Functionalized Biogenic Nanoparticles for use in Emerging Biomedical Applications: A Review

2020 ◽  
Vol 05 ◽  
Author(s):  
Samvidha Das ◽  
Aman Bhardwaj ◽  
Lalit M. Pandey
Keyword(s):  
Biomedical Applications ◽  
Colloidal Stability ◽  
Dna Nanoparticles ◽  
Chemical Reagents ◽  
Functionalized Nanomaterials ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Properties Of Materials ◽  
Nano Size ◽  
Biogenic Nanoparticles

Background: The widespread uses of nanomaterials for healthcare and biomedical applications such as their anti-cancer activity, anti-oxidant activity and antimicrobial activity, have been avidly studied in recent decades. Owing to the cytotoxicity and harmful by-product generation associated with chemical reagents, plant and microbial-based approach have been preferred for the synthesis purposes. Results: These synthesized nanoparticles possess characteristic properties attributed to their nano-size compared to their macroscopic counterparts. Further, the functionalization of nanomaterials via chemical, physical and biofunctionalization techniques improves the intrinsic, tactile, and associated properties of materials and devices. The functionalized nanomaterials have been explored for the improved colloidal stability, development of smart nanocapsules, DNA-nanoparticles conjugates, protein-nanoparticles conjugates and nano-antibiotics. Conclusion: In this review, the synthesis of biogenic nanoparticles, their properties and applications are explored, and its surface modification and implications towards improved properties are emphasized.

Role of Rasayan Churna in outbreak of Covid -19 as preventive and curative aspect

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1208-1212
Author(s):  
Amol Madhav Deshpande ◽  
Mayuri Amol Deshpande
Keyword(s):  
Recurrent Infection ◽  
Symptomatic Patient ◽  
H1n1 Influenza ◽  
Drug Of Choice ◽  
Asymptomatic Patients ◽  
Diseased Person ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Immune Booster ◽  
Respiratory Droplets

In last two decade world suffer with three epidemic diseases like SARS-CoV, H1N1 influenza, MERS –CoV and presently the world under a pandemic of Covid-19, out of these SARS-CoV, MERS –CoV and Covid-19 are form the same virus call as corona, which primary present on bats and transferred from animal to human, and then it transfer from human to human mostly by respiratory droplets or in the direct contact with the diseased person, these recurrent infection of corona virus is the burning issue in the word, so to avoid these recurrent infections good habitual behaviour with regular immune booster medicine should be taken which can be used in both normal and symptomatic patient for this Rasayan churna  is the best drug of choice as it is used for  rejuvenation therapy. From literally study from various recourses it is found that Rasayan churna have property anti-depressant, anti-xylotic, Immunomodulatory, Anti-diabetes, anti hypertensive, anti-inflammatory, Anti-toxic effects, Anti-arthritic, Anti-cancer effects, Anti-microbial effect, and Anti-oxidant which can be useful in preventive aspect of Covid -19 in all phase like normal individual, also can be used in asymptomatic patients and symptomatic patients, clinical study can be performed for the same to evaluate the result.

1,4-Dihydropyridine: A Dependable Heterocyclic Ring with the Promising and the Most Anticipable Therapeutic Effects

2019 ◽  
Vol 19 (15) ◽  
pp. 1219-1254 ◽  
Author(s):  
Abhinav Prasoon Mishra ◽  
Ankit Bajpai ◽  
Awani Kumar Rai
Keyword(s):  
Calcium Ion ◽  
Heterocyclic Compounds ◽  
Channel Blocker ◽  
Heterocyclic Ring ◽  
Therapeutic Effects ◽  
Voltage Gated ◽  
Therapeutic Benefits ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Synthetic Medicinal

: Nowadays, heterocyclic compounds act as a scaffold and are the backbone of medicinal chemistry. Among all of the heterocyclic scaffolds, 1,4-Dihydropyridine (1,4-DHP) is one of the most important heterocyclic rings that possess prominent therapeutic effects in a very versatile manner and plays an important role in synthetic, medicinal, and bioorganic chemistry. The main aim of the study is to review and encompass relevant studies related to 1,4-DHP and excellent therapeutic benefits of its derivatives. An extensive review of Pubmed-Medline, Embase and Lancet’s published articles was done to find all relevant studies on the activity of 1,4-DHP and its derivatives. 1,4-DHP is a potent Voltage-Gated Calcium Channel (VGCC) antagonist derivative which acts as an anti-hypertensive, anti- anginal, anti-tumor, anti-inflammatory, anti-tubercular, anti-cancer, anti-hyperplasia, anti-mutagenic, anti-dyslipidemic, and anti-ulcer agent. From the inferences of the study, it can be concluded that the basic nucleus, 1,4-DHP which is a voltage-gated calcium ion channel blocker, acts as a base for its derivatives that possess different important therapeutic effects. There is a need of further research of this basic nucleus as it is a multifunctional moiety, on which addition of different groups can yield a better drug for its other activities such as anti-convulsant, anti-oxidant, anti-mutagenic, and anti-microbial. This review would be significant for further researches in the development of several kinds of drugs by representing successful matrix for the medicinal agents.

