scholarly journals Prevalence and Factors Associated with Hepatic Steatosis and Fibrosis Using Fibroscan in HIV-positive Patients Treated with Anti-retroviral (ARV) Medicines Referred to the Biggest Hospital in Tehran, 2018 to 2019

2020 ◽  
Vol 14 (1) ◽  
pp. 108-113
Author(s):  
Mehrnaz Rasoulinejad ◽  
Seyed Ahmad Seyed Alinaghi ◽  
Masoud Reza Sohrabi ◽  
Banafsheh Moradmand Badie ◽  
Seyed Ali Dehghan Manshadi ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Hepatic Steatosis ◽  
Transient Elastography ◽  
Cross Sectional Study ◽  
Health Concern ◽  
Hiv Positive ◽  
People Living With Hiv ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Infection Period

Background: Liver injury is a characteristic feature of HIV infection, which is the second most common cause of mortality among HIV positive patients. Non-alcoholic fatty liver disease (NAFLD) has become a new concern in the management of people living with HIV (PLWH). The condition encompasses a spectrum of diseases from non-alcoholic steatohepatitis (NASH) to fibrosis and cirrhosis. The current study was to evaluate hepatic steatosis and fibrosis using fibroscan among PLWH treated with anti-retroviral (ARV) medicines. Methods: The present research was designed as a cross-sectional study and 100 HIV positive patients under antiretroviral treatment (ART) were enrolled in the study. All PLWH, including 49 men (49%) and 51 women (51%) (Mean age of 39.9 years), were evaluated by Transient Elastography (TE) in Imam Khomeini Hospital during 2018 and 2019. Results: The mean CD4 count was 610 cells/μl, 4% with CD4 < 200 cells/μl, 30% between 201 and 500cells/μl, and 66% with CD4 >500 cells/μl. Based on the TE result, 10% of patients had significant fibrosis (F2:6% and F3:4%) and most of the patients had mild fibrosis (F1:77%). A significant, direct relationship was found between HIV infection duration and fibrosis, especially in the duration of more than five years of the disease. There was no significant association between liver fibrosis and other factors (P>0.05). Conclusion: The presence of hepatic fibrosis and steatosis demonstrates the main health concern for PLWH mono-infection, and mainly transient elastography is recommended for HIV mono-infected patients, especially if their infection period is over five years.

scholarly journals Prevalence of syphilis in people living with HIV/AIDS: A Hospital based Cross-Sectional Study

2020 ◽  
Vol 10 (1) ◽  
pp. 42-45
Author(s):  
Suresh Jaiswal ◽  
Laxman Banstola ◽  
Manisha Shrestha ◽  
Srijana Sapkota ◽  
Sujan Sharma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Transmitted Disease ◽  
Cross Sectional Study ◽  
Public Hospitals ◽  
Health Concern ◽  
Hiv Positive ◽  
People Living With Hiv ◽  
Sectional Study ◽  
Syphilis Infection ◽  
Cross Sectional

Introduction: Syphilis, a sexually transmitted disease is one of the oldest diseases caused by the bacterium Treponema pallidum, has been a major public health concern worldwide. The aim is to find out the prevalence of syphilis and its risk factors among people with HIV at Western Regional hospital in Nepal. Methods: A hospital-based cross-sectional study was conducted at one of the largest public hospitals in Western Region of Nepal. A consecutive 90 HIV-positive patients were recruited prospectively from December 2016 to February 2017. Blood samples and data on sociodemographic and risk factors were collected. Serum were diagnosed for syphilis using Rapid Plasma Reagin (RPR) test. Results: The prevalence of syphilis infection was 12.2% in HIV positive participants. Syphilis occurred exclusively in male 7 comparatively 4 in female. Seropositivity of syphilis was seen higher in married than unmarried HIV infected individuals. Syphilis prevalence seems to increase with increasing age, with the highest rate in the age group 35–50 years. A decreasing rate of syphilis was observed with increasing educational level, where illiterate HIV-positive participants had higher infection compared with those having at least a certificate. Conclusion: Higher prevalence of syphilis in people with HIV infection demands the need to target this people to prevent the transmission of both infections. Testing for all HIV-infected people for syphilis and management of the infected would have clinical and epidemiological importance.

