Research on the Physiological Basis of Population Dynamics in Relation to Ecotoxicology

1987 ◽  
Vol 19 (11) ◽  
pp. 21-37 ◽  
Author(s):  
S A. L. M. Kooijman ◽  
A. O. Hanstveit ◽  
N. van der Hoeven

One of the main obstacles that hampers ecotoxlcology is the poor insight into the relationship between physiological and population dynamics. The role of laboratory experiments, modeling, mathematical analysis and computer simulation studies is discussed in research aiming at this relation. Energy and nutrient budgets of organisms are found to be of vital importance. This paper evaluates the progress that has been made in concrete efforts to work out energy and nutrient budgets for simple freshwater plankton systems stressed by toxic chemicals with different modes of action.

2021 ◽  
pp. 716-732
Author(s):  
Peter Saunders

A key goal of any welfare state is to promote social justice by tackling inequality and poverty. This chapter reviews some of the ideas and evidence that have informed the debate about the causes of differences in inequality and poverty, including alternative interpretations of the meaning of both as policy objectives and how each can be measured. Although the two concepts are often related, they are conceptually distinct: inequality captures differences in economic outcomes, while poverty covers those with inadequate economic resources. Estimating the impact of policy on either variable is difficult because of the many other factors involved. Examining cross-country differences provides an insight into the impacts of different policies introduced in otherwise broadly similar countries. These studies have shown that transfers and taxes reduce inequality and poverty, and also that those countries that spend more on social programmes have less inequality and lower poverty rates, but the relationship is weak and there are many exceptions. While considerable progress has been made in understanding the role of the welfare state in accounting for these differences, we are a long way from fully understanding the many complex interactions that are the drivers of inequality and poverty.


2019 ◽  
Vol 58 (2) ◽  
pp. 249-259
Author(s):  
Joseph Acquisto

This essay examines a polemic between two Baudelaire critics of the 1930s, Jean Cassou and Benjamin Fondane, which centered on the relationship of poetry to progressive politics and metaphysics. I argue that a return to Baudelaire's poetry can yield insight into what seems like an impasse in Cassou and Fondane. Baudelaire provides the possibility of realigning metaphysics and politics so that poetry has the potential to become the space in which we can begin to think the two of them together, as opposed to seeing them in unresolvable tension. Or rather, the tension that Baudelaire animates between the two allows us a new way of thinking about the role of esthetics in moments of political crisis. We can in some ways see Baudelaire as responding, avant la lettre, to two of his early twentieth-century readers who correctly perceived his work as the space that breathes a new urgency into the questions of how modern poetry relates to the world from which it springs and in which it intervenes.


Author(s):  
Miriam Bak McKenna

Abstract Situating itself in current debates over the international legal archive, this article delves into the material and conceptual implications of architecture for international law. To do so I trace the architectural developments of international law’s organizational and administrative spaces during the early to mid twentieth century. These architectural endeavours unfolded in three main stages: the years 1922–1926, during which the International Labour Organization (ILO) building, the first building exclusively designed for an international organization was constructed; the years 1927–1937 which saw the great polemic between modernist and classical architects over the building of the Palace of Nations; and the years 1947–1952, with the triumph of modernism, represented by the UN Headquarters in New York. These events provide an illuminating allegorical insight into the physical manifestation, modes of self-expression, and transformation of international law during this era, particularly the relationship between international law and the function and role of international organizations.


2012 ◽  
Vol 37 (3) ◽  
pp. 295-318 ◽  
Author(s):  
Michael Yeo

One of the main issues in the long-form census controversy concerned the relationship between science and politics. Through analysis of the arguments and underlying assumptions of four influential and exemplary interventions that were made in the name of science, this paper outlines a normative account of this relationship. The paper nuances the science-protective ideals that critics invoked and argues that such conceptual resources are needed if science is to be protected from undue political encroachment. However, in their zeal to defend the rights of science critics claimed for it more than its due, eclipsing the value dimension of policy decisions and failing to respect the role of politics as the rightful locus of decision making for value issues. An adequate normative account of the relationship between science and politics in public policy must be capable not only of protecting science from politics but also of protecting politics from science.


Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1790
Author(s):  
Lei Zhang ◽  
Ruohan Jia ◽  
Huizhen Li ◽  
Huarun Yu ◽  
Keke Ren ◽  
...  

Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury, cancer, hepatic fibrosis, Parkinson’s disease, and Alzheimer’s disease. Therefore, ferroptosis has become one of the research hotspots for disease treatment and attracted extensive attention in recent years. This review mainly summarizes the relationship between ferroptosis and various diseases classified by the system, including the urinary system, digestive system, respiratory system, nervous system. In addition, the role and molecular mechanism of multiple inhibitors and inducers for ferroptosis are further elucidated. A deeper understanding of the relationship between ferroptosis and multiple diseases may provide new strategies for researching diseases and drug development based on ferroptosis.


