Therapeutic and Nutraceutical Potential of Bioactive Compounds in Aegle marmelos (L.): An Overview

2019 ◽  
Vol 15 (4) ◽  
pp. 306-317
Author(s):  
Ena Gupta ◽  
Snehlata Shakyawar ◽  
Shanthy Sundaram
Keyword(s):  
Bioactive Compounds ◽  
Potential Role ◽  
Antioxidant Properties ◽  
Natural Antioxidants ◽  
Review Article ◽  
Aegle Marmelos ◽  
Prevention And Treatment ◽  
History Of ◽  
Health Promoting ◽  
Anti Fungal

Aegle Marmelos (L.) Correa (A. marmelos), is a medicinal plant of Rutaceae family having a long history of curative property in traditional medicine. This plant is a rich source of bioactive compounds and natural antioxidants which can be isolated from its various parts such as fruit (carotenoids, tannins, flavonoids, ascorbic acid, marmelosin, marmelide, psoralen, aurapten, luvangetin); leaf (phenols, lupeol, skimmianine, citral, aegeline, eugenol, citronella, marmesinine) and bark (marmin, skimmianine, fagarine) etc. Many clinical and pre-clinical researches suggest the therapeutic applications of A. marmelos, such as anti-bacterial, anti-fungal, anti-viral, anti-ulcer, anti-diabetic, anticancer, anti-inflammatory and antioxidant properties which play a potential role in the prevention and treatment of various diseases. This review article focuses on exploring novel bioactive compounds of the above plant possessing potential therapeutic and health promoting applications.

Antioxidant Capacity, Phytochemical Analysis and Identification of Active Compounds in Anchomanes difformis

2020 ◽  
Vol 10 (4) ◽  
pp. 446-458 ◽  
Author(s):  
Toyin Dorcas Alabi ◽  
Nicole Lisa Brooks ◽  
Oluwafemi Omoniyi Oguntibeju
Keyword(s):  
Antioxidant Capacity ◽  
Bioactive Compounds ◽  
Microbial Growth ◽  
Antioxidant Properties ◽  
Natural Antioxidants ◽  
Therapeutic Agents ◽  
Phytochemical Analysis ◽  
Flavonoid Content ◽  
The Family ◽  
Health Promoting

Background: Anchomanes difformis (ENGL: Blume) is a specie of flowering plants in the family Araceae. Anchomanes difformis is commonly reported for ameliorating hyperglycemia, inflammation, ulcer, malaria, and inhibiting microbial growth. Objective: This study evaluated total yields of phytochemicals present, measured antioxidant capacities and identified bioactive compounds in the leaves and rhizome extracts of A. difformis using solvents of different polarity (ethyl acetate, ethanol and water). Methods: Total polyphenolic, flavonoid content and alkaloids were measured, ORAC, TEAC and FRAP were performed as antioxidant capacity indices, and identification of bioactive compounds was done using UPLC-MS and HPLC. Results: All extracts contained polyphenols, flavonols, flavanols, and alkaloids in varying concentrations. All extracts exhibited antioxidant properties. However, aqueous leaves extract had the highest antioxidant properties and polyphenols with significance (p<0.05). Thirty-four compounds were identified altogether in the leaves and rhizome. Conclusion: A. difformis leaves and rhizome are potential sources of natural antioxidants and can serve as potential therapeutic agents against diseases linked with oxidative stress. Presence of health-promoting compounds indicates possible ameliorative potentials of A. difformis.

scholarly journals Bioactive compounds and antioxidant properties of dried apricot

2013 ◽  
pp. 193-205 ◽  
Author(s):  
Jasna Canadanovic-Brunet ◽  
Jelena Vulic ◽  
Gordana Cetkovic ◽  
Sonja Djilas ◽  
Vesna Tumbas-Saponjac
Keyword(s):  
Bioactive Compounds ◽  
Food Industry ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Natural Antioxidants ◽  
Carotenoid Content ◽  
Power Method ◽  
Food Ingredient ◽  
Free Radical Scavenging Activities

Dried apricot was extracted using two different solvents: 80% ethanol and hexane. The contents of total phenolics, flavonoids and anthocyanins were determined in ethanol apricot extract (EAE), while the carotenoid content was determined in hexane apricot extracts (HAE) by spectrophotometric method. The detected amounts of bioactive compounds in dried apricot were: phenolics 498.13 ? 12.04 mg GAE/100g DA, flavonoids 218.45 ? 14.14 mg R/100g DA and anthocyanins 3.08 ? 0.40 mg CGE/100g DA. In dried apricot the ?-carotene was present in the amount of 0.56 ? 0.03 mg/100g DA. Some individual phenolic compounds in EAE were determined by HPLC analysis and the most dominant compound was gallic acid (35.02 ? 1.65 mg/100g DA). Free radical scavenging activities of EAE and HAE were tested spectrophotometrically using stable DPPH radicals and reducing power method. The EC50 value for EAE was 2.05 ? 0.06 mg/ml and for HAE was 6.28 ? 0.01 mg/ml. The RP0.5 values determined by reducing power method were 6.11 ? 0.01 mg/ml for EAE and 62.04 ? 0.03 mg/ml for HAE. The results indicate that dried apricot can be a valuable source of natural antioxidants and can be used as a functional food ingredient in the food industry.