Progress and Prospects in Translating Nanobiotechnology in Medical Theranostics

2020 ◽  
Vol 16 (5) ◽  
pp. 685-707 ◽  
Author(s):  
Amna Batool ◽  
Farid Menaa ◽  
Bushra Uzair ◽  
Barkat Ali Khan ◽  
Bouzid Menaa
Keyword(s):  
Biological Properties ◽  
Chemical Characteristics ◽  
Intrinsic Properties ◽  
The Past ◽  
Profound Influence ◽  
Functionalized Nanomaterials ◽  
Physico Chemical ◽  
Properties Of Materials ◽  
Targeted Drug ◽  
And Performance

: The pace at which nanotheranostic technology for human disease is evolving has accelerated exponentially over the past five years. Nanotechnology is committed to utilizing the intrinsic properties of materials and structures at submicroscopic-scale measures. Indeed, there is generally a profound influence of reducing physical dimensions of particulates and devices on their physico-chemical characteristics, biological properties, and performance. The exploration of nature’s components to work effectively as nanoscaffolds or nanodevices represents a tremendous and growing interest in medicine for various applications (e.g., biosensing, tunable control and targeted drug release, tissue engineering). Several nanotheranostic approaches (i.e., diagnostic plus therapeutic using nanoscale) conferring unique features are constantly progressing and overcoming all the limitations of conventional medicines including specificity, efficacy, solubility, sensitivity, biodegradability, biocompatibility, stability, interactions at subcellular levels. : This review introduces two major aspects of nanotechnology as an innovative and challenging theranostic strategy or solution: (i) the most intriguing (bare and functionalized) nanomaterials with their respective advantages and drawbacks; (ii) the current and promising multifunctional “smart” nanodevices.

scholarly journals Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 261
Author(s):  
Orlando Donoso-González ◽  
Lucas Lodeiro ◽  
Álvaro E. Aliaga ◽  
Miguel A. Laguna-Bercero ◽  
Soledad Bollo ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Colloidal Stability ◽  
Biomedical Application ◽  
Drug Loading ◽  
Gold Nanostars ◽  
Raman Optical Activity ◽  
Cationic Group ◽  
Low Cytotoxicity ◽  
Stability Limits ◽  
Zeta Potential Analysis

Gold nanostars (AuNSs) exhibit modulated plasmon resonance and have a high SERS enhancement factor. However, their low colloidal stability limits their biomedical application as a nanomaterial. Cationic β-cyclodextrin-based polymer (CCD/P) has low cytotoxicity, can load and transport drugs more efficiently than the corresponding monomeric form, and has an appropriate cationic group to stabilize gold nanoparticles. In this work, we functionalized AuNSs with CCD/P to load phenylethylamine (PhEA) and piperine (PIP) and evaluated SERS-based applications of the products. PhEA and PIP were included in the polymer and used to functionalize AuNSs, forming a new AuNS-CCD/P-PhEA-PIP nanosystem. The system was characterized by UV–VIS, IR, and NMR spectroscopy, TGA, SPR, DLS, zeta potential analysis, FE-SEM, and TEM. Additionally, Raman optical activity, SERS analysis and complementary theoretical studies were used for characterization. Minor adjustments increased the colloidal stability of AuNSs. The loading capacity of the CCD/P with PhEA-PIP was 95 ± 7%. The physicochemical parameters of the AuNS-CCD/P-PhEA-PIP system, such as size and Z potential, are suitable for potential biomedical applications Raman and SERS studies were used to monitor PhEA and PIP loading and their preferential orientation upon interaction with the surface of AuNSs. This unique nanomaterial could be used for simultaneous drug loading and SERS-based detection.

scholarly journals Structure-Based Designing, Solvent Less Synthesis of 1,2,3,4-Tetrahydropyrimidine-5-carboxylate Derivatives: A Combined In Vitro and In Silico Screening Approach

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4424
Author(s):  
Uzma Arshad ◽  
Sibtain Ahmed ◽  
Nusrat Shafiq ◽  
Zaheer Ahmad ◽  
Aqsa Hassan ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Catalytic Amount ◽  
Pyrimidine Derivatives ◽  
Qsar Studies ◽  
Lead Compounds ◽  
Biological Potential ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Vitro Analysis