scholarly journals Anolunula in Fingernails among Patients Infected with HIV

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Pratik Gahalaut ◽  
Nitin Mishra ◽  
Sandhya Chauhan ◽  
Mir Mubashir Ali ◽  
Madhur Kant Rastogi ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Cross Sectional Study ◽  
Negative Control ◽  
Hiv Positive ◽  
Control Group ◽  
Cross Sectional ◽  
Significant Difference ◽  
Stage 1 ◽  
And Control ◽  
Hiv Negative

Lunula is the white, half-moon shaped area seen in proximal ends of some nails. Though a few studies have described the nail changes that can occur in association with HIV infection, none of these paid much attention to lunula. Aims and Objectives. To study the lunula in fingernails among HIV infected patients. Materials and Methods. An observational, cross-sectional study to record presence of lunula in 168 HIV-positive patients and compare it with age and sex matched 168 healthy HIV-negative control. Anolunula (absence of lunula) in HIV-positive patients was correlated with CD4 counts, stages of HIV infection, time since patient was diagnosed as HIV-positive, and status of antiretroviral therapy. Results. Anolunula was present in significantly more fingernails in HIV-positive patients compared to HIV-negative controls. There was a highly significant difference for total anolunula (anolunula in all fingernails) in study and control group. Incidence of total anolunula was directly proportional to the stage of HIV infection, increasing progressively as the HIV infection advances from stage 1 to stage 4. Conclusion. Absence of lunula is related to not only HIV infection per se but also the stages of HIV infection.

Transactional Sex Among Women Accessing Antiretroviral Care in Sagamu, Nigeria: A Descriptive Survey

2018 ◽  
Vol 39 (4) ◽  
pp. 225-231 ◽  
Author(s):  
Victor Jide Animasahun ◽  
Oluwafolahan O. Sholeye ◽  
Bankole K. Oyewole
Keyword(s):  
Hiv Transmission ◽  
Cross Sectional Study ◽  
Transactional Sex ◽  
Health Concern ◽  
Treatment Center ◽  
People Living With Hiv ◽  
Food Ration ◽  
Cross Sectional ◽  
Assistance Programs ◽  
Ogun State

HIV prevalence and transmission is still of public health concern in low-resource climes like Nigeria. Transactional sex is a well-known risk factor for HIV transmission. This study therefore assessed the prevalence of transactional sex and associated factors among women attending the antiretroviral clinic in Sagamu, Nigeria. A cross-sectional study was carried out among 204 women attending antiretroviral treatment center in Sagamu, Ogun State, Nigeria, selected via total population recruitment. Data were collected using a validated, semistructured questionnaire. Respondents’ written informed consent was obtained. The mean age of respondents was 38.3 ± 9.0 years. Two thirds (66%) were in monogamous marriages. About two thirds (64.2%) had at least secondary education. Almost 50% spent more than half of their income on food. About 90% had commenced antiretroviral therapy. The prevalence of transactional sex was 7.4%. Household size ( p = .031), marital status ( p = .015), reduction of food ration ( p = .010), skipping of medication ( p = .001), and starving for a whole day ( p = .044) were associated with transactional sex. Food assistance programs, socioeconomic empowerment schemes, and targeted counseling should be given to people living with HIV to halt HIV transmission.

scholarly journals Barriers to Acceptance of Provider-Initiated Testing and Counseling among Men Who Have Sex with Men in Shenyang, China: A Cross-Sectional Study

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Qinghai Hu ◽  
Junjie Xu ◽  
Zhenxing Chu ◽  
Jing Zhang ◽  
Ke Yun ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Hiv Testing ◽  
Cross Sectional Study ◽  
Multivariate Logistic Regression Model ◽  
People Living With Hiv ◽  
Cross Sectional ◽  
Aids Knowledge ◽  
Sex With Men ◽  
Testing And Counseling ◽  
Hiv Aids