scholarly journals POTENSI SENYAWA BIOAKTIF MESOCARP BUAH LONTAR (Borassus fl abeliffer L.) SEBAGAI SUMBER ANTIOKSIDAN ALAMI (Potency of Mesocarp Bioactive Compounds in Lontar Fruit (Borassus fl abeliffer L.) as A Source of Natural Antioxidant)

2014 ◽  
Vol 34 (03) ◽  
pp. 277 ◽  
Author(s):  
Eny Idayati ◽  
Suparmo Suparmo ◽  
Purnama Darmadji
Keyword(s):  
Bioactive Compounds ◽  
Antioxidant Properties ◽  
Chemical Properties ◽  
Natural Antioxidants ◽  
Chromatography Method ◽  
Carotene Content ◽  
Palm Fruit ◽  
Dpph Method ◽  
Total Fat ◽  
Physical And Chemical

This study was aimed to characterize the physical and chemical properties of borassus palm fruit mesocarp, to determine the best type of solvent to extract bioactive compounds by maceration method, and to evaluate the antioxidant properties of bioactive compounds using DPPH (1,1-difenil-2-pikrilhidrazil) method. Carotenoid was separated based on TLC(thin layer chromatography) method, which produced spots. To confi rm the results, the spots were scanned using UV-vis spectrofotometry. The results showed that the water content of borassus fruit mesocarp was 77.31%, while total fat, ash content, and tannin were 0.11%, 1.43%, 0.08%, respectively. Total Carotenoid was 8324.6 µg/100g with β carotene content was 6217.48 microgram/100g. The best solvent used in extracting the bioactive compounds was ethanol and acetone with (1:1) ratio. The highest yield was 4.3% and bioactive compounds in palm fruit mesocarpextracts as antioxidants was about 87% as carried out by DPPH method, so it could become a potential antioxidant. TLC Identifi cation produced two spots. One spot was identifi ed as carotenoids from xanthophyll group and the other one was β-carotene.Keywords: Natural antioxidants, borassus palm fruit mesocarp, bioactive compounds ABSTRAKPenelitian ini bertujuan untuk karakterisasi senyawa bioaktif dalam mesocarp buah lontar berdasarkan sifat fisik dan kimia, mengetahui jenis pelarut terbaik untuk mengekstrak senyawa bioaktif dengan metode maserasi, serta mengevaluasi sifat antioksidan senyawa bioaktif mesocarp dengan metode DPPH (1,1-difenil-2-pikrilhidrazil). Dasarpemisahan karotenoid dengan metoda KLT (kromatografi  lapis tipis) pada ekstrak lalu dikuatkan dengan hasil scanning menggunakan spektrofotometer UV-Vis. Hasil penelitian menunjukkan bahwa mesocarp buah lontar mengandung kadar air 77,31%; total lemak 0,11%, kadar abu 1,43%; tanin 0,08%; total karotenoid 8324,6 µg/100g dengan kandungan senyawa  karoten 6217,48 µg/100g. Perlakuan pelarut terbaik untuk proses ekstraksi senyawa bioaktif adalah etanol dan aseton dengan rasio (1:1). Hasil rendemen tertinggi yaitu 4,3% dan potensi senyawa bioaktif dalam ekstrak mesocarp buah lontar sebagai antioksidan dengan metode DPPH yaitu sekitar 87%, sehingga berpotensi sebagai salahsatu senyawa antioksidan. Identifi kasi dengan metode KLT yang menghasilkan 2 noda yaitu noda 1 diduga karotenoid dari golongan xantofi l dan noda 2 yatu  karoten.Kata kunci: Antioksidan alami, mesocarp lontar, senyawa bioaktif

scholarly journals Medicinal Plants from Brazilian Cerrado: Antioxidant and Anticancer Potential and Protection against Chemotherapy Toxicity

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
José Tarcísio de Giffoni de Carvalho ◽  
Débora da Silva Baldivia ◽  
Daniel Ferreira Leite ◽  
Laura Costa Alves de Araújo ◽  
Priscilla Pereira de Toledo Espindola ◽  
...  
Keyword(s):  
Cell Death ◽  
Medicinal Plants ◽  
Antioxidant Properties ◽  
Natural Antioxidants ◽  
Review Article ◽  
Malignant Cells ◽  
Cell Toxicity ◽  
Brazilian Cerrado ◽  
Therapeutic Approaches ◽  
Chemotherapy Toxicity

