scholarly journals The role of diacereins in the treatment of osteoarthritis from the point of view of a new paradigm of pathogenesis

2021 ◽  
Vol 2 (4) ◽  
pp. 79-84
Author(s):  
L. N. Eliseeva ◽  
S. V. Kartashova

Among the most common diseases of humanity in patients of the older age group, there is an articular pathology with degenerative changes in the hyaline cartilage, which significantly limits the functional activity of the locomotor apparatus. The rapid development of experimental scientific research in recent decades has made it possible to revise the concept of the pathogenesis of this process with confirmation of the leading role of inflammation in the development of functional and structural damage in this disease. These new data supported the change in the name of the disease from “osteoarthros” to “osteoarthritis” and justified the positive effects of individual drugs. The proposed lecture material discloses the topic of the modern understanding of the pathogenesis of osteoarthritis and the additional benefits of using drugs from the diacerein group due to their anti‑inflammatory and chondroprotective effect.

2019 ◽  
pp. 22-29
Author(s):  
Н. В. Фрадкіна

The purpose and tasks of the work are to analyze the contemporary Ukrainian mass culture in terms of its value and humanistic components, as well as the importance of cultural studies and Ukrainian studies in educational disciplines for the formation of a holistic worldview of modern youth.Analysis of research and publications. Scientists repeatedly turned to the problems of the role of spirituality in the formation of society and its culture. This problem is highlighted in the publications by O. Losev, V. Lytvyn, D. Likhachev, S. Avierintsev, M. Zakovych, I. Stepanenko and E. Kostyshyn.Experts see the main negative impact of mass culture on the quality approach, which determines mass culture through the market, because mass culture, from our point of view, is everything that is sold and used in mass demand.One of the most interesting studies on this issue was the work by the representatives of Frankfurt School M. Horkheimer and T. Adorno «Dialectics of Enlightenment» (1947), devoted to a detailed analysis of mass culture. Propaganda at all socio-cultural levels in the form is similar in both totalitarian and democratic countries. It is connected, according to the authors, with the direction of European enlightenment. The tendency to unify people is a manifestation of the influence of mass culture, from cinema to pop. Mass culture is a phenomenon whose existence is associated with commerce (accumulation in any form – this is the main feature of education), in general, the fact that it exists in this form is related to the direction of the history of civilization.Modern mass culture, with its externally attractive and easily assimilated ideas and symbols, appealing to the trends of modern fashion, becomes a standard of prestigious consumption, does not require intense reflection, allows you to relax, distract, not teach, but entertains, preaches hedonism as the main spiritual value. And as a consequence, there are socio-cultural risks: an active rejection of other people, which leads to the formation of indifference; cruelty as a character trait; increase of violent and mercenary crime; increase in the number of alcohol and drug addicts; anti-patriotism; indifference to the values of the family and as a result of social orphanhood and prostitution.Conclusions, perspectives of research. Thus, we can conclude that modern Ukrainian education is predominantly formed by the values of mass culture. Namely, according to the «Dialectic» by Horkheimer and Adorno, «semi-enlightenment becomes an objective spirit» of our modern society.It is concluded that only high-quality education can create the opposite of the onset of mass culture and the destruction of spirituality in our society. It is proved that only by realizing the importance of cultivating disciplines in the educational process and the spiritual upbringing of the nation, through educational reforms, humanitarian knowledge will gradually return to student audiences.Formation of youth occurs under the influence of social environment, culture, education and self-education. The optimal combination of these factors determines both the process of socialization itself and how successful it will be. In this context, one can see the leading role of education and upbringing. It turns out that the main task of modern education is to spread its influence on the development of spiritual culture of the individual, which eventually becomes a solid foundation for the formation of the individual. Such a subject requires both philosophical and humanitarian approaches in further integrated interdisciplinary research, since the availability of such research will provide the theoretical foundation for truly modern educational and personal development.


Resources ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 87
Author(s):  
Yury Nurulin ◽  
Inga Skvortsova ◽  
Iosif Tukkel ◽  
Marko Torkkeli

Knowledge has always been, and still is, a crucial source of economy. However, during the past few years we have seen a growing interest in treating knowledge as a significant organizational resource for innovation. This trend coincides with the rapid development of ICT, indicating the strong influence that ICTs have on the processes of creating, disseminating, and using knowledge. At present, issues of innovation management and knowledge management are studied independently, which creates a certain gap in the systemic understanding of the innovation development processes. The paper proposes an integrated approach to the issues mentioned. The hierarchy and taxonomy of knowledge are considered from the point of view of their influence on decision-making at different stages of the innovation lifecycle. Our proposition complements and contributes to several recent models of decision-making developed in the frame of the innovation process.


