methods: The Stroke Investigative Research and Educational Network (SIREN) is a multicenter, case-control study involving 15 sites in Ghana and Nigeria. Cases include adults aged ≥18 years with evidence of an acute stroke. Controls were age-and-gender matched stroke-free adults. Detailed evaluations for vascular, lifestyle, stroke severity and outcomes were performed. We used conditional logistic regression to estimate adjusted odds ratios (aOR) of vascular risk factors of stroke. Results: Among 3,553 stroke cases, 813(22.9%) were young, 1441(40.6%) were middle-aged and 1299(36.6%) were elderly. Five modifiable risk factors were consistently associated with stroke occurrence regardless of age namely hypertension, dyslipidemia, diabetes mellitus, regular meat consumption and non-consumption of green vegetables. Among the 5 co-shared risk factors, the effect size, aOR(95%CI) of dyslipidemia, 4.13(2.64-6.46), was highest among the young age group, hypertension, 28.93(15.10-55.44) and non-consumption of vegetables 2.34(1.70-3.23) was highest among the middle-age group while diabetes, aOR of 3.50(2.48-4.95) and meat consumption, 2.40(1.76-3.26) were highest among the elderly age group. Additionally, among the young age group cigarette smoking and cardiac disease were associated with stroke. Furthermore, physical inactivity and salt intake were associated with stroke in the middle-age group while cardiac disease was associated with stroke in the elderly age group. Conclusions: Age has a profound influence on the profile, magnitude and direction of effect sizes of vascular risk factors for stroke occurrence among West Africans. Population-level prevention of stroke must target both co-shared dominant risk factors as well as factors that are unique to specific age bands in Africa.

Effect of pre-cooling agent on intensity of pricking pain at intraoral injection site in adults: An experimental study.

2021 ◽  
pp. 1-12
Author(s):  
Munazza Aziz ◽  
Shahbaz Ahmed ◽  
Fazal-ur-Rehman Qazi ◽  
Farah Naz ◽  
Marina Shah ◽  
...  
Keyword(s):  
Injection Site ◽  
Pain Perception ◽  
Topical Anesthesia ◽  
Adult Patients ◽  
P Value ◽  
Age Group ◽  
Restorative Treatment ◽  
Cooling Agent ◽  
Infiltration Anesthesia

Abstract Objective: To determine the effect of pre-cooling agent on the intensity of pricking pain at the intraoral injection site in adult patients. Method: An in-vivo interventional study, using split-mouth technique was conducted in the Department of Operative Dentistry, Dr. Ishrat-ul-Ebad Khan Institute of Oral Health Sciences, DUHS, Karachi, between September 2018 to August 2019. Total 152 adult patients meeting the inclusion criteria were selected, and consent form was signed to investigate the pricking pain perception during needle administration. Topical anesthesia (benzocaine gel) was applied on left side (control) for 1 min whereas on the experimental (right) side the refrigerated cartridge was placed for 2 minutes. Infiltration anesthesia was then administered on both sides respectively. Patient’s pain perception ratings were measured through Visual analog scale (VAS). After profound anesthesia was achieved, restorative treatment was performed under rubber dam isolation. Statistical analysis was done using SPSS Version 24. Results: The effect of pre-cooling agent i.e. refrigerated cartridge, was statistically significant (P-value <0.05) on the intensity of pricking pain at the intraoral injection site among the age group of 41 to 50 years and female participants of 21to 30 years whereas the effect of pre-cooling agent was found statistically insignificant among the male participants of the age group of 21 to 30 years and irrespective of gender within 31 to 40 years of age. Conclusion: Pre-cooling agent was found effective in decreasing pricking pain sensed by the patients. Precooling agent can be used without topical anesthesia before administering infiltration because cryoanesthesia Continuous...

scholarly journals Healthy aging profile in octogenarians in Brazil

2016 ◽  
Vol 24 (0) ◽  
Author(s):  
Ana Cristina Viana Campos ◽  
Efigênia Ferreira e Ferreira ◽  
Andréa Maria Duarte Vargas ◽  
Lúcia Hisako Takase Gonçalves
Keyword(s):  
Older Adults ◽  
Decision Tree ◽  
Healthy Aging ◽  
Age Groups ◽  
Population Based ◽  
P Value ◽  
Age Group ◽  
Monthly Income ◽  
Tree Model ◽  
Socioeconomic Characteristics

ABSTRACT Objective: to identify the healthy aging profile in octogenarians in Brazil. Method: this population-based epidemiological study was conducted using household interviews of 335 octogenarians in a Brazilian municipality. The decision-tree model was used to assess the healthy aging profile in relation to the socioeconomic characteristics evaluated at baseline. All of the tests used a p-value < 0.05. Results: the majority of the 335 participating older adults were women (62.1%), were aged between 80 and 84 years (50.4%), were widowed (53.4%), were illiterate (59.1%), had a monthly income of less than one minimum wage (59.1%), were retired (85.7%), lived with their spouse (63.8%), did not have a caregiver (60.3%), had two or more children (82.7%), and had two or more grandchildren (78.8%). The results indicate three age groups with a healthier aging profile: older adults aged 80 to 84 years (55.6%), older adults aged 85 years and older who are married (64.9%), and older adults aged 85 and older who do not have a partner or a caregiver (54.2%). Conclusion: the healthy aging profile of octogenarians can be explained by age group, marital status, and the presence of a caregiver.

scholarly journals Transcervical resection of endometrium as a conservative management of dysfunctional uterine bleeding in premenopausal patients

2019 ◽  
Vol 8 (11) ◽  
pp. 4208
Author(s):  
Girish A. Pote ◽  
Namita Nandkumar Raut
Keyword(s):  
Uterine Bleeding ◽  
Reproductive Age ◽  
Response To Treatment ◽  
P Value ◽  
Uterine Perforation ◽  
Efficacy Rate ◽  
Age Group ◽  
Dysfunctional Uterine Bleeding ◽  
Bleeding Score ◽  
Transcervical Resection

Background: Dysfunctional uterine bleeding (DUB) affects 10% to 15% women of reproductive age group. A prospective observational study was performed to study the efficacy, rate of satisfaction and adverse effects of Transcervical resection of endometrium (TCRE) in the treatment of DUB in premenopausal women.Methods: 30 patients with DUB attending the hospital underwent TCRE and patients were followed up after 6 week, 3 months, 6 months up to 1 year and there bleeding score was calculated. Their response to treatment, complications and satisfaction rate were studied.Results: 43.3% of the women in this study were in the age group of 40-44 years. Post TCRE, 43.33% (n=13) had hypomenorrhea. 33.33% (n=10) had regular cycle, 13.33% (n=4) women had amenorrhea and 10% (n=3) had no response and underwent hysterectomy. 86.66% (n=26) women were satisfied with the treatment whereas 13.33% (n=4) were not satisfied. One patient had uterine perforation and serosal bowel injury due to extended cautery injury. Bleeding reduced considerably and a statistically significant (paired t-test, p-value <0.05) difference was observed in pre and post procedure (6 weeks, 3 months, 6 months and 1 year) bleeding scores.Conclusions: Considering advantages like shorter operative time, uterine conservation and early mobility TCRE is a procedure of choice in patients in whom hysterectomy is either technically difficult or medically contraindicated or in those who are not suitable for long term medical management.

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