The use of natural antioxidants in cancer therapy has increased: first, due to the potential of natural antioxidants to kill tumour cells and second, because of their capacity to protect healthy cells from the damage caused by chemotherapy. This review article discusses the antioxidant properties of extracts obtained from medicinal plants from the Brazilian Cerrado and the cell death profile induced by each of these extracts in malignant cells. Next, we describe the capacity of other medicinal plants from the Cerrado to protect against chemotherapy-induced cell toxicity. Finally, we focus on recent insights into the cell death profile induced by extracts from Cerrado plants and perspectives for future therapeutic approaches.

scholarly journals Valorization of Natural Antioxidants for Nutritional and Health Applications

2021 ◽  
Author(s):  
Pedro Ferreira-Santos ◽  
Zlatina Genisheva ◽  
Claudia Botelho ◽  
Cristina Rocha ◽  
José António Teixeira
Keyword(s):  
Bioactive Compounds ◽  
Antioxidant Properties ◽  
Chemical Properties ◽  
Health Benefit ◽  
Natural Antioxidants ◽  
Extraction Process ◽  
Extraction Methods ◽  
In Vivo Studies

The significant increase in the world population age, 47 years in 1950 to 73 years in 2020, resulted in an increase in aging related diseases as well as in degenerative diseases. In consequence, researchers have been focusing in the development of new therapies, with a particular emphasis on the use of compounds with antioxidant properties, namely phytochemicals, such as polyphenols and carotenoids. Several in vitro and in vivo studies have demonstrated the phytochemicals antioxidant capacity. Their use is broad, as they can be part of food supplements, medicine and cosmetics. The health benefit of antioxidant phytochemicals is an indisputable question. Phytochemical properties are highly influenced by the natural matrix as well as by extraction process, which have a key role. There are several extraction methods that can be applied depending on the chemical properties of the bioactive compounds. There is a wide range of solvents with different polarities, which allows a selective extraction of the desired target family of compounds. Greener technologies have the advantage to reduce extraction time and solvent quantity in comparison to the most traditional methods. This chapter will focus on the different green extraction strategies related to the recovery of antioxidant bioactive compounds from natural sources, their nutritional and health potential.

scholarly journals Differences in Bioactive Protein and Vitamin Status of Milk Obtained from Polish Local Breeds of Cows

2020 ◽  
Vol 20 (1) ◽  
pp. 287-298 ◽  
Author(s):  
Aneta Brodziak ◽  
Jolanta Król ◽  
Joanna Barłowska ◽  
Zygmunt Litwińczuk ◽  
Anna Teter ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Whey Proteins ◽  
Antioxidant Properties ◽  
Antimicrobial Properties ◽  
Processing Plant ◽  
Vitamin Status ◽  
Holstein Friesian ◽  
Health Promoting ◽  
Β Lactoglobulin ◽  
Β Carotene

AbstractThe aim of the study was to compare the content of selected bioactive whey proteins and lipophilic vitamins, which largely determine the bioactive status of milk, in milk obtained from local breeds of cows raised in Poland (Polish Red, White-Backed and Simmental) and Polish Holstein-Friesian cows. Basic chemical composition and content of selected bioactive compounds (β-lactoglobulin, α-lactalbumin, lactoferrin, bovine serum albumin, and vitamins: E, A, D3 and β-carotene) in 550 milk samples were analysed. The milk produced by local breeds proved to be a more valuable source of whey proteins and lipophilic vitamins than that of the Polish Holstein-Friesians. It was distinguished by its content of all bioactive compounds, including those with antioxidant properties, i.e. vitamins E, A and D3 and β-lactoglobulin, and antimicrobial properties, mainly lactoferrin. Therefore, the milk of cows of local breeds should be considered a valuable material for processing, especially at the level of the farm or small local processing plant, to produce products that are richer in health-promoting compounds. The promotion of milk from local breeds can therefore be an opportunity for the farms that raise them.

scholarly journals Enhancement of antioxidant properties of Triticum durum obtained by traditional spontaneous fermentation in underground silos

2021 ◽  
Vol 43 ◽  
pp. e57080
Author(s):  
Nabila Benhamada ◽  
Tayeb Idoui
Keyword(s):  
Triticum Durum ◽  
Antioxidant Properties ◽  
Reducing Power ◽  
Natural Antioxidants ◽  
Total Phenolic ◽  
Fermented Foods ◽  
Spontaneous Fermentation ◽  
Natural Fermentation ◽  
Health Promoting ◽  
The Impact

