An Insight into Synthetic Strategies for Schiff Base Derivatives with Diverse Biological Activities

2020 ◽  
Vol 17 ◽  
Author(s):  
Jagseer Singh ◽  
Pooja A. Chawla ◽  
Md. Jawaid Akhtar ◽  
Bhupinder Kumar
Keyword(s):  
Schiff Base ◽  
Schiff Bases ◽  
Biological Activities ◽  
Biologically Active ◽  
Biological Processes ◽  
Schiff Base Derivatives ◽  
Active Moiety ◽  
Comprehensive Knowledge ◽  
Key Points ◽  
Insight Into

Abstract:: Schiff base or imine or azomethine is one of the most important organic compounds that has been reported to play a significant role in various biological processes. The group is a part of natural or non-natural compounds and is involved as important precursors as diversified agents and as intermediates for the synthesis of biologically active agents. The review outlines the detailed design strategy, synthesis and structure-activity relationship studies of different Schiff bases for various biological activities. We have tried to outline the key points of various researchers with respect to biological activities. The results of different studies demonstrate Schiff bases as a linker in many synthetic compounds displaying a broad range of activities. We believe that the present review will provide comprehensive knowledge about medicinal importance of Schiff bases and serve as important literature in designing the synthesis of novel molecules containing Schiff base as pharmacophore or biologically active moiety.

scholarly journals Synthesis and Evaluation of Schiff Bases of 4-Amino-5-(chlorine substituted phenyl)-4H-1,2,4-triazole-3-thione as Antimicrobial Agents

2020 ◽  
Vol 41 (1) ◽  
pp. 26-35
Author(s):  
Kishor Devkota ◽  
Govinda Pathak ◽  
Bhushan Shakya
Keyword(s):  
Schiff Base ◽  
Schiff Bases ◽  
Antimicrobial Agents ◽  
Triazole Ring ◽  
Antimicrobial Activities ◽  
Biologically Active ◽  
Spectral Techniques ◽  
Schiff Base Derivatives ◽  
Bacteria And Fungi ◽  
Different Strains

Triazole ring system has attracted a continuously growing interest of synthetic organic chemists and those dealing with the medicinal compounds due to its versatile potential to interact with biological systems. Schiff bases are also considered as one of the most biologically active compounds.  The aim of the present study was to synthesize new Schiff bases bearing triazole nucleus and to assess their antimicrobial activities. Four new Schiff base derivatives of 1,2,4-triazole-3-thione were synthesized by combining two different pharmacophores viz. triazole nucleus and Schiff base moiety and were characterized by spectral techniques (UV, FT-IR, and NMR). The Schiff bases were evaluated for antibacterial (Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae) and antifungal (Candida albicans) activities. The synthesized compounds exhibited good to moderate activities against different strains of bacteria and fungi tested.

Recent reports on Pyridoxal derived Schiff base complexes

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Samik Gupta
Keyword(s):  
Schiff Base ◽  
Schiff Bases ◽  
Vitamin B6 ◽  
Biological Activities ◽  
Coordination Complexes ◽  
Aldehyde Group ◽  
Schiff Base Complexes ◽  
Fine Chemicals ◽  
Active Core ◽  
Insight Into

Abstract Pyridoxal and Pyridoxal 5-phosphate are two among the six aqua soluble vitamers of vitamin B6. They can form Schiff bases readily due to the presence of aldehyde group. Schiff bases can offer diverse coordination possibilities for many transition metals as has been found in a large volume of research till now. The coordination complexes thus formed gives insight into the active core structure and enzymatic activities of vit B6 containing enzymes. Apart from that, these complexes have been found useful as catalysts for synthesis of fine chemicals, as sensors and for their diverse biological activities.

scholarly journals Synthesis, Characterization and Antimicrobial Properties of Schiff Bases Derived from Condensation of 8-Formyl-7-hydroxy-4-methylcoumarin and Substituted Triazole Derivatives

2009 ◽  
Vol 6 (s1) ◽  
pp. S239-S246 ◽  
Author(s):  
Kumar Sanjeev S. Lamani ◽  
Oblennavar Kotresh ◽  
Mohammed Shafi A. Phaniband ◽  
Jagannath C. Kadakol
Keyword(s):  
Schiff Base ◽  
Schiff Bases ◽  
Elemental Analysis ◽  
Mass Spectra ◽  
Biological Activities ◽  
Antimicrobial Properties ◽  
Biologically Active ◽  
Amino Group ◽  
H Nmr ◽  
Derivatives Of