Author(s):  
N.V DEVDARIANI ◽  
◽  
E.V RUBTSOVA ◽  

This article presents the methodological development of lectures, material which may be used in the study course "Philosophy", "Philosophy of science and technology" and "concepts of modern natural Sciences" (cmns) for students of the Humanities in Russian universities. This lecture on "Philosophical understanding of the concept of "life": biocentricity picture of the world" presents the main approaches to the idea of the modern scientific picture of the world. Such a summary of the lecture material, according to the authors, due to the need to change existing approaches to teaching of specific disciplines. In particular those which involve integrated knowledge from different scientific disciplines and the subject of study which are universal categories and phenomena. It is noted that in the conditions of modern technogenic civilization machineoriented, justified is the issue of revision of existing views about the current ideological approach to the basic concepts, components of a comprehensive scientific picture of the world. In this article, the authors examine biocentricity picture of the world in which the author focuses on the leading role of the life. It is concluded that a comprehensive summary of the lecture material various areas of scientific knowledge, contributes to the formation of metacognitive abilities of students in the course of studying the above disciplines.


Author(s):  
Yevhen Nakhlik

The article draws a parallel between P. Kulish’s and I. Franko’s disposition to the age-related ideological autorevision. It is argued that, experiencing evolution of the worldview and creative work, revising his own early radical social impulses caused by the ‘national radical stage’ (Franko’s definition) of liberation movement in Halychyna, mature Franko in 1896 – 1907 got closer to the views of P. Kulish, especially those of the late period of his life (1874 – 1897). Like the latter, Franko defended the right to worldview evolution and changing views. These typological coincidences consisted also in the movement from the center-left forces to the right-centered ones; the transition to the primacy of the national idea over the social one; the drastic national self-criticism and simultaneous emphasis on the nation-building and state-building; gradual reorientation from the idea of social revolutionary development of society to evolutionary progress and moderate “means and ways of acting and speaking” (as Franko called it); the warnings against admiring communist illusion, against ochlocracy; and, finally, in the focus on the leading role of the nationally conscious Ukrainian intellectuals in the liberation struggle. Ideological and formal parallels between Franko and Kulish were revealed not only in the letters and journalism, but also in Franko’s practice of grounding his works on the materials of the national, biblical and Christian history and mythology (i. e. literary historicism and mythologism, focused on the present, the future and the author’s personality; symbolic autobiography). From this point of view it is worth to compare:  “Pisnia Budushchyny” (“Song of Future”) – “Try Braty” (“Three Brothers”); “Pokhoron” (“Funeral”), “Ivan Vyshenskyi” – “Velyki Provody” (“Great Farewell Procession”), “Marusia Bohuslavka”, “Dramovana Trylohiia” (“Drama-like Trilogy”); “Moisei” (“Moses”) – “Mahomet i Khadyza” (“Muhammad and Hadiza”), “Duma-Perestoroha, Velmy na Potomni Chasy Potribna” (“Warning Refl ections that will be Needed in Future”); “Strashnyi Sud” (“The Last Judgement”) – “Kulish u Pekli” (“Kulish in Hell”); “Slavianska Oda” (“Slavic Ode”) – “Tsarski Slova” (“Royal Words”).


2021 ◽  
Vol 15 (1) ◽  
pp. 23-33
Author(s):  
Natalya Michailovna Mosina ◽  
Nina Valentinovna Kazaeva

The subject of this paper is visual perception verbs in the Erzya-Mordvin and Finnish languages from the point of view of their semantic characteristics in comparison. Depending on the leading role of the sensory system, which, along with the visual system, plays a major role in perception, one distinguishes between auditory, tactile, olfactory and gustatory perception. This verbal group has a sensuous level of interrelations. Being verbs of perception, they are aimed at objects that have physical characteristics, whereas many of them are focused on the perception of concepts. In this regard, the verbs of perception develop a polysemy that goes in different directions. The novelty of the research lies in the comparative study of the lexical level of the Erzya-Mordvin and Finnish languages, which will allow us to tackle some theoretic aspects of Finno-Ugric linguistics in the future. The problem associated with the study of the semantics of perception verbs, or perceptual activity, is of relevance. Therefore, the purpose of this research is to describe the structure of the semantic field of verbs of one aspect of perception, namely the visual one: to determine the nuclear and peripheral verbal units using the material of the languages under study; to describe the system of meanings of verbal lexemes in the Erzya and Finnish languages, to analyze the polysemy of the studied verbal group in each of the above languages; to reveal additional semantic connotations in verbal lexemes; of particular interest is also the comparative study of the specifics of expression of the same semantic meaning in the context of far-related languages, in this case, Erzya and Finnish.


2021 ◽  
pp. 145-156
Author(s):  
Karol Piwoński

The aim of this article is to analyse the position and role of the European Commission in the procedure provided in the regulation on a general regime of conditionality for the protection of the European Union’s budget. For this purpose the scheme of this procedure was analysed, by interpreting the relevant regulations using the dogmatic method and considering opinions of the EU institutions and views of the scholars. A comparative method has also been applied. The new position of the Commission in the procedure for protection of the EU budget has been compared with the position it plays in the existing instruments. The analysis made from the point of view of the position of individual institutions in the new procedure, although it does not allow predicting how they will be implemented. The conducted analysis demonstrates that the European Commission – an institution of Community character – has gained wide competences, and in applying them it has been given a wide range of discretion. On the one hand, the introduced regulations exemplify a new paradigm in creating mechanisms for protection of the rule of law. On the other hand, they raise doubts as to their compliance with EU law. However, they undoubtedly constitute a decisive step towards increasing the effectiveness of the EU's instruments for the rule of law protection.