Fermented foods have made important contributions to human diets for thousands of years and continue to do so. Their health-promoting benefits are attracting increasingly attention. The present study was conducted to evaluate the impact of natural fermentation on antioxidant properties of traditionally fermented wheat (Triticum durum) compared to unfermented samples. Initially, the samples were submitted to traditional spontaneous fermentation. Subsequently, an aqueous extract was obtained and used to determine polyphenolic and flavonoid contents. Moreover, the antioxidant potential was also measured through the determination of the scavenging ability against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals, reducing power and hydrogen peroxide scavenging activity. The results showed that the total phenolic and total flavonoid contents were significantly increased in fermented wheat. Moreover, the antioxidant activity was more effective in fermented than in unfermented wheat. Thus, natural fermentation can enhance natural antioxidants in wheat and transform it into a healthy food or ingredient with multi-functional properties which can be used in the food industry.

scholarly journals Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives

Cosmetics ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 106
Author(s):  
Hien Thi Hoang ◽  
Ju-Young Moon ◽  
Young-Chul Lee
Keyword(s):  
Phenolic Compounds ◽  
Oxidative Damage ◽  
Plant Extracts ◽  
Aging Process ◽  
Biological Activities ◽  
Antioxidant Properties ◽  
Natural Antioxidants ◽  
Review Article ◽  
Cosmetic Formulation

In recent years, interest in the health effects of natural antioxidants has increased due to their safety and applicability in cosmetic formulation. Nevertheless, efficacy of natural antioxidants in vivo is less documented than their prooxidant properties in vivo. Plant extracts rich in vitamins, flavonoids, and phenolic compounds can induce oxidative damage by reacting with various biomolecules while also providing antioxidant properties. Because the biological activities of natural antioxidants differ, their effectiveness for slowing the aging process remains unclear. This review article focuses on the use of natural antioxidants in skincare and the possible mechanisms underlying their desired effect, along with recent applications in skincare formulation and their limitations.

scholarly journals Antioxidant Activity and Phenolic Content of Soybean Seeds Extracts

2017 ◽  
Vol 17 (2) ◽  
pp. 121 ◽  
Author(s):  
Dejan Prvulović ◽  
Đorđe Malenčić ◽  
Jegor Miladinović
Keyword(s):  
Nutritional Value ◽  
Total Phenolics ◽  
Antioxidant Properties ◽  
Natural Antioxidants ◽  
Soybean Seeds ◽  
Breeding Programs ◽  
Soybean Cultivars ◽  
Need To Evaluate ◽  
Health Promoting ◽  
Agricultural Plants

Plants are a good source of natural antioxidants and could provide protection against harmful free radicals. Phenolic compounds were found to be an important part of human diet and are considered as active principles in many medicinal and agricultural plants. Detailed information about health-promoting components of different soybean cultivars could lead to a better understanding and an increased consumption of this crop, including its use in functional foods. The objective of this study was to determine total phenolics, total tannins, total flavonoids and antioxidant capacity with different assays of five Serbian soybean cultivars (Merkur, Sava, Valjevka, Venera and Victoria) extracted with three different solvents (70% acetone, 70% ethanol and 70% methanol). Total phenolics varied among cultivars and among applied solvents. Antioxidant properties highly depended on a solvent used for extraction. Such results highlight an existing variability in soybean seeds and emphasise the need to evaluate diversity and to support conventional breeding programs to improve soybean nutritional value.

scholarly journals Health Promoting Effects of Phytochemicals from Brassicaceae: A Review

2013 ◽  
Vol 1 (03) ◽  
pp. 120-131 ◽  
Author(s):  
Savinder Kaur Mann ◽  
Namita Khanna
Keyword(s):  
Fruits And Vegetables ◽  
Inflammatory Diseases ◽  
Antioxidant Properties ◽  
Natural Antioxidants ◽  
Epidemiological Studies ◽  
Potential Treatment ◽  
Chronic Inflammatory Diseases ◽  
The Past ◽  
Disease States ◽  
Health Promoting

Over the past several years, natural antioxidants have attracted considerable interest as potential treatment for a wide variety of disease states, including cancer and other causes e.g. chronic inflammatory diseases and aging. Therefore, plant derived antioxidants are now receiving a special attention as they possess good antioxidant properties and hence a worldwide trend towards the use of natural phytochemicals present in fruits and vegetables have been reported. Numerous epidemiological studies indicate that consumption of cruciferous vegetables is associated with prevention of cardiovascular diseases and reduced incidence of cancers of the gastrointestinal tract and other sites. The substances that seem to be responsible for these properties are phenolic compounds (phenolic acids, flavonoids, polyphenols etc.) and sulphur-containing organic compound glucosinolates and their derived products. The present review focuses on the health promoting effects of phytochemicals and their beneficial bioactivities in Brassicaceae.

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