A high prevalence of HIV infection is present among men who have sex with men (MSM) in China, but many people living with HIV or AIDS (PLWHs) are unaware of their HIV infection status. Provider-initiated HIV testing and counseling (PITC) is a streamlined model that can significantly enhance HIV detection and detect infections earlier. However, PITC has not yet been widely applied, and no studies have been conducted on MSM’s attitudes towards PITC in China. In this study, a total of 438 MSM were recruited in Shenyang city. A multivariate logistic regression model showed that certain conditions made MSM more accepting of PITC: those who had attended VCT (voluntary counseling and testing) more than three times (odds ratio [OR]: 2.95, 95% CI: 1.36–6.37), those who considered PITC beneficial for family and friends (OR: 1.91, 95% CI: 1.25–2.92), those who obtained HIV/AIDS knowledge from brochures (OR: 2.52, 95% CI: 1.64–3.87), those who obtained HIV/AIDS knowledge from the Internet (OR: 1.66, 95% CI: 1.07–2.58), and those who were highly aware of their own risk of being infected with HIV (OR: 2.84, 95% CI: 1.37–5.91). To improve acceptance of PITC among MSM in China, stronger efforts are needed to lower the psychosocial barriers to receiving PITC, to promote HIV/AIDS awareness, and to encourage the extension of HIV testing.

scholarly journals Effect of HIV Infection on Mortality in Patients with Tuberculosis in Asia: A Meta-Analysis

2020 ◽  
Author(s):  
Liza Laela Abida ◽  
◽  
Bhisma Murti ◽  
Hanung Prasetya ◽  
◽  
...  
Keyword(s):  
Hiv Infection ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Cross Sectional ◽  
Risk Of Mortality ◽  
Hiv Mortality ◽  
Keywords Hiv

ABSTRACT Background: TB/HIV coinfectioned remains the leading cause of mortality among people living with HIV (PLHIV). The purpose of this study was to explore the effect of HIV infection on mortality in patients with tuberculosis in Asia. Subjects and Method: This was meta-analysis and systematic review. The study was conducted by collecting published studies from Google Scholar, PubMed, Springer Link, Hindawi, Clinical Key, and ProQuest databases, from 2010 to 2020. Keywords used “HIV” AND “mortality” OR “HIV Mortality” OR “Tuberculosis Mortality” AND “cross sectional” AND “adjusted odd ratio”. The inclusion criteria were full text, using English or Indonesian language, using cross-sectional study design, and reporting adjusted odds ratio. The articles were selected by PRISMA flow chart. The quantitative data were analyzed using random effect model run on Review Manager 5.3. Results: 5 studies in Asia (Thailand, China, Malaysia, and Oman) were included for this study. Meta analysis study reported that HIV elevated the risk of mortality in patients with tuberculosis (aOR= 3.45; 95% CI= 1.14 to 10.45; p = 0.030). Conclusion: HIV elevates the risk of mortality in patients with tuberculosis. Keywords: HIV, mortality, Tuberculosis Correspondence: Liza Laela Abida. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: 085640115633. DOI: https://doi.org/10.26911/the7thicph.01.52

scholarly journals Clinicoepidemiological Profile of Elderly PLHIV Attending a Tertiary Care Center in South India

2017 ◽  
Vol 16 (6) ◽  
pp. 620-623 ◽  
Author(s):  
Deepak Madi ◽  
Neha Ramakrishnan ◽  
Bhaskaran Unnikrishnan ◽  
John Ramapuram ◽  
Basavaprabhu Achappa ◽  
...  
Keyword(s):  
Care Center ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
World Health ◽  
Hiv Positive ◽  
People Living With Hiv ◽  
Age Group ◽  
Elderly Age ◽  
Cross Sectional ◽  
Route Of Transmission

Background: Physicians are coming across a considerable number of HIV-positive patients belonging to older age-group, in practice. They pose a challenge as they might present with advanced forms and comorbid conditions. We aimed to describe the clinicoepidemiological profile of elderly people living with HIV. Methodology: We conducted a cross-sectional study at Kasturba Medical College, Mangalore. We analyzed the record of 120 patients from 2009 to 2014. Descriptive statistics were used to describe sociodemographic and clinical profile of patients. Results: Of 786 HIV-positive patients, 120 were elderly. Mean age was 55.9 ± 6.1 years. Majority 68% were male. In all, 63.33% were male. Commonest route of transmission was heterosexual intercourse, most presented at World Health Organization (WHO) stage 1 (64.17%). In all, 77.5% had hypertension and 26.6% had tuberculosis. The median CD4 count at presentation was 245 cells/mm3 (145-426 cells/mm3). Forty-two percent were late presenters (CD4 <200 cells/mm3). Conclusion: Treating physician should have a high index of suspicion in diagnosing HIV among elderly age-group.

