Antimicrobial Effect of Quercus robur L. Leaves Selective Extracts from the Mezi Mountain of Djeniene Bourezg (West of Algeria)

2020 ◽  
Vol 16 (8) ◽  
pp. 1181-1190
Author(s):  
Elhassan Benyagoub ◽  
Nouria Nabbou ◽  
Amal Dine
Keyword(s):  
Clavulanic Acid ◽  
Quercus Robur ◽  
Biological Activities ◽  
Antifungal Susceptibility ◽  
Diffusion Method ◽  
Dilution Method ◽  
Medicinal Species ◽  
Disk Diffusion Method ◽  
Amoxicillin Clavulanic Acid ◽  
Microbial Strains

Background: Algeria, by its vast terrestrial extent and its climatic variation, has an abundant, rich and varied flora in which it was counted many aromatic and medicinal species that provide bioactive compounds characterized by their broad biological activities. In this context, this work is based on the evaluation of the antimicrobial activity of Quercus robur L. leaves extracts (Family of Fagaceae). Methods: Firstly, the collected plant material was defatted; then, the extraction of tannins and saponins was carried out according to a standard protocol where the extracts obtained were tested on some uropathogenic microbial strains by disk diffusion method with the determination of the Minimum Inhibitory Concentrations (MICs) by broth macro-dilution method. Results: The extraction yield of the selective extracts was 7.93 and 16.94% for tannins and saponins, respectively. The antibiotic resistance profile of the tested strains showed a resistance relatively important to several antibiotics, namely amoxicillin +clavulanic acid and ampicillin for Escherichia coli, while Pseudomonas aeruginosa showed resistance to amoxicillin+clavulanic acid, amikacin, cefotaxime and ceftazidime. However, Staphylococcus aureus was susceptible to penicillin, gentamicin, ofloxacin and chloramphenicol. Antifungal susceptibility testing has been shown that Candida albicans was susceptible to amphotericin B, econazole and it was clinically categorized as intermediate to miconazole drug. For antimicrobial tests, the tannins and saponins extracts exhibited a low to strong inhibitory effect at tested concentrations lower than 30 mg/mL (ranged from no inhibition to an inhibition zone diameter of 17.5 mm), depending on dose levels and tested microbial strains. Conclusion: This activity is proportional to the tested concentrations, knowing that tannins extract was more active compared to saponins extract. For this, Q. robur could constitute an important source for drug discovery.

scholarly journals Prevalence, seasonality, and antimicrobial resistance of thermotolerant Campylobacter isolated from broiler farms and slaughterhouses in East Algeria

2020 ◽  
Vol 13 (6) ◽  
pp. 1221-1228
Author(s):  
Mohamed Baali ◽  
Mohamed Lounis ◽  
Hanan Laidouci Al Amir ◽  
Ammar Ayachi ◽  
Ahcen Hakem ◽  
...  
Keyword(s):  
Clavulanic Acid ◽  
Antimicrobial Agents ◽  
Health Hazard ◽  
Control Measures ◽  
Diffusion Method ◽  
Contamination Rate ◽  
Isolation And Identification ◽  
Initial Finding ◽  
Disk Diffusion Method ◽  
Amoxicillin Clavulanic Acid

Aim: The current study was carried out to determine the prevalence, seasonality, and antimicrobial profile of thermotolerant Campylobacter isolated from broiler chickens in Batna, East Algeria, from June 2016 to June 2018. Materials and Methods: A total of 960 samples, including 480 cloacal swabs, 240 cecal contents, and 240 neck skin samples collected from 6 poultry farms and 12 slaughterhouses, were included in this study. After isolation and identification, susceptibility to seven antimicrobial agents was tested by the disk diffusion method. The seasonality of Campylobacter infection at broiler farms was statistically analyzed. Results: The data showed that 65%, 55%, and 70% of the cloacal swab, neck skin, and cecal content samples were contaminated with thermotolerant Campylobacter strains, respectively (p<0.05). Among the isolated campylobacteria, Campylobacter jejuni was the predominant species (73.5%). Sampling season exhibited a significant impact on the prevalence of Campylobacter (p<0.01), with peak occurrence in summer. All of the isolates were susceptible to gentamicin and resistant to ampicillin and amoxicillin/clavulanic acid, while 83.3% of them were resistant to erythromycin. Interestingly, 16 different resistance profiles were noted, with the combination of "ampicillin, amoxicillin/clavulanic acid, chloramphenicol, erythromycin, and tetracycline" being the most common, identified in 20.7% of isolated strains. Conclusion: This study demonstrates the presence of a high contamination rate of multidrug-resistant Campylobacter in farms and slaughterhouses in East Algeria. These findings underscore the need to apply strict control measures to avoid any associated public health hazard among Algerian consumers. This initial finding of the contamination of poultry with this zoonotic pathogen in East Algeria suggests the value of periodic comprehensive evaluation of associated disease in poultry as well as in humans in this region.

