scholarly journals Infectious diseases '98. II. Advances in treatments. 4. Treatments of infectious diseases of the topics. 1) Helicobacter Pylori infectious disease.

1998 ◽  
Vol 87 (11) ◽  
pp. 2263-2267
Author(s):  
TAKASHI SHIMOYAMA
Keyword(s):  
Infectious Disease ◽  
Helicobacter Pylori ◽  
Infectious Diseases

scholarly journals HLA and Infectious Diseases

2009 ◽  
Vol 22 (2) ◽  
pp. 370-385 ◽  
Author(s):  
Jenefer M. Blackwell ◽  
Sarra E. Jamieson ◽  
David Burgner
Keyword(s):  
Infectious Disease ◽  
Infectious Diseases ◽  
Human Leukocyte Antigen ◽  
Molecular Basis ◽  
Selective Pressure ◽  
Human Leukocyte ◽  
Acquired Immunity ◽  
Leukocyte Antigen ◽  
Extreme Variability ◽  
Classical Human Leukocyte Antigen

SUMMARY Following their discovery in the early 1970s, classical human leukocyte antigen (HLA) loci have been the prototypical candidates for genetic susceptibility to infectious disease. Indeed, the original hypothesis for the extreme variability observed at HLA loci (H-2 in mice) was the major selective pressure from infectious diseases. Now that both the human genome and the molecular basis of innate and acquired immunity are understood in greater detail, do the classical HLA loci still stand out as major genes that determine susceptibility to infectious disease? This review looks afresh at the evidence supporting a role for classical HLA loci in susceptibility to infectious disease, examines the limitations of data reported to date, and discusses current advances in methodology and technology that will potentially lead to greater understanding of their role in infectious diseases in the future.

scholarly journals Drivers of Infectious Disease Seasonality: Potential Implications for COVID-19

2021 ◽  
pp. 074873042098732
Author(s):  
N. Kronfeld-Schor ◽  
T. J. Stevenson ◽  
S. Nickbakhsh ◽  
E. S. Schernhammer ◽  
X. C. Dopico ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Infectious Diseases ◽  
Multidisciplinary Approach ◽  
Preliminary Assessment ◽  
Epidemiological Evidence ◽  
Wide Range ◽  
Human Coronaviruses ◽  
Induced Changes ◽  
And Behavior ◽  
Timing Phase

Not 1 year has passed since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19). Since its emergence, great uncertainty has surrounded the potential for COVID-19 to establish as a seasonally recurrent disease. Many infectious diseases, including endemic human coronaviruses, vary across the year. They show a wide range of seasonal waveforms, timing (phase), and amplitudes, which differ depending on the geographical region. Drivers of such patterns are predominantly studied from an epidemiological perspective with a focus on weather and behavior, but complementary insights emerge from physiological studies of seasonality in animals, including humans. Thus, we take a multidisciplinary approach to integrate knowledge from usually distinct fields. First, we review epidemiological evidence of environmental and behavioral drivers of infectious disease seasonality. Subsequently, we take a chronobiological perspective and discuss within-host changes that may affect susceptibility, morbidity, and mortality from infectious diseases. Based on photoperiodic, circannual, and comparative human data, we not only identify promising future avenues but also highlight the need for further studies in animal models. Our preliminary assessment is that host immune seasonality warrants evaluation alongside weather and human behavior as factors that may contribute to COVID-19 seasonality, and that the relative importance of these drivers requires further investigation. A major challenge to predicting seasonality of infectious diseases are rapid, human-induced changes in the hitherto predictable seasonality of our planet, whose influence we review in a final outlook section. We conclude that a proactive multidisciplinary approach is warranted to predict, mitigate, and prevent seasonal infectious diseases in our complex, changing human-earth system.

scholarly journals Application of 3D bioprinting in the prevention and the therapy for human diseases

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Hee-Gyeong Yi ◽  
Hyeonji Kim ◽  
Junyoung Kwon ◽  
Yeong-Jin Choi ◽  
Jinah Jang ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Infectious Diseases ◽  
Rapid Development ◽  
In Vitro Models ◽  
Delivery Systems ◽  
Advanced Technology ◽  
3D Bioprinting ◽  
Disease Research ◽  
Infectious Disease Research

AbstractRapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious diseases. To speed up the drug discovery process, the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery systems. In this regard, layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease research. In addition, the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines, therapeutics, and relevant delivery systems. Herein, we discuss the potential of 3D bioprinting technologies for the control of infectious diseases. We also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.

Contemporary Plagues and Social Progress

PEDIATRICS ◽  
1980 ◽  
Vol 66 (3) ◽  
pp. 458-461
Author(s):  
Thomas H. Weller
Keyword(s):  
Infectious Disease ◽  
Infectious Diseases ◽  
Malignant Disease ◽  
Diarrheal Disease ◽  
Political Process ◽  
Social Progress ◽  
The Public ◽  
National Congress ◽  
Health Field ◽  
Opening Session

