scholarly journals Monitoring of BALB/C strain mice health, investigation of behavior, hematological parameters under the effect of an electromagnetic field

2019 ◽  
Vol 75 (03) ◽  
pp. 6194-2019
Author(s):  
JUDITA ZYMANTIENE ◽  
RASA ZELVYTE ◽  
VIDA JUOZAITIENE ◽  
VAIDAS OBERAUSKAS ◽  
ALGIS NOREIKA ◽  
...  
Keyword(s):  
Body Weight ◽  
Mobile Phone ◽  
Mobile Phones ◽  
Electromagnetic Waves ◽  
Histopathological Examination ◽  
Hematological Parameters ◽  
Behavior Characteristics ◽  
Brain Behavior ◽  
The Brain

The aim of this study was to investigate the effect of electromagnetic fields on BALB/c strain mice on their health, body weight, behavior characteristics, hematological parameters and histopathological findings in the brain. The mice of the experimental groups were exposed to electromagnetic waves by using Nokia 230 and Samsung 19300 Galaxy S III mobile phones situated at 2 cm from the cages. In the present study, it can be concluded that the exposure of mice to mobile phone radiation had an effect on the structure of the brain, behavior and body weight. The waves of mobile phones increased activity characteristics and changed some behavioral categories of mice and also decreased their body weight. Histopathological examination revealed mild edema of neutrophils and degeneration of some neurons and glial cells in the brains of experimental mice. The results of the present study showed that a using mobile phone had an influence on in vivo systems.

scholarly journals Toxicological evaluation of aqueous extract of the traditional Chinese formula Qing Hao Gan Cao

2021 ◽  
Author(s):  
Yongchun Li ◽  
Hui Zhang ◽  
Shanshan Chen ◽  
Liutao Zhao ◽  
Jie Wu ◽  
...  
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Toxicity Test ◽  
Artemisia Annua ◽  
Hematological Parameters ◽  
Organ Weight ◽  
Toxicological Evaluation ◽  
Subacute Toxicity ◽  
Qing Hao

Abstract Qing Hao Gan Cao (QHGC), a Chinese medicinal formula containing Artemisia annua and Glycyrrhizae Radix et Rhizoma, has been used to treat sunstroke and as an antiviral agent for more than 800 years. It has not previously been subject to a toxicological safety evaluation in acute and subacute (28 days) studies. Therefore, the acute and subacute toxicity of an aqueous extract of QHGC were evaluated in vivo. For the QHGC preparation, the botanical raw materials were crushed into pieces and mixed in the ratio of 10:1 in distilled water for 12 h, then boiling three times for 2 h each time. The three decoctions were mixed and filtered, then spray-dried with hot air at 160°C for 30 min, and stored at room temperature. For the acute toxicity test, 72.0 g/kg of QHGC extract was administered by gavage to male and female mice. Body weight, general observations, and autopsy results were recorded. No mortality or toxicity signs were observed during the studies. For the subacute toxicity test, 4.0, 8.0, or 16.0 g/kg/day of QHGC extract was administered to rats for 28 days. General observations and mortality, body weight, biochemical and hematological parameters, organ weight, and pathological morphology were analyzed. The acute and subacute toxicity studies did not show significant changes in body weight, general observations, hematology and biochemical parameters, organ weight, and liver, spleen, stomach, duodenum, testis, ovary, lung, heart, and kidney histopathological analyses. The consumption of QHGC aqueous extract can be considered safe within the conditions of this study.

Effects of mobile phone use on pedestrian crossing behavior and safety at unsignalized intersections

2019 ◽  
Vol 46 (5) ◽  
pp. 381-388
Author(s):  
Hualong Zhang ◽  
Cunbao Zhang ◽  
Feng Chen ◽  
YuanYuan Wei
Keyword(s):  
Logistic Regression ◽  
Regression Model ◽  
Mobile Phone ◽  
Mobile Phones ◽  
Logistic Regression Model ◽  
Field Survey ◽  
Mobile Phone Use ◽  
Unsignalized Intersections ◽  
Behavior Characteristics ◽  
Pedestrian Crossing