Two biologically active classes of compounds coumarins and triazoles were employed to form the Schiff bases. The synthesized Schiff baseviz., 3-aryl-[(1-isocyano-4-methyl-7-hydroxycoumarin)]-5-methyl-1,3,4-triazoline-2-one and its substituents were obtained by the condensation of amino group of mono and disubstituted derivatives of 3-methyl-5-oxo-1,2, 4-triazoles with 8-formyl-7-hydroxy-4-methylcoumarin in alcohol. The characterization were studied by elemental analysis, IR,1H NMR and mass spectra. The biological activities of the compounds were assayed against two bacterial via,B. subtilis, E.coliand two fungal strainsA. niger, C.albican. The results indicate that the present compounds may serve as better fungicides when compared to bactericides. The synthesized compounds have turned to be wonder compounds possessing antimicrobial properties.

scholarly journals Synthesis of Biologically Active Molecules through Multicomponent Reactions

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 505 ◽  
Author(s):  
Daniel Insuasty ◽  
Juan Castillo ◽  
Diana Becerra ◽  
Hugo Rojas ◽  
Rodrigo Abonia
Keyword(s):  
Multicomponent Reaction ◽  
Biological Property ◽  
Multicomponent Reactions ◽  
Organic Molecules ◽  
Biological Activities ◽  
Biologically Active ◽  
Vast Number ◽  
Key Points ◽  
Reported Data ◽  
Synthetic Approaches

Focusing on the literature progress since 2002, the present review explores the highly significant role that multicomponent reactions (MCRs) have played as a very important tool for expedite synthesis of a vast number of organic molecules, but also, highlights the fact that many of such molecules are biologically active or at least have been submitted to any biological screen. The selected papers covered in this review must meet two mandatory requirements: (1) the reported products should be obtained via a multicomponent reaction; (2) the reported products should be biologically actives or at least tested for any biological property. Given the diversity of synthetic approaches utilized in MCRs, the highly diverse nature of the biological activities evaluated for the synthesized compounds, and considering their huge structural variability, much of the reported data are organized into concise schemes and tables to facilitate comparison, and to underscore the key points of this review.

scholarly journals Spectroscopic Elucidation of Some Complexes of Vanillin Semicarbazone

2021 ◽  
Vol 37 (4) ◽  
pp. 826-832
Author(s):  
Navneet Sinha ◽  
Rajnish Kumar ◽  
Vijay Pratap Singh ◽  
Deepak KUMAR ◽  
Shivadhar Sharma
Keyword(s):  
Schiff Base ◽  
Biological Activities ◽  
Free Ligand ◽  
Esr Spectra ◽  
Biologically Active ◽  
Distortion Parameter ◽  
Axial Ligands ◽  
Distorted Octahedral ◽  
Semicarbazide Hydrochloride ◽  
Uv Visible

3-Phenyl-4-methoxybenzaldehyde undergoes condensation with semicarbazide hydrochloride to form a Schiff-base i.e. 3-phenyl-4-methoxybenzaldehyde semicarbazone (abbreviated as MBS). It undergoes complexation with Vanadium(II), Manganese(II), and Copper(II). The comparison of FTIR-spectra of complexes with that of free ligand helps ascertain the coordination points of ligand through the nitrogen of –CH=N– group and oxygen of group. The axial ligands have been varied by chloride, acetate and nitrate ions. The UV/Visible and ESR spectra of complexes predicts their tetragonally distorted octahedral (D4h) symmetry. The tetragonal distortion parameter (Dt) is observed maximum for chloride while it is minimum for nitrate along z-axis. Both vanillin and semicarbazide are established biologically active compounds and hence their biological activities may be enhanced by their complexation and than a versatile field may be developed for further exploration.

scholarly journals A review on biological activities of Schiff base ligand and their metal complexes

2020 ◽  
Vol 13 (1) ◽  
pp. 217-221
Author(s):  
P.M. Jadhav
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Carbonyl Compounds ◽  
Biological Activities ◽  
Condensation Reaction ◽  
Cytotoxic Activities ◽  
Wide Range ◽  
Enzymatic Agents ◽  
Dye Industry

Schiff bases and their metal complexes are wide range of biological applications and are synthesized from the condensation reaction of amino compounds with carbonyl compounds. Schiff base and their metal complexes have a wide variety of applications in food and dye industry, agrochemical, polymer, catalysis, analytical chemistry, antifertility, antiinflammatory activity, antiradical activity, and biological system as enzymatic agents. Several have reviewed them of their antimicrobial, antibacterial, antifungal, antitumor, and cytotoxic activities. This review summarized the most promising biological activities of Schiff bases and their metal complexes

scholarly journals A review on versatile applications of novel Schiff bases and their metal complexes