Prevalence and antimicrobial resistance of Salmonella and Yersinia in the feces of hunted wildlife in Abeokuta, Nigeria

2019 ◽  
Vol 72 (4) ◽  
Author(s):  
Olufemi Ernest Ojo ◽  
Oluwaseyi Oluwadaisi Ogunjobi ◽  
Mufutau Atanda Oyekunle ◽  
Morenike Atinuke Dipeolu ◽  
Ebenezer Babatunde Otesile
Keyword(s):  
Antimicrobial Resistance ◽  
Clavulanic Acid ◽  
Nalidixic Acid ◽  
Biochemical Characterization ◽  
Diffusion Method ◽  
Wild Rodents ◽  
Culture Methods ◽  
Disk Diffusion Method ◽  
Amoxicillin Clavulanic Acid ◽  
Cricetomys Gambianus

Meat from wildlife contributes significantly to food security and income generation in many African communities. Salmonellae and yersiniae are important causes of foodborne infections. This study investigated the presence and antimicrobial resistance of salmonellae and yersiniae in the fecal contents of hunted wild rodents and ruminants at a wildlife meat-processing center in Abeokuta, Nigeria. Bacteria were isolated and identified by selective culture methods and biochemical characterization. Antimicrobial susceptibility was determined by the Kirby Bauer disk diffusion method. Salmonellae were isolated from 15 (9.8%) and yersiniae from 11 (7.2%) samples out of 153. Salmonellae were detected in nine cane rats (Thryonomys swinderianus), five royal antelopes (Neotragus pygmaeus) and one African giant rat (Cricetomys gambianus). Yersiniae were detected in eight cane rats, two royal antelopes and one waterbuck (Kobus ellipsiprymnus). The levels of resistance in Salmonella isolates were 100% for ampicillin and ceftiofur, 93.3% for tetracycline, 33.3% for cefotaxime, 26.7% for ceftazidime, 13.3% for amoxicillin/clavulanic acid, nalidixic acid and sulfamethoxazole/trimethoprim, and 6.7% for gentamicin, streptomycin and norfloxacin. The levels of resistance in yersiniae isolates were 81.8% for ampicillin, 72.7% for ceftiofur, 63.6% for nalidixic acid, 54.5% for cefotaxime, ceftazidime and sulfamethoxazole/trimethoprim, 36.4% for tetracycline, 27.3% for amoxicillin/clavulanic acid and streptomycin, 18.2% for ciprofloxacin, and 9.1% for chloramphenicol and gentamicin. All the isolates showed multiresistance to antimicrobials from at least three different classes. The detection of antimicrobial resistant salmonellae and yersiniae in wildlife is of veterinary and public health significance as these organisms can be transmitted to domestic animals and humans.

scholarly journals Antimicrobial susceptibility of Actinobacillus pleuropneumoniae strains isolated from pig's clinical samples in Serbia

2016 ◽  
Vol 72 (10) ◽  
pp. 637-640
Author(s):  
Jadranka Žutić ◽  
Ljiljana Pavlović ◽  
Oliver Radanović ◽  
Vladimir Radosavljević ◽  
Branislav Kureljušić ◽  
...  
Keyword(s):  
Clavulanic Acid ◽  
Antimicrobial Agents ◽  
Actinobacillus Pleuropneumoniae ◽  
Diffusion Method ◽  
Clinical Samples ◽  
Disk Diffusion Method ◽  
Bacterial Diseases ◽  
Porcine Pleuropneumonia ◽  
Amoxicillin Clavulanic Acid ◽  
Resistance Rates