For this address at the opening session of the First Mexican National Congress of Infectious Diseases in Children (ler, Congreso National de Infectologia Pediatrica), I have chosen as my title "Contemporary Plagues and Social Progress." While in medicine the term plague usually refers to diseases caused by Pasteurella pestis, the word has broader meanings and usages. It describes that which smites or troubles, can refer to an afflictive evil or anything troublesome or vexatious, or can be applied to any malignant disease, especially those that are contagious. It can be used as an expression of annoyance, as a mild oath, or with the implication of harassment. Thus, today we are concerned with the plague of plagues, the afflictive evils of the cumulative insults of infectious disease. Additionally, we might be tempted to cast a plague on the system of medical education and on the political process that neither conveys the continuing importance of infectious diseases nor funds the mechanisms for their containment. Or, should the shoe be on the other foot? Should not society cast a plague on us? As experts in the field of infectious disease, have we not failed to publicize that, on a global basis, the combination of diarrheal disease and malnutrition is the leading cause of death in infants and children? Has not our successful use of antibiotics induced unjustified public complacency regarding the problems of infectious disease? Why have our low-keyed reports of resistant typhoid bacilli, or pneumococci or of gonococci failed to dispel the prevalent mystique that science has controlled infectious agents, leaving cancer and heart disease in the public eye as the major unconquered problems in the health field?

scholarly journals A socio-economic approach to One Health policy research in southern Africa

2012 ◽  
Vol 79 (2) ◽  
Author(s):  
Kim A. Kayunze ◽  
Angwara D. Kiwara ◽  
Eligius Lyamuya ◽  
Dominic M. Kambarage ◽  
Jonathan Rushton ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Health Policy ◽  
Infectious Diseases ◽  
Burden Of Disease ◽  
One Health ◽  
Animal Health ◽  
Policy Research ◽  
Well Being ◽  
Cultural Economic ◽  
Emerging Zoonoses

One-health approaches have started being applied to health systems in some countries in controlling infectious diseases in order to reduce the burden of disease in humans, livestock and wild animals collaboratively. However, one wonders whether the problem of lingering and emerging zoonoses is more affected by health policies, low application of one-health approaches, or other factors. As part of efforts to answer this question, the Southern African Centre for Infectious Disease Surveillance (SACIDS) smart partnership of human health, animal health and socio-economic experts published, in April 2011, a conceptual framework to support One Health research for policy on emerging zoonoses. The main objective of this paper was to identify which factors really affect the burden of disease and how the burden could affect socio-economic well-being. Amongst other issues, the review of literature shows that the occurrence of infectious diseases in humans and animals is driven by many factors, the most important ones being the causative agents (viruses, bacteria, parasites, etc.) and the mediator conditions (social, cultural, economic or climatic) which facilitate the infection to occur and hold. Literature also shows that in many countries there is little collaboration between medical and veterinary services despite the shared underlying science and the increasing infectious disease threat. In view of these findings, a research to inform health policy must walk on two legs: a natural sciences leg and a social sciences one.

scholarly journals The Global Infectious Diseases Epidemic Information Monitoring System—a tool for travel health management (Preprint)

2020 ◽  
Author(s):  
Ruiling Dong ◽  
Jianan He ◽  
Jie Sun ◽  
Xin Shi ◽  
Ying Ye ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Infectious Diseases ◽  
Monitoring System ◽  
Language Processing ◽  
Health Management ◽  
Health Staff ◽  
Learning Technology ◽  
Web Crawler ◽  
Travel Health ◽  
Information Monitoring

BACKGROUND Obtaining comprehensive epidemic information for the targeted global infection disease is crucial for travel health. However, different infectious disease information websites may have various purposes which may lead misunderstanding for travelers and travel health staff for the accurate epidemic control and managmement. OBJECTIVE Developed A Global Infectious Diseases Epidemic Information Monitoring System (GIDEIMS)，in order to get comprehensive and timely global epidemic information. METHODS Distributed web crawler and cloud agent acceleration technology are used to automatically collect epidemic information for more than 200 infectious diseases from 26 established epidemic websites and Baidu news. Natural language processing and in-depth learning technology have been developed to intelligently process epidemic information collected in 28 languages. Currently, the GIDEIMS presents world epidemic information using a geographical map, including date, disease name and reported cases of different countries , epidemic situations in China, etc. RESULTS In order to make a practical assessment of the GIDEIMS, on July 16, 2019, We checked infectious disease data collected from GIDEIMS and other websites. Compared with the Global Incident Map and Outbreak News Today, GIDEIMS provided more comprehensive information on human infectious diseases. GIDEIMS is currently used in the Health Quarantine Department of Shenzhen Customs District (Shenzhen, China), and is recommended to the Health Quarantine Administrative Department of the General Administration of Customs (China) and travel health-related departments. CONCLUSIONS GIDEIMS provides a helpful tool for travelers and travel health management staff with travel health management.

scholarly journals Human factors in emerging infectious diseases

2021 ◽  
Vol 2 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Scott B. Halstead
Keyword(s):  
Infectious Disease ◽  
Infectious Diseases ◽  
Human Factors ◽  
Emerging Infectious Diseases ◽  
Emerging Infectious Disease ◽  
Emerging Disease ◽  
Human Behaviour ◽  
Microbial World ◽  
Underlying Causes ◽  
Methods Of Control

When the underlying causes and mechanisms of emerging infectious disease problems are studied carefully, human behaviour is often involved. Even more often, the only methods of control or prevention available are to change human behaviour. Several major recent emerging disease problems can be cited. It is sometimes emphasized that it is human carelessness, human excesses, human ignorance or human habits of conquest or leisure which contribute directly to the biological niches that microorganisms are all too capable of exploiting. We must look at ourselves as the engines of microbial opportunism. It is not likely that we will ever conquer the microbial world;we must look instead to control the human factors that contribute to emergence.

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