2019 ◽  
Vol 8 (4) ◽  
pp. 675-681
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Carbonyl Compounds ◽  
Biological Activities ◽  
Schiff Base Complexes ◽  
Amino Compound ◽  
Azomethine Group ◽  
Catalytic Activities ◽  
Schiff Base Metal Complexes

Metal complexes synthesized from Schiff bases and furthermore Schiff bases are versatile in nature. Such types of compounds were prepared from the condensation of an amino compound with carbonyl compounds (aldehyde or ketone) during which the carbonyl group is replaced by an imine or azomethine group. Schiff bases and their derivatives are widely employed in industries, polymers, dyes and medicative and pharmaceutical fields and additionally exhibit biological activities like antibacterial, antifungal, anti-inflammatory, antimalarial, antiviral, and antipyretic properties. Many Schiff base metal complexes exhibit glorious catalytic activities in numerous mechanisms. Their several applications in homogenous and heterogeneous catalysis were according troughout last decade. Several Schiff base complexes were helpful for their application as catalysts in reactions involving at high temperatures because of the high thermal and moisture stabilities. This text totally based on literature review with examples of the most promising applied Schiff bases and their complexes in several areas, summarizing the applications of Schiff bases and their numerous derivatives and complexes.

scholarly journals Synthesis and Screening of Biologically Active Schiff bases of Benzothiazoles and its Zinc and Lanthanum Metal Complexes

2021 ◽  
Vol 37 (1) ◽  
pp. 187-193
Author(s):  
D. G. Anuse ◽  
V. J. Desale ◽  
B. R. Thorat ◽  
D. D. Anuse ◽  
S. G. Jagadhani ◽  
...  
Keyword(s):  
Metal Complex ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Zinc Chloride ◽  
Biological Activities ◽  
Biologically Active ◽  
Lanthanum Chloride ◽  
Schiff’S Bases ◽  
Schiff's Bases ◽  
Derivatives Of

The substituted 2-Aminobenzothiazole and ethyl 2-(4-formyl-3-hydroxyphenyl)-4-methylthiazole-5-carboxylate in methanol mix together and heat the reaction mixture for overnight, It gives Schiff’s bases (derivatives of substituted aminobenzothiazole) 3. This compound 3 when treated with Zinc Chloride it gives Zinc metal complex of Schiff’s bases 4 and if compound 3 was treated with Lanthanum chloride gives Lanthanum metal complex of Schiff’s bases 5, which shows marked biological activities.

scholarly journals Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective Drugs

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 3036
Author(s):  
Ashraf A. Aly ◽  
Alaa A. Hassan ◽  
Maysa M. Makhlouf ◽  
Stefan Bräse
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Biologically Active ◽  
Biological Applications ◽  
Active Moiety ◽  
Interesting Class

Mercapto-substituted 1,2,4-triazoles are very interesting compounds as they play an important role in chemopreventive and chemotherapeutic effects on cancer. In recent decades, literature has been enriched with sulfur- and nitrogen-containing heterocycles which are used as a basic nucleus of different heterocyclic compounds with various biological applications in medicine and also occupy a huge part of natural products. Therefore, we shed, herein, more light on the synthesis of this interesting class and its application as a biologically active moiety. They might also be suitable as antiviral and anti-infective drugs.

Aluminium(III) Derivatives of Monofunctional Bidentate Schiff Bases

1973 ◽  
Vol 28 (3-4) ◽  
pp. 153-157 ◽  
Author(s):  
R. N. Prasad ◽  
J. P. Tandon
Keyword(s):  
Schiff Base ◽  
Ir Spectra ◽  
General Formula ◽  
Schiff Bases ◽  
Molecular Association ◽  
Molecular Weights ◽  
Schiff Base Derivatives ◽  
Stoichiometric Ratios ◽  
Derivatives Of

Reactions of aluminium iso-propoxide with monofunctional bidentate Schiff bases having the general formula 2-HOC10H6CH:NR (where R = C2H5, n C3H7, iso-C3H7, n-C4H9, iso-C4H9, sec-C4H9, tert-C4H9 and C6H5) in different stoichiometric ratios have yielded Al(OPri)2(SB), Al(OPri)(SB)2 and Al(SB)3 type of products (where SB is the anion of the corresponding Schiff base, SBH). The ebullioscopic determination of molecular weights shows that the di-iso-propoxy mono- Schiff base derivatives are dimeric; the tris- Schiff base derivatives are monomeric and for the mono-iso-propoxy bis- Schiff base derivatives, molecular association is ~1.4. The IR spectra of a few representative derivatives have been recorded and possible structures indicated.

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