scholarly journals The Relationship between HIV Duration, Insulin Resistance and Diabetes Risk

2021 ◽  
Vol 18 (8) ◽  
pp. 3926
Author(s):  
Eduard Tiozzo ◽  
Allan Rodriguez ◽  
Janet Konefal ◽  
Gary J. Farkas ◽  
Jennifer L. Maher ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Hiv Infection ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Long Term Effects ◽  
Cross Sectional ◽  
Living With Hiv ◽  
The Relationship

The risk of developing Type 2 Diabetes Mellitus in people living with HIV (PLWH) can be four times greater and can occur at an earlier age and even without the presence of obesity compared to those without HIV. Therefore, the purpose of this analytical cross-sectional study was to determine the relationship between HIV duration and glucose metabolism among PLWH. Eighty-two PLWH were categorized into shorter (≤15 years) or longer HIV duration (≥16 years) and then compared for differences in demographics, physical and clinical characteristics, biomarkers, and dietary intake. Compared to those with shorter HIV duration (n = 34), those with longer HIV duration (n = 48) were on average older (p = 0.02), reported lower consumption of alcohol (p = 0.05), had higher levels of homeostasis model assessment of insulin resistance (HOMA-IR, p = 0.02), were also more likely to be a woman (p = 0.06), and have higher levels of fasting insulin (p = 0.06). When adjusted for age and body weight, the levels of HOMA-IR and fasting insulin were higher (p = 0.02 and p = 0.04) with longer compared to shorter HIV duration, respectively. Longer exposure to HIV infection is associated with impaired insulin sensitivity. Continuing research aimed at the long-term effects of HIV infection and (antiretroviral therapy) is required.

scholarly journals Assessment of the Association of HIV Infection with Hepatic Steatosis or Fibrosis: a Cross-Sectional, Case-Control Study

2021 ◽  
Author(s):  
Paula Debroy ◽  
Sanjana Nagraj ◽  
Natalia Chamorro-Pareja ◽  
Neva Castro ◽  
Alejandro de Leon ◽  
...  
Keyword(s):  
Risk Factor ◽  
Hiv Infection ◽  
Hepatic Steatosis ◽  
Independent Risk Factor ◽  
People Living With Hiv ◽  
City Hospital ◽  
Advanced Fibrosis ◽  
Cross Sectional ◽  
Care Clinic ◽  
Living With Hiv

Abstract Background: Human immunodeficiency virus (HIV) infection and antiretroviral therapy have been associated with non-alcoholic fatty liver disease (NAFLD), but few studies have evaluated whether HIV infection is an independent risk factor for the development of hepatic steatosis and advanced liver fibrosis. Objectives: To study the prevalence and severity of hepatic steatosis and advanced fibrosis in people living with HIV and control outpatients. Methods: We conducted a cross-sectional analysis of relevant data from 875 pairs of individuals belonging to an HIV-dedicated outpatient clinic and an adult primary care clinic of an inner-city hospital. Hepatic Steatosis Index (HSI) and FIB-4 index were calculated as non-invasive measures of steatosis and fibrosis, respectively. A multivariate logistic regression analysis was performed to assess predictors of steatosis and advanced fibrosis. Results: The prevalence of hepatic steatosis, determined by HSI ≥36, was higher in HIV-negative subjects (71.5% vs. 65.4%, p=0.006). The prevalence of advanced fibrosis, determined by FIB-4 index ≥3.25, was higher in the HIV-positive group (7% vs. 1.7%, p <0.001). Multivariable analysis did not identify HIV infection to be an independent risk factor for hepatic steatosis (p=0.068) and advanced fibrosis. Conclusions: In this cohort, hepatic steatosis was more prevalent in non-HIV infected patients, while advanced fibrosis had a higher prevalence in people living with HIV. HIV infection was not found to be an independent risk factor for either hepatic steatosis or fibrosis.

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