Objective: In this study, small molecules possessing tetrahydropyrimidine derivatives have been synthesized having halogenated benzyl derivatives and carboxylate linkage. As previously reported, FDA approved halogenated pyrimidine derivatives prompted us to synthesize novel compounds in order to evaluate their biological potential. Methodology: Eight pyrimidine derivatives have been synthesized from ethyl acetoacetate, secondary amine, aromatic benzaldehyde by adding catalytic amount of CuCl2·2H2O via solvent less Grindstone multicomponent reagent method. Molecular structure reactivity and virtual screening were performed to check their biological efficacy as an anti-oxidant, anti-cancer and anti-diabetic agent. These studies were supported by in vitro analysis and QSAR studies. Results: After combined experimental and virtual screening 5c, 5g and 5e could serve as lead compounds, having low IC50 and high binding affinity.

scholarly journals A New Approach to Obtaining Nano-Sized Graphene Oxide for Biomedical Applications

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1327
Author(s):  
Paulina Bolibok ◽  
Bartosz Szymczak ◽  
Katarzyna Roszek ◽  
Artur P. Terzyk ◽  
Marek Wiśniewski
Keyword(s):  
Graphene Oxide ◽  
Biomedical Applications ◽  
Effective Concentration ◽  
New Approach ◽  
Spectral Changes ◽  
Dimethyl Sulfoxide Solution ◽  
Aggregation Processes ◽  
Initial Oxygen ◽  
Half Maximal Effective Concentration ◽  
Nano Size

Graphene oxide (GO) is one of the most exciting and widely used materials. A new method of nanographene oxide (n-GO) formation is presented. The described unique sequence of ultrasonication in dimethyl sulfoxide solution allows us to obtain different sizes of n-GO sheets by controlling the timing of the cutting and re-aggregation processes. The obtained n-GO exhibits only minor spectral changes, mainly due to the formation of S-containing surface groups; thus, it can be concluded that the material is not reduced during the process. Maintaining the initial oxygen functionalities together with the required nano-size (down to 200 nm) and high homogeneity are beneficial for extensive applications of n-GO. Moreover, we prove that the obtained material is evidently biocompatible. The calculated half-maximal effective concentration (EC50) increases by 5-fold, i.e., from 50 to 250 µg/mL, when GO is converted to n-GO. As a consequence, the new n-GO neither disturbs blood flow even in the narrowest capillaries nor triggers a toxic influence in surrounding cells. Thus, it can be a serious candidate for drugs and biomolecule carriers administered systemically.

Pre-coating layered double hydroxide nanoparticles with albumin to improve colloidal stability and cellular uptake

2015 ◽  
Vol 3 (16) ◽  
pp. 3331-3339 ◽  
Author(s):  
Zi Gu ◽  
Huali Zuo ◽  
Li Li ◽  
Aihua Wu ◽  
Zhi Ping Xu
Keyword(s):  
Layered Double Hydroxide ◽  
Cellular Uptake ◽  
Biomedical Applications ◽  
Colloidal Stability ◽  
New Strategy ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

We introduced a new strategy of albumin pre-coating to effectively stabilise layered double hydroxide (LDH) nanoparticles for biomedical applications.

scholarly journals Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2846
Author(s):  
Seung Hyuk Im ◽  
Dam Hyeok Im ◽  
Su Jeong Park ◽  
Justin Jihong Chung ◽  
Youngmee Jung ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Drug Carrier ◽  
Micelle Formation ◽  
Weak Stability ◽  
Critical Fields ◽  
Physical Strength ◽  
Anti Cancer

Polylactide (PLA) is among the most common biodegradable polymers, with applications in various fields, such as renewable and biomedical industries. PLA features poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA) enantiomers, which form stereocomplex crystals through racemic blending. PLA emerged as a promising material owing to its sustainable, eco-friendly, and fully biodegradable properties. Nevertheless, PLA still has a low applicability for drug delivery as a carrier and scaffold. Stereocomplex PLA (sc-PLA) exhibits substantially improved mechanical and physical strength compared to the homopolymer, overcoming these limitations. Recently, numerous studies have reported the use of sc-PLA as a drug carrier through encapsulation of various drugs, proteins, and secondary molecules by various processes including micelle formation, self-assembly, emulsion, and inkjet printing. However, concerns such as low loading capacity, weak stability of hydrophilic contents, and non-sustainable release behavior remain. This review focuses on various strategies to overcome the current challenges of sc-PLA in drug delivery systems and biomedical applications in three critical fields, namely anti-cancer therapy, tissue engineering, and anti-microbial activity. Furthermore, the excellent potential of sc-PLA as a next-generation polymeric material is discussed.

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