Porcine pleuropneumonia, caused by Actinobacillus pleuropneumoniae is one of the most important bacterial diseases of the pig respiratory tract. One hundred and forty eight Actinobacillus pleuropneumoniae strains isolated from pig's clinical samples were tested for their susceptibility to 11 antimicrobials by disk diffusion method. Isolates were obtained from the pathoanatomically altered pig's lung that died with signs of respiratory disease. Antimicrobial discs with following concentration were used: ampicillin 10 µg, amoxicillin 10 µg, amoxicillin/clavulanic acid 20/10 µg, cefotaxime 30 µg, gentamicin 10 µg, penicillin 10 IU, streptomycin 10 µg, tetracycline 30 µg, enrofloxacin 5µg, lincospectin 15/200 µg, florfenicol 30 µg and trimethoprim/sulfamethoxazole 1.25/23.75 µg. Isolated strains showed various susceptibility to tested antimicrobials. Seventy-five percent of isolates were resistant to one or more drugs frequently used in the treatment of pig's diseases at farms in Serbia. All 148 isolates were susceptible to cefotaxime, enrofloxacin and florfenicol, while 96% of them were susceptible to amoxicillin/clavulanic acid and lincospectin. Susceptibility of isolates to amoxicillin, gentamicin and trimethoprim/sulfamethoxazole were 91%, 77% and 64%, respectively. The highest resistance rates were determined for tetracycline and streptomycin, 34% and 31%, respectively. When compared to our previous results, we noticed a decrease in resistance to tetracyclines and trimethoprim/sulfamethoxazole. Our results indicate that A. pleuropneumoniae strains isolated from pig's clinical samples in Serbia show high susceptibility to antimicrobial agents which are most often used in the pig industry.

scholarly journals Escherichia coli of Ready-to-Eat (RTE) Meats Origin Showed Resistance to Antibiotics Used by Farmers

Antibiotics ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 869
Author(s):  
Abdulai Abass ◽  
Frederick Adzitey ◽  
Nurul Huda
Keyword(s):  
Escherichia Coli ◽  
Clavulanic Acid ◽  
Bacterial Infections ◽  
Tertiary Education ◽  
Antibiotic Usage ◽  
Diffusion Method ◽  
Resistance Pattern ◽  
Disk Diffusion Method ◽  
E Coli ◽  
Amoxicillin Clavulanic Acid

Bacterial foodborne infections, including meat-derived infections, are globally associated with diseases and some deaths. Antibiotics are sometimes used to treat bacterial infections. The use of antibiotics by farmers contributes to the development of resistance by foodborne pathogens. This study aimed to investigate the antibiotics used by farmers and the occurrence of antibiotic-resistant Escherichia coli in ready-to-eat (RTE) meat sources. Data was obtained from livestock farmers through the administration of semistructured questionnaires (n = 376) to obtain information on their demographics, knowledge and antibiotic usage. The procedure in the USA Food and Drug Administration (FDA)’s Bacteriological Analytical Manual was used for E. coli detection. Antibiotic resistance test was performed using the disk diffusion method. The findings revealed that most of the farmers were male (74.5%), were aged 30−39 years (28.5%), had tertiary education (30.3%) and had 6−10 years of experience in livestock husbandry. Sheep (65.7%) were the most reared livestock, and antibiotics were mostly used to treat sick animals (36.7%). Tetracycline (27.7%) was the most common antibiotic used by farmers, followed by amoxicillin/clavulanic acid (18.6%) and trimethoprim/sulfamethoxazole (11.7%). Most farmers (56.1%) said they had knowledge of antibiotic usage. The prevalence of E. coli in RTE meats was lowest in pork (6.0%) and highest in chevon (20.0%). E. coli isolates from RTE meats were highly resistant to teicoplanin (96.77%), tetracycline (93.55%), amoxicillin/clavulanic (70.97%), azithromycin (70.97%) and trimethoprim/sulfamethoxazole (58.06%) but was susceptible to chloramphenicol (93.55%), ciprofloxacin (61.29%) and ceftriaxone (58.06%). The multiple antibiotic index ranged from 0.22 to 0.78. Multidrug resistance (93.55%) was high among the E. coli isolates. The resistance pattern AmcAzmTecTeSxt (amoxicillin/clavulanic acid–azithromycin–telcoplanin–tetracycline–trimethoprim/sulfamethoxazole) was the most common. The use of antibiotics by farmers must be well regulated. Sellers of RTE meats also ought to take hygiene practices seriously to keep meat safe and healthy for public consumption.

