scholarly journals Porous Inorganic and Hybrid Systems for Drug Delivery: Future Promise in Combatting Drug Resistance and Translation to Botanical Applications

2019 ◽  
Vol 26 (33) ◽  
pp. 6107-6131 ◽  
Author(s):  
Junling Guo ◽  
Bruno D. Mattos ◽  
Blaise L. Tardy ◽  
Vanessa M. Moody ◽  
Gao Xiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Relevant Literature ◽  
Industrial Applications ◽  
Porous Particles ◽  
Metalorganic Framework ◽  
One Step ◽  
Delivery Vehicles ◽  
Therapeutic Properties ◽  
Organic Particles

Background: Porous micro- and nanoparticles have the capacity to encapsulate a large quantity of therapeutics, making them promising delivery vehicles for a variety of applications. This review aims to highlight the latest development of inorganic and hybrid (inorganic/ organic) particles for drug delivery with an additional emphasis on combatting drug resistant cancer. We go one step further and discuss delivery applications beyond medicinal delivery, as there is generally a translation from medicinal delivery to botanic delivery after a short lag time. Methods: We undertook a search of relevant peer-reviewed publications. The quality of the relevant papers was appraised using standard tools. The characteristics of the papers are described herein, and the relevant material and therapeutic properties are discussed. Results: We discuss 4 classes of porous particles in terms of drug delivery and theranostics. We specifically focus on silica, calcium carbonate, metal-phenolic network, and metalorganic framework particles. Other relevant biomedically relevant applications are discussed and we highlight outstanding therapeutic results in the relevant literature. Conclusion: The findings of this review confirm the importance of studying and utilizing porous particles for therapeutic delivery. Moreover, we show that the properties of porous particles that make them promising for medicinal drug delivery also make them promising candidates for agro-industrial applications.

scholarly journals One step emission tunable synthesis of PEG coated Ag2S NIR quantum dots and the development of receptor targeted drug delivery vehicles thereof

2016 ◽  
Vol 4 (11) ◽  
pp. 1941-1950 ◽  
Author(s):  
D. Asik ◽  
M. B. Yagci ◽  
F. Demir Duman ◽  
H. Yagci Acar
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Folic Acid ◽  
Targeted Drug Delivery ◽  
Single Step ◽  
Drug Delivery Vehicles ◽  
Theranostic Nanoparticles ◽  
One Step ◽  
Delivery Vehicles ◽  
Targeted Drug

Emission tunable Ag2S–PEG–folic acid QDOTs synthesized in a single step in water are effective theranostic nanoparticles.

Magnetic-responsive microparticles with customized porosity for drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (91) ◽  
pp. 88157-88167 ◽  
Author(s):  
Yuan Gao ◽  
Ming-Wei Chang ◽  
Zeeshan Ahmad ◽  
Jing-Song Li
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Porous Particles ◽  
One Step

One step engineering of drug-loaded magnetic porous particles for controlled release and targeting.

Dendrimers: General Aspects, Applications and Structural Exploitations as Prodrug/Drug-delivery Vehicles in Current Medicine

2018 ◽  
Vol 18 (5) ◽  
pp. 439-457 ◽  
Author(s):  
Merina Mariyam ◽  
Kajal Ghosal ◽  
Sabu Thomas ◽  
Nandakumar Kalarikkal ◽  
Mahima S. Latha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
General Aspects

Novel Phospholipid-Based Labrasol Nanomicelles Loaded Flavonoids for Oral Delivery with Enhanced Penetration and Anti-Brain Tumor Efficiency

2020 ◽  
Vol 17 (3) ◽  
pp. 229-245
Author(s):  
Gang Wang ◽  
Junjie Wang ◽  
Rui Guan
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Oral Delivery ◽  
Safe Delivery ◽  
Drug Delivery Vehicles ◽  
Therapeutic Benefits ◽  
Delivery Vehicles ◽  
The Brain

Background: Owing to the rich anticancer properties of flavonoids, there is a need for their incorporation into drug delivery vehicles like nanomicelles for safe delivery of the drug into the brain tumor microenvironment. Objective: This study, therefore, aimed to prepare the phospholipid-based Labrasol/Pluronic F68 modified nano micelles loaded with flavonoids (Nano-flavonoids) for the delivery of the drug to the target brain tumor. Methods: Myricetin, quercetin and fisetin were selected as the initial drugs to evaluate the biodistribution and acute toxicity of the drug delivery vehicles in rats with implanted C6 glioma tumors after oral administration, while the uptake, retention, release in human intestinal Caco-2 cells and the effect on the brain endothelial barrier were investigated in Human Brain Microvascular Endothelial Cells (HBMECs). Results: The results demonstrated that nano-flavonoids loaded with myricetin showed more evenly distributed targeting tissues and enhanced anti-tumor efficiency in vivo without significant cytotoxicity to Caco-2 cells and alteration in the Trans Epithelial Electric Resistance (TEER). There was no pathological evidence of renal, hepatic or other organs dysfunction after the administration of nanoflavonoids, which showed no significant influence on cytotoxicity to Caco-2 cells. Conclusion: In conclusion, Labrasol/F68-NMs loaded with MYR and quercetin could enhance antiglioma effect in vitro and in vivo, which may be better tools for medical therapy, while the pharmacokinetics and pharmacodynamics of nano-flavonoids may ensure optimal therapeutic benefits.