Using mobile phones can be a source of distraction for pedestrians when crossing streets, it is especially dangerous at unsignalized intersections. To investigate the effects of mobile phone use on pedestrian crossing behavior and safety at unsignalized intersections, we carried out a field survey at three selected locations in Wuhan, China. Then, the pedestrians’ crossing behavior characteristics were statistically analyzed, and a logistic regression model was established to quantitatively analyze pedestrian safety. The results showed that 15.6% of pedestrians used mobile phones when crossing unsignalized intersections and 64.1% of them were young pedestrians. Pedestrians using mobile phones while crossing unsignalized intersections were at higher risk of accident, crossed more slowly, and were less likely to look at traffic status than those not using a mobile phone. Moreover, the probability of conflicts when watching the screen, talking, and listening to music are 2.704, 1.793, and 1.114 times greater, respectively, than those who do not use a mobile phone.

scholarly journals In vitro and in vivo Activities of Psidium guajava and Azadirachta indica Leaf Extracts and solvent Fractions against Salmonella Typhi

2021 ◽  
pp. 56-71
Author(s):  
Adetutu Adewale ◽  
Olaniyi Deborah Temitope ◽  
Awodugba Tamilore ◽  
Owoade Abiodun Olusoji ◽  
Olaniyan, Lamidi Waheed B. ◽  
...  
Keyword(s):  
Body Weight ◽  
Hematological Parameters ◽  
Sub Saharan Africa ◽  
Male Rats ◽  
Carrier Status ◽  
Leaf Extracts ◽  
Salmonella Infections ◽  
Neem Leaves

Typhoidal salmonella infections remain a challenge in the health care system in sub-Saharan Africa. Carrier status and advent of multi-drug resistant S. Typhi strains have necessitated the search for new drug leads. Hence, this study aims at investigating P. guajava and A. indica leaves for anti-salmonella activities. Guava and neem leaves were extracted by maceration in methanol and fractionated by solvent partitioning. In vitro activities were assessed by agar well diffusion and broth micro-dilution methods. Sixty male rats were randomized to 10 groups of 6 animals each for the in vivo experiments. Groups of rats except, normal control, were induced with 0.5McFarland of S. Typhi suspension orally. Treatment groups received 200 mg/kg body weight of extracts and fractions, and the control groups were treated with 14.29mg/kg body weight of ciprofloxacin and 1%v/v DMSO for 7 days post-infection. Biochemical parameters were determined spectrophotometrically. Hematological parameters were analyzed with automated hematology diagnostic machine. All fractions of P. guajava and three of A. indica inhibited S. Typhi growth with Zone of Inhibition (ZI) ranging from 11-15 mm. Active fractions inhibited 48.60-62.45% of S. Typhi biofilm formation at 25 mg/mL with Minimum Bactericidal Inhibitory Concentration (MBIC) of 0.39-12.5 mg/mL. All fractions improved body weight of treated rats and inhibited bacteremia at 44.75 and 95.94%. Hematological parameters improved in all fractions-treated rats. MDA was not significantly (p<0.05) altered in all groups. One fraction of P. guajava (ePg) lowered the elevated level in concentration of Nitric oxide (NO) while all fractions enhanced the lowered activity of SOD. Elevated (lactate dehydrogenase (LDH), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and bilirubin (BIL) were lowered by all fractions to various extents in treated rats. Fractions of P. guajava, and A. indica could be further considered for identification of active anti-salmonella principle(s).

scholarly journals In vivo activities of ceftriaxone and vancomycin against Borrelia spp. in the mouse brain and other sites.

1996 ◽  
Vol 40 (11) ◽  
pp. 2632-2636 ◽  
Author(s):  
R J Kazragis ◽  
L L Dever ◽  
J H Jorgensen ◽  
A G Barbour
Keyword(s):  
Body Weight ◽  
Lyme Disease ◽  
Positive Control ◽  
Negative Control ◽  
Scid Mice ◽  
Immunodeficient Mice ◽  
Infected Adult ◽  
The Brain