scholarly journals Preparation and Antibacterial Properties of Substituted 1,2,4-Triazoles

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Ionuţ Ledeţi ◽  
Vasile Bercean ◽  
Anda Alexa ◽  
Codruţa Şoica ◽  
Lenuţa-Maria Şuta ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Biological Activities ◽  
Antibacterial Properties ◽  
Pharmaceutical Formulations ◽  
Diffusion Method ◽  
Dilution Method ◽  
Bacterial Strains ◽  
Disk Diffusion Method

Background. Both 1,2,3- and 1,2,4-triazoles are nowadays incorporated in numerous antibacterial pharmaceutical formulations.Aim. Our study aimed to prepare three substituted 1,2,4-triazoles and to evaluate their antibacterial properties.Materials and Methods. One disubstituted and two trisubstituted 1,2,4-triazoles were prepared and characterised by physical and spectroscopic properties (melting point, FTIR, NMR, and GC-MS). The antibacterial properties were studied against three bacterial strains:Staphylococcus aureus(ATCC 25923),Escherichia coli(ATCC 25922), andPseudomonas aeruginosa(ATCC 27853), by the agar disk diffusion method and the dilution method with MIC (minimal inhibitory concentration) determination.Results. The spectroscopic characterization of compounds and the working protocol for the synthesis of the triazolic derivatives are described. The compounds were obtained with 15–43% yields and with high purities, confirmed by the NMR analysis. The evaluation of biological activities showed that the compounds act as antibacterial agents againstStaphylococcus aureus(ATCC 25923), while being inactive againstEscherichia coli(ATCC 25922) andPseudomonas aeruginosa(ATCC 27853).Conclusions. Our results indicate that compounds containing 1,2,4-triazolic moiety have great potential in developing a wide variety of new antibacterial formulations.

scholarly journals CORRELATE BETWEEN BIOFILM FORMATION AND AZOLE ANTIFUNGAL SUSCEPTIBILITY AGAINST PLANKTONIC AND SESSILE CANDIDA ALBICANS CLINICAL ISOLATES

2021 ◽  
Vol 71 (3) ◽  
pp. 1089-93
Author(s):  
Saira Salim ◽  
Raja Kamran Afzal ◽  
Shahzad Hassan ◽  
Aamir Ikram ◽  
Amir Hussain ◽  
...  
Keyword(s):  
Biofilm Formation ◽  
Antifungal Susceptibility ◽  
Clinical Isolates ◽  
Diffusion Method ◽  
Military Hospital ◽  
Dilution Method ◽  
P Value ◽  
Disk Diffusion Method ◽  
Broth Microdilution Method ◽  
Dose Dependent

Objective: To assess the correlation between biofilm formation and azole antifungal susceptibility against plank tonic and sessile clinical isolates of C.albicans. Study Design: Prospective observational study. Place and Duration of Study: Combined Military Hospital Peshawar, from Jun 2016 to Sep 2017. Methodology: All standard microbiological procedures were carried out according to latest Clinical & laboratory standard institute (CLSI) guidelines. After gram staining and presumptive identification on CHRO Magar Candida, the isolates were biochemically identified by API AUX Candida as C.albicans. Planktonic antifungal susceptibility was carried out by Kirby Bauer disk diffusion method on 300 C.albicans isolates. Broth microdilution method was used to determine Minimum inhibitory concentration (MICs) of plank tonic cells and micro titer assay was used for assessment of biofilm formation by C.albicans. Results: In planktonic antifungal susceptibility, fluconazole was susceptible against 195 (65%) and voriconazole against 241 (80%) C. albicans isolates. C. albicans was found susceptible dose dependent (SDD) to fluconazole in 28 (9%) and to voriconazole in 21 (7%) isolates. Seventy-seven (26%) and 38 (13%) C.albicans isolates were found fluconazole and voriconazole resistant, respectively. Sessile antifungal susceptibility was carried out through broth micro dilution method in which 160 (53%) were susceptible, 42 (14%) were susceptible dose dependent SDD and 98 (33%) were resistance to voriconazole, and 161 (54%) were susceptible, 36 (12%) were SDD and 103 (34%) were found resistant to fluconazole. Biofilm forming isolates of C.albicans were observed to be 285 (95%).The p-value is highly significance i.e. <0.01 between......