2020 ◽  
pp. 215-247
Author(s):  
Claudia Yubero Bernabé ◽  
María García Hernández

El sureste de Madrid ha sido recientemente incorporado en la agenda política regional como oportunidad para el reequilibrio turístico del territorio. El objetivo de este trabajo es evaluar el papel de los 6 principales programas acometidos desde su capacidad para generar adhesión entre los agentes locales y articulación de la red de gestión pública del turismo. El resultado del análisis refleja la realidad de unas relaciones intracomarcales débiles y polarizadas por el gobierno regional, así como un sector económico diversificado (que dificulta la adhesión del sector privado a los programas). Solo algunos atisbos de cooperación en “la periferia de la periferia” emergen como efectos positivos de tales programas. Se llama la atención hacia las limitaciones en la construcción de un destino rural de base comarcal en territorios periféricos bajo influencia metropolitana. The southeast of Madrid has recently been incorporated into the regional political agenda as an opportunity for the tourist rebalancing of the territory. The objective of this work is to evaluate the role of the 6 main programs undertaken from the point of view of their capacity to generate articulation in this destination. The result of the analysis reflects the reality of weak relationships at the intra-regional level that are polarized by the regional government, as well as a diversified economic sector (which hinders the engagement of the private sector to public programs). Only a few glimpses of cooperation in “the periphery of the periphery” emerge as positive effects of such programs. Attention is drawn to the limitations in the construction of a rural destination with a regional base in peripheral territories under metropolitan influence.  


Author(s):  
Dmytro Pylypenko ◽  

The article is devoted to the definition of the classification of principles of criminal executive law. The article presents the views and positions of leading domestic scientists on this issue. Scientific concepts on the perception of the factor of systematics of the principles of criminal executive law as one of the key elements of the current branch of criminal executive law are analyzed. The focus is on the key elements of the system of principles of criminal executive law and existing theoretical concepts on this issue. Scientific positions on the quantitative and qualitative component of the system of principles of criminal executive law are given. The article draws attention to the fact that the quantitative criterion of principles is one of the debatable issues among scholars, most of whom tend to the "triad" of principles of criminal executive law, which consists of common law, intersectoral and sectoral principles. The article expresses the author's view on the mandatory consideration of the category of common law principles in the system of principles of criminal executive law as one of the key ones. It is proved that the leading role of these principles is determined by their essential characteristics, which reflect the natural and legal nature of common law principles. This circumstance, in turn, has a decisive influence on the entire legal system of the state. The author's opinion on the synonymous meaning of the categories "principles of law" and "legal principles" is expressed in the article. The scientific position on the existence of both institutions and sub-institutions within the framework of criminal executive law is supported. The author's point of view on the quantitative and qualitative composition of the system of principles of criminal executive law is expressed within the article. It has been proven that the system of these principles should have five key elements. Which include the following principles: common law, intersectoral, sectoral, institutional, subinstitutional.


Animals ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 119 ◽  
Author(s):  
Giovanni Sogari ◽  
Mario Amato ◽  
Ilaria Biasato ◽  
Silvana Chiesa ◽  
Laura Gasco

Recently, insects have received increased attention as an important source of sustainable raw materials for animal feed, especially in fish, poultry, and swine. In particular, the most promising species are represented by the black soldier fly (Hermetia illucens, HI), the yellow mealworm (Tenebrio molitor, TM), and the common house fly (Musca domestica, MD). Although rapid development is expected, insects remain underutilized in the animal feed industry mainly due to technical, financial, and regulatory barriers. In addition, few works have analyzed consumer and stakeholder points of view towards the use of insects as animal feed. In this article, we summarize the main findings of this body of research and provide a discussion of consumer studies regarding the consumption of animals fed with insects. Our review suggests that consumer acceptance will not be a barrier towards the development of this novel protein industry. Furthermore, we conclude that it will be of interest to understand whether the use of this more sustainable feed source might increase consumer willingness to pay for animal products fed with insects and whether the overall acceptability, from a sensory point of view, will be perceived better than conventional products. Finally, the main challenges of the feed farming industry are addressed.


2021 ◽  
Vol 17 (3) ◽  
pp. 106-119
Author(s):  
T. O. Nikolaeva

The participation of platelets in the development of atherothrombosis in acute forms of cardiovascular diseases is generally recognized and well studied, while their significance in the pathogenesis of vascular atherosclerosis, starting from the earliest stages, requires further study. This article analyzes the role of platelets in the pathogenesis of atherosclerosis. Modern views on the pathogenesis of atherosclerosis, platelet-endothelial interactions, molecular mechanisms of platelet activation, platelet immune function from the point of view of the initial stages of atherogenesis, studies of the effect of antiplatelet therapy in primary and secondary prevention of atherosclerosis are considered. The leading role of platelets in the inflammatory and immune reactions of the human body is indicated, which is realized due to a complex of immune receptors, adhesion molecules and mediators.


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