Borrelia burgdorferi, the agent of Lyme disease, and B. turicatae, a neurotropic agent of relapsing fever, are susceptible to vancomycin in vitro, with an MIC of 0.5 microgram/ml. To determine the activity of vancomycin in vivo, particularly in the brain, we infected adult immunocompetent BALB/c and immunodeficient CB-17 scid mice with B. burgdorferi or B. turicatae. The mice were then treated with vancomycin, ceftriaxone as a positive control, or normal saline as a negative control. The effectiveness of treatment was assessed by cultures of blood and brain and other tissues. Ceftriaxone at a dose of 25 mg/kg of body weight administered every 12 h for 7 to 10 days eliminated cultivable B. burgdorferi or B. turicatae from all BALB/c or scid mice in the study. Vancomycin at 30 mg/kg administered every 12 h was effective in eliminating infection from immunodeficient mice if treatment was started within 3 days of the onset of infection. If treatment with vancomycin was delayed for 7 days or more, vancomycin failed to eradicate infection with B. burgdorferi or B. turicatae from immunodeficient mice. The failure of vancomycin in eradicating established infections in immunodeficient mice was associated with the persistence of viable spirochetes in the brain during antibiotic treatment.

A Study on Predictable Model of Waterproofing for Mobile Phone Using Finite Element Analysis Based on Evaluation of Seal Rubber

2012 ◽  
Author(s):  
Hojin Jeon ◽  
Hyongwon Seo ◽  
Myunghan Kim ◽  
Jungyoul Kim
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Finite Element Model ◽  
Mobile Phone ◽  
Mobile Phones ◽  
Evaluation Method ◽  
Element Model ◽  
Element Analysis ◽  
Rubber Material ◽  
Behavior Characteristics

Recently, product manufacturers of mobile phone have to meet to high demands that allow their products endure variable bad environments exposed throughout the customers’ use. Especially, mobile phones need to resist to high humidity and general waterproofing that is prevalent in everyday usage. However, most previous studies related to seal material or methods for sealing assembly have been focused on heavy industry or automotive industry. In this paper, the aim is to predict waterproof possibility of mobile phone by using finite element analysis in design step. The criteria of waterproof condition for mobile phones was based on IEC60529 IPX-7 level[1]. This paper studied behavior characteristics and properties of the specialized rubber material for sealing the mobile phone housing. Constitutive equation for specialized seal rubber material was applied to the 3rd order Ogden function. Then, the correlation with test and finite element model was studied. Using the correlated finite element model for specialized seal rubber, evaluated behavior characteristics for seal rubber 2D shape and studied waterproof possibility analysis 3D model of mobile phone. The proposed suggestion is expected to predict waterproof possibility for mobile phone efficiently. Evaluation method of 2D finite element model will be useful for decision design specification of seal rubber shape at preceding design step. And evaluation method of 3D finite element model will predict waterproof possibility before tooling the mold and will save the costs at development step in industry.

scholarly journals Measurement and Calculation of SAR Due to 900 MHz Electromagnetic Waves

2021 ◽  
Author(s):  
Fatemeh Seif ◽  
Milad Omidi ◽  
Mohamad Reza Bayatiani ◽  
Mahdi Ghorbani
Keyword(s):  
Electric Field ◽  
Mobile Phones ◽  
Electromagnetic Waves ◽  
Specific Absorption Rate ◽  
Public Awareness ◽  
Mean Value ◽  
Threshold Values ◽  
Public Concern ◽  
Awareness Programs ◽  
The Brain

Purpose: The widespread use of mobile phones and Base Transceiver Stations (BTSs) has generated public concern about exposure to Electromagnetic (EM) waves. In this study, the electric field intensity and Specific Absorption Rate (SAR) in the emergency, general hospitalization, radiology, and laboratory departments of four hospitals in Arak (Iran) are reported. Materials and Methods: Electric field strength in the 900 MHz frequency band was obtained using a TES 592 radiometer. Then, SAR induced in the brain, skin, fat and bone tissues were calculated based on equations and the obtained values were compared with the thresholds recommended by the International Commissions. Results: The obtained results showed that the electric field’s mean value was 1.334 V/m which is almost 2.7% of the threshold introduced by the International Commission on Non-Ionizing Radiation Protection (ICNIRP) and 2.6% of the threshold adopted by the Institute of Electrical and Electronics Engineers (IEEE). The highest SAR value was 1.6 W/kg for the skin, which is lower than the threshold values presented by ICNIRP (2 W/kg) and IEEE (1.6 W/kg). Conclusion: The findings of the present work show that for both quantities in Arak hospitals the SAR values are less than the thresholds announced by IEEE and ICNIRP committees. To deal with the concerns of the community that is generally caused by a lack of awareness, the executions of educational and public awareness programs are recommended.