The In vitro Evaluation of the Antimicrobial Activity of Quercus robur L. Methanolic and Aqueous Leaves’ Extracts, from the Algerian High Plateaus Against some Uropathogenic Microbial Strains

2019 ◽  
Vol 18 (5) ◽  
pp. 262-274
Author(s):  
E. Benyagoub ◽  
N. Nabbou ◽  
S. Boukhalkhel ◽  
I. Dehini
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Enterococcus Faecalis ◽  
Fusidic Acid ◽  
Quercus Robur ◽  
Diffusion Method ◽  
Phytochemical Analysis ◽  
Microbial Strains

The medicinal value of the plants is due to their chemical components that bring a definite physiological action on the human body to prevent the diseases. In this work, we investigated the antimicrobial activity of leaves’ extracts of Quercus robur L., collected from the Algerian upper highlands, on ten bacterial strains and one fungal strain known to be pathogenic. First, we performed a qualitative phytochemical analysis, and second, antimicrobial activity tests performed by agar diffusion method (disc and well) with the determination of MIC by broth macro-dilution method. Given the results, it appears that obtained macerates of Quercus robur L. were rich in bioactive phytoconstituents such as alkaloids, anthraquinones, saponins, tannins, and other components. The yield of aqueous and methanolic macerates of leaves was 8.5 ± 1.41 and 22.4 ± 4.36%, respectively. The bacterial resistance was relatively important to several antibiotics, namely, ampicillin, amoxicillin + clavulanic acid for strains of Escherichia coli and Salmonella sp. However, Staphylococcus aureus strains were resistant to fusidic acid, penicillin, and oxacillin; while Enterococcus faecalis was resistant to fusidic acid, penicillin, oxacillin, and ticarcillin. The antibacterial activity of the macerates toward tested microbial strains showed that the aqueous and methanolic macerates of the leaves were proportional to the tested concentration and active not only against Gram-positive and Gram-negative bacteria but also on the fungal species Candida albicans. The estimated MIC for Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus was in the order of 10 mg/mL, which seems more effective than toward Salmonella sp., Klebsiella pneumoniae, Pseudomonas aeruginosa, and Candida albicans which were in the order of 30 mg/mL. These preliminary results confirm that the part of the studied plant had a very good antimicrobial activity that was proportional to the serial concentrations of the tested extracts.

Antimicrobial Susceptibility Pattern of Staphylococcus Species from Clinical Samples

2020 ◽  
Author(s):  
Muhammad Ali
Keyword(s):  
Clavulanic Acid ◽  
Antibiotic Susceptibility ◽  
Vaginal Swab ◽  
Diffusion Method ◽  
Clinical Samples ◽  
Susceptibility Pattern ◽  
Mannitol Salt Agar ◽  
Agar Disc ◽  
Microbiological Methods ◽  
Amoxicillin Clavulanic Acid

The research was aimed to evaluate the antibiotic susceptibility pattern of Staphylococcus species from clinical samples obtained from some hospitals in Kano metropolis, Nigeria. The ear swab, high vaginal swab (HVS), wound swab and urine samples from the patients attending the hospitals were collected and inoculated onto the surface of freshly prepared Nutrient agar for bacterial isolation. The bacteria isolated were identified by conventional microbiological methods namely; Gram staining, biochemical test (such as catalase, coagulase, and DNase test), mannitol salt agar and heamolysis test. The isolates were subjected to antibiotic susceptibility testing using the agar disc diffusion method. The result showed that S. aureus was highly susceptible to Ciprofloxacin 105 (68.63%), Gentamicin 102 (66.67%), Levofloxacin 95 (62.08%) and Amikacin 90 (58.82%), S. epidermidis was highly susceptible to Gentamicin 13 (61.90%), Levofloxacin 12 (57.14%) and Nitrofurantoin 11 (52.38%) while S. saprophyticus was highly susceptible to Cefoxitin 7 (77.78%), Gentamicin 6 (66.67%) and Nitrofurantoin 5 (55.56%). On the other hand, S. aureus was highly resistant to Cefuroxime 153 (100%), Ceftazidime 150 (98.04%), Amoxicillin/clavulanic acid 120 (78.43%) and Cloxacillin 111 (72.55%), S. epidermidis was highly resistant to Ceftazidime 20 (95.24%), Cloxacillin 19 (90.48%) then Cefoxitin, Erythromycin and Amoxicillin/clavulanic acid with 15 (71.43%) both. S. saprophyticus was highly resistant to Cefepime 9 (100%), Cloxacillin 8 (88.89%), Ceftazidime 7 (77.78%), Imipenem and Erythromycin with 6 (66.67%) respectively. There is a statistical difference in the sensitivity of the isolates against the antibiotics used at p<0.05. It is concluded that Staphylococcus species develop resistance to some classes of antibiotics.