An experimental and theoretical study of the abrasion performance of digital light processing parts

2020 ◽  
pp. 095440542098133
Author(s):  
Mehdi Kazemi ◽  
Abdolreza Rahimi
Keyword(s):  
Layer Thickness ◽  
Normal Load ◽  
Digital Light Processing ◽  
One Step ◽  
Pin On Disk ◽  
The Relationship ◽  
Influential Parameters ◽  
Disk Method ◽  
Normal Angle

Generally, interactions at surface asperities are the cause of wear. Two-Thirds of wear in industry occurs because of the abrasive or adhesive mechanisms. This research presents an analytical model for abrasion of additive manufactured Digital Light Processing products using pin-on-disk method. Particularly, the relationship between abrasion volume, normal load, and surface asperities’ angle is investigated. To verify the proposed mathematical model, the results of this model are verified with the practical experiments. Results show that the most influential parameters on abrasion rate are normal load and surface’s normal angle. Abrasion value increases linearly with increasing normal load. The maximum abrasion value occurs when the surface’s normal angle during fabrication is 45°. After the asperities are worn the abrasion volume is the same for all specimens with different surface’s normal angle. Though layer thickness does not directly affect the wear rate, but surface roughness tests show that layer thickness has a great impact on the quality of the abraded surface. When the thickness of the layers is high, the abraded surface has deeper valleys, and thus has a more negative skewness. This paper presents an original approach in abrasion behavior improvement of DLP parts which no research has been done on it so far; thus, bringing the AM one step closer to maturity.

scholarly journals Smoothing additive manufactured parts using ns-pulsed laser radiation

2021 ◽  
Author(s):  
Florian Kuisat ◽  
Fernando Lasagni ◽  
Andrés Fabián Lasagni
Keyword(s):  
Surface Roughness ◽  
Mechanical Performance ◽  
State Of The Art ◽  
Pulsed Laser ◽  
Industrial Applications ◽  
Laser Source ◽  
Pulsed Laser Radiation ◽  
Current State ◽  
The Impact

AbstractIt is well known that the surface topography of a part can affect its mechanical performance, which is typical in additive manufacturing. In this context, we report about the surface modification of additive manufactured components made of Titanium 64 (Ti64) and Scalmalloy®, using a pulsed laser, with the aim of reducing their surface roughness. In our experiments, a nanosecond-pulsed infrared laser source with variable pulse durations between 8 and 200 ns was applied. The impact of varying a large number of parameters on the surface quality of the smoothed areas was investigated. The results demonstrated a reduction of surface roughness Sa by more than 80% for Titanium 64 and by 65% for Scalmalloy® samples. This allows to extend the applicability of additive manufactured components beyond the current state of the art and break new ground for the application in various industrial applications such as in aerospace.

scholarly journals Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 427
Author(s):  
Amin Mirzaaghasi ◽  
Yunho Han ◽  
So-Hee Ahn ◽  
Chulhee Choi ◽  
Ji-Ho Park
Keyword(s):  
Drug Delivery ◽  
Therapeutic Potential ◽  
Hek293t Cell ◽  
Biological Properties ◽  
Context Analysis ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Diseased State ◽  
Sepsis And Septic Shock

Exosomes have attracted considerable attention as drug delivery vehicles because their biological properties can be utilized for selective delivery of therapeutic cargoes to disease sites. In this context, analysis of the in vivo behaviors of exosomes in a diseased state is required to maximize their therapeutic potential as drug delivery vehicles. In this study, we investigated biodistribution and pharmacokinetics of HEK293T cell-derived exosomes and PEGylated liposomes, their synthetic counterparts, into healthy and sepsis mice. We found that biodistribution and pharmacokinetics of exosomes were significantly affected by pathophysiological conditions of sepsis compared to those of liposomes. In the sepsis mice, a substantial number of exosomes were found in the lung after intravenous injection, and their prolonged blood residence was observed due to the liver dysfunction. However, liposomes did not show such sepsis-specific effects significantly. These results demonstrate that exosome-based therapeutics can be developed to manage sepsis and septic shock by virtue of their sepsis-specific in vivo behaviors.

Yoga and Wellness—Key Insights from the Study on General Yoga Programme

2021 ◽  
Vol 14 (1) ◽  
pp. 51-63
Author(s):  
Rabindra Acharya ◽  
Gopal P. Mahapatra ◽  
Kadamibini Acharya
Keyword(s):  
Relevant Literature ◽  
Health And Wellness ◽  
Human Beings ◽  
Recent Past ◽  
Facilitative Role ◽  
Quality Of Living ◽  
The Impact ◽  
Simplified Form

Human beings have always strived towards excellence and progress since time immemorial. Industrialisation, automation and technological disruptions have led to increased comfort and quality of living of human beings and enhanced output, productivity and efficiency. Consequently, of late, health and wellness are receiving increased attention globally. Stress and stress-related diseases and workplace-related ailments have significantly increased over the last few decades and gained attention from society and industrial organisations. In the recent past, in the coronavirus pandemic context, wellness has been focused upon in many countries, communities and organisations worldwide. Yoga has been part of the Indian ethos for centuries. In this article, the authors discuss the General Yoga Programme (GYP), its broad coverage, and the impact it has had on the participants in terms of their wellness. With the help of a survey of the participants and linking it to relevant literature and research in the field, the authors highlight how GYP is a useful tool for enhancing various wellness dimensions. They recommend that GYP in its simplified form can be extended to the workplace; and also, HR professionals can play a facilitative role in the process.

Sign in / Sign up

Export Citation Format

Share Document