scholarly journals Smartloss: A Personalized Mobile Health Intervention for Weight Management and Health Promotion

2016 ◽  
Vol 4 (1) ◽  
pp. e18
Author(s):  
Corby K Martin ◽  
L. Anne Gilmore ◽  
John W Apolzan ◽  
Candice A Myers ◽  
Diana M Thomas ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Behavior Change ◽  
Mobile Phone ◽  
Weight Management ◽  
Mobile Phones ◽  
Mobile Health ◽  
Treatment Fidelity ◽  
Health Improvement ◽  
The Individual

Background Synonymous with increased use of mobile phones has been the development of mobile health (mHealth) technology for improving health, including weight management. Behavior change theory (eg, the theory of planned behavior) can be effectively encapsulated into mobile phone-based health improvement programs, which is fostered by the ability of mobile phones and related devices to collect and transmit objective data in near real time and for health care or research professionals and clients to communicate easily. Objective To describe SmartLoss, a semiautomated mHealth platform for weight loss. Methods We developed and validated a dynamic energy balance model that determines the amount of weight an individual will lose over time if they are adherent to an energy intake prescription. This model was incorporated into computer code that enables adherence to a prescribed caloric prescription determined from the change in body weight of the individual. Data from the individual are then used to guide personalized recommendations regarding weight loss and behavior change via a semiautomated mHealth platform called SmartLoss, which consists of 2 elements: (1) a clinician dashboard and (2) a mobile phone app. SmartLoss includes and interfaces with a network-connected bathroom scale and a Bluetooth-connected accelerometer, which enables automated collection of client information (eg, body weight change and physical activity patterns), as well as the systematic delivery of preplanned health materials and automated feedback that is based on client data and is designed to foster prolonged adherence with body weight, diet, and exercise goals. The clinician dashboard allows for efficient remote monitoring of all clients simultaneously, which may further increase adherence, personalization of treatment, treatment fidelity, and efficacy. Results Evidence of the efficacy of the SmartLoss approach has been reported previously. The present report provides a thorough description of the SmartLoss Virtual Weight Management Suite, a professionally programmed platform that facilitates treatment fidelity and the ability to customize interventions and disseminate them widely. Conclusions SmartLoss functions as a virtual weight management clinic that relies upon empirical weight loss research and behavioral theory to promote behavior change and weight loss.

scholarly journals Mobile Phone Electromagnetic Waves and Its Effect on Human Ejaculated Semen: An in vitro Study

2012 ◽  
Vol 3 (1) ◽  
pp. 15-21 ◽  
Author(s):  
SS Vasan ◽  
Srinivas Belur Veerachari
Keyword(s):  
Mobile Phone ◽  
Dna Fragmentation ◽  
Mobile Phones ◽  
Electromagnetic Waves ◽  
In Vitro Study ◽  
Human Semen ◽  
Fragmentation Index ◽  
Increasing Demand ◽  
Dna Fragmentation Index

ABSTRACT Mobile phones usage has seen an exponential growth recently. With this increasing demand, the amount of electromagnetic radiation (EMR) exposed is also increasing. Hence, we studied the effect of these radiations on ejaculated human semen and speculate the contribution of these harmful radiations in male infertility. Samples exposed to EMR showed a significant decrease in sperm motility and viability, increase in reactive oxygen species (ROS) and DNA fragmentation index (DFI) compared to unexposed group. We concluded that mobile phones emit electromagnetic waves which lead to oxidative stress in human semen and also cause changes in DNA fragmentation. We extrapolate these findings to speculate that these radiations may negatively affect spermatozoa and impair male fertility. How to cite this article Veerachari SB, Vasan SS. Mobile Phone Electromagnetic Waves and Its Effect on Human Ejaculated Semen: An in vitro Study. Int J Infertility Fetal Med 2012;3(1):15-21.