scholarly journals Antifungal Susceptibility and Biofilm Production of Candida spp. Isolated from Clinical Samples

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Munmun B. Marak ◽  
Biranthabail Dhanashree
Keyword(s):  
Antifungal Susceptibility ◽  
Clinical Information ◽  
Antibiotic Use ◽  
Microtiter Plate ◽  
Vaginal Swab ◽  
Diffusion Method ◽  
Clinical Samples ◽  
Candida Spp ◽  
Disk Diffusion Method ◽  
Biofilm Production

Objective. The study aims to speciate clinical Candida isolates and detect their biofilm-forming ability and antifungal resistance. Methods. All the Candida spp. isolated from different clinical samples like pus, urine, blood, and body fluid were included in the study. Biofilm production was tested by the microtiter plate method. Antifungal susceptibility was studied by the disk diffusion method. Patient’s demographic details such as age, sex, and clinical information were collected. Presence of other risk factors such as diabetes mellitus, history of antibiotic use, and any urinary tract instrumentations was also recorded. Results. Among 90 Candida species isolated, most predominant species was found to be C. albicans (45.5%) followed by C. tropicalis (28.88%), C. krusei (20%), C. glabrata (3.33%), and C. parapsilosis (2.22%). Candida spp. were isolated from urine (43%), BAL/sputum (18.88%), high vaginal swab (8.88%), suction tips (7.77%), blood and wound swabs (6.66%), pus (3.33%), bile aspirate (2.22%), and deep tissue (1.11%). A larger number of females were affected than males, and the age group of 51 to 60 years was more susceptible to candidiasis. A higher number of C. albicans isolates produced biofilm followed by C. parapsilosis, C. tropicalis, and C. krusei. However, C. glabrata showed no biofilm production in our study. All Candida isolates were 100% sensitive to amphotericin B. Voriconazole was the next effective drug with 81.11% susceptibility. 24.44% of strains were resistant to fluconazole. Conclusion. Speciation of Candida isolates, detection of ability to form the biofilm, and monitoring of antifungal susceptibility testing are necessary for appropriate treatment.

Synthesis, Characterizations, and Biological Effects Study of Some Quinoline Family

2016 ◽  
pp. 160-196
Author(s):  
Messai Amel
Keyword(s):  
Antibacterial Activity ◽  
Single Crystal ◽  
Biological Activities ◽  
Biological Effects ◽  
Diffusion Method ◽  
Quinoline Derivatives ◽  
Single Crystal Diffraction ◽  
Disk Diffusion Method ◽  
New Approach ◽  
Gram Negative

The objective of this work is the synthesis of new quinoline molecules which could have some biological activities. This chapter reported a new approach to the synthesis of some quinoline derivatives. The Baylis-Hillman reaction on 2-methoxy-3-formyl quinoléines derivatives have applied in order to obtain Baylis-Hillman adducts. The products are characterized by FTIR, NMR and X-ray single crystal diffraction .Also, a study of the antibacterial activity of the 3-(2-chloro quinoline)-3-hydroxy-2 methylene propanonitrile products synthesized have been explored. This assessment is made by using the disk diffusion method. The results showed that the 3-(2'-chloroquinoline)-3-hydroxy-2-methylenepropanonitril derivatives present a good antibacterial effectiveness against the strains tested Gram-positive and no antibacterial potency was observed against the stains Gram-negative used in the test.

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