2006 ◽  
Vol 290 (6) ◽  
pp. F1295-F1302 ◽  
Author(s):  
Stan F. J. van de Graaf ◽  
Joost G. J. Hoenderop ◽  
René J. M. Bindels

The epithelial Ca2+ channels TRPV5 and TRPV6 are the most Ca2+-selective members of the TRP channel superfamily. These channels are the prime target for hormonal control of the active Ca2+ flux from the urine space or intestinal lumen to the blood compartment. Insight into their regulation is, therefore, pivotal in our understanding of the (patho)physiology of Ca2+ homeostasis. The recent elucidation of TRPV5/6-associated proteins has provided new insight into the molecular mechanisms underlying the regulation of these channels. In this review, we describe the various means of TRPV5/6 regulation, the role of channel-associated proteins herein, and the relationship between both processes.


2014 ◽  
Vol 37 (6) ◽  
pp. E8 ◽  
Author(s):  
Matthew Womeldorff ◽  
David Gillespie ◽  
Randy L. Jensen

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with an exceptionally poor patient outcome despite aggressive therapy including surgery, radiation, and chemotherapy. This aggressive phenotype may be associated with intratumoral hypoxia, which probably plays a key role in GBM tumor growth, development, and angiogenesis. A key regulator of cellular response to hypoxia is the protein hypoxia-inducible factor–1 (HIF-1). An examination of upstream hypoxic and nonhypoxic regulation of HIF-1 as well as a review of the downstream HIF-1–regulated proteins may provide further insight into the role of this transcription factor in GBM pathophysiology. Recent insights into upstream regulators that intimately interact with HIF-1 could provide potential therapeutic targets for treatment of this tumor. The same is potentially true for HIF-1–mediated pathways of glycolysis-, angiogenesis-, and invasion-promoting proteins. Thus, an understanding of the relationship between HIF-1, its upstream protein regulators, and its downstream transcribed genes in GBM pathogenesis could provide future treatment options for the care of patients with these tumors.


2010 ◽  
pp. 1848-1861
Author(s):  
Luiz Antonio Joia ◽  
Paulo Sérgio da Silva Sanz

Since the early 1990s, research has been conducted in an attempt to establish a viable and reliable manner of measuring the intangible assets, also referred to as the intellectual capital, of companies. Several models have been devised, most of them using indicators to evaluate the intangible assets of a given undertaking. In this chapter, exploratory field study methodology is used to analyse the behaviour of the “customer retention” indicator, which has been widely used to evaluate a company’s relationship capital. Two of the largest Brazilian e-retailing groups are analysed in order to obtain an in-depth insight into the behaviour of their frequent customers via their digital channel. Conclusions are presented, indicating that the role of frequent customers in e-retailing companies can sometimes be widely divergent from that presented in existing academic literature. Finally, recommendations are made in order to reach a clearer understanding of the conundrum of valuing a company’s intellectual capital via taken-for-granted indicators.


2020 ◽  
Vol 11 ◽  
Author(s):  
Kathleen A. Moore ◽  
Austin Campbell

Abstract Intimate relationships are an integral part of our lives, but the rate of relationship breakups is high. We explored the role of the investment model and the traits that influence investments on relationship satisfaction among 146 volunteers (age M = 28.76 years, SD = 10.23). Relationship satisfaction was predicted by investments, which in turn were predicted by attachment, personality and love style. Clinicians working with individuals or couples with relationship issues may benefit from knowing how invested they are in the relationship and their love style. Insight into imbalances in these constructs between partners may be used to facilitate relationship satisfaction.


2016 ◽  
Vol 75 (3) ◽  
pp. 789-793
Author(s):  
David Arnold

As studies of technology in modern Asia move from production to consumption, and from big machines to small, so they confront increasingly complex and nuanced issues about the relationship between the local, the regional, and the global; between political economy and culture; and, perhaps most crucially, between technology and modernity. From a South Asian perspective (and perhaps from a Southeast Asian one as well), many of these issues are inescapably bound up with the Western colonial presence, decolonization, and the post-independence quest for national self-sufficiency and economic autarky. In East Asia, as the articles by Antonia Finnane and Thomas Mullaney demonstrate, the issues play out somewhat differently, not least because of the pivotal role of Japan as a major regional force, an industrial nation, and an imperial power. In South Asia in the period covered by these essays, Japan was a far more marginal presence, with only some industrial goods—such as textiles, bicycles, or umbrella fittings—finding a market there by the mid-1930s. At their height in 1933–34, some 17,000 Japanese bicycles were imported into India (out of nearly 90,000 overall), and in 1934–35, barely 1,400 sewing machines (out of 83,000); within three years this had fallen to less than 700. However, as Nira Wickramasinghe has recently demonstrated with respect to Ceylon (colonial Sri Lanka), Japan had a significance that ranged well beyond its limited commercial impact: it inspired admiration for the speed of its industrialization, for its scientific and technological prowess, and as the foremost exemplar of an “Asian modern” (Wickramasinghe 2014, chap. 5). One other way in which Japan figured in postwar regional history was through demands for compensation made in 1946 for sewing machines destroyed by Japanese bombing (or the looting that accompanied it) and the occupation of the Andaman Islands. And yet, relatively remote though Japan and China might be from South Asia's consumer history, across much of the Asian continent there was a common chronology to this unfolding techno-history, beginning in the 1880s and 1890s and dictated less evidently by the politics of war and peace than by the influx of small machines, of which sewing machines and typewriters were but two conspicuous examples.


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