scholarly journals Assessment of the In Vivo Release and Biocompatibility of Novel Vesicles Containing Zinc in Rats

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4101
Author(s):  
Liliana Mititelu-Tartau ◽  
Maria Bogdan ◽  
Daniela Angelica Pricop ◽  
Beatrice Rozalina Buca ◽  
Ana-Maria Pauna ◽  
...  
Keyword(s):  
Body Weight ◽  
Zinc Chloride ◽  
Histopathological Examination ◽  
Chitosan Solution ◽  
Lipid Vesicles ◽  
Biochemical Tests ◽  
Phagocytic Capacity ◽  
In Vivo Release ◽  
Group I

This paper is focused on the in vivo release and biocompatibility evaluation in rats of some novel systems entrapping zinc chloride in lipid vesicles. The particles were prepared by zinc chloride immobilization inside lipid vesicles made using phosphatidylcholine, stabilized with 0.5% chitosan solution, and dialyzed for 10 h to achieve a neutral pH. The submicrometric systems were physico-chemically characterized. White Wistar rats, assigned into four groups of six animals each, were treated orally with a single dose, as follows: Group I (control): deionized water 0.3 mL/100 g body weight; Group II (Zn): 2 mg/kg body weight (kbw) zinc chloride; Group III (LV-Zn): 2 mg/kbw zinc chloride in vesicles; Group IV (LVC-Zn): 2 mg/kbw zinc chloride in vesicles stabilized with chitosan. Haematological, biochemical, and immune parameters were assessed after 24 h and 7 days, and then liver fragments were collected for histopathological examination. The use of zinc submicrometric particles—especially those stabilized with chitosan—showed a delayed zinc release in rats. No substantial changes to blood parameters, plasma biochemical tests, serum complement activity, or peripheral neutrophils phagocytic capacity were noted; moreover, the tested substances did not induce liver architectural disturbances. The obtained systems provided a delayed release of zinc, and showed good biocompatibility in rats.

scholarly journals Toxicopathological effects of lead acetate on the brain of male mice

2012 ◽  
Vol 36 (0E) ◽  
pp. 340-346
Author(s):  
Bassim M. Jwad
Keyword(s):  
Body Weight ◽  
Blood Vessels ◽  
Lead Acetate ◽  
Histopathological Examination ◽  
Clinical Signs ◽  
Physiological Saline ◽  
Inflammatory Cells ◽  
Stomach Tube ◽  
Toxic Dose ◽  
The Brain

The aim of the present study is to determine the influence of different doses of lead acetate on the central nerves system. 25 Swiss strain white mice were used, each weighing about 30 –32 g, divided into three groups, first group (n=10) treated with 0.5 ml. contain 150 mg/kg/body weight lead acetate via stomach tube daily for 40 days, second group (n=10) treated with 0.5 ml. contain 300 mg/kg/body weight lead acetate via stomach tube daily for 40 days. While the third group (n=5) served as control and were given mammalian physiological saline. Clinical signs were reported during the course of the study, then at day 40 post treatment , all animal were sacrificed and post mortem examination was done and any gross lesions were reported, then the pieces of brain was fixed in 10% formalin for 72 hours .The pathological results showed congestion of cerebellum and cerebrum of both treated group but the 2nd group was more sensitive. Histopathological examination of 1st group expressed moderate pathological lesions, characterized by extracellular edema around neuron cells and Virchow Robbin space , as well as proliferation of astrocyets in the white matter , also central chromatolysis of neurons and Nissle granules with homogenous pink their cytoplasm in 1st G. while in 2nd G the main lesions characterized by severe congestion of blood vessels with inflammatory cells infiltration in the lumen of arachnoids' space and brain parenchyma as well as hemorrhage with aggregation of microglia in the wall of blood vessels which characterized by round shape and clear cytoplasm (microgliosis). Also severe neuron degeneration, with Alzheimer's type-II astrocyets are reported in other animals characterized by pairs observed surrounded by clear space. And there is no clear pathological lesion in control group.In conclusion the present study investigated that the lead acetate affected on the brain tissue, and the degree of influence depended on the concentration